- |||||||||| zonisamide / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Pregnancy-Related Changes in Zonisamide and Oxcarbazepine Clearance (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_338;
Without compensatory dose adjustments, WWE on ZNS or OXC during their pregnancy will likely have lower serum concentrations and a higher risk for seizure worsening.Future directions:Several pregnant women on ZNS and OXC will complete pregnancies in the near future. We will expand our pharmacokinetic analyses to include those women and to assess if there is a correlation between the pregnancy ASM concentrations and seizure control.
- |||||||||| Fycompa (perampanel) / Eisai, carbamazepine / Generic mfg.
Use of Perampanel Without Therapeutic Drug Monitoring (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_284;
Perampanel is metabolized by the CYP3A4&5 system, and use of ASDs that are inducers this system can significantly reduce perampanel concentrations.1 Thus, the prediction of the appropriate dose is difficult and lack of the ability to use therapeutic drug monitoring to guide treatment may lengthen the duration of trial and error seen in this study. In the subject eventually needing 22 mg/day, the dose escalation may have been done more rapidly if it were known that the levels produced by the usual perampanel doses were low.
- |||||||||| levetiracetam / Generic mfg.
Risk of Seizure Recurrence in Patients Who Undergo Meningioma Resection (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_283;
Conclustions Those who presented with preoperative seizures were significantly more likely to develop epilepsy after craniotomy and excision of meningioma when antiseizure medication was discontinued. It might be preferable to continue antiseizure medications for a longer period of time in this patient population.
- |||||||||| tacrolimus / Generic mfg., methylprednisolone / Generic mfg., carbamazepine / Generic mfg.
Efficacy of Intensive Treatment for Intractable Seizures in a Case of Adult-Onset Rasmussen Syndrome (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_281;
We challenged cessation of ZNS, dose increase of CBZ and LTG, and addition of clobazam...Conclustions This case highlights the importance of intensive treatment including oral corticosteroid, T-cell inactivating drugs, IVIG, IVMP, VNS, and AEDs for seizure reduction in therapy of patients with adult-onset RS. Especially, in addition to basic immunotherapy, VNS along with the best-adjusted AEDs should be considered in progressive cases.
- |||||||||| levetiracetam / generics
Preclinical, Journal: Nose-to-brain delivery of levetiracetam after intranasal administration to mice. (Pubmed Central) - Nov 24, 2019
Complementarily, an in vivo intranasal repeated dose toxicity study was performed and no relevant histopathological alterations were observed. The herein proposed non-invasive and safe intranasal administration route allowed a direct nose-to-brain delivery of levetiracetam and is a promising strategy for the treatment of DRE.
- |||||||||| levetiracetam / generics
Journal: Three-dimensional (3-D) printing technology exploited for the fabrication of drug delivery systems. (Pubmed Central) - Nov 23, 2019
However, some drawbacks such as suitability of manufacturing techniques and the available excipients for 3-D printing need to be addressed to ensure simple, feasible, reliable and reproducible 3-D printed fabrication 3-D printing is a revolutionary in pharmaceutical technology to cater the present and future needs of individualised medicines. Nonetheless, more investigations are required on its manufacturing aspects in terms cost effectiveness, reproducibility and bioequivalence.
- |||||||||| aripiprazole / Generic Mfg., olanzapine / Generic Mfg.
Journal: Intellectual Disability and Psychotropic Medications. (Pubmed Central) - Nov 22, 2019
While examining his extremities, joints, and abdomen, there was no obvious source of pain.What are your next steps? How would you support this family, both in the immediate management of his self-injury and long-term care needs for this medically and behaviorally complex adolescent?
- |||||||||| levetiracetam / generics
Clinical, Journal: Levetiracetam versus phenytoin in children with status epilepticus. (Pubmed Central) - Nov 22, 2019
There was no significant adverse effect in both the groups. Levetiracetam is more effective than phenytoin for seizure control for 24 h in children with status epilepticus, and it is safe and effective as a second-line therapy.
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial primary completion date: LEV-AD: Levetiracetam for Alzheimer's Disease-Associated Network Hyperexcitability (clinicaltrials.gov) - Nov 22, 2019
P2a, N=36, Recruiting,
Levetiracetam is more effective than phenytoin for seizure control for 24 h in children with status epilepticus, and it is safe and effective as a second-line therapy. Trial completion date: Dec 2019 --> Aug 2020 | Trial primary completion date: Dec 2019 --> Aug 2020
- |||||||||| levetiracetam / generics
Clinical, Journal: Levetiracetam is a useful alternative to phenytoin for epileptic seizures in children. (Pubmed Central) - Nov 18, 2019
Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet 2019;393:2125-34.This trial was funded by the NIHR Health Technology Assessment Programme (project number 12/127/134).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000790/levetiracetam-vs-phenytoin-in-stopping-childrens-prolonged-epileptic-seizures.
- |||||||||| levetiracetam / generics
Journal: Epilepsia partialis continua following a Western variant tick-borne encephalitis. (Pubmed Central) - Nov 14, 2019
Our patient was treated with intravenous levetiracetam, with a subsequent clinical recovery and a disappearance of epileptiform discharges. The rapid clinic and electroencephalographic response to levetiracetam confirm that it can be a promising therapeutic option for treatment of EPC.
- |||||||||| Fycompa (perampanel) / Eisai, carbamazepine / Generic Mfg.
