levetiracetam / Generic mfg. 
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 185 Diseases   81 Trials   81 Trials   6476 News 


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  • ||||||||||  Trileptal (oxcarbazepine) / Novartis
    [VIRTUAL] Evaluation of antiepileptic medication level monitoring in the inpatient setting. () -  Dec 26, 2020 - Abstract #ASHP2020ASHP_2007;    
    The primary outcomes for this evaluation are the percentage of patients receiving an antiepileptic medication who had a trough drawn and the percentage of patients with a trough drawn properly. Data collection will begin once the evaluation has been submitted to and approved by the IRB.
  • ||||||||||  Vimpat (lacosamide) / UCB, Daiichi Sankyo
    [VIRTUAL] Efficiency and Safety of Undiluted Intravenous Push Levetiracetam and Lacosamide () -  Dec 26, 2020 - Abstract #ASHP2020ASHP_1928;    
    The primary outcome is the time from order entry to medication administration of the initial AED dose ordered for immediate use. Secondary outcomes include time from order entry to pharmacist verification, time from pharmacist verification to medication administration, rate of overdue doses, rate of adverse drug reactions (hypotension, bradycardia, and infusion reactions), and cost.
  • ||||||||||  Humira (adalimumab) / Eisai, AbbVie, Trileptal (oxcarbazepine) / Novartis
    [VIRTUAL] The clinical use of immunosuppressants and anti-epileptic drug therapies in the treatment of Neuro-Behcet's in a patient with unspecified dementia and epileptic seizure () -  Dec 26, 2020 - Abstract #ASHP2020ASHP_1699;    
    Treatment was initiated with haloperidol, loxapine, lorazepam, phenytoin, levetiracetam, topiramate, lacosamide, adalimumab, hibiclens, and theragran...For ulcers, PD4 inhibitor apremilast is the only FDA approved medication...Anti-epileptic drugs (AED) phenytoin, oxcarbazepine or carbamazepine can control seizures in most patients...Although the combination of dementia, epilepsy and intellectual disabilities seen together in this patient is rare, it is a predictable complication of NBD. Recognition of these symptoms is critical to initiating appropriate therapy.
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] Medication utilization evaluation of the use of levetiracetam serum levels () -  Dec 26, 2020 - Abstract #ASHP2020ASHP_1543;    
    Levetiracetam levels were not clearly indicated in 93.9% of the levels evaluated, which was associated with a cost of $19,836. A proposed solution to avoid unnecessary orders of levetiracetam levels would be to educate neurologists, hospitalists, and emergency department providers and develop a standard of care across providers to determine when levetiracetam levels should be drawn.
  • ||||||||||  ceftriaxone / Generic mfg.
    [VIRTUAL] Early aggressive, interventions in a massive acetaminophen overdose () -  Dec 26, 2020 - Abstract #ASHP2020ASHP_1053;    
    This case describes one of the largest acute acetaminophen overdoses reported in the literature. It reinforces that early interventions with high-dose NAC and hemodialysis in massive acetaminophen overdoses may lead to minimal hepatic toxicity and favorable patient outcomes.
  • ||||||||||  donepezil / Generic mfg.
    [VIRTUAL] TREATMENT OPTIONS FOR SLEEP-RELATED EPILEPTIC SPIKING IN EARLY ALZHEIMER’S DISEASE () -  Dec 24, 2020 - Abstract #ADPD2021ADPD_1050;    
    We will test the standard ADdrugs donepezil and memantine, anti-epileptic drugs levetiracetam and lamotrigine, gamma-secretase inhibitor semagacestat and an anti-inflammatory tetracycline derivative minocycline at doses with no overt motor manifestations. Sleep-related epileptic spiking in AD is treatable with clinically approved drugs.
  • ||||||||||  Ryanodex (dantrolene) / Eagle Pharma, Comfyde (carisbamate) / J&J, SK Bio
    Review, Journal:  Novel therapeutics for treating organophosphate-induced status epilepticus co-morbidities, based on changes in calcium homeostasis. (Pubmed Central) -  Dec 19, 2020   
    These Ca elevations had their origin in Ca release from the intracellular stores such that blockade with antagonists like dantrolene, carisbamate, and levetiracetam lowered OP-SE mediated Ca plateau and afforded significant neuroprotection. Since the Ca plateau lasts for a prolonged period, our studies suggest that blocking it after the control of SE may represent a unique target for development of novel countermeasures to prevent long term Ca mediated OP-SE neuropsychiatric comorbidities such as depression, anxiety, and acquired epilepsy (AE).
  • ||||||||||  levetiracetam / Generic mfg.
    Clinical, Journal:  Effect of levetiracetam drug on antioxidant and liver enzymes in epileptic patients: case-control study. (Pubmed Central) -  Dec 18, 2020   
    The results of our study indicated that LEV increased liver enzymes Also, treatment with this drug did not improve oxidative stress, but this could be due to the different in the dietary antioxidant intake. Routine screening of the liver and antioxidant enzymes in patients with chronic use of LEV is recommended.
