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185 Diseases |  |
81 Trials |
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81 Trials |  |
6476 News |  |
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- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Epilepsy and pregnancy. Experience in a Latin American neurology center. () - Nov 28, 2020 - Abstract #AES2020AES_363;
Patients who worsened their seizure frequency had focal epilepsy. There was a 9% rate of maternal complications during pregnancy.
- levetiracetam / Generic mfg.
[VIRTUAL] Paroxysmal kinesigenic dyskinesia and early infantile epileptic encephalopathy in a boy heterozygous for the de novo R853Q mutation (c.2558 G>A) in the SCN2A gene. () - Nov 28, 2020 - Abstract #AES2020AES_354;
SCN2A should be added to the list of channelopathies with PD-epilepsy association. Funding: No funding was received .
- levetiracetam / Generic mfg.
[VIRTUAL] Towards developing an EEG biomarker indicative for the efficacy of antiseizure drug. () - Nov 28, 2020 - Abstract #AES2020AES_352;
Nevertheless, prospective studies are needed to assess the added value of the developed EEG biomarker in a clinical setting. Funding: Pieter van Mierlo is funded by the Swiss National Science Foundation grant No.
- Vimpat (lacosamide) / UCB, Daiichi Sankyo
[VIRTUAL] Lacosamide and Levetiracetam for the treatment of Non-Convulsive Status Epilepticus () - Nov 28, 2020 - Abstract #AES2020AES_324;
However, levetiracetam was found to be more effective when given as a third line agent or later. Our study shows lacosamide to be valid as a therapeutic option in the treatment of NCSE as compared with levetiracetam.
- levetiracetam / Generic mfg.
[VIRTUAL] Once-daily levetiracetam extended-release form improves medication compliance in adolescent epilepsy patients () - Nov 28, 2020 - Abstract #AES2020AES_322;
The reduced number of medication doses improved patient satisfaction and medication compliance. Funding: None.
- Vimpat (lacosamide) / UCB, Daiichi Sankyo
[VIRTUAL] Safety and Tolerability of Lacosamide for Neonatal Seizures in Preterm Infants () - Nov 28, 2020 - Abstract #AES2020AES_311;
Preliminary analysis of vEEG data shows a trend towards a greater than 50% decrease in seizure burden after LCS administration. Prospective randomized clinical trials are needed to further characterize its efficacy in preterm and term infants.
- Cerebyx (fosphenytoin) / Pfizer, Nobelpharma
[VIRTUAL] Post-Traumatic Seizure Prophylaxis After Mild Traumatic Brain Injury: Analysis of Practice Patterns () - Nov 28, 2020 - Abstract #AES2020AES_310;
The main drivers for AED administration appear to be the presence of an intracranial lesion on admission imaging and the academic center of practice. Funding: TRACK-TBI Network
- [VIRTUAL] Prescribing errors of high carbohydrate medications for children on the Ketogenic Diet () - Nov 28, 2020 - Abstract #AES2020AES_302;
A CDS system embedded within the EMR identified only 21% of errors occur in designated in-patient neurology units. Most errors occurred in other areas of the hospital.
- Actemra IV (tocilizumab) / Roche, JW Pharma, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche, Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] New Onset Refractory Status Epilepticus treated successfully with Tocilizumab () - Nov 28, 2020 - Abstract #AES2020AES_299;
Many recent studies have identified cytokines associated with poorly controlled epilepsy. Recent research has shown that uncontrolled seizures lead to an inflammatory cascade, with rising IL-6 levels, blood-brain barrier disruption and seizure propagation.
- levetiracetam / Generic mfg.
[VIRTUAL] Studies on possible interactions between Anti-Xa-NOAC and levetiracetam () - Nov 28, 2020 - Abstract #DGN2020DGN_583;
- Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] Electroconvulsive therapy as a last resort for suprarefractory status epilepticus in a patient with severe NMDA-R-Ab autoimmune encephalitis and decompression hemicraniectomy () - Nov 28, 2020 - Abstract #DGN2020DGN_513;
Even if there are indications from case series of a possible effectiveness of ECT in SRSE, there is no evidence both prospective data on the effectiveness of ECT in SRSE and clear recommendations on therapy escalation beyond the use of general anesthetics. The use of an ECT in hemicraniectomized patients, as in our case, is because of the changed Anatomy poses a particular challenge and has not yet been described in the literature; from our point of view can In individual cases, ECT may be helpful for SRSE despite hemicraniectomy.
- dexamethasone / Generic mfg.
