 |
185 Diseases |  |
81 Trials |
|
81 Trials |  |
6476 News |  |
| «12...5354555657585960616263...8182» |
- Epidiolex (cannabidiol) / GW Pharma
[VIRTUAL] Epidiolex In Adult Patients with Lennox-Gastaut Syndrome (LGS): The Pittsburgh Experience () - Nov 28, 2020 - Abstract #AES2020AES_1128;
Most experienced adverse effects were reported to be somnolence and diarrhea especially in patients taking Clobazam. Funding: none
- olanzapine / Generic mfg., levetiracetam / Generic mfg., clobazam / Generic mfg.
[VIRTUAL] Case Series and Literature Review on Electroencephalogram Variations in a Creutzfeldt Jakob Disease () - Nov 28, 2020 - Abstract #AES2020AES_1075;
The MRI brain changes with cortical ribboning and 14-3-3 protein for CJD was positive in all of the patients of this case series. Funding: None
- Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
[VIRTUAL] Efficacy of adjunctive eslicarbazepine acetate in patients with focal seizures, according to baseline seizure frequency: a post-hoc analysis of data from a Phase IV clinical trial () - Nov 28, 2020 - Abstract #AES2020AES_1074;
P4
In this real-world open-label study, ESL was effective for the treatment of focal seizures across the range of patient baseline seizure frequencies. Funding: Study funded by Sunovion Pharmaceuticals Inc.
- Vimpat (lacosamide) / UCB, Daiichi Sankyo
[VIRTUAL] Efficacy of adjunctive lacosamide in the treatment of primary generalized tonic-clonic seizures: subgroup analyses of a double-blind, randomized, placebo-controlled trial () - Nov 28, 2020 - Abstract #AES2020AES_1043;
P3
Efficacy findings in all subgroups were consistent with the overall population. Funding: UCB Pharma-sponsored
- Epidiolex (cannabidiol) / GW Pharma
[VIRTUAL] Efficacy and Safety of Cannabidiol (CBD) in Patients with Treatment-Resistant Epilepsies (TREs) in the Expanded Access Program (EAP): Additional Efficacy Data for Convulsive and Nonconvulsive Seizure Subtypes () - Nov 28, 2020 - Abstract #AES2020AES_1041;
These results support the long-term use of CBD for patients with TREs with a variety of convulsive and nonconvulsive seizure subtypes. Funding: GW Research Ltd.
- Epidiolex (cannabidiol) / GW Pharma, lamotrigine liquid oral suspension / OWP Pharma
[VIRTUAL] Long-term Efficacy and Safety of Cannabidiol (CBD) in Patients with Tuberous Sclerosis Complex (TSC): 4-year Results from the Expanded Access Program (EAP) () - Nov 28, 2020 - Abstract #AES2020AES_1038;
Add-on CBD resulted in sustained seizure reduction in patients with TSC for up to 192 weeks with an acceptable safety profile. Funding: GW Research Ltd
- levetiracetam / Generic mfg.
[VIRTUAL] Prescribing trends of antiepileptic drugs (AED) and mood stabilizers (MS) among pregnant women between 2011 and 2017 in France. Study from the French national health insurance database (SNDS). () - Nov 28, 2020 - Abstract #AES2020AES_1025;
This trend increased after RMR, especially before pregnancy. However, exposure levels during the first trimester of pregnancy remain high.
- carbamazepine / Generic mfg.
[VIRTUAL] Subject-specific factors are correlated with intracranial interictal epileptiform discharges in refractory epilepsy () - Nov 28, 2020 - Abstract #AES2020AES_1005;
Our findings confirmed, with intracranial recordings, that IED rates were higher in regions near SOZs relative to regions distant from SOZs. They also suggest that IED rates may be a new metric to consider when assessing ASM efficacy.
- levetiracetam / Generic mfg.
