levetiracetam / Generic mfg. 
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  • ||||||||||  levetiracetam / Generic mfg., Cerebyx (fosphenytoin) / Pfizer, Nobelpharma
    Clinical, Journal:  Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. (Pubmed Central) -  Dec 19, 2019   
    P3
    In the context of benzodiazepine-refractory convulsive status epilepticus, the anticonvulsant drugs levetiracetam, fosphenytoin, and valproate each led to seizure cessation and improved alertness by 60 minutes in approximately half the patients, and the three drugs were associated with similar incidences of adverse events. (Funded by the National Institute of Neurological Disorders and Stroke; ESETT ClinicalTrials.gov number, NCT01960075.).
  • ||||||||||  Zarontin (ethosuximide) / Pfizer
    Preclinical, Journal:  Characterization of Epileptic Spiking Associated With Brain Amyloidosis in APP/PS1 Mice. (Pubmed Central) -  Dec 1, 2019   
    These data show that by only adding a pair of hippocampal deep electrodes and EMG to routine cortical epidural screw electrodes and by taking into account underlying cortical oscillations, one can drastically refine the analysis of cortical spike data. This new approach provides a powerful tool to preclinical testing of potential new treatment options for AD related epilepsy.
  • ||||||||||  levetiracetam / generics
    Journal:  Images: Facial cataplexy with demonstration of persistent eye movements. (Pubmed Central) -  Nov 29, 2019   
    The diagnosis of cataplexy is often missed, due to clinicians being unfamiliar with the findings and the lack of ability to induce sufficient emotional responses to trigger an episode. This example of cataplexy is also quite characteristic of the "cataplectic facies." The ability to observe the infrequently observed phenomenon of cataplexy serves as a reminder that consciousness is preserved, as are extra-ocular muscle movements.
  • ||||||||||  levetiracetam / Generic mfg.
    Efficacy of Levetiracetam in Patients with STXBP1 Encephalopathy with Epilepsy (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1579;    
    Conclustions This study suggests that a group of patients who harbor STXBP1 mutations may respond to levetiracetam favorably. A prospective study with a larger sample size is warranted to confirm these findings.
  • ||||||||||  Fycompa (perampanel) / Eisai, pregabalin / Generic mfg.
    Perampanel-Induced Hair Curling in a Patient with Epilepsy Associated with Pitt Hopkins Syndrome (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1573;    
    We report on a change in hair texture from straight to curly after the introduction of parampanel. There is no clear explanation for this side effect, but it should be discussed with patients taking valproate whenever parampanel is added to the treatment.
  • ||||||||||  Briviact (brivaracetam) / UCB
    Brivaracetam Is More Effective Than Levetiracetam in the Treatment of Experimental Benzodiazepine-Refractory Status Epilepticus (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1551;    
    Studies of acute neuronal injury showed strong neuroprotection in all groups treated with ketamine. Conclustions This experiment demonstrates that brivaracetam in more effective than higher-dose levetiracetam in stopping seizures in this model of RSE, and confirms that combinations of a GABAA receptor allosteric stimulator, a NMDA receptor antagonist and an antiepileptic drug are superior to monotherapy in treating RSE.
  • ||||||||||  lamotrigine liquid oral suspension / OWP Pharma, Trileptal (oxcarbazepine) / Novartis
    Multinodular and Vacuolating Neuronal Tumors of the Temporal Lobe (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1516;    
    She has rare breakthrough seizures on zonisamide...Also, it is unclear whether lesionectomy is sufficient, or if these patients require 2-step epilepsy surgery with invasive monitoring to define epileptic zone margins beyond radiographic margins. Larger multi-center case series would help to answer these questions.
  • ||||||||||  Trileptal (oxcarbazepine) / Novartis
    Awareness of Seizures: Patient Report and RNS Record (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1515;    
    It can also be challenging to differentiate focal seizures without awareness from non-epileptic hypervigilant behaviors by patients’ descriptions. RNS ECog recordings provide further objective electrophysiological evidence, and therefore could be helpful in the diagnosis and treatment.
  • ||||||||||  Briviact (brivaracetam) / UCB
    Use of Brivaracetam in Cases of Acquired Pathologic Myoclonus (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1512;    
    This may suggest the potential of an additive benefit in spite of a similar mechanism of action between levetiracetam and brivaracetam. It is unclear if this effect would be similar in the absence of levetiracetam.
  • ||||||||||  levetiracetam / Generic mfg.
    12p13.33 Microdeletion in Child with Epilepsy and Intellectual Disability (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1498;    
    Further study focusing on careful phenotyping across the lifespan to understand the potential contributions of genetic modifiers and environmental influence on the expressivity of 12p13 deletion and associated characteristics will be invaluable to further determine the impact that 12p13 deletion have on human psychopathology. Figure
  • ||||||||||  Standardized Pathway Implementation for the Treatment of Pediatric Status Epilepticus (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1492;    
    Intranasal midazolam and intravenous lorazepam were specified as first line benzodiazepines (BZD), second line medication options were expanded (see Figure 1), and midazolam was recommended as the initial third line continuous infusion...Considering all second line medications given (with and without SE), more valproic acid (p=0.0001) and less levetiracetam (p=0.008) were provided post-pathway, but this was not associated with reduced frequency of fosphenytoin and phenobarbital dosing (p=0.957)...While different second line medications were prescribed post-pathway, the overall incidence of requiring one and two doses of second-line medication was unchanged. Further analyses will evaluate whether these changes were associated with changes in patient outcome.
