levetiracetam / Generic mfg. 
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 185 Diseases   81 Trials   81 Trials   6476 News 


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  • ||||||||||  levetiracetam / Generic mfg.
    Enrollment open:  Pharmacologic Modulation of Hippocampal Activity in Psychosis (clinicaltrials.gov) -  May 11, 2020   
    P2,  N=60, Recruiting, 
    We suggest starting early in childbearing age women with epilepsy. Not yet recruiting --> Recruiting
  • ||||||||||  levetiracetam / Generic mfg.
    Clinical, Journal:  Clinical Features and Evaluation in Terms of Prophylaxis of Patients With Febrile Seizures. (Pubmed Central) -  May 8, 2020   
    One hundred and ninety-five patients were followed without treatment, while 48.6% of the patients were treated with rectal diazepam, 23.3% with sodium valproate, 23.3% with levetiracetam and 4.6% with phenobarbital...Febrile seizures are generally benign and have a low risk of developing epilepsy. Determining the risk factors is essential for the treatment and follow-up plan.
  • ||||||||||  ethosuximide / Generic mfg.
    Preclinical, Journal:  Antiepileptogenic effects of Ethosuximide and Levetiracetam in WAG/Rij rats are only temporary. (Pubmed Central) -  May 1, 2020   
    Further refinement of the methodology is needed to identify signals in reports with ages under 2 years and to capture signals specific to the paediatric population as a risk group. Overall, these results demonstrate that the antiepileptogenic effects of both ethosuximide and levetiracetam on absence seizure development and associated depressive-like behaviour in this model are only temporary.
  • ||||||||||  levetiracetam / Generic mfg.
    Enrollment closed:  Treating Hyperexcitability in AD With Levetiracetam (clinicaltrials.gov) -  Apr 24, 2020   
    P2,  N=85, Active, not recruiting, 
    Trial completion date: Oct 2020 --> May 2020 Recruiting --> Active, not recruiting
  • ||||||||||  Vimpat (lacosamide) / UCB, Daiichi Sankyo, levetiracetam / Generic mfg.
    Journal:  Status epilepticus - time is brain and treatment considerations. (Pubmed Central) -  Apr 23, 2020   
    Recruiting --> Active, not recruiting Randomized clinical trials are needed to determine the role for newer generation anticonvulsants and nonpharmacologic modalities for the treatment of epilepticus remains and evaluate the long-term outcomes associated with continuous anesthetics.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Behavioral Changes Under Levetiracetam Treatment in Dogs. (Pubmed Central) -  Apr 23, 2020   
    One quarter of the dogs without pre-existing behavioral abnormalities developed behavioral changes associated with the administration of LEV (10/40). Based on these results, the authors conclude that behavioral changes can occur in dogs being administered LEV, and this should be taken into consideration when discussing treatment options with owners.
  • ||||||||||  levetiracetam / Generic mfg.
    Clinical, Journal:  Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report. (Pubmed Central) -  Apr 22, 2020   
    Whereas the new human astrovirus subtypes have been recently associated with central nervous system infection, this is the first case of encephalitis in an immunocompetent child due to classic human astrovirus. Considering that classic human astroviruses are the third most common etiological agents of viral gastroenteritis in children, we believe that human astroviruses as causative agents for central nervous system infections should be considered more often, especially in children and infants with preceding gastroenteritis.
  • ||||||||||  lacosamide / Generic mfg., levetiracetam / Generic mfg.
    Trial suspension:  Seizure Prophylaxis in Patients With Glioma or Brain Metastasis (clinicaltrials.gov) -  Apr 22, 2020   
    P2,  N=232, Suspended, 
    Considering that classic human astroviruses are the third most common etiological agents of viral gastroenteritis in children, we believe that human astroviruses as causative agents for central nervous system infections should be considered more often, especially in children and infants with preceding gastroenteritis. Recruiting --> Suspended
  • ||||||||||  levetiracetam / Generic mfg.
    Review, Journal:  Forced normalization: A systematic review. (Pubmed Central) -  Apr 16, 2020   
    Antipsychotic drug use does not predict complete resolution of psychiatric symptoms in comparison with AED withdrawal. Although there is a positive response to treatment in patients with FN triggered by drugs, the prognosis is obscure in patients with surgery triggered FN.
  • ||||||||||  carbamazepine / Generic mfg.
    Retrospective data, Review, Journal:  The medical treatment of epilepsy in the elderly: A systematic review and meta-analysis. (Pubmed Central) -  Apr 15, 2020   
    There is some evidence for AED use in the elderly with epilepsy. More evidence is required, comparing newer AEDs to prior generations as well as examining the effects of determinants such as frailty, to guide clinicians when treating this rapidly growing patient population.
  • ||||||||||  lacosamide / Generic mfg., levetiracetam / Generic mfg.
    Trial completion date, Trial primary completion date:  Seizure Prophylaxis in Patients With Glioma or Brain Metastasis (clinicaltrials.gov) -  Apr 15, 2020   
    P2,  N=232, Recruiting, 
    Mechanistically, LEV inhibited the JAK2-STAT3 signaling pathway and reduced neuronal injury around the hematoma, and ameliorated brain edema, all of which promoted recovery of nerve function after hemorrhage. Trial completion date: Jan 2021 --> Jan 2023 | Trial primary completion date: Jan 2021 --> Jan 2023
  • ||||||||||  carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
    Clinical, Review, Journal:  Clinical characteristics and epilepsy in genomic imprinting disorders: Angelman syndrome and Prader-Willi syndrome. (Pubmed Central) -  Apr 11, 2020   
    Notably, carbamazepine, oxcarbazepine, and vigabatrin should be avoided, since these may induce nonconvulsive status epilepticus...Early diagnosis and teamwork intervention, including geneticists, neurologists, rehabilitation physicians, and pulmonologists, are important. Epilepsy is common in patients with AS, and after proper treatment, seizures could be effectively controlled in late childhood or early adulthood for both AS and PWS patients.
  • ||||||||||  carbamazepine / Generic mfg.
    [VIRTUAL] Epilepsy and pediatric multiple sclerosis (Room Amsterdam) -  Apr 9, 2020 - Abstract #EAN2020EAN_2287;    
    As epilepsy started before the MS onset and before DMT using in some patients, so seizures can be one of the clinical disease manifestations. Epilepsy in MS is focal and well treatable.
  • ||||||||||  vigabatrin / Generic mfg., levetiracetam / Generic mfg.
    [VIRTUAL] Kabuki syndrome: epilepsy features (Room: Screen A4) -  Apr 9, 2020 - Abstract #EAN2020EAN_2090;    
    Therapy with vigabatrin, levetiracetam, valproic acid didn’t achieve seizure control. This clinical case has shown a refractory form of epilepsy rare for genetic Kabuki syndrome - West syndrome with the early beginning of spasms with the good answer to hormonal therapy and insufficient efficiency of vigabatrin and other AEDs
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] SCN1A mutation and focal epilepsy: diagnosis and application in adults (Room: Screen A4) -  Apr 9, 2020 - Abstract #EAN2020EAN_2087;    
    After pregnancy, her treatment was changed to Levetiracetam. In adults with epilepsy and personal or familiar history of febrile seizures during childhood, the study of the SCN1A gene should be considered, as it may have prognostic and therapeutic implications, both in patients and their offspring.