- |||||||||| Briviact (brivaracetam) / UCB
Real-world Study of Brivaracetam in the United States () - Mar 6, 2022 - Abstract #AAN2022AAN_1569;
Main eligibility criteria included a history of focal seizures, age ≥16 years, and lifetime history or concomitant use of ≥1 of four specific antiseizure medications (ASMs): levetiracetam/lamotrigine/oxcarbazepine/carbamazepine. BRV demonstrated long-term effectiveness in this US observational study.
- |||||||||| levetiracetam / Generic mfg.
Retrospective data, Review, Journal: Levetiracetam for Seizure Prophylaxis in Neurocritical Care: A Systematic Review and Meta-analysis. (Pubmed Central) - Mar 4, 2022
Studies are needed to determine whether these children could benefit from adjunct bone fragility therapies. Based on the current moderately to seriously biased heterogeneous data, which frequently used low and possibly subtherapeutic doses of levetiracetam, our meta-analyses did not demonstrate significant reductions in seizure incidence and neither supports nor refutes the use of levetiracetam prophylaxis in TBI, SAH, or ICH. Levetiracetam may be preferred post supratentorial neurosurgery. More high-quality randomized trials of prophylactic levetiracetam are warranted.
- |||||||||| bumetanide / Generic mfg.
Review, Journal: Novel Therapeutics for Neonatal Seizures. (Pubmed Central) - Mar 4, 2022
We present emerging therapies in clinical and preclinical development for the treatment of acute symptomatic neonatal seizures. Lastly, we discuss the role of precision therapies for genetic neonatal-onset epilepsies and address barriers and goals for developing new therapies for clinical care.
- |||||||||| phenytoin / Generic mfg., levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal: The effect of antiepileptic drugs on re-myelinization of axons: Phenytoin, levetiracetam, carbamazepine, and valproic acid, used following traumatic brain injury. (Pubmed Central) - Mar 4, 2022
Antiepileptic drug selection after traumatic brain injury is an important medical matter. Although the patient-oriented selection is essential, the study suggests that the choice of phenytoin, levetiracetam carbamazepine, and valproic acid will, respectively, have an accelerating effect for axonal healing.
- |||||||||| carbamazepine / Generic mfg.
Journal: Potential for improved retention rate by personalized antiseizure medication selection: A register-based analysis. (Pubmed Central) - Mar 3, 2022
Although the patient-oriented selection is essential, the study suggests that the choice of phenytoin, levetiracetam carbamazepine, and valproic acid will, respectively, have an accelerating effect for axonal healing. We conclude that personalized ASM selection could improve retention rates and that national registers have potential as big data sources for personalized medicine in epilepsy.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Factors affecting breastfeeding in women with epilepsy. (Pubmed Central) - Mar 3, 2022
The initiation rate and duration of breastfeeding were significantly lower in WWE than in healthy women without epilepsy and were significantly associated with several factors. Identification of potential barriers to breastfeeding in WWE may lead to development of intervention strategies that can improve breastfeeding rates in WWE to maximize positive health outcomes for WWE and their infants.
- |||||||||| levetiracetam / Generic mfg.
Journal: Targeting hippocampal amyloidogenesis with SV2A protein modulator levetiracetam. (Pubmed Central) - Mar 3, 2022
In contrast, monomers of Aβ and Aβ had negligible impact on studied processes. Our data suggests that in the course of progression of neuroinflammation oligomeric forms of Aβ and Aβ can compromise the SV fusion machinery and that antiepileptic agent levetiracetam, acting on SV recycling and restricting overexcitation is able to affect APP processing and Aβ generation within the hippocampus in vivo.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Epilepsy and Pregnancy. (Pubmed Central) - Mar 3, 2022
Practitioners should discuss the risks of various obstetric complications; potential anatomic teratogenicity and neurodevelopmental dysfunction related to fetal antiseizure medication exposure; and a plan of care during pregnancy, delivery, and postpartum. Women with epilepsy should also be reassured that the majority of pregnancies are uneventful.
- |||||||||| levetiracetam / Generic mfg.
Preclinical, Journal: Diclofenac sodium enhances the antiepileptic effect of levetiracetam in pilocarpine induced epileptic mice model. (Pubmed Central) - Feb 26, 2022
Results showed significant improvement in the latencies to first (P<0.001) and continuous seizures (P<0.05), duration of the continuous seizure (p=0.001), and survival rate (P<0.01) in the combination treatment group as compared to the control or individual drug treatment groups. DFS enhances the efficacy of LEV, however, further mechanistic studies will be required to conclude if DFS can be given in combination with LEV for epilepsy treatment.