[VIRTUAL] NEUROTOXICITY SECONDARY TO INTRATECAL CHEMOTHERAPY IN A PATIENT WITH ACUTE LYMPHBLASTIC LEUKEMIA (ALL) () - Nov 26, 2020 - Abstract #HEMO2020HEMO_284;
In the following weeks, he presented resolution of the ataxic syndrome and control of seizures with the use of Levetiracetam...In this protocol, the regimen is triple therapy, 15 mg MTX, 40 mg Ara-C and 4 mg dexamethasone... In ALL, QT IT is a fundamental part of treatment, but neurological complications represent a challenge due to the diversity and potential severity of clinical manifestations.
- || verapamil / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: Moyamoya-like vasculopathy associated to MYH9-related thrombocytopenia manifested by multiple cerebral ischemic lesions: a case report. (Pubmed Central) - Nov 25, 2020
To our knowledge there are few cases described in the literature presenting with cerebral hemorrhagic events but none of them with multiple cerebral ischemic lesions. As these cases are very rare, it is important to gather evidence regarding the best approach and treatment strategy.
- | levetiracetam / Generic mfg.
New P2 trial: TRIP: Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease (clinicaltrials.gov) - Nov 24, 2020
P2, N=28, Not yet recruiting, Sponsor: The University of Queensland
- || Fycompa (perampanel) / Eisai, levetiracetam low dose (AGB101) / AgeneBio
Clinical, Journal: Experience of Low Dose Perampanel to Add-on in Glioma Patients with Levetiracetam-uncontrollable Epilepsy. (Pubmed Central) - Nov 21, 2020
Our study revealed anti-epileptic efficacy of low dose PER 2-4 mg as first add-on therapy to LEV in glioma patients who have failed or intolerable to LEV monotherapy. Low dose PER added on to LEV may have favorable efficacy with tolerable adverse effects in glioma patients with LEV-uncontrollable epilepsy.
- | carbamazepine / Generic mfg.
Journal: The Effects of Antiepileptic Medications on Lipid Profile, Thyroid Panel, and Vitamin Level. (Pubmed Central) - Nov 21, 2020
These medications do not affect the levels of thyroid hormones in comparison to levetiracetam and the control group. Although carbamazepine and valproic acid are metabolized in the liver, liver enzyme monitoring is required; they have only affected liver enzyme values as much as levetiracetam and the control group.
- || levetiracetam / Generic mfg.
Clinical, Journal: Maintenance of plasma levels of levetiracetam in subcutaneous, continuous and prolonged palliative infusion by elastomeric infusors (Pubmed Central) - Nov 19, 2020
Although carbamazepine and valproic acid are metabolized in the liver, liver enzyme monitoring is required; they have only affected liver enzyme values as much as levetiracetam and the control group. No abstract available
- | Cerebyx (fosphenytoin) / Pfizer, Nobelpharma
Journal: Medical management of status epilepticus: Emergency room to intensive care unit. (Pubmed Central) - Nov 19, 2020
Either lorazepam or diazepam are suitable IV agents...Although only phenytoin (and its prodrug fosphenytoin) and phenobarbitone are licensed for established SE, a now considerable body of evidence and international consensus supports the utility of both levetiracetam and valproate as options in established status...Two adequately powered randomized open studies in children have recently reported, supporting the use of levetiracetam as an alterantive to phenytoin. The results of a large double blind study also including valproate are also imminent, and together likely to change practice in benzodiazepine-resistant SE.
- || levetiracetam / Generic mfg.
Retrospective data, Review, Journal: Therapeutic effect of intravenous levetiracetam in status epilepticus: A meta-analysis and systematic review. (Pubmed Central) - Nov 19, 2020
IV LEV may have a better tolerability than other AEDs do. More RCTs are needed to validate the role of IV LEV in status epilepticus.
- ||| levetiracetam / Generic mfg.
Review, Journal, Adverse events: Pyridoxine supplementation for levetiracetam-related neuropsychiatric adverse events: A systematic review. (Pubmed Central) - Nov 19, 2020
This systematic review suggests that pyridoxine might be of benefit in relieving LEV-related NPAEs. However, the quality of the evidence is poor, and better-designed prospective studies that include quantitative as well as qualitative data are needed to define the role of pyridoxine in the management of LEV-related NPAEs.
- || levetiracetam / Generic mfg.
