- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg.
Enrollment open: Seizure Prophylaxis in Patients With Glioma or Brain Metastasis (clinicaltrials.gov) - Sep 30, 2020
P2, N=232, Recruiting,
These findings reveal the high clinical relevance, and ensuant critical need for further investigation into these drug combinations, particularly focusing on valproic acid prescribing with factor Xa inhibitors. Suspended --> Recruiting
- |||||||||| levetiracetam / Generic mfg.
Enrollment open: R33: Levetiracetam in Early Psychosis (clinicaltrials.gov) - Sep 24, 2020
P2, N=84, Recruiting,
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- |||||||||| levetiracetam / Generic mfg.
Journal: Levetiracetam treatment ameliorates LRRK2 pathological mutant phenotype. (Pubmed Central) - Sep 24, 2020
Interestingly, LEV significantly counteracts the effect of LRRK2 G2019S pathological mutant expression in three different cellular experimental models. Our data strongly suggest that LEV treatment may have a neuroprotective effect on LRRK2 pathological mutant toxicity and that LEV repositioning could be a viable compound for PD treatment.
- |||||||||| levetiracetam / Generic mfg.
Journal: Levetiracetam for Benzodiazepine-Refractory Status Epilepticus. (Pubmed Central) - Sep 24, 2020
Our data strongly suggest that LEV treatment may have a neuroprotective effect on LRRK2 pathological mutant toxicity and that LEV repositioning could be a viable compound for PD treatment. No abstract available
- |||||||||| levetiracetam / Generic mfg.
Journal: Breach Rhythm May Be Suppressed as a Form of Todd's Paralysis. (Pubmed Central) - Sep 23, 2020
When seizure activity was suppressed by anticonvulsive medication with levetiracetam, breach rhythm appeared...Therefore, it is reasonable to assume that it was in some way suppressed by the seizure activity in our primary EEG recordings. The appearance of the breach rhythm after the complete suppression of seizure activity by antiepileptic drug treatment shows that breach rhythm is not purely the result of a skull defect but is related to the functional state of the brain tissue beneath.
- |||||||||| zonisamide / Generic mfg., levetiracetam / Generic mfg.
[VIRTUAL] A Case of Lance Adams Syndrome with See-Saw Nystagmus () - Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_1209;
Our patient with LAS and associated SSN expands the spectrum of etiology of SSN and to our knowledge this is the first PHM case with combination of SSN. There are many etiologies of SSN, but the proposed mechanism in our case is inactivation of the torsional eye-velocity integrator, the interstitial nucleus of Cajal, with sparing of the torsional fast-phase generator, the rostral interstitial nucleus of MLF.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg., Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
[VIRTUAL] Frontal Cavernous angioma manifested as acquired dystonic tremor: Two case reports () - Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_348;
He was trailed on Levetiracetam, Lamotrigine, Clonazepam etc. with no benefit and EEG was normal...She was also treated with Eslicarbazepine, Levetiracetam for suspected EPC, thereafter with Trihexyphenidyl with no improvement... Our two atypical cases strengthen our knowledge about slow dystonic tremor as an uncommon feature of frontal cavernoma.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
[VIRTUAL] Caspr2 antibody associated spinal myoclonus () - Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_309;
Differentiation from psychogenic myoclonus may be difficult. Diagnosis should trigger a search for underlying malignancy. This abstract has been submitted, but not yet accepted, to be presented at the ANZAN Annual Meeting 2020.
- |||||||||| risperidone / Generic mfg., Egis
[VIRTUAL] Novel GNO1 mutation in monozygotic twins responsive to DBS () - Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_162;
Various medications including benzodiazepines, benztropine, risperidone, tetrabenazine, topiramate and levetiracetam were used in order to abolish hyperkinetic movements without significant benefit. Neurodevelopmental disorders with involuntary movements are becoming increasingly recognized as GNAO1 mutation-associated neurological disorders and DBS should perhaps be considered earlier in the course to prevent prolonged hospitalizations and other potential complications.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] A Young Patient with Paroxysmal Choreoathetosis () - Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_104;
The clinical description and phenomenology of this movement disorder is not yet defined with very few cases report in the literature (less than 60 patients to our knowledge). Here we present a detailed video case of a patient with paroxysmal choreoathetosis with epilepsy and global developmental delay.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Choreoathetosis post lentiform nucleus ischemic Stroke: A unique pathology and presentation () - Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_103;
Chorea is characterized by irregular, purposeful, jerky, rapid, brief and unstained movements which can involve whole body or one side of body with preference for distal body parts. Lesion of subthalamic nucleus causes reduction in Globus pallidus inhibitory output in Thalamus which in return results in excitation of cortex with resultant hyperkinetic movement disorders.
