- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Review, Journal: Feasibility of Using Oral Fluid for Therapeutic Drug Monitoring of Antiepileptic Drugs. (Pubmed Central) - Nov 4, 2021
Using OF may improve the acceptability and accessibility and reduce the cost of AED TDM. Clinical implementation requires standardized collection protocols, more rigorously defined OF reference ranges, and further studies to determine the relevance to clinically important outcomes.
- |||||||||| levetiracetam / Generic mfg., epinephrine / Generic mfg.
RINGING SHOT: TINNITUS AS A POSSIBLE SIDE EFFECT TO THE NEW COVID19 MRNA VACCINE (Hall B (1st Floor); Monitor 01) - Nov 2, 2021 - Abstract #ACAAI2021ACAAI_697;
No significant abnormalities were found and while she improved clinically, her tinnitus has persisted for months despite treatments with corticosteroids, levetiracetam and antibiotics...Neurological complications of vaccines are very rare and not well understood. Reactivation of a dormant virus or a crossed antigenic reaction between a protein in the vaccine and the nervous system are suggested mechanisms.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
[VIRTUAL] A Comprehensive Approach to Lance-adams Syndrome: A Case Report () - Nov 1, 2021 - Abstract #AAPMR2021AAPMR_459;
It is both physically and emotionally challenging. A comprehensive approach, including proper medications and psychotherapy, can facilitate and enhance the rehabilitation process.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Postoperative seizures following endoscopic third ventriculostomy and choroid plexus cauterization: a case series. (Pubmed Central) - Oct 30, 2021
In patients who received prophylactic perioperative levetiracetam, the postoperative seizure incidence dropped to 0% compared with 47% in those who did not receive prophylactic perioperative levetiracetam. This finding indicates that the use of prophylactic perioperative levetiracetam may be efficacious in the prevention of clinical seizures in this patient population.
- |||||||||| amantadine / Generic mfg.
Review, Journal: Management of Tardive Syndrome: Medications and Surgical Treatments. (Pubmed Central) - Oct 30, 2021
Anti-dyskinetic drugs are separated into 3 tiers: 1) vesicular monoamine transporter type 2 inhibitors, which have level A evidence, are approved for use in TS and are recommended first-choice agents; 2) drugs with lower level of evidence for efficacy including clonazepam, Ginkgo biloba, and amantadine; and 3) drugs that have the potential to be beneficial, but currently have insufficient evidence including levetiracetam, piracetam, vitamin B, melatonin, baclofen, propranolol, zolpidem, and zonisamide...Current therapies, though improved, are symptomatic. Next steps should focus on the prevention and reversal of the pathogenic process.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
Review, Journal: Physiology-Based Treatment of Myoclonus. (Pubmed Central) - Oct 30, 2021
Segmental and peripheral myoclonus are often resistant to treatment, but anticonvulsants and botulinum toxin injections may be of utility depending upon the case. Pharmacological treatments are often hampered by scarce evidence-based knowledge, adverse effects, and variable efficacy of medications.
- |||||||||| vigabatrin / Generic mfg., sodium valproate / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: Clinical manifestations and epilepsy treatment in Japanese patients with pathogenic CDKL5 variants. (Pubmed Central) - Oct 30, 2021
Our patients showed more severe global developmental delay than those in previous studies and had intractable epilepsy, likely because previous studies had lower numbers of males. Further studies are needed to investigate appropriate therapy for CDD, such as AED polytherapy or combination treatment involving ACTH, KD, and AEDs.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: A case of juvenile CLN1- challenge in diagnosis and epilepsy treatment. (Pubmed Central) - Oct 30, 2021
Diagnosis was made at the age of 12 years, based on palmitoyl protein-thioesterase (PPT) enzyme deficiency and genetic testing that documented a homozygous exon missense mutation in the CLN1 gene (PPT1, c.541G>A, p.Val181Met).DiscussionEpilepsy in all NCL patients is a major clinical issue and presumed related to neuronal excitation and epileptogenesis. The treatment of status epilepticus, in juvenile CLN1 patients, presents a particular challenge and requires monitoring of potential serious pharmacologic side effects of therapy.