[VIRTUAL] Antiseizure Medication Levels Affect Neuropsychological Outcomes at Age 2 Years in the MONEAD Study () - Nov 28, 2020 - Abstract #AES2020AES_975;
Such an exposure-dependent effect would be expected for teratogens. These secondary analyses need to be confirmed in this and other cohorts at older ages, where neuropsychological testing is more sensitive to cognitive outcomes.
- Briviact (brivaracetam) / UCB, Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
[VIRTUAL] Network Meta-analysis Comparing the Psychiatric Treatment-emergent Adverse Events of Eslicarbazepine Acetate and Brivaracetam () - Nov 28, 2020 - Abstract #AES2020AES_968;
Using the NMA technique described, ESL was associated with a profile suggesting a lesser likelihood of psychiatric TEAEs, relative to BRV; however, these differences were not statistically significant. Funding: Sunovion Pharmaceuticals Inc.
- Fycompa (perampanel) / Eisai
[VIRTUAL] Perampanel for the Treatment of Epilepsy in a Patient with Generalized Tonic-Clonic Seizures and Myoclonic Jerks () - Nov 28, 2020 - Abstract #AES2020AES_946;
GTC seizure freedom has been sustained since March 2019 in this adult male patient on perampanel monotherapy (6 mg/day), with no adverse events reported. Funding: Medical writing support, under the direction of Dr Holtzman, was provided by Rebecca Furmston, PhD, of CMC AFFINITY, McCann Health Medical Communications, funded by Eisai Inc., in accordance with Good Publication Practice guidelines.
- lamotrigine liquid oral suspension / OWP Pharma
[VIRTUAL] A Case of Ictal Asystole in Temporal Lobe Epilepsy () - Nov 28, 2020 - Abstract #AES2020AES_945;
Left TLE in particular is associated with autonomic-induced cardiorespiratory phenomena such as ictal bradycardia and ictal central apnea, due to the role of the left insular region in parasympathetic regulation demonstrated through cortical stimulation and lesional studies. 2, 3.
- levetiracetam / Generic mfg.
[VIRTUAL] Levetiracetam preferentially acts at neuronal synapses that only express SV2A () - Nov 28, 2020 - Abstract #AES2020AES_938;
The in vivo efficacy of LEV was most notable in BKO mice, and this efficacy was preserved in a dose-related manner against the drug-resistant 6 Hz 44 mA seizure. LEV may preferentially act at synapses critical to evoked focal, but not generalized, seizures.
- Diacomit (stiripentol) / Biocodex, Meiji Seika
[VIRTUAL] Observational Study to Investigate Cognition and Other Non-seizure Comorbidities in Children and Adolescents with Dravet Syndrome: Patient Analysis of the BUTTERFLY Study () - Nov 28, 2020 - Abstract #AES2020AES_936;
Importantly, the data collected indicate that the selected cognition measures are valid and appropriate for use in patients with DS, as all patients were able to complete either the BSID-III or WPPSI-IV. There is evidence of heterogeneity and large variability between patients, and substantially decreased abilities in comparison to children at the same chronological age level.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Unusual Presentation of Attenuated Form of Glycine Encephalopathy as Refractory Focal Epilepsy in Infancy. () - Nov 28, 2020 - Abstract #AES2020AES_934;
Initial presentation can be non-specific and preliminary work-up unrevealing. CSF analysis may not be diagnostic as the levels were reported by our lab as essentially normal.
- Briviact (brivaracetam) / UCB
[VIRTUAL] Brivaracetam: Long term experience in Mexico () - Nov 28, 2020 - Abstract #AES2020AES_905;
B: Patients on levetiracetam (LVT) treatment and switched to brivaracetam due to undesirable adverse events...The most common and useful combination was with lacosamide...The primary adverse effect was a long-lasting drowsy-lethargic state, which impeded patients' daily activities. Funding: No funding was required for this study
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Epilepsy and Electrical Status Epilepticus in Sleep that Redefines the Clinical Spectrum of Potocki-Lupski Syndrome () - Nov 28, 2020 - Abstract #AES2020AES_886;
EEG abnormalities have been reported including diffuse background slowing focal and generalized epileptiform discharges. While non-epileptic behavioral spells and abnormal movements are common in patients with developmental delays, neither clinical nor electrographic seizures have been previously reported in PTLS patients.