  • ||||||||||  Vimpat (lacosamide) / UCB, Daiichi Sankyo
    Clinical, Journal:  The effect of lacosamide on psychiatric comorbidities in patients with epilepsy. (Pubmed Central) -  Dec 17, 2020   
    LCM polytherapy may have less negative influence on psychiatric comorbidities in patients with epilepsy compared with other antiseizure medications, and may also improve seizure severity. While LCM polytherapy might improve psychiatric symptoms as seizures improve, a small number of patients experienced worsening of psychiatric symptoms despite seizure improvement.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Transient epileptic amnesia diagnosed using long-term electroencephalography. (Pubmed Central) -  Dec 17, 2020   
    Treatment with levetiracetam resulted in complete recovery and seizure freedom that was confirmed on a second long-term EEG. Given the favourable outcome with antiseizure treatment, our case study illustrates the role of long-term EEG monitoring in patients with recurrent transient amnesia to establish a correct diagnosis [Published with video sequence].
  • ||||||||||  temozolomide / Generic mfg., levetiracetam / Generic mfg.
    Clinical, Journal:  Association between survival and levetiracetam use in glioblastoma patients treated with temozolomide chemoradiotherapy. (Pubmed Central) -  Dec 16, 2020   
    The multivariate analysis showed age (hazard ratio [HR], 1.02; P < 0.001), postoperative KPS score (HR 0.99; P = 0.002), complete tumour resection (HR 0.52; P < 0.001), MGMT promoter methylation (HR 0.75; P < 0.001), and LEV use (HR 0.72; P = 0.011) were significantly associated with OS. In conclusion, LEV use was associated with prolonged survival in patients with GBM treated with concurrent TMZ chemoradiotherapy.
  • ||||||||||  levetiracetam / Generic mfg.
    Biomarker, Journal:  Patterns and prognostic markers for treatment response in generalized epilepsies. (Pubmed Central) -  Dec 16, 2020   
    Despite of a high rate of seizure control, the chance of achieving seizure control and acceptable side effects at first attempt was low due to inverse association of effectiveness and side effects of the three most commonly used drugs. Routinely assessed clinical parameters were not indicative for response to specific drugs.
  • ||||||||||  levetiracetam / Generic mfg.
    Clinical, Journal:  Pharmacological treatment and SUDEP risk: A nationwide population-based case-control study. (Pubmed Central) -  Dec 16, 2020   
    Routinely assessed clinical parameters were not indicative for response to specific drugs. These results provide support for the importance of medication adherence and intensified AED treatment for patients with poorly controlled GTCS in the efforts to reduce SUDEP risks and suggest that comedication with statins may reduce risks.
  • ||||||||||  Briviact (brivaracetam) / UCB
    Journal:  Brivaracetam-A good alternative for the treatment of muscle cramps (Pubmed Central) -  Dec 16, 2020   
    These results provide support for the importance of medication adherence and intensified AED treatment for patients with poorly controlled GTCS in the efforts to reduce SUDEP risks and suggest that comedication with statins may reduce risks. Further studies are needed to demonstrate the effect of brivaracetam on muscle cramps.
  • ||||||||||  zonisamide / Generic mfg., levetiracetam / Generic mfg.
    Clinical, Journal:  Metabolic Profiling of the Cerebrospinal Fluid in Pediatric Epilepsy. (Pubmed Central) -  Dec 1, 2020   
    The roles of 1,5-anhydroglucitol in epilepsy in older children and in levetiracetam and zonisamide treatment remain to be explained. Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine.
  • ||||||||||  Xarelto (rivaroxaban) / J&J, Bayer
    Clinical, Journal:  Rivaroxaban Plasma Levels and Levetiracetam: A Case Report. (Pubmed Central) -  Dec 1, 2020   
    Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine. No abstract available
  • ||||||||||  levetiracetam / Generic mfg.
    Preclinical, Journal:  2-Deoxyglucose terminates pilocarpine-induced status epilepticus in neonatal rats. (Pubmed Central) -  Dec 1, 2020   
    No abstract available Our results suggest that the glycolysis inhibitor 2-DG acts quickly to reduce neuronal hyperexcitability and effectively suppress ongoing seizure activity, which may provide translational value in the treatment of neonatal SE.
  • ||||||||||  Vimpat (lacosamide) / UCB, Daiichi Sankyo, Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
    Journal:  Initiating antiepilepsy treatment: An update of expert consensus in Spain. (Pubmed Central) -  Nov 28, 2020   
    With respect to the choice of initial monotherapy depending on the type of epilepsy and the patient's age/sex profile, it is agreed to avoid valproic acid (VPA) in women with childbearing potential, with levetiracetam (LEV) and lamotrigine (LTG) being the preferable options in generalized epilepsy...In the elderly, LEV, lacosamide (LCM), eslicarbazepine acetate (ESL) and LTG are considered the most suitable drugs for initiating treatment...In conclusion, as the ILAE definition states, there are different situations that lead to treatment initiation after a first seizure. When choosing the first ASM, the type of epilepsy, childbearing potential and drug-drug interaction are key factors.
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] Trait impulsivity in Juvenile Myoclonic Epilepsy () -  Nov 28, 2020 - Abstract #AES2020AES_1175;    
    Increased seizure frequency and absent circadian seizure pattern moderate BIS score, suggesting disruption of both cortico-striatal and thalamocortical networks as a shared mechanism between seizures and impulsivity in JME. These findings warrant consideration of impulsivity as a distinct target of intervention, and as a stratifying factor for AED treatment in JME, and perhaps other types of epilepsy.