- |||||||||| levetiracetam / Generic mfg.
Review, Journal: Is there a link between bacteriuria and a reversible encephalopathy in dogs and cats? (Pubmed Central) - Sep 20, 2020
Bacteriological culture of urine was positive in each animal and neurological deficits improved or resolved with initiation of antibiosis ± fluid therapy and levetiracetam. While further studies are needed to definitively confirm or refute the link between bacteriuria and a reversible encephalopathy, urine bacteriological culture should be considered in veterinary patients presented with acute onset forebrain neuro-anatomical localisation, even in the absence of clinical signs of lower urinary tract inflammation.
- |||||||||| ondansetron / Generic mfg., amitriptyline / Generic mfg.
Clinical, Review, Journal: Management of cyclic vomiting syndrome in adults: Evidence review. (Pubmed Central) - Sep 19, 2020
While further studies are needed to definitively confirm or refute the link between bacteriuria and a reversible encephalopathy, urine bacteriological culture should be considered in veterinary patients presented with acute onset forebrain neuro-anatomical localisation, even in the absence of clinical signs of lower urinary tract inflammation. This evidence review helps inform the accompanying guideline for the management of adults with CVS which is aimed at helping clinicians, patients, and policymakers, and should improve patient outcomes.
- |||||||||| ondansetron / Generic mfg., amitriptyline / Generic mfg.
Clinical, Review, Journal: Guidelines on management of cyclic vomiting syndrome in adults by the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association. (Pubmed Central) - Sep 19, 2020
For acute attacks, the committee conditionally recommends using serotonin antagonists, such as ondansetron, and/or triptans, such as sumatriptan or aprepitant to abort symptoms...The committee recommended screening and treatment for comorbid conditions such as anxiety, depression, migraine headache, autonomic dysfunction, sleep disorders, and substance use with referral to appropriate allied health services as indicated. Techniques like meditation, relaxation, and biofeedback may be offered as complementary therapy to improve overall well-being and patient care outcomes.
- |||||||||| Briviact (brivaracetam) / UCB
Clinical, Journal: Brivaracetam efficacy and safety in focal epilepsy. (Pubmed Central) - Sep 17, 2020
Behavioral adverse effects seemed less common that with LEV, and most patients switched to BRV after experiencing behavioral adverse effects on LEV reported improvement. Prior or anticipated intolerability to LEV is the strongest indication for BRV in clinical practice.
- |||||||||| NN1213 / Novo Nordisk
Trial completion date, Trial primary completion date: SPAR: Seizure Prophylaxis in Aneurysm Repair (clinicaltrials.gov) - Sep 15, 2020
P4, N=79, Active, not recruiting,
Prior or anticipated intolerability to LEV is the strongest indication for BRV in clinical practice. Trial completion date: Jun 2020 --> Jun 2024 | Trial primary completion date: Jun 2020 --> Jun 2024
- |||||||||| lactulose / Generic mfg., levetiracetam / Generic mfg.
[VIRTUAL] Hyperammonemia Over 500 µmol/L as a Cause of the Seizure () - Sep 15, 2020 - Abstract #ACG2020ACG_2852;
Early detection and treatment of hyperammonemia with medical and supportive management is crucial. Ammonia is a dialyzable agent and can be easily removed via renal replacement therapy.
- |||||||||| Flagyl (metronidazole) / SLA
[VIRTUAL] A Case Description of Clostridium Glycolicum and Clostridium Paraputrificum Bacteremia From Complicated Diverticulitis () - Sep 15, 2020 - Abstract #ACG2020ACG_1122;
She was empirically treated with levetiracetam/fosphenytoin for possible seizures and vancomycin/meropenem/metronidazole for sepsis...She was treated with ceftriaxone and metronidazole for 3 weeks given her allergies to penicillin and ciprofloxacin...In our case, sigmoid diverticulitis could be considered a pre-disposing factor but given her past history she will need an outpatient work-up rule out malignancy. This case should heighten the awareness of these particular clostridium species as a clinically important organism and every effort should be made to investigate them further.