- levetiracetam / Generic mfg.
[VIRTUAL] STXBP1.ca - A prospective natural history study of STXBP1 disorders () - Nov 28, 2020 - Abstract #AES2020AES_875;
Neuropsychiatric development includes ID, hypotonia, movement disorder & features of ASD, behavioural & socio-emotional disturbance. Sleep breathing disorders & scoliosis may appear in adolescence.
- levetiracetam low dose (AGB101) / AgeneBio
[VIRTUAL] Association of First and Second-line Medication Dosing and Progression to Pediatric Refractory Convulsive Status Epilepticus (the pSERG cohort) () - Nov 28, 2020 - Abstract #AES2020AES_853;
Refractoriness of SE may be related to a variety of different factors, and some may be independent of the therapeutic approach. Funding: ERF, PERF.
- [VIRTUAL] Limbic Encephalitis Presenting with Faciobrachial Dystonic Seizures After History of Successfully Treated Thymoma Type B-3 with Excellent Neurocognitive Outcome with Early Immunotherapy () - Nov 28, 2020 - Abstract #AES2020AES_843;
Though antibody markers allow confirmation of autoimmune encephalitis, early clinical suspicion is paramount for prompt treatment with immunotherapy which can improve outcomes. In our patient, clinical suspicion for limbic encephalitis with FBDS was rapidly treated with IVIG and he has remained seizure-free for 7 years with no residual cognitive deficits on repeat neuropsychiatric testing.
- [VIRTUAL] Comb Like Rhythm on EEG in Vitamin B6 Responsive Epilepsy (ALDH7A1 mutation) in Newborn () - Nov 28, 2020 - Abstract #AES2020AES_842;
However, we noted this in patient with vitamin B6 responsive epilepsy which was genetically proven. Therefore, we believe that presence of this comb like rhythm is not specific for any particular metabolic encephalopathy and diagnostic evaluation with vitamin B6 supplementation should be tried along with other metabolic & genetic screening evaluation.
- Xcopri (cenobamate) / SK Biopharmaceuticals, Arvelle Therap
[VIRTUAL] Efficacy of Cenobamate by Concomitant Antiseizure Medications in Patients With Uncontrolled Focal Seizures: Post-hoc Analysis of a Phase 3, Multicenter, Open-Label Study () - Nov 28, 2020 - Abstract #AES2020AES_830;
Relevant clinical outcomes were generally consistent by baseline ASM. The AE profile of the combinations was consistent with the known profiles of these ASMs, and no new tolerability issues were identified.
- clobazam / Generic mfg.
[VIRTUAL] Efficacy of Clobazam in Dravet Syndrome () - Nov 28, 2020 - Abstract #AES2020AES_815;
And only 12 % showed side effect . Age and Sex did not affect the outcome of clobazam .
- zonisamide / Generic mfg., levetiracetam / Generic mfg.
[VIRTUAL] When walking becomes seizure: a case report () - Nov 28, 2020 - Abstract #AES2020AES_792;
Potential described triggers for spells caused by ambulation include afferent proprioceptive stimuli or more complex cortical motor planning. The key clinical feature that differentiates these reflex seizures from a movement disorder is the altered awareness typical of epileptic events.
- levetiracetam / Generic mfg.
[VIRTUAL] Tremor as a Probable Adverse Drug Reaction to Levetiracetam: A Case Report () - Nov 28, 2020 - Abstract #AES2020AES_766;
Though rare, it is important for epileptologists and neurologists to be aware of this debilitating side effect. This will allow appropriate management by LEV cessation and help prevent addition of unnecessary medications for tremor.