Review, Journal: Levetiracetam and cutaneous adverse reactions: A systematic review of descriptive studies. (Pubmed Central) - Nov 19, 2020
Clinicians should be aware of the possible CADRs induced by LEV to avoid the development of a potentially fatal condition. Immediate withdrawal of the drug and supporting care seem to be effective in the management of the CADRs.
- | clonazepam / Generic mfg., levetiracetam / Generic mfg.
Journal: Continuous epileptic negative myoclonus as the first seizure type in atypical benign epilepsy with centrotemporal spikes. (Pubmed Central) - Nov 18, 2020
Ignorance of midline spikes mainly in Cz or Pz in BECTS might lead to missed diagnosis of ENM. Whether benzodiazepines are viable as a choice of BECTS variants with electrical status epilepticus in sleep when ENM is the first symptom still needs a large sample evidence-based observation.
- || levetiracetam / Generic mfg.
Clinical, Journal: Behavioral alterations associated with levetiracetam in pediatric epilepsy. (Pubmed Central) - Nov 18, 2020
Adverse behavioral effects may significantly affect quality of life for patients and families, diminishing the tolerability of treatment. To ensure successful therapy and improve medical decision-making, it is essential to consider predisposing factors for drug-related adverse effects and to regularly assess for behavioral alterations during treatment.
- | levetiracetam / Generic mfg.
Retrospective data, Journal: Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort. (Pubmed Central) - Nov 18, 2020
This therapy should be used early in the treatment in EMAS. This study also identified a bidirectional link between cognitive and seizure outcomes.
- || levetiracetam / Generic mfg.
Clinical, Review, Journal: "Neonatal seizure: how reliable is its diagnosis and treatment? A mini review of previous knowledge". (Pubmed Central) - Nov 18, 2020
It was also observed that phenobarbital prescription was reduced while newer anti-seizure medication such as levetiracetam was further prescribed...Moreover, both the diagnosis and treatment of seizures should be re-evaluated based on neonatal characteristics. In the recent decade, new less harmful anti-seizure medications are being replaced with old ones.
- || levetiracetam / Generic mfg.
Clinical, Journal: Evaluation of the Efficacy of LevetiracetamPlus Iron in Comparison With Iron Alone in Controlling and Reducing the Frequency of Breath-Holding Spells in Children Aged 6 Months to 5 Years. (Pubmed Central) - Nov 18, 2020
In this study, the mean number of attacks was 3.94 ± 2.69 before treatment and 1.71 ± 1.99after treatmentin the group A,while it was 6.39 ± 5.7 before treatment and 0.37 ± 1.03after treatment in the group B.The mean number of attacksafter treatment was lower in group B than in group A. In fact, there was a significant difference between the two groups in terms of the number of attacks after treatment (P = 0.003). Levetiracetam plus iron is more effective than iron alone in reducing BHSs in children aged 6 months to 5 years.
- || levetiracetam / Generic mfg.
Clinical, Journal: Efficacy and safety of levetiracetam in the off-label treatment of neonatal seizures. (Pubmed Central) - Nov 14, 2020
Levetiracetam plus iron is more effective than iron alone in reducing BHSs in children aged 6 months to 5 years. Levetiracetam shows good efficacy, safety and tolerability for the long-term neonatal seizure treatment.
- || levetiracetam / Generic mfg.
Review, Journal: Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia. (Pubmed Central) - Nov 14, 2020
Recently evaluated treatment strategies-at least in part-target excess glutamatergic activity, e.g. N-acetyl-cysteine (NAC), levetiracetam, and mGluR2/3 modulators. We here review the evidence for the central implication of the hippocampus-VTA axis in schizophrenia-related pathology, discuss its symptom-related implications with a particular focus on aberrant assignment of salience, and evaluate some of its short-comings and prospects for drug discovery.
- | carbamazepine / Generic mfg.
Retrospective data, Journal: Trends in antiepileptic drug treatment and effectiveness in clinical practice in England from 2003 to 2016: a retrospective cohort study using electronic medical records. (Pubmed Central) - Nov 14, 2020
Treatment trends often were not aligned with era-relevant guidance. However, our results suggest a slight improvement in epilepsy treatment outcomes over the 13-year period.