- |||||||||| levetiracetam / Generic mfg.
Enrollment closed: 1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients (clinicaltrials.gov) - Sep 15, 2020
P4, N=82, Active, not recruiting,
This case should heighten the awareness of these particular clostridium species as a clinically important organism and every effort should be made to investigate them further. Recruiting --> Active, not recruiting
- |||||||||| Briviact (brivaracetam) / UCB
Retrospective data, Journal: Brivaracetam substituting other antiepileptic treatments: Results of a retrospective study in German epilepsy centers. (Pubmed Central) - Sep 12, 2020
Incidences of behavioral AEs before (3-month baseline) and after brivaracetam initiation in patients who withdrew levetiracetam were 19.2% and 8.0%, respectively (5.0% and 7.7% in patients who withdrew other AEDs). Brivaracetam was effective and well-tolerated in patients who required a change in AED drug regimen and initiated adjunctive brivaracetam in German clinical practice.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Seizures and sepsis. Think outside the brain. A case report. () - Sep 12, 2020 - Abstract #EUSEM2020EUSEM_876;
In view of the tachycardia, tachypnea, metabolic acidosis and seizures, empirical antibiotics were given to the patient and they were loaded with intravenous levetiracetam...It is also worth remembering a detailed clinical assessment by the emergency physician will avoid them falling trap to cognitive biases like anchoring bias. Sepsis induced brain dysfunction has an increased morbidity and mortality and can often be multifactorial
- |||||||||| meropenem / Generic mfg., Daewon Pharmaceutical
[VIRTUAL] When Opportunity Strikes: A Case Of A 67-year-old With History Of Cardiac Transplant Developing New-onset Seizures (Poster Hall - ePosters) - Sep 10, 2020 - Abstract #HFSA2020HFSA_387;
Case Description : A 67-year-old male 4 months post orthotopic heart transplant (OHT), without induction therapy, tolerating appropriate immunosuppression and antimicrobial prophylaxis presented to an outside hospital (OSH) for new-onset seizures and fevers of up to 104 o F. At the OSH he was started on Keppra and underwent a brain MRI showing enhancing masses with edema, suspicious for metastatic disease with primary lung carcinoma, as the patient had a known lung nodule pre-OHT...He began IV Meropenem and Bactrim since all evidence was suggestive of infection and not malignancy...These infections can lead to clinical manifestations that may be mistaken for malignancy at centers lacking expertise in transplant medicine. Transplant patients should be aware of the risks of chronic immunosuppression therapy and counseled to return to the implanting center for serious conditions.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo, levetiracetam / Generic mfg.
Clinical, Journal: Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy. (Pubmed Central) - Sep 10, 2020
The combination therapy greatly increased the quality of life score and the 1-year drug retention rate. To sum up, levetiracetam tablets combined with LCM significantly enhanced the therapeutic effect and improved the neural function in patients with refractory partial seizures, however this therapy may cause a slight adverse effect on BMD and bone metabolism in the short term.
- |||||||||| dexamethasone / Generic mfg., dexamethasone oral solution, dexamethasone intensol oral solution / Generic mfg., levetiracetam / Generic mfg.
Journal: Phenytoin Seizure Prophylaxis Therapy Resulting in Severe Thrombocytopenia After Brain Tumor Debulking Surgery. (Pubmed Central) - Sep 9, 2020
CONCLUSIONS Phenytoin-induced thrombocytopenia is considered a rare event, but it has life-threatening consequences. The first and cornerstone management of this event is the cessation of phenytoin, followed by consideration of appropriate management based on the level of thrombocytopenia severity, and avoiding concomitant therapy of phenytoin and the use of dexamethasone as neurosurgical-related seizure prophylaxis.
- |||||||||| meropenem / Generic mfg., Daewon Pharmaceutical
[VIRTUAL] Drug reaction with eosinophilia and systemic symptoms complicated by haemophagocytic lymphohistiocytosis: is screening required? () - Sep 9, 2020 - Abstract #BAD2020BAD_39;
The admission was complicated by pneumonia, requiring vancomycin and piperacillin with tazobactam, later switching to meropenem...Prednisolone 60 mg daily was initiated, but, despite this, the patient continued to deteriorate, with persistent high fevers and the development of multiorgan failure...A joint decision to treat the patient with dexamethasone and anakinra was made, following which gradual clinical and biochemical improvement was observed, and the patient was able to leave the ICU after a further 3 weeks...Distinguishing findings in HLH include hyperferritinaemia, hypertriglyceridaemia, hypofibrinogenaemia and the presence of haemophagocytosis on biopsy of lymphoid organs. We propose using these features as the basis for screening for HLH in all critically ill patients with DRESS.
