levetiracetam / Generic mfg. 
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  • ||||||||||  levetiracetam / Generic mfg., carbamazepine / Generic mfg.
    Journal:  Umbilical Cord, Maternal Milk, and Breastfed Infant Levetiracetam Concentrations Monitoring at Delivery and during Early Postpartum Period. (Pubmed Central) -  Apr 7, 2021   
    The mean milk/maternal serum concentration ratio was 1.14 ± 0.27 (2-4 days postpartum) and 1.04 ± 0.24 (7-31 days postpartum) while the mean infant/maternal serum concentration ratio was markedly lower (0.19 ± 0.13 and 0.14 ± 0.05, respectively); (4) levetiracetam was found in the umbilical cord at a concentration similar to those in maternal serum. All of the breastfed infant serum concentrations were below the reference range used for the general epileptic population.
  • ||||||||||  Review, Journal:  Anticonvulsant and antipsychotic medications in the pharmacotherapy of panic disorder: a structured review. (Pubmed Central) -  Apr 7, 2021   
    The small-to-modest sample size, the lack of control groups and the open-label and short-term nature of most of the reviewed studies hinder definitive conclusions regarding either the short-term and long-term efficacy of antipsychotic and anticonvulsant medications or their potential long-term side effects. Some atypical antipsychotic and anticonvulsant medications may have a role in the treatment of some PD patients, mostly when more conventional approaches have not been successful, but the quality of supporting evidence is limited.
  • ||||||||||  levetiracetam / Generic mfg.
    Clinical, Journal:  Does levetiracetam use affect Visual Evoked Potentials (VEP) in the treatment of childhood epilepsy? (Pubmed Central) -  Apr 7, 2021   
    Some atypical antipsychotic and anticonvulsant medications may have a role in the treatment of some PD patients, mostly when more conventional approaches have not been successful, but the quality of supporting evidence is limited. The data obtained in this study showed that levetiracetam use affected VEP amplitude outcome but did not affect VEP latency outcome in pediatric patients.
  • ||||||||||  gabapentin / Generic mfg.
    Clinical, Review, Journal:  Efficacy and safety of therapeutic plasma exchange in stiff person syndrome. (Pubmed Central) -  Apr 7, 2021   
    We review the literature regarding the efficacy and safety profile of TPE in exacerbation of SPS unresponsive to medical therapy. The procedure seems to have a good safety profile as an adjunct therapy for exacerbation of SPS not responding to standard medical therapy in this patient population.
  • ||||||||||  lorazepam / Generic mfg.
    [VIRTUAL] Seizure secondary to Fluzone Quadrivalent vaccination in a patient with severe mental illness: A case report () -  Apr 4, 2021 - Abstract #CPNP2021CPNP_115;    
    At the time of the seizure, the patient was receiving haloperidol per institution protocol...During her admission at the emergency department, she sustained a second seizure and was placed on levetiracetam, cefepime and lorazepam... In our case report, a temporal relationship was seen between the administration of the 2019-2020 Fluzone® Quadrivalent vaccine and a seizure in a patient with no known history of seizure disorder.
  • ||||||||||  levetiracetam / Generic mfg., clobazam / Generic mfg.
    [VIRTUAL] Use of Prescription Cannabidiol for the Management of Seizure Disorders at an Integrated Care Center () -  Apr 4, 2021 - Abstract #CPNP2021CPNP_57;    
    A median of 3 (IQR 2, 4) other AEDs were continued concurrently with CBD, most commonly levetiracetam (47%) and clobazam (46%). A real-world cohort of patients prescribed CBD revealed often lengthy and complex pharmacologic and non-pharmacologic pathways to CBD prescription and continued concurrent AED therapy.
  • ||||||||||  levetiracetam / Generic mfg., fosphenytoin / Generic mfg.
    [VIRTUAL] Post-traumatic epilepsy – current treatment (Room Amsterdam) -  Apr 3, 2021 - Abstract #EAN2021EAN_54;    
    Post-traumatic epilepsy is treated with anti-seizure medication recommended for focal epilepsy. Surgery can be considered for select patients.
  • ||||||||||  levetiracetam / Generic mfg.
    Clinical, Journal:  A unique case of multiple calvarial hemangiomas with one large symplastic hemangioma. (Pubmed Central) -  Apr 1, 2021   
    Histopathology and radiology examinations confirmed the diagnosis as symplastic hemangioma, on top of a pre-existing cavernous hemangioma. To the best of our knowledge, this is the first case of a calvarial symplastic hemangioma, which we report here.