  • ||||||||||  levetiracetam / Generic mfg.
    Description and Outcomes of a New Onset Epilepsy Clinic for Adults (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1488;    
    These findings highlight the early identification of adjustment challenges to living with epilepsy. This novel clinic provides an opportunity to offer timely support and intervention in order to encourage acceptance, build resilience, and foster collaborative medical management in the care of PWE .
  • ||||||||||  levetiracetam / Generic mfg., Potiga (ezogabine / retigabine) / Xenon
    Evaluation of the Acute Anticonvulsant Efficacy of Fenfluramine in Mouse Models of Acute and Chronic Seizures (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1387;    
    Conclustions Acute administration of FFA exerted dose-dependent anticonvulsant effect in the mouse MES test, a model of tonic-clonic seizures in humans, an observation aligning with the clinical experience with FFA in Dravet syndrome. FFA may also have activity against focal seizures that secondarily generalize, but effects in different models were inconsistent, suggesting that further studies are warranted.
  • ||||||||||  lacosamide / Generic mfg., levetiracetam / Generic mfg.
    Utility of Inpatient Brain MRI and EEG for New-Onset Seizures: A Five-Year Single Hospital Experience (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1361;    
    Conclustions At our institution, patients presenting with new-onset seizure and a normal neurologic exam typically have additional testing such as MRI brain and EEG as an outpatient, whereas those who present with an abnormal neurologic exam often have these tests done on an inpatient basis. This retrospective chart review of the utility of such testing in the inpatient setting supports the continued practice of obtaining these tests when deemed necessary by a neurologist as they frequently led to a change in acute management or an anticipated change in future outpatient management.
  • ||||||||||  lacosamide / Generic mfg., levetiracetam / Generic mfg.
    Analysis of the Time to Follow Up After Status Epilepticus: A Retrospective Cohort Study (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1357;    
    Patients who did follow up in the outpatient were refractory with monthly seizures on an average of two medications. Those who had a shorter latency to their outpatient visits had a significantly lower average number of seizures which underlines the importance of continued care after the resolution of status epilepticus.
  • ||||||||||  levetiracetam / Generic mfg., Cerebyx (fosphenytoin) / Pfizer, Nobelpharma
    Established Status Epilepticus Treatment Trial (ESETT): Primary Outcome Analysis (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1249;    
    Results Enrollment and data analysis of primary cohort is now complete. Conclustions Analysis of the primary outcome will be presented at the Annual meeting of the American Epilepsy Society.
  • ||||||||||  carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
    Antiepileptic Drug Use and Pregnancy Outcomes in African American Women with Epilepsy (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1164;    
    The other AEDs used were oxcarbazepine (OXC) and phenytoin (PHT)...The only major congenital malformation (carbamazepine) in the cohort also occurred in an AA woman taking carbamazepine...Despite the overall safety profile of newer AEDs reported in national registries, our cohort of mostly AA WWE showed slightly more adverse pregnancy and fetal outcomes which could be due to the low use of pre-conception folic acid use and higher incidence of unplanned pregnancies. Medical provider and patient education is essential in planning pregnancies and prescribing folic acid as AA WWE may be exposed to slightly higher risks of complications in pregnancy than reported in existing national registries.
  • ||||||||||  levetiracetam / Generic mfg.
    Seizure Outcomes in Patients with Concurrent Epilepsy and Multiple Sclerosis (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1163;    
    Future aims include a comparison of seizure outcomes in patients with epilepsy but without MS. These findings might indicate the need for specialized epilepsy care in these group of patients and consideration of surgical management.
  • ||||||||||  levetiracetam / Generic mfg.
    Typical Development in Infants Exposed to Lamotrigine or Levetiracetam In Utero. (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1148;    
    Conclustions This data provides reassuring evidence regarding the early developmental outcome of children exposed in utero to lamotrigine or levetiracetam. Longer term follow up is required to inform on the development of more complex cognitive functioning in children exposed to these medications.
  • ||||||||||  vigabatrin / Generic mfg., levetiracetam / Generic mfg.
    Cannabidiol (CBD) Treatment in Patients with Seizures Associated with Tuberous Sclerosis Complex: A Randomized, Double-blind, Placebo-Controlled Phase 3 Trial (GWPCARE6) (Hall E) -  Nov 28, 2019 - Abstract #AES2019AES_1120;    
    P3
    Patients were randomized (2:2:1:1) to receive a plant-derived pharmaceutical formulation of highly purified CBD in oral solution (Epidiolex®; 100 mg/mL) at 25 mg/kg/d (CBD25) or 50 mg/kg/d (CBD50) dose or matched placebo for 16 wks (4-wk titration and 12-wk maintenance phase)...Valproate (45%), vigabatrin (33%), levetiracetam (29%), and clobazam (27%) were the most common concomitant AEDs...Conclustions CBD reduced TSC-associated seizures vs placebo with similar efficacy between the 25 and 50 mg/kg/d doses. Given that the safety profile of 25 mg/kg/d was superior to 50 mg/kg/d, the lower dose range confers a superior benefit to risk ratio.