- |||||||||| Fycompa (perampanel) / Eisai, lamotrigine liquid oral suspension / OWP Pharma
Novel Gene Abnormality in Epilepsy with Myoclonic-Astatic Seizures (Doose Syndrome) () - Dec 12, 2021 - Abstract #AES2021AES_1716;
Our patient does not present with the classic history, physical, and imaging findings associated with that disorder. Such findings include rapidly progressive encephalopathy, feeding difficulties, progressive microcephaly, lens subluxation, and loss of gray-white matter in the cerebral cortex & basal ganglia on MRI imaging.
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg., ethosuximide / Generic mfg.
Heterozygous GOSR2 Mutation Associated Epilepsy and Muscular Dystrophy () - Dec 12, 2021 - Abstract #AES2021AES_1691;
The gene should be included in both gene panels for neuromuscular as well as epilepsy syndromes. Our case also revealed associated absence and myoclonic epilepsy and expands the phenotypic spectrum of this rare disorder.
- |||||||||| levetiracetam / Generic mfg.
A Case Series on Antiepileptic Drug Use in Peritoneal Dialysis () - Dec 12, 2021 - Abstract #AES2021AES_1614;
It remains unknown the impact different modes and intensities of PD have on the pharmacokinetic profile of AEDs. Still, in our small cohort, patients on levetiracetam had excellent seizure control suggesting this medication may be a potential option for patients with ESRD receiving HD.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
A Novel Platform Supports Characterization of SYNGAP1-related Disorder Through Generation of Real World Evidence () - Dec 12, 2021 - Abstract #AES2021AES_1478;
The most common AEDs were: levetiracetam (n=41, 57.8%), clobazam (n=39, 54.9%), lamotrigine (n=39, 54.9%), and valproate (n=36, 50.7%). To our knowledge, this work represents the largest cohort of SYNGAP1-related disorder described to date, demonstrating the unique potential of real world evidence to expand understanding of rare epilepsy syndromes.
- |||||||||| Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Effects of Eslicarbazepine Acetate on Bone Density and on Bone Metabolism () - Dec 12, 2021 - Abstract #AES2021AES_1469;
Neither osteodensitometry nor bone metabolism parameters showed significant group effects after one year of treatment with eslicarbazepine acetate. Individual fluctuations were observed, however, which may warrant monitoring particularly in patients under polytherapy.
- |||||||||| midazolam hydrochloride / Generic mfg.
Myoclonic Status Epilepticus Secondary to Hyperammonemia () - Dec 12, 2021 - Abstract #AES2021AES_1417;
At high levels, ammonia can cross the blood-brain barrier and is converted into glutamine which acts as an osmolyte and increases cerebral volume. Myoclonic status epilepticus is a rare complication of hyperammonemia with a poor prognosis due to complications like cerebral edema and multisystem failure.
- |||||||||| lorazepam / Generic mfg.
Blue Lotus-Induced Seizures in Active Duty Soldier () - Dec 12, 2021 - Abstract #AES2021AES_1403;
The trend of Blue Lotus drug abuse is anticipated to become more widespread in the coming months. As use of Blue Lotus becomes more pervasive, it’s critical for medical providers to recognize the drug and understand its devastating complications.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
Pregnancy and Neonatal Outcomes in Women with Epilepsy Exposed to Lacosamide During Pregnancy () - Dec 12, 2021 - Abstract #AES2021AES_1394;
Women in our cohort were all on polytherapy which might have contributed to the increased rate of miscarriage as previously reported in published literature. Conclusions regarding a causal relationship between LCM and miscarriage could thus be misleading based on our data alone.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
The Treatment of Epilepsy in Older Adults: A National Survey () - Dec 12, 2021 - Abstract #AES2021AES_1358;
Our surveyed geriatricians and neurologists (with and without epilepsy training) differed in their approach to ASM choice as well as surgical treatments. This may relate to the lack of clear and accepted clinical practice guidelines.