  • ||||||||||  lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
    Journal:  Diagnosing Status Epilepticus (Pubmed Central) -  Apr 1, 2021   
    Abnormal cEEG findings during status epilepticus vary from rhythmic delta activity and epileptiform and generalized periodic discharges to ictal discharges. Accurate diagnosis of status epilepticus using MRI and cEEG can offer earlier intervention, such as prompt administration of benzodiazepines, midazolam, lorazepam, ultimately resulting in a good recovery.
  • ||||||||||  Strensiq (asfotase alfa) / Alexion Pharma
    [VIRTUAL] A Rare Case of Perinatal Hypophosphatasia Treated With Asfotase Alfa () -  Mar 27, 2021 - Abstract #ENDO2021ENDO_3194;    
    Despite the early initiation of asfotase alfa the patient's bone mineralization remains severely low and is not in a safe range to proceed with G-tube, broviac, or tracheostomy placement. The current management goal is to maximize bone mineralization in preparation for the life-sustaining procedures mentioned above.
  • ||||||||||  lacosamide / Generic mfg., levetiracetam / Generic mfg.
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Seizure Prophylaxis in Patients With Glioma or Brain Metastasis (clinicaltrials.gov) -  Mar 25, 2021   
    P2,  N=5, Terminated, 
    The current management goal is to maximize bone mineralization in preparation for the life-sustaining procedures mentioned above. N=232 --> 5 | Trial completion date: Jan 2023 --> Feb 2021 | Recruiting --> Terminated | Trial primary completion date: Jan 2023 --> Dec 2020; Did not enroll as planned
  • ||||||||||  Trileptal (oxcarbazepine) / Novartis
    Clinical, Journal:  Trends in prescribing patterns of antiepileptic drugs among older adult inpatients in a Brazilian tertiary center. (Pubmed Central) -  Mar 23, 2021   
    Phenytoin was the main suboptimal AED prescribed in our population, and convulsive SE and acute symptomatic seizures associated with some etiologies were independent risk factors for phenytoin prescription. These results suggest ongoing commitment to reducing the prescription of suboptimal AEDs, particularly phenytoin in Brazilian emergence rooms.
  • ||||||||||  levetiracetam / Generic mfg.
    Clinical, Journal:  Acute Symptomatic Seizures in Critically Ill Patients with COVID-19: Is There an Association? (Pubmed Central) -  Mar 19, 2021   
    Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy. Further studies are needed to elucidate the risk of seizures and benefit of monitoring in this population.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  A Rare Cause of a Eosinophilic Lung Disease (Pubmed Central) -  Mar 19, 2021   
    The patient was then treated with oral corticosteroids for a few months, and the antiepileptic medication was switched to levetiracetam...As well, the eosinophilic lung disease might have been caused by valproic acid. Similar cases have been described in the literature.
  • ||||||||||  levetiracetam / Generic mfg.
    Review, Journal:  Experimental Therapeutic Strategies in Epilepsies Using Anti-Seizure Medications. (Pubmed Central) -  Mar 19, 2021   
    Medications such as Levetiracetam, valproic acid, and lamotrigine are at the forefront of these patients' treatment...However, it should be noted that some of these patients still do not respond to existing treatments; therefore, the limited ability of current therapies has fueled research efforts for the development of novel treatment strategies. Thus, it seems that in addition to surgical measures, we should look for more specific agents that have less adverse events and have a greater effect in stopping seizures.
  • ||||||||||  levetiracetam / Generic mfg., carbamazepine / Generic mfg.
    Journal:  Neurocognition after prenatal levetiracetam, lamotrigine, carbamazepine or valproate exposure. (Pubmed Central) -  Mar 18, 2021   
    Consistent with previous research, valproate-exposed children experienced more problems compared to three other common antiepileptic drugs, while children exposed to lamotrigine, carbamazepine or levetiracetam revealed little to no problems. This illustrates the need for systematic follow-up of prenatally exposed children, to support pre-pregnancy counseling and treatment decisions in women of reproductive age.
  • ||||||||||  Trileptal (oxcarbazepine) / Novartis
    Clinical, Journal, Monotherapy:  Metabolic syndrome and obstructive sleep apnea syndrome among patients with epilepsy on monotherapy. (Pubmed Central) -  Mar 18, 2021   
    Because there are minimal differences in efficacy at this time, clinicians should consider alternative factors when deciding on an antiepileptic drug (AED). Higher frequency of MetS and OSAS risk should be kept in mind on clinical follow-up of patients with epilepsy receiving monotherapy.