- levetiracetam / Generic mfg., acyclovir / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
[VIRTUAL] COVID-19 and De Novo Right Occipitoparietal Seizures: A Case Report () - Nov 28, 2020 - Abstract #AES2020AES_738;
To our knowledge, this is the first described case of new onset occipital seizures presenting as COVID-19. This case therefore illustrates the importance of considering new occipital seizures in patients with visual phenomena accompanied by COVID-19 symptoms.
- clozapine / Generic mfg.
[VIRTUAL] Comparative analysis of clozapine and JHU37160 in chemogenetic seizure suppression in a mouse model for drug-resistant temporal lobe epilepsy () - Nov 28, 2020 - Abstract #AES2020AES_729;
JHU37160 is a suitable chemogenetic agonist, however seizure suppressive effects lasted shorter compared to clozapine. Levetiracetam did not suppress seizures in this study.
- levetiracetam / Generic mfg.
[VIRTUAL] Neuromonitoring at the height of a pandemic: EEG findings in patients with COVID-19 () - Nov 28, 2020 - Abstract #AES2020AES_727;
The most common reasons for EEG monitoring were persistent encephalopathy or witnessed seizure/shaking activity. About a third of these patients had additional CNS injury including ischemic stroke or anoxic brain injury.
- XEN1101 / Xenon, lamotrigine liquid oral suspension / OWP Pharma
[VIRTUAL] Cortical oscillations to measure anti-epileptic drug activity in clinical trials () - Nov 28, 2020 - Abstract #AES2020AES_680;
Spectral fingerprints should be further investigated to provide robust and objective biomarkers of target engagement in human clinical trials. Funding: This study represents an independent research supported by the National Institute for Health Research (NIHR)-Well come King’s Clinical Research Facility and the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London.
- Xcopri (cenobamate) / SK Biopharmaceuticals, Arvelle Therap, Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Dose Adjustments to Concomitant Antiseizure Medications: Post-hoc Analysis of a Phase 3, Open-Label Study of Cenobamate for the Treatment of Uncontrolled Focal Seizures () - Nov 28, 2020 - Abstract #AES2020AES_646;
Decreasing doses of phenytoin, clobazam, and lacosamide were the earliest clinically performed. Funding: SK Life Science, Inc.
- Vimpat (lacosamide) / UCB, Daiichi Sankyo
[VIRTUAL] Levetiracetam, Lamotrigine, Lacosamide and Topiramate monotherapy; Database Analysis from an Epilepsy Center () - Nov 28, 2020 - Abstract #AES2020AES_639;
Lamotrigine monotherapy was associated with the highest seizure free rate. Dropout rates were the highest for topiramate compared to the other three ASM.
- Briviact (brivaracetam) / UCB
[VIRTUAL] Cumulative Plasma Exposure, Not Singular Concentrations, Yields a Best Correlation for Brivaracetam, Levetiracetam to Photoparoxysmal Abolition in Photosensitive Epilepsy: Results of Randomized, Double-blind, Crossover Study () - Nov 28, 2020 - Abstract #AES2020AES_638;
P2/3
Singular Ln plasma concentrations do not correlate well. Frequent plasma samples are needed when evaluating novel AED compounds in the ‘Photosensitivity Model of Epilepsy’ to calculate cumulative [AED] exposure.
- levetiracetam / Generic mfg., topiramate / Generic mfg.
[VIRTUAL] Recent Epilepsy Treatment Prescribing Trends for Veterans Show Improvement. () - Nov 28, 2020 - Abstract #AES2020AES_636;
The use of phenytoin across all age groups significantly decreased over time. Female Veterans were more likely to be prescribed new ASMs, particularly levetiracetam, lamotrigine and topiramate, reflecting gender awareness in prescribing habits.
- Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche, Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] The Clinical Spectrum of Nicotinic Acetylcholine Receptor Antibody Associated Encephalitis () - Nov 28, 2020 - Abstract #AES2020AES_618;
We report 3 cases of medically intractable encephalitis/epilepsy with highly variable presentations, all associated with positive α3-AChR Ab as the only anti-neuronal antibody and identifiable etiology. Funding: None
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Corpus Callosotomy and Intracranial Electroencephalogram: Multi-Staged Diagnostic Procedure for Epileptogenic Focus Lateralization and Localization in Medically Refractory Focal Epilepsy Syndrome for Epilepsy Surgery () - Nov 28, 2020 - Abstract #AES2020AES_593;
While CC has no therapeutic benefit in focal epilepsy syndromes, it has emerged with diagnostic value. Only a few studies have discussed the role of CC and iEEG, as a multi-staged diagnostic procedure for the lateralization and localization of an epileptogenic focus prior to epilepsy surgery.
- Fycompa (perampanel) / Eisai
[VIRTUAL] Effect of Concomitant Anti-Seizure Medications (ASMs) During Long-Term (52 weeks) Adjunctive Perampanel Treatment in Japanese Pediatric Patients (Aged 4– < 12 Years): Post Hoc Analysis of Study 311 () - Nov 28, 2020 - Abstract #AES2020AES_592;
P3
Consistent with the overall population, these data suggest long-term adjunctive perampanel is generally well tolerated and seizure control is sustained for up to 52 weeks in Japanese pediatric patients with POS (with/without SGS), irrespective of baseline ASM use. Funding: Eisai Inc.
- leucovorin calcium / Generic mfg.
[VIRTUAL] Non-Convulsive Status Epilepticus as a Manifestation of Methotrexate-Induced Leukoencephalopathy () - Nov 28, 2020 - Abstract #AES2020AES_580;
She showed a gradual progressive improvement in global aphasia, cognitive dysfunction, and right hemiparesis in the weeks, currently she is undergoing rehabilitation treatment in the rehabilitation department. Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
- ketamine / Generic mfg.
[VIRTUAL] Epidemiology of Status Epilepticus at a Tertiary Medical Center () - Nov 28, 2020 - Abstract #AES2020AES_568;
Non-compliance with home AEDs was seen in almost half of patients with prior history of epilepsy. Only a third of video-EEGs showed seizures.
- lamotrigine liquid oral suspension / OWP Pharma
[VIRTUAL] Sunflower syndrome in two pairs of monozygotic twins () - Nov 28, 2020 - Abstract #AES2020AES_545;
Both pairs were concordant in epilepsy syndrome and had seizure onset within a short time of each other, consistent with published data on age of seizure onset as a familial trait, and epilepsy syndrome concordance rates in monozygotic twins. Overlapping but distinct ranges of seizure semiologies were seen within pairs.
- Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Antiseizure Medication Concentration Trends in Pregnancy and Postpartum: Results from The MONEAD Study () - Nov 28, 2020 - Abstract #AES2020AES_542;
In addition, women on LTG experienced a significant drop in DNCs throughout pregnancy with the lowest DNCs occurring in the 3rd trimester - indicating that women on LTG might require more than one dose change during pregnancy. Funding: NINIDS and NICHD U01-NS038455, U01-NS050659 and 2U01-NS038455.
- Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
[VIRTUAL] Safety and Tolerability of Eslicarbazepine Acetate as Adjunctive Treatment in Adult Patients with Focal- Onset Seizures according to one Concomitant Antiepileptic Drug: Data from Four Double-Blind Pivotal Phase III Studies () - Nov 28, 2020 - Abstract #AES2020AES_538;
ESL as add-on to treatment regimens containing LEV appeared to be associated with lower incidences of some TEAEs. These findings are consistent with published literature and support the use of ESL as adjunctive therapy to one baseline AED.