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial primary completion date: LEV-AD: Levetiracetam for Alzheimer's Disease-Associated Network Hyperexcitability (clinicaltrials.gov) - Sep 3, 2020
P2a, N=36, Active, not recruiting,
We propose using these features as the basis for screening for HLH in all critically ill patients with DRESS. Trial primary completion date: Aug 2020 --> Dec 2020 | Trial completion date: Aug 2020 --> Dec 2021
- |||||||||| levetiracetam / Generic mfg.
Journal: The synaptic vesicle glycoprotein 2: structure, function, and disease relevance. (Pubmed Central) - Sep 1, 2020
First, SV2A plays a role in neuronal excitability and as such is the specific target for the antiepileptic drug levetiracetam...Thus, SV2 proteins are intriguing in their potentially diverse roles within the presynaptic terminal, and several recent developments have enhanced our understanding and appreciation of the protein family. Here we review the structure and function of SV2 proteins as well as their relevance to disease and therapeutic development.
- |||||||||| levetiracetam / Generic mfg.
Journal: Investigating and managing neonatal seizures in the UK: an explanatory sequential mixed methods approach. (Pubmed Central) - Aug 29, 2020
Our data has helped reveal some of the reasons for current practice and decision making. Suggestions to improve certainty include: educational initiatives to improve the ability of neonatal staff to describe suspicious events, greater use of video, closer working between neonatologists and neurologists, further research, and a national discussion to reach a consensus on a standardised approach to managing neonatal epileptic seizures.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy. (Pubmed Central) - Aug 28, 2020
Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal, Monotherapy: Effectiveness of Levetiracetam Monotherapy in Pediatric Patients With Epilepsy. (Pubmed Central) - Aug 27, 2020
About one-third (32.4%) of patients reported adverse effects, with irritability, moodiness, and depression being the most common. Despite a number of patients that reported adverse events, levetiracetam monotherapy was found to be potentially effective in this cohort of children with epilepsy and warrants further, prospective studies.
- |||||||||| Briviact (brivaracetam) / UCB
Clinical, Journal: Outcomes in three cases after brivaracetam treatment during pregnancy. (Pubmed Central) - Aug 27, 2020
Despite a number of patients that reported adverse events, levetiracetam monotherapy was found to be potentially effective in this cohort of children with epilepsy and warrants further, prospective studies. While the absence of major congenital malformations in these cases is encouraging, further data are needed to determine the safety of brivaracetam in pregnancy.
- |||||||||| levetiracetam / Generic mfg.
Journal: Intravascular large B-cell lymphoma with multiple intracranial hemorrhages diagnosed by brain biopsy (Pubmed Central) - Aug 27, 2020
Levetiracetam was administered to prevent the seizures that were assumed to occur due to the cerebral cortex lesions; however, convulsive seizure recurred with a depressed level of consciousness...Biopsy of a new cerebral lesion was carried out and the lesion was pathologically diagnosed as IVLBCL with hemorrhages. IVLBCL should be noted as one of the differential diagnoses not only in case with multiple infarct lesions, but also in case with multiple hemorrhages.
- |||||||||| leucovorin calcium / Generic mfg., methotrexate / Generic mfg.
[VIRTUAL] TOXICITY PROFILE AND CLEARANCE OF HIGH DOSE METHOTREXATE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA - EXPERIENCE FROM A TERTIARY CANCER CENTRE OF INDIA (Foyer) - Aug 26, 2020 - Abstract #SIOP2020SIOP_891;
Significant drug interactions included co-administration of oral voriconazole in 8.7%(n=36) infusions resulting in skin rash, prolonged hepatic dysfunction, prolonged MTX clearance and oral levetiracetam in 3.4%(n=16) infusions resulting in prolonged MTX clearance. Conclusions HDMTX can be safely administered in children with ALL by implementing strict hydration protocol, alkalinisation, administration by trained staff nurse, drug level monitoring at 54-hour time point and adjusted dosing of leucovorin rescue with serious toxicities limited to less than 10% of the infusions.
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