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] Early Post-Stroke Seizures in Qatar () -  Mar 18, 2021 - Abstract #AAN2021AAN_1783;    
    This is the first study to determine the rate and epidemiology of early PSS in Qatar. With the burden of stroke rising in Qatar and elsewhere in the Middle East, it is important to understand early PSS in this region.
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] Optimal Dose of Levetiracetam for Seizure Prophylaxis in Neurocritical Care Patients () -  Mar 18, 2021 - Abstract #AAN2021AAN_1752;    
    Recognizing the early imaging findings of EEE can assist with timely diagnosis and treatment. Over 50% of patients who received 500 mg BID (7 mg/kg/dose) maintenance levetiracetam dosing had subtherapeutic levels, while 1000 mg BID (11 mg/kg/dose) was more likely to generate therapeutic levels.
  • ||||||||||  gabapentin / Generic mfg., sertraline / Generic mfg.
    [VIRTUAL] Drug-induced Myoclonus in a Patient on Continuous Dobutamine Infusion () -  Mar 18, 2021 - Abstract #AAN2021AAN_1325;    
    Adjusting infusion rate or route of administration may help ameliorate symptoms. Levetiracetam may also be useful for symptomatic treatment in patients where the infusion cannot be adjusted or stopped.
  • ||||||||||  Trileptal (oxcarbazepine) / Novartis
    [VIRTUAL] Alternative Medications for Paroxysmal Kinesigenic Dyskinesia () -  Mar 18, 2021 - Abstract #AAN2021AAN_1317;    
    In addition to carbamazepine, low doses of lamotrigine, oxcarbazepine, and phenytoin appear to be effective in PKD. However, levetiracetam and valproate may be ineffective options for PKD.
  • ||||||||||  levetiracetam / Generic mfg., fosphenytoin / Generic mfg.
    [VIRTUAL] Refractory Focal Status Epilepticus as Presenting Symptom of COVID-19 () -  Mar 18, 2021 - Abstract #AAN2021AAN_1260;    
    EEG did not demonstrate obvious seizure focus, but in the case of small seizure foci, scalp EEG can be unremarkable as would be expected in this case. To our knowledge, this is the first known case in the United States of a patient with Covid-19 presenting with the initial symptom of focal status epilepticus.
  • ||||||||||  lorazepam / Generic mfg.
    [VIRTUAL] COVID-19 associated Posterior Reversible Encephalopathy Syndrome () -  Mar 18, 2021 - Abstract #AAN2021AAN_1200;    
    Our case suggests that PRES is another neurological complication that can be caused by COVID-19 infection. PRES occurs due to blood-brain barrier disruption and endothelial dysfunction which may be one of the COVID-19 pathophysiological mechanisms that can affect the nervous system.
  • ||||||||||  lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg.
    [VIRTUAL] Pediatric Phencyclidine (PCP) Intoxication: First Reported Human MRI and EEG Findings () -  Mar 18, 2021 - Abstract #AAN2021AAN_904;    
    The patient’s EEG and late MRI findings are analogous to animal models of PCP intoxication, including high voltage frontally predominant delta waves, and global volume loss. Early diffusion restriction and T2 hyperintensity in white matter seen in our patient are unique findings not previously described.
  • ||||||||||  lorazepam / Generic mfg., midazolam hydrochloride / Generic mfg., bupropion / Generic mfg.
    [VIRTUAL] Bupropion Overdose Induced Reversible Burst Suppression and Myoclonic Seizures () -  Mar 18, 2021 - Abstract #AAN2021AAN_854;    
    Usually, burst suppression is consistent with a severe diffuse disturbance of cerebral function and typically indicates a poor prognosis. However, the burst suppression pattern associated with bupropion overdose is completely reversible, and treatment with anti-seizure medication may result in faster recovery.
  • ||||||||||  levetiracetam / Generic mfg.
    [VIRTUAL] Seizures After Liver Transplant () -  Mar 18, 2021 - Abstract #AAN2021AAN_852;    
    In our study, along 10 years, 1 in 10 liver transplant patients developed epileptic seizures, mostly in the context of severe systemic disorders. Our annual survival was similar to literature (79%)