- |||||||||| levetiracetam / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Hemiconvulsion-Hemiplegia Like Syndrome in an Adolescent Patient () - Dec 12, 2021 - Abstract #AES2021AES_1351;
Prolonged ictal activity provoking inflammation and increase in blood-brain-barrier permeability play a role in the pathogenesis of severe cases of excitotoxic injury resulting in neuronal death in the seizure circuit. Early recognition and treatment of status epilepticus is imperative to prevent permanent cerebral injury.
- |||||||||| levetiracetam / Generic mfg., quinidine sulfate / Generic mfg.
Successful Use of Quinidine to Treat Refractory Myoclonic and Astatic Seizures in a Patient with KCNT1 Variant () - Dec 12, 2021 - Abstract #AES2021AES_1338;
To date, our patient has achieved seizure-free status after being started on quinidine and has been simultaneously weaned off levetiracetam and phenobarbital. Thus, quinidine may be a viable option for treatment of patients with KCNT1 mutations who have myoclonic and astatic seizures refractory to traditional antiseizure medications.
- |||||||||| Briviact (brivaracetam) / UCB
Brivaracetam Clearance Changes During Pregnancy in Women with Epilepsy () - Dec 12, 2021 - Abstract #AES2021AES_1325;
Further investigation is necessary to assess BRV use in larger cohorts, with baseline measurements, formal pharmacokinetic modeling with hours post-dose, and assessment of seizure control relative to alterations in concentrations. Based on our observed clearance fluctuations, TDM is recommended for patients on BRV.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group
Characterization of Brain Region Activation in Various Mouse Seizure Models () - Dec 12, 2021 - Abstract #AES2021AES_1298;
These data suggest there is differential activation of brain regions following a 6 Hz or MES seizure, which is consistent with previously published literature. Ongoing studies are investigating the effects of mechanistically distinct ASD’s to block brain region recruitment of a 6 Hz or MES seizure and provide insight into the mechanisms of pharmacosensitivity of clinically used ASDs.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
On the Digital Psychopharmacology of Antiseizure Medications () - Dec 12, 2021 - Abstract #AES2021AES_1285;
Our data demonstrate that experimenter-free instrumented home cage chambers can reveal unique psychopharmacological profiles for ASMs with distinct mechanisms of action, providing protocols for the screening of pipeline ASM candidates and models that may predict ASM side effects. In ongoing experiments, we extend this analysis to a third water soluble ASM (lacosamide), and explore the effects of ASM polytherapy and dose dependence.
- |||||||||| Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Psychiatric Treatment-Emergent Adverse Events in Patients with Focal Seizures Receiving Adjunctive Eslicarbazepine Acetate in a Phase IV Clinical Trial () - Dec 12, 2021 - Abstract #AES2021AES_1265;
P4
In a recently completed real-world, Phase IV study of ESL taken as a first adjunctive therapy with levetiracetam or lamotrigine monotherapy, or as later adjunctive therapy in treatment-resistant patients with focal seizures, psychiatric disorder treatment-emergent adverse events (TEAEs) were reported in 22 of 102 patients in the safety population (21.6%). Psychiatric disorder TEAEs were more frequent, and tended to be reported earlier, in patients receiving adjunctive ESL as later therapy for focal seizures compared with patients receiving ESL as the first adjunctive therapy.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo, lamotrigine liquid oral suspension / OWP Pharma, Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) / Gilead
Transient Atrial Fibrillation Following Generalized Tonic-Clonic Seizure in Epileptic Patients with HIV () - Dec 12, 2021 - Abstract #AES2021AES_1253;
Appropriate management for AF should be considered after weighing the risk and benefits. Further studies with larger sample size are needed to assess any possible association between the increased risk for postictal AF after GTCS in epileptic patients with HIV.
- |||||||||| Fycompa (perampanel) / Eisai
Use of Perampanel in the Treatment of Refractory Generalized Epilepsy in Children () - Dec 12, 2021 - Abstract #AES2021AES_1228;
PER can be used as an adjunct therapy in children with refractory generalized epilepsies to achieve seizure free state as seen in two of our cases and considerable improvement in the first patient with absence epilepsy. Specific improvement in generalized spike and wave discharges and ictal patterns is consistent with a robust clinical and electrographic response.
