levetiracetam / Generic mfg. 
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 185 Diseases   81 Trials   81 Trials   6476 News 


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  • ||||||||||  Zerbaxa (ceftolozane /tazobactam) / Merck (MSD)
    [VIRTUAL] A Triple Threat? Baclofen Toxicity and Posterior Reversible Encephalopathy Syndrome in the Setting of AKI () -  Oct 27, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_3767;    
    The initial presenting signs of infection had been improving with ceftolozane and tazobactam...Levetiracetam, antihypertensives, and continued antibiotic therapy were provided...The role of AKI in the development of PRES is not entirely understood; however, the hypertension-hyperperfusion theory remains a leading consideration in our patient. Management decisions in our patient included forgoing dialysis, blood pressure control, and the use of anti-seizure medications.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Status epilepticus 2020. (Pubmed Central) -  Oct 26, 2020   
    No abstract available No abstract available
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] Efficacy of anticonvulsant therapy in glioma patients () -  Oct 24, 2020 - Abstract #SNO2020SNO_581;    
    In this single-institution retrospective cohort study, we evaluate the effect of commonly prescribed anticonvulsant levetiracetam on incidence of post-operative seizures and overall survival in primary glioma patients...Furthermore, anti-convulsant therapies do not demonstrate a survival benefit in our study. These results provide a rationale for re-evaluating the use of anti-convulsant medications in glioma patients that do not have seizure symptoms.
  • ||||||||||  Journal:  Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? (Pubmed Central) -  Oct 24, 2020   
    In addition, there are preclinical antiepileptogenic data for anakinra, rapamycin, fingolimod, and erythropoietin, although these medications have potential for more serious side effects...Here, we review animal and human antiepileptogenic evidence for these medications. We highlight the gaps in our knowledge for each molecule that need to be filled in order to consider clinical translation, and we suggest a platform of preclinical antiepileptogenesis evaluation of potentially repurposable molecules or their combinations going forward.
  • ||||||||||  levetiracetam low dose (AGB101) / AgeneBio
    Trial completion date, Trial primary completion date:  Effects of Low-dose Levetiracetam on Clinical Symptoms, Cognition and Hippocampal Hyperactivity in Schizophrenia (clinicaltrials.gov) -  Oct 22, 2020   
    P=N/A,  N=30, Recruiting, 
    We highlight the gaps in our knowledge for each molecule that need to be filled in order to consider clinical translation, and we suggest a platform of preclinical antiepileptogenesis evaluation of potentially repurposable molecules or their combinations going forward. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
  • ||||||||||  Trileptal (oxcarbazepine) / Novartis
    Journal:  A Rapid LC-MS-MS Method for the Quantitation of Anti-Epileptic Drugs in Urine. (Pubmed Central) -  Oct 21, 2020   
    The resulting concentration data was curated to eliminate specimens that could indicate an individual was non-compliant with their therapy (i.e., positive for illicit drugs) and yielded between 20 and 1700 concentration points from the patient specimens, depending on the analyte. The resulting raw quantitative urine data set is presented as preliminary reference ranges to assist with interpreting urine drug concentrations for the nine aforementioned antiepileptic medications and metabolites.
  • ||||||||||  levetiracetam / Generic mfg.
    Retrospective data, Review, Journal:  Levetiracetam for convulsive status epilepticus in childhood: systematic review and meta-analysis. (Pubmed Central) -  Oct 20, 2020   
    The resulting raw quantitative urine data set is presented as preliminary reference ranges to assist with interpreting urine drug concentrations for the nine aforementioned antiepileptic medications and metabolites. Levetiracetam is comparable to phenytoin, fosphenytoin and valproate as a second line treatment of paediatric CSE.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Kineret (anakinra) / SOBI
    Enrollment change, Trial completion date, Trial primary completion date:  Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants (clinicaltrials.gov) -  Oct 19, 2020   
    P=N/A,  N=1600, Recruiting, 
    Studies from larger cohorts may clarify the optimal treatment and pathophysiology of ARIA. N=500 --> 1600 | Trial completion date: Sep 2020 --> Sep 2021 | Trial primary completion date: Sep 2020 --> Sep 2021
  • ||||||||||  lithium / Generic mfg., ibuprofen / Generic mfg., quetiapine / Generic mfg.
    [VIRTUAL] CRITICAL CARE COMPLICATIONS OF LITHIUM TOXICITY () -  Oct 12, 2020 - Abstract #CHEST2020CHEST_2755;    
    Here, we discuss the critical care management of two cases of lithium toxicity-associated seizures.CASE PRESENTATION: Case 1:A 54-year-old female with schizophrenia on lithium and quetiapine recently initiated on a course of ibuprofen for sciatica presented with nausea, vomiting, diarrhea, and altered sensorium...Her metabolic encephalopathy slowly improved, with eventual transfer to the psychiatric ward for further medication titration.Case 2:A 67-year-old female with bipolar disorder on lithium and haloperidol recently discharged after titration of medications in the psychiatric ward presented with altered sensorium...The trachea was intubated and anti-epileptics were initiated including a midazolam drip, levetiracetam load, lacosamide, and fosphenytoin... Lithium is a high-risk medication necessitating regular monitoring, with potential severe neurotoxicity.