- | NN1213 / Novo Nordisk
Trial completion date, Trial primary completion date: TELSTAR: Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation (clinicaltrials.gov) - Nov 13, 2020
P=N/A, N=172, Recruiting, Sponsor: University of Twente
However, our results suggest a slight improvement in epilepsy treatment outcomes over the 13-year period. Trial completion date: Dec 2020 --> May 2022 | Trial primary completion date: Mar 2020 --> Aug 2021
- || Briviact (brivaracetam) / UCB
P4 data, Retrospective data, Journal: First clinical postmarketing experiences in the treatment of epilepsies with brivaracetam: a retrospective observational multicentre study. (Pubmed Central) - Nov 12, 2020
The present study shows that results of the phase III studies on BRV match data from real life clinical settings. Brivaracetam seems to be a useful alternative in patients who have suffered adverse effects while taking LEV.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Retrospective data, Journal, Monotherapy: Effects on executive functions of antiepileptic monotherapy in pediatric age. (Pubmed Central) - Nov 12, 2020
Levetiracetam was the only antiseizure medication that led to slight improvements in executive functioning; whereas carbamazepine led to deteriorations in cognitive functioning. Further research using double-blinded, placebo-controlled trials are needed to confirm these results.
- || Briviact (brivaracetam) / UCB
Clinical, Journal: Efficacy, retention, and safety of brivaracetam in adult patients with genetic generalized epilepsy. (Pubmed Central) - Nov 12, 2020
Brivaracetam shows good responder and retention rates in GGE and is generally well tolerated. It is an appropriate alternative treatment for GGE, especially in refractory epilepsy and when other AEDs are not tolerated.
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Differential antiseizure medication sensitivity of the Affective Reactivity Index: A randomized controlled trial in new-onset pediatric focal epilepsy. (Pubmed Central) - Nov 12, 2020
Both child and parent/guardian versions of the ARI appear sensitive to medication-induced irritability associated with LEV on both the group and individual levels. The findings extend the applicability of ARI from characterizing the presence of clinical irritability as a psychiatric diagnostic feature to a more modifiable aspect of behavior change related to medication management and support its use in clinical trial applications.
- || levetiracetam / Generic mfg.
Clinical, Journal: Seizure Prophylaxis in Unruptured Aneurysm Repair: A Randomized Controlled Trial. (Pubmed Central) - Nov 12, 2020
The findings extend the applicability of ARI from characterizing the presence of clinical irritability as a psychiatric diagnostic feature to a more modifiable aspect of behavior change related to medication management and support its use in clinical trial applications. Perioperative seizure prophylaxis with levetiracetam does not reduce the rate of seizures as compared to controls in patients undergoing surgical repair of UIAs.
- | levetiracetam / Generic mfg.
Biomarker, Retrospective data, Journal: Nosocomial Infections among Patients with Intracranial Hemorrhage: A Retrospective Data Analysis of Predictors and Outcomes. (Pubmed Central) - Nov 7, 2020
Collectively, these findings suggest that nosocomial infections are common among patients with intracranial hemorrhage and can be predictable by considering certain risk factors. Future studies are warranted to evaluate the efficacy of implementing infection control strategies or protocols on these patients to achieve better therapeutic outcomes.
- | levetiracetam / Generic mfg.
Journal: Tensor decomposition of TMS-induced EEG oscillations reveals data-driven profiles of antiepileptic drug effects. (Pubmed Central) - Nov 7, 2020
Further, this effect was stronger under the intake of levetiracetam. This study demonstrates, for the first time, that PARAFAC can easily disentangle the effects of subject, drug condition, frequency, time and space in TMS-induced oscillations.
- | levetiracetam / Generic mfg.
Enrollment change, Trial completion date, Trial primary completion date: LEVNEONAT-1: Levetiracetam Treatment of Neonatal Seizures: Safety and Efficacy Phase II Study (clinicaltrials.gov) - Nov 5, 2020
P2, N=30, Recruiting, Sponsor: University Hospital, Tours
This study demonstrates, for the first time, that PARAFAC can easily disentangle the effects of subject, drug condition, frequency, time and space in TMS-induced oscillations. N=50 --> 30 | Trial completion date: Mar 2020 --> Mar 2022 | Trial primary completion date: Mar 2020 --> Feb 2022
- || levetiracetam / Generic mfg.
Clinical, Journal: Levetiracetam for prophylactic treatment of pediatric migraine: A randomized double-blind placebo-controlled trial. (Pubmed Central) - Nov 4, 2020
N=50 --> 30 | Trial completion date: Mar 2020 --> Mar 2022 | Trial primary completion date: Mar 2020 --> Feb 2022 Levetiracetam may be useful in migraine prevention and may decrease migraine episodes and severity.
- || levetiracetam / Generic mfg.