- Fycompa (perampanel) / Eisai
[VIRTUAL] Efficacy and Safety of Perampanel as First Adjunctive Therapy in Patients with Partial-Onset Seizures: Post Hoc Analysis of the FAME Study by First-Line Antiepileptic Drug and Perampanel Dose () - Nov 28, 2020 - Abstract #AES2020AES_528;
P4
Perampanel at low doses (e.g. 4–6 mg/day) was effective in achieving seizure control and response with favorable tolerability in pts with POS regardless of first-line concomitant AED use. Funding: Eisai Korea Inc.
- Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
[VIRTUAL] Concordance in seizure frequency data between paper and electronic seizure capture methods in a Phase IV clinical trial () - Nov 28, 2020 - Abstract #AES2020AES_527;
P4
In this real-world, open-label study of ESL in patients with focal seizures, stronger concordance in daily seizure frequency was observed between paper and electronic seizure diaries compared with a paper diary and seizure detection watch. Funding: Study funded by Sunovion Pharmaceuticals Inc.
- zonisamide / Generic mfg., levetiracetam / Generic mfg.
[VIRTUAL] Adjusting to living with Epilepsy: Do those with controlled seizures have a better quality of life? () - Nov 28, 2020 - Abstract #AES2020AES_523;
Assessing quality of life in a clinical setting is challenging, as mood state alone is a poor proxy measure. All PWE would potentially benefit from early psychological support to reduce their fears around the risk of future seizures and help to maintain their sense of role in the wider community.
- [VIRTUAL] An Online Survey of Caregivers for Patients with SCN8A Developmental and Epileptic Encephalopathy (SCN8A-DEE) or SCN8A-Related Epilepsy () - Nov 28, 2020 - Abstract #AES2020AES_522;
The patients in this study who previously tried and stopped various medications indicated general dissatisfaction with current treatment options and suggested ongoing unmet therapeutic needs in this heterogeneous patient population. Funding: The Cute Syndrome Foundation received funds from Xenon for this patient survey and other projects/events.
- Vimpat (lacosamide) / UCB, Daiichi Sankyo
[VIRTUAL] Central Apnea and Seizures in a COVID-19 Pediatric Patient () - Nov 28, 2020 - Abstract #AES2020AES_499;
It remains to be seen whether COVID-19 may precipitate an increase in SUDEP in patients with epilepsy. Funding: No funding received.
- carbamazepine / Generic mfg.
[VIRTUAL] TD567, A Novel Carboxyphenolcyclohexenone as a Drug Candidate for the Treatment of Post-traumatic Epilepsy () - Nov 28, 2020 - Abstract #AES2020AES_480;
TD567 is being advanced to first-in-man studies with the aim of developing it as a treatment for PTE. Funding: [supported in full by OB Pharmaceuticals]
- levetiracetam / Generic mfg.
[VIRTUAL] EEG Findings in COVID-19: A Case Report of Two Patients () - Nov 28, 2020 - Abstract #AES2020AES_456;
This report adds to the literature further cases of EEG abnormalities seen in COVID-19 patients with encephalopathy. Similarly to others, we found nonspecific indicators of encephalopathy like diffuse slowing as well as epileptiform activity including bifrontally-predominant discharges and seizures.
- lorazepam / Generic mfg., levetiracetam / Generic mfg.
[VIRTUAL] Monitoring electrographic and subtle clinical seizures on continuous ICU EEG monitoring- time to medication administration: a quality improvement study () - Nov 28, 2020 - Abstract #AES2020AES_412;
Once ordered, medications are administered faster overnight which may reflect differences in resources depending on time of day. Standardizing medication ordering and delivery processes could improve treatment times which may improve seizure burden and subsequent outcome.
- zonisamide / Generic mfg.
[VIRTUAL] Efficacy, Safety and Need for Dosing Change of Zonisamide During Pregnancy in Women with Epilepsy () - Nov 28, 2020 - Abstract #AES2020AES_364;
Our findings indicate that ZNS levels can decrease during pregnancy and may require dose adjustments. They also suggest that ZNS may be an effective, well tolerated, and safe treatment for pregnant women with epilepsy.