Preclinical, Journal: AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. (Pubmed Central) - Nov 14, 2019
Incubation with perampanel up-regulated glutamine synthetase expression in glioblastoma cells, whereas treatment with valproic acid and levetiracetam downregulated excitatory amino acid transporter-2 expression. Overall, our data suggest that perampanel acts as an anticonvulsive drug and additionally mediated anti-tumorigenic effects.
- |||||||||| levetiracetam / generics, topiramate / generics
Clinical, Journal: Clinical characteristics of PCDH19-female limited epilepsy (Pubmed Central) - Nov 14, 2019
The efficiency of antiepileptic drugs were 65% (33/51) in sodium valproate, 63% (27/43) in levetiracetam and 59% (20/34) in topiramate. The clinical features of PCDH19-FE are characterized by clustering of seizures, focal seizures in most cases, sensitivity to fever mostly, focal discharges principally in EEG, varied degrees of intellectual disability or movement disorder, combined with autism spectrum disorders in partial and high efficiency in sodium valproate or levetiracetam treatment.
- |||||||||| cefazolin / generics, levetiracetam / generics
T2-WEIGHTED IMAGING MAY BE INDICATIVE OF DRUG DISTRIBUTION IN GLIOBLASTOMA PATIENTS () - Nov 12, 2019 - Abstract #SNO2019SNO_1692;
Grouping samples according the the radiographic appearance revealed that levetiracetam BPR had a similar pattern of values to that of FLAIR intensities and cefazolin BPR had a similar pattern to T2, further supporting the regression analysis results. CONCLUSIONS Local concentrations of drug may be related to T2-weighted signals (T2Gd and T2FLAIR) rather than the gadolinium distribution on T1Gd images.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
CD19-Targeting CAR-T Cell Therapy in CNS Lymphoma (Hall B, Level 2 (Orange County Convention Center)) - Nov 7, 2019 - Abstract #ASH2019ASH_5811;
P1
No grade 3 or higher CRS or NT were noted. Expansion phase enrollment continues currently and an intraventricular route of CAR-T cell delivery will also be evaluated for potentially improved antitumor effects.
- |||||||||| Briviact (brivaracetam) / UCB
Journal: Brivaracetam for epilepsy. (Pubmed Central) - Nov 6, 2019
More than a third of patients with epilepsy cannot achieve freedom from seizures despite taking multiple medications. This article compares brivaracetam to levetiracetam, and provides guidelines for the safe and effective use of brivaracetam.
- |||||||||| risperidone / Generic Mfg., Egis
Clinical, Journal: Levetiracetam-Related Mania-Like Symptoms: An Adolescent Case. (Pubmed Central) - Nov 3, 2019
Hereby, we report mania-like symptoms with levetiracetam use in a 15-year-old boy. Mania-like symptoms emerged 3 weeks after starting levetiracetam and disappeared after adding risperidone to ongoing levetiracetam treatment.
- |||||||||| levetiracetam / generics
Clinical, PK/PD data, Journal: Pharmacokinetic and Pharmacodynamic Evaluation of Intravenous Levetiracetam in Children With Epilepsy. (Pubmed Central) - Nov 2, 2019
Therefore, IV LEV was a well-tolerated and effective alternative in children with acute unprovoked seizures, and models for the PK and time to repeated seizure recurrence after LEV were successfully developed. In particular, the current use of a weight-based IV LEV dosing regimen in pediatric children is practical.
- |||||||||| carbamazepine / Generic Mfg.
Clinical, Journal: Epilepsy in children with congenital hemiparesis secondary to perinatal ictus (Pubmed Central) - Nov 2, 2019
The 30% of children with perinatal stroke and CH present a risk of epilepsy during childhood. Children with ischemic strock have the highest risk, so they will require a follow-up aimed at detecting prematurely the epilepsy and start a treatment.
- |||||||||| levetiracetam / generics
Clinical Factors and Molecular Markers Associated with Postoperative Seizures in Glioblastoma (Ballroom Lawn) - Oct 29, 2019 - Abstract #SNO2019SNO_1232;
We identified several risk factors for postoperative seizures in glioblastoma patients, most of which were clinical (seizure as chief complaint, the antiepileptic chosen for prophylaxis, and extent of resection), while some were molecular and linked to genes whose products have demonstrated links to epileptogeneicity (Chromosome 10, EGFR). These findings may assist physicians in detecting glioblastoma patients that are at higher risk for postoperative seizures and in providing prophylaxis to reduce morbidity.
- |||||||||| levetiracetam / generics
Clinical, Journal: Therapeutic Drug Monitoring of Levetiracetam in Select Populations. (Pubmed Central) - Oct 27, 2019
In patients who are pregnant, LEV levels are likely to decline as pregnancy progresses due to changes in glomerular filtration rate and remain variable in the post-partum period. Routine TDM of levetiracetam is not recommended for all populations, however, it may be beneficial to maintain an individual therapeutic range in patients where the PK of LEV may be altered, such as in patients who are critically ill patients, pregnant, pediatrics or elderly.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Kineret (anakinra) / SOBI
Trial completion date, Trial primary completion date: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants (clinicaltrials.gov) - Oct 22, 2019
P=N/A, N=500, Recruiting,
Routine TDM of levetiracetam is not recommended for all populations, however, it may be beneficial to maintain an individual therapeutic range in patients where the PK of LEV may be altered, such as in patients who are critically ill patients, pregnant, pediatrics or elderly. Trial completion date: Sep 2019 --> Sep 2020 | Trial primary completion date: Sep 2019 --> Sep 2020
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