- |||||||||| Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Effect of Modal and Maximum Dose in Patients with Focal Seizures Receiving Adjunctive ESL in a Phase IV Clinical Trial () - Dec 12, 2021 - Abstract #AES2021AES_1204;
P4
In a real-world, Phase IV study of ESL as a first adjunctive therapy with levetiracetam (LEV) or lamotrigine (LTG) monotherapy (Arm 1), or as a later adjunctive therapy following current/prior use of 1–2 ASMs (Arm 2) in patients with focal seizures, retention rates were 81.8% and 63.8% (Hixson J, et al... Stratification of the data from the Phase IV study of adjunctive ESL showed that retention rates and reduction in SSF at 24 weeks is mostly driven by patients receiving the lowest allowed ESL maintenance dose of 800 mg, regardless of whether ESL was taken as a first or as a later adjunctive therapy.
- |||||||||| ezogabine (pediatric formulation of potiga) / Xenon
Strain Dependent Differences in Response to Antiseizure Drugs (ASDs) in Mouse Acute Seizure Models () - Dec 12, 2021 - Abstract #AES2021AES_1197;
This analysis was essential to determine if there were any significant differences in either seizure thresholds or responses to a battery of commonly used ASDs in either different strains of mice or the same strain over a period of time. Rigor and reproducibility are essential for a screening program and this investigation suggests that strain dependent and animal supplier differences could influence experimental results.
- |||||||||| vigabatrin / Generic mfg., levetiracetam / Generic mfg., topiramate / Generic mfg.
Clinical Algorithm for Identification of Children at Risk for Infantile Spasms Relapse () - Dec 12, 2021 - Abstract #AES2021AES_1160;
Additional consideration of slowing on follow-up EEG, developmental delay before treatment, and deep grey matter injury can allow physicians to identify who will relapse with higher PPV. The study was limited by small sample size.
- |||||||||| Briviact (brivaracetam) / UCB
Real-World Study of Brivaracetam in the United States () - Dec 12, 2021 - Abstract #AES2021AES_1136;
Main eligibility criteria included a history of focal seizures, age ≥ 16 years, and lifetime history or current concomitant use of ≥ 1 of four specific antiseizure medications (ASMs): levetiracetam, lamotrigine, oxcarbazepine, or carbamazepine. BRV was well tolerated and effective in one of the first US real-world evidence studies examining BRV in a real-world setting, as reflected by a 12-month retention of 57.1%.
- |||||||||| gabapentin / Generic mfg., carbamazepine / Generic mfg.
Nonconvulsive Status Epilepticus in the Setting of Cannabidiol Adjunctive Therapy () - Dec 12, 2021 - Abstract #AES2021AES_1048;
CBD may have also triggered NCSE in our patient because of its pharmacokinetic interactions with his other ASMs, specifically by increasing tiagabine levels. There is still a need to better understand CBD’s molecular targets to prevent this rare complication.
- |||||||||| levetiracetam / Generic mfg.
Postpartum Depression in Women with Epilepsy: Lamotrigine vs Levetiracetam Monotherapy () - Dec 12, 2021 - Abstract #AES2021AES_1022;
This finding is clinically reassuring for physicians and women maintained on levetiracetam who may be concerned about PPD due to hormonal fluctuations. Additionally, seizure worsening during postpartum period did not have a strong correlation with a depressed mood in our small cohort.
- |||||||||| oxcarbazepine / Generic mfg.
Oxcarbazepine Use and the Risk of Infantile Spasms Among Children with Epilepsy () - Dec 12, 2021 - Abstract #AES2021AES_1003;
In this preliminary analysis, oxcarbazepine was associated with a greater risk of ISS compared to levetiracetam. Though the sample size was small and residual confounding cannot be ruled out, our study results warrant further investigation on whether sodium channel blockers may be causally linked to ISS in infants.
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