- |||||||||| glibenclamide / Generic mfg., ceftriaxone / Generic mfg.
Journal: Drug Repurposing in Neurological Disorders: Implications for Neurotherapy in Traumatic Brain Injury. (Pubmed Central) - Feb 25, 2022
Edaravone, glyburide, ceftriaxone, levetiracetam, and progesterone have been selected due to their potential role as putative TBI neurotherapeutic agents. These drugs are Food and Drug Administration-approved for purposes other than brain injuries; however, preclinical and clinical studies have shown their efficacy in ameliorating the various detrimental outcomes of TBI.
- |||||||||| gabapentin / Generic mfg.
Clinical, Review, Journal: Neurodevelopmental outcomes in children exposed to newer antiseizure medications: A systematic review. (Pubmed Central) - Feb 25, 2022
Exposure to certain newer ASMs, such as lamotrigine and levetiracetam, does not thus far appear to impact certain aspects of neurodevelopment, but further delineation across the different neurodevelopmental domains and dosage levels is required. A lack of data cannot be inferred to represent safety of newer ASMs, which are yet to be investigated.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Retrospective data, Journal: Levetiracetam Prophylaxis for Children Admitted With Traumatic Brain Injury. (Pubmed Central) - Feb 24, 2022
We still observed important variability in neuroimaging characteristics and TBI severity for children on prophylaxis. Thus, further study of ASM prophylaxis and prevention of pediatric EPTSs is warranted.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal, Heterogeneity: Clinical heterogeneity in patients with myoclonus associated to COVID-19. (Pubmed Central) - Feb 24, 2022
Our 6 cases highlight the heterogeneity of the clinical spectrum of myoclonus associated to COVID-19 (MYaCO). MYaCO pathogenesis is suspected to be due to an immune-mediated para- or post-infectious phenomenon; nevertheless, further research is needed to elucidate this hypothesis.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Efficacy of levetiracetam as first-line therapy for neonatal clinical seizures and neurodevelopmental outcome at 12 months of age. (Pubmed Central) - Feb 23, 2022
Neurodevelopmental outcome of the infants was assessed with Ankara Development Screening Inventory and results suggested favorable neurodevelopmental outcome in 69.7% of the infants with at the end of the 1-year follow-up with LEV monotherapy. In conclusion, this retrospective cross-sectional study demonstrated that IV LEV is an effective first-line therapy for treating neonatal clinical seizures and LEV monotherapy effect was sustained during the first year follow-up.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Journal: Adult-onset mitochondrial movement disorders: a national picture from the Italian Network. (Pubmed Central) - Feb 23, 2022
Movement disorders, mainly ataxia and parkinsonism, are important findings in adult primary mitochondrial diseases. This study underlies the importance of looking for a mitochondrial etiology in the diagnostic flowchart of a movement disorder and may help direct genetic screening in daily practice.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Journal: All-optical monitoring of excitation-secretion coupling demonstrates that SV2A functions downstream of evoked Ca entry. (Pubmed Central) - Feb 22, 2022
The far-red fluorescence of this indicator enables multiplexing with the fluorescent glutamate sensor iGluSnFR for detection of presynaptic Ca influx and glutamate release at the same axonal boutons. Evoked glutamate release probability was reduced in SV2A KO neurons without a change in presynaptic Ca entry, suggesting that SV2A supports vesicle fusion by increasing the functional availability, or efficiency, of the Ca -regulated membrane fusion machinery.
- |||||||||| tranexamic acid oral / Generic mfg.
Review, Journal: Management of traumatic brain injury: a narrative review of current evidence. (Pubmed Central) - Feb 22, 2022
The use of tranexamic acid in the management of traumatic brain injury has been the focus of several studies, with one large randomised controlled trial suggesting a reduction in all-cause mortality within 24 h of injury...For seizure management, levetiracetam appears to be as effective as phenytoin, but the optimal dose remains unclear...Further research is needed in order to determine the optimal package of care and interventions. There is a need for research studies to focus on patient-centred outcome measures such as long-term neurological recovery and quality of life.
- |||||||||| What Hiding Under the Uremia? A Rare Case Presentation and Miraculous Recovery with Clevidipine. (Area A, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_4530;
To control her blood pressure, she wasstarted on as needed intravenous hydralazine and labetalol...PRESand uremic encephalopathy can have many overlapping symptoms such as headaches, confusion, andseizures. Considering that renal disease and uncontrolled hypertension often co-exist together, it isimportant to have a high index of suspicion for PRES syndrome in patients being treated for uremicencephalopathy.