Clinical, Journal: A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria. (Pubmed Central) - Nov 4, 2020
P1/2, P2
Levetiracetam may be useful in migraine prevention and may decrease migraine episodes and severity. Enteral LVT offers an affordable option for seizure control in pediatric CM and is safer than phenobarbital.
- || levetiracetam / Generic mfg.
Clinical, Journal: Germline de novo variants in CSNK2B in Chinese patients with epilepsy. (Pubmed Central) - Nov 4, 2020
Levetiracetam was the most commonly used drug in seizure-free patients (5/7)...CSNK2B-related epilepsy is relatively easy to be controlled. The zinc-binding domain appears to be the hotspot region for mutation.
- || carbamazepine / Generic mfg.
Clinical, Journal: Pharmacological monitoring of antiepileptic drugs in epilepsy patients on haemodialysis. (Pubmed Central) - Nov 3, 2020
The concentration-to-dose ratios for levetiracetam, valproic acid, phenytoin, and carbamazepine were significantly lower after than before haemodialysis. The majority of patients with epilepsy on haemodialysis had cerebrovascular diseases, and therapeutic drug monitoring for levetiracetam, valproic acid, and phenytoin, before and after haemodialysis, is needed to ensure proper dosing.
- | Trileptal (oxcarbazepine) / Novartis
Journal, HEOR, Monotherapy: Need for pharmacoeconomic consideration of antiepileptic drugs monotherapy treatment in persons with epilepsy. (Pubmed Central) - Nov 3, 2020
Newer AEDs have comparatively better efficacy, though not significant than conventional AEDs. However, the additional cost per unit improvement is quite high with newer AEDs, necessitating pharmacoeconomic consideration in epilepsy treatment.
- || Foscavir (foscarnet) / Pfizer, Clinigen
Clinical, Journal: Clinical, radiological, and electroencephalographic features of HHV-6 encephalitis following hematopoietic stem cell transplantation. (Pubmed Central) - Nov 3, 2020
Anti-epileptics used were phenytoin, levetiracetam, and valproic acid...Salient EEG characteristics include periodic discharges or overt temporal lobe seizures. MRI findings are T2/FLAIR signal hyperintensities, mainly in the temporal lobes.
- || levetiracetam / Generic mfg.
Clinical, Journal: Prophylactic antiepileptic treatment with levetiracetam for patients undergoing supratentorial brain tumor surgery: a two-center matched cohort study. (Pubmed Central) - Nov 2, 2020
Prophylactic treatment with levetiracetam after brain tumor surgery showed no statistically significant effect in preventing postoperative seizures. However, in case a postoperative infarction occurs, its administration might be indicated.
- | zonisamide / Generic mfg., levetiracetam / Generic mfg.
Journal: Diagnosis and long-term management of post-traumatic seizures in a white-crowned pionus (Pionus senilis). (Pubmed Central) - Nov 2, 2020
However, in case a postoperative infarction occurs, its administration might be indicated. Long-term management of PTS in a pionus was achieved with levetiracetam and zonisamide administration.
- || carbamazepine / Generic mfg.
Clinical, Journal: Observational multicentre study into the use of antiepileptic drugs in Spanish neurology consultations. (Pubmed Central) - Oct 31, 2020
The majority of patients received new AEDs. The combination of classic and new AEDs was more frequently prescribed to patients with refractory epilepsy or with associated comorbidities.
- || levetiracetam / Generic mfg.
Clinical, Journal, Monotherapy: Monitoring of biochemical parameters and coagulation tests in children with epilepsy treated with levetiracetam monotherapy. (Pubmed Central) - Oct 31, 2020
The combination of classic and new AEDs was more frequently prescribed to patients with refractory epilepsy or with associated comorbidities. No abstract available
- || Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Analysis of pharmacotherapy regimen and costs in patients with drug-resistant epilepsy following vagus nerve stimulation therapy: a single-center study (Poland). (Pubmed Central) - Oct 28, 2020
With the rising costs of healthcare, the importance of economic efficiency is becoming increasingly relevant. VNS is a reasonable option for saving money in the healthcare system while ensuring measurable clinical and therapeutic outcomes over the long term.
- || Clinical, Journal: A Comparative Study on the Efficacy of Levetiracetam and Carbamazepine in the Treatment of Rolandic Seizures in Children: An Open-Label Randomized Controlled Trial. (Pubmed Central) - Oct 28, 2020
No significant changes had been reported regarding the duration of seizure attacks in both groups after treatment. This study showed encouraging results for using levetiracetam, with acceptable results and fewer side effects for the treatment of children with BCECTS in Iran.