- |||||||||| Akineton (biperiden) / Endo, AbbVie, Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Biomarker, Review, Journal: Selected Molecular Targets for Antiepileptogenesis. (Pubmed Central) - Oct 30, 2021
Among the approved non-antiepileptic drugs, antiepileptogenic potential seems to reside in losartan (a blocker of angiotensin II type 1 receptors), biperiden (an antiparkinsonian drug), nonsteroidal anti-inflammatory drugs, antioxidative drugs and minocycline (a second-generation tetracycline with anti-inflammatory and antioxidant properties)...Exceptionally, in this regard, our own original data presented here point to c-Fos as an early seizure duration, but not seizure intensity-related, marker of early epileptogenesis. Further research of reliable markers of early epileptogenesis is definitely needed to improve the process of designing adequate antiepileptogenic therapies.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma, ciltacabtagene autoleucel (LCAR-B38M) / J&J
[VIRTUAL] INCIDENCE, MITIGATION, AND MANAGEMENT OF NEUROLOGIC ADVERSE EVENTS IN PATIENTS WITH MULTIPLE MYELOMA TREATED WITH CILTACABTAGENE AUTOLEUCEL (CILTA-CEL) IN CARTITUDE-2 () - Oct 27, 2021 - Abstract #HEMO2021HEMO_962;
P2
Cilta-cel (0.75 × 106 [range 0.5– 1.0 × 106] CAR+ viable T cells/kg) was given as a single infusion 5–7 days after start of lymphodepletion (cyclophosphamide 300 mg/m2 + fludarabine 30 mg/m2 daily for 3 days)...Management strategies include evaluating infectious and paraneoplastic etiologies upon observation of ICANS ≥grade 1, administration of tocilizumab (if concurrent with cytokine release syndrome [CRS], all grade of ICANS) and/or dexamethasone (grade 2/3) or methylprednisolone (grade 4)...Two of the 3 patients received supportive measures to treat ICANS, including levetiracetam and steroids; all 3 had concurrent CRS and all recovered...No movement or neurocognitive disorders were reported.Discussion Early detection and management of neurologic adverse events can lead to better treatment outcomes.Conclusion Neurologic adverse events were generally manageable in patients with MM following treatment with cilta-cel. With a median of 5.8 months of follow-up, there were no movement or neurocognitive disorders in patients from Cohort A.
- |||||||||| Fycompa (perampanel) / Eisai
Clinical, Journal: Adjunctive Perampanel in Older Patients With Epilepsy: A Multicenter Study of Clinical Practice. (Pubmed Central) - Oct 27, 2021
The available literature suggests the use of sulthiame, levetiracetam, or clobazam as first-line agents for the treatment of BECTS. Adjunctive perampanel was associated with improvement in seizure control and good tolerability in a real-life setting and can represent a viable therapeutic option in older patients with epilepsy.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg., topiramate / Generic mfg.
Journal: A de novo nonsense mutation of STXBP1 causes early-onset epileptic encephalopathy. (Pubmed Central) - Oct 27, 2021
Levetiracetam, clonazepam, and topiramate showed antiepileptic effects in the Tg(hSTXBP1) larvae to different extents. Our findings in the newly generated mutant line of zebrafish suggested that zebrafish recapitulated clinical phenotypes associated with human STXBP1 mutation, which provided an appropriate in vivo model for epilepsy research.
- |||||||||| phenytoin / Generic mfg., levetiracetam / Generic mfg.
Review, Journal: Treating Status Epilepticus: Phenytoin Versus Levetiracetam. (Pubmed Central) - Oct 22, 2021
This review focuses on several clinical studies that have directly compared the effectiveness of phenytoin and levetiracetam in suppressing SE seizure activity. Additionally, this review highlights several advantages of using levetiracetam over phenytoin in this clinical context.
- |||||||||| levetiracetam / Generic mfg.
Clinical, PK/PD data, Journal: Pharmacokinetics of levetiracetam in neurosurgical ICU patients. (Pubmed Central) - Oct 22, 2021
Our study examined the population PK of levetiracetam in a critically ill neurosurgical population. We found that this population displayed higher clearance and required higher doses to achieve target levels.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
[VIRTUAL] Thymoma Associated with Autoimmune Multifocal Cortical Encephalitis and Subsequent Myasthenia Gravis () - Oct 21, 2021 - Abstract #ANA2021ANA_408;
Our case report is only the third reported case of thymoma-associated multifocal cortical encephalitis, which shows that autoimmune encephalitis can extend to cortical regions outside the limbic system. We should consider autoimmune encephalitis in the differential diagno sis of patients with myasthenia gravis or thymoma who develop new cognitive symptoms.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Generalized Myoclonus in a COVID-19 Patient: Case Report () - Oct 21, 2021 - Abstract #ANA2021ANA_312;
A para or post infec tious auto-immune mechanism is thought more likely, though a trans-neuronal spread is also possible. This associa tion warrants further evaluation to clarify the underlying pathophysiological mechanism and to govern optimal treatment.