  • ||||||||||  vancomycin / Generic mfg., levetiracetam / Generic mfg.
    [VIRTUAL] A RARE CAUSE OF RHABDOMYOLYSIS DUE TO SEVERE HYPERNATREMIA () -  Oct 12, 2020 - Abstract #CHEST2020CHEST_2725;    
    He is compliant with Keppra...He received 3 liters of normal saline in the emergency room and was started on vancomycin and cefepime... It is important to consider rhabdomyolysis in the differential diagnosis of patients with severe hypernatremia especially in patients with acute renal failure.
  • ||||||||||  ceftriaxone / Generic mfg.
    [VIRTUAL] ANTI-NMDA RECEPTOR ENCEPHALITIS: A DIAGNOSTIC CHALLENGE FOR THE INTERNIST () -  Oct 12, 2020 - Abstract #CHEST2020CHEST_1424;    
    Her past history was significant for seizures two years back, managed with valproic acid 500 mg BID and levetiracetam 500 mg BID...Initial treatment with ceftriaxone, acyclovir and dexamethasone was started... Early diagnosis and prompt initiation of treatment can potentially limit the worsening of psychiatric and neurological symptoms over the course of the disease and in our patient may have led to a better outcome.
  • ||||||||||  [VIRTUAL] Gabapentin Toxicity in Existing and Developing Renal Failure (On-Demand) -  Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_3019;    
    There seems to be a graded increase in toxicity with the corresponding deterioration of renal function. Heightened awareness about medication toxicity developing in renal failure is important to prevent significant adverse effects.
  • ||||||||||  Trileptal (oxcarbazepine) / Novartis
    Journal:  Valproic Acid Impacts the Growth of Growth Plate Chondrocytes. (Pubmed Central) -  Oct 9, 2020   
    The COX-2 inhibitor NS-398 attenuated the effects of VPA up-regulating COX-2 expression and decreased VPA-induced caspase 3 expression. The use of VPA in children should be closely monitored or replaced, where appropriate, by AEDs which do not apparently affect the growth plate chondrocytes.
  • ||||||||||  Fycompa (perampanel) / Eisai, Catalyst Pharma
    Enrollment open:  Effect of Perampanel on Peritumoral Hyperexcitability in HGG (clinicaltrials.gov) -  Oct 5, 2020   
    P1/2,  N=20, Recruiting, 
    The importance of its pharmacokinetic monitoring in clinical pharmacy stands out, thereby enabling the optimization of antiepileptic drug therapy. Not yet recruiting --> Recruiting
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] Levetiracetam for Sleep Disturbances in Huntington’s Disease () -  Sep 30, 2020 - Abstract #ANA2020ANA_612;    
    Currently, enough clinical evidence does not exist to support the use of levetiracetam or its analog piracetam in HD patients suffering from sleep disorders. Levetiracetam may provide some clinical benefits in promoting sleep efficiency, but additional research to understand the long-term effects of this medication on HD patients is required.
  • ||||||||||  Vimpat (lacosamide) / UCB, Daiichi Sankyo, levetiracetam / Generic mfg.
    [VIRTUAL] A Case Report of Mesial Temporal Lobe Epilepsy Misdiagnosed as Cyclic Vomiting Syndrome () -  Sep 30, 2020 - Abstract #ANA2020ANA_497;    
    The aforementioned patient was diagnosed with cyclic vomiting syndrome due to stereotypical episodes of vomiting and marijuana use. It is imperative to include epileptic seizures on the list of possible diagnoses in patients with otherwise unexplained nausea and vomiting to allow for earlier diagnosis and treatment.
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] A Rare Case of Autonomic Epilepsy () -  Sep 30, 2020 - Abstract #ANA2020ANA_488;    
    Autonomic epilepsy is diagnosed when the primary manifestation is autonomic symptoms with or without impairment of consciousness. Recognition is key, antiepileptic medications are effective and seizure control is important to prevent complications like sudden unexplained death.
  • ||||||||||  Fycompa (perampanel) / Eisai
    [VIRTUAL] Late Perampanel Treatment Stops Severe Midazolam-Refractory Status Epilepticus () -  Sep 30, 2020 - Abstract #ANA2020ANA_486;    
    Perampanel is potent in stopping midazolam- refractory SE even when given 60 min following SE onset. Used as a late second-line treatment, perampanel is more effective in terminating SE than valproate, levetiracetam, fosphenytoin or lacosamide in this animal model of severe benzodiazepine-refractory SE.