- |||||||||| levetiracetam / Generic mfg., propranolol / Generic mfg.
Paroxysmal Sympathetic Hyperactivity: Autonomic Instability in Traumatic Brain Injury (Area A, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_4529;
There are about 8-10% of TBI survivors affected by this complication...However, treatment-related events such as prolonged respiratory support in the intensive care unit (ICU), and a delay in early neurological rehabilitation, may lead to the deterioration of neurological function. This is a common syndrome and failure to recognize it is associated with increased morbidity and mortality, higher health costs, longer hospitalizations and poorer outcomes.
- |||||||||| lorazepam / Generic mfg., levetiracetam / Generic mfg.
Air Rises: A Unique Case of Pneumocephalus Secondary to Intrapleural Fibrinolytic Therapy (Area G, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_2875;
Ativan was provided due to concern for seizure but provided no benefit...She was urgently transferred to the ICU and treated with levetiracetam for seizure prophylaxis.She was placed in Trendelenburg position and treated with 15L nonrebreather mask to facilitate gaseous diffusion...Hyperbaric oxygenation therapy is important, aimed at establishing a diffusion gradient to eliminate gaseous bubbles. This case highlights the importance of considering air embolism as a cause of neurologic deterioration in patients receiving intrapleural fibrinolytics.
- |||||||||| Probable Creutzfeldt-Jakob Disease in the Context of a Recent COVID-19 Infection (Area J, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1276;
He was started on empiric Ceftriaxone, Ampicillin, Vancomycin, and Acyclovir for suspected meningitis...He was started on Levetiracetam and Fosphenytoin...Unfortunately, an autopsy was not performed for definitive diagnosis given his death before the resulting 14-3-3. This case serves to increase awareness to the possible association between COVID-19 and neurologic decline as well as to highlight the importance of a thorough physical examination.
- |||||||||| Austrian Syndrome: An Unusual Case of Subarachnoid Hemorrhage as a Result of Meningitis (Area K, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1240;
Austrian syndrome is a rare triad of meningitis, endocarditis, and pneumonia. Meningitis should be considered early in patients with risk factors and supporting clinical findings, including evidence of non-traumatic and non-aneurysmal subarachnoid hemorrhage.
- |||||||||| Immune Reconstitution Syndrome in a Renal Transplant Recipient in Patient with Disseminated Cryptococcus (Area K, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1199;
Infectious work up was sent while starting empiric therapy with vancomycin and piperacillin/tazobactam for presumed pneumonia...He developed refractory nonconvulsive status epilepticus requiring keppra, lacosamide and midazolam infusion raising a concern for hydrocephalus and intracranial hypertension (ICH)...IRS has been observed in 5-11% SOT recipients after starting antifungal therapy. Discontinuation or reduction in immunosuppression in transplant recipients and start of effective antifungal therapy in the setting of disseminated fungal disease has been associated with dysregulated immune response leading to IRS.
- |||||||||| Therapeutic Implications of Combined IVIG and Steroid Therapy in West Nile Encephalitis (Area K, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1197;
Studies have shown in immunocompromised murine models, WNV persists in the CNS, eventually causing encephalitis similar to immuno-compromised patients...Few case reports have described steroid use to successfully treat a patient with WNE. Further research is sorely needed to investigate treatment modalities in WNE.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
Pembrolizumab Induced Encephalitis; Catching Diagnosis Early Is the Key (Area G, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1157;
After seizure and infectious etiologies were ruled out, started treatment with 1mg/kg of solumedrol and later increased to pulse dose steroids...Severe cases often requires permanent discontinuation of ICPI, pulse dose steroids and for refractory cases escalation of immunosuppressive treatment with IVIg, plasma exchange, rituximab, methotrexate, azathioprine and mycophenolate...Knowledge about occurrence and high degree of suspicion is important for early diagnosis. Early diagnosis is important as patients respond well with treatment.
- |||||||||| levetiracetam / Generic mfg.
Negative Pressure Pulmonary Edema Secondary to Generalized Tonic Clonic Seizures (Area F, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1030;
Recognition and management of acute hypoxic respiratory failure due to NPPE is critical. Aggressive supportive management can prevent tracheal intubation, while adherence to anti-epileptic medications and smoking cessation can lower the odds of having similar episodes in the future.
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