- |||||||||| carbamazepine / Generic mfg.
[VIRTUAL] Total Daily Dosage of Anti-Epileptic Drugs in Women with Epilepsy with Subsequent Pregnancies () - Oct 21, 2021 - Abstract #ANA2021ANA_222;
This variation may reflect differences in the timing of level testing, variability in practitioner dosage change during different pregnancies amongst other factors. The doses used during an initial pregnancy may be useful in guiding dose management in successive pregnancies, but frequent testing of levels may still be needed.
- |||||||||| levetiracetam / Generic mfg.
[VIRTUAL] Complete Heart Block Mimicking Recurrent Seizures: A Case of Convulsive Syncope () - Oct 21, 2021 - Abstract #ANA2021ANA_204;
In the clinical setting, convulsive syncope needs to be considered in the differential diagnosis of recurrent seizures-like episodes. Video EEG with simultaneous EKG recording is very key in making the distinction between the two diagnoses as it can reveal syncope from a cardiovascular cause such as a heart block or cardiac arrhythmia which can prevent a misdiagnosis of epilepsy.
- |||||||||| midazolam hydrochloride / Generic mfg.
[VIRTUAL] Status Epilepticus in the Setting of COVID-19 Infection () - Oct 21, 2021 - Abstract #ANA2021ANA_202;
While the exact mechanism of how COVID19 causes SE is currently unknown, COVID-19 has been associated with various neurological conditions. Our patient developed a convulsive SE originating focally from the right hemisphere associated with severe COVID-19 infection.
- |||||||||| ketamine / Generic mfg., lorazepam / Generic mfg.
[VIRTUAL] Testing the Salzburg Criteria in Cefepime Induced Non-Convulsive Status Epilepticus () - Oct 21, 2021 - Abstract #ANA2021ANA_201;
Initial attempt to classify the pattern as ictal using clinical and EEG improvement from IV anti-seizure medications in this case failed, but both EEG and clinical improvement was seen after 24 hours of IV ketamine infusion. Our report highlights need to quantify the time interval that should be used to define NCSE in the Salzburg criteria through the trial of IV anti-seizure medication.
- |||||||||| donepezil / Generic mfg.
[VIRTUAL] A Case Report of Cerebral Amyloid Angiopathy Related Inflammation () - Oct 21, 2021 - Abstract #ANA2021ANA_96;
Her medications included donepezil, fluoxetine and levothyroxine...The area was felt to be epileptogenic so patient was placed on Keppra 500 mg BID...MRI demonstrates unifocal or multifocal white matter hyper-intensity lesions in an asymmetric pattern, 5. Evidence of CAA in the form of cerebral micro/macrobleeds, 6) Absence of neoplastic or infectious causes.
- |||||||||| carbamazepine / Generic mfg.
Journal: Prescription pattern of antiepileptic drugs in a tertiary care center of India. (Pubmed Central) - Oct 20, 2021
Sodium VPA, a highly prescribed AED, results in good control of generalized seizures, whereas focal seizures are well controlled by CBZ alone as well as in combination. The present study highlights the commonly prescribed combinations of AEDs resulting in control of different types of seizures.
- |||||||||| levetiracetam / Generic mfg., fosphenytoin / Generic mfg.
Journal: Update on the management of status epilepticus. (Pubmed Central) - Oct 20, 2021
There is a continuous, albeit relatively slow progress in knowledge regarding different aspect of status epilepticus; recent findings refine some treatment strategies and help improving patients' outcomes. Further high-quality studies are clearly needed to further improve the management of these patients, especially those with severe, refractory status epilepticus forms.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg.
Clinical, Journal, Combination therapy: Effect of levetiracetam in combination with topiramate on immune function, cognitive function, and neuronal nutritional status of children with intractable epilepsy. (Pubmed Central) - Oct 20, 2021
Overall, the data demonstrate that the proposed model for DS is suitable for screening novel compounds for the ability to block hyperthermia-induced seizures and that heterozygous mice can be evaluated repeatedly over the course of several weeks, allowing for higher throughput screening. Levetiracetam in combination with topiramate is associated with reduced inflammatory response and improved immune function, cognitive function, and neuronal nutritional status in children with intractable epilepsy.
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