- |||||||||| phenytoin / Generic mfg., levetiracetam / Generic mfg.
Journal: Survey About Second-Line Agents for Pediatric Convulsive Status Epilepticus. (Pubmed Central) - May 6, 2022 This affirms treatment initiation with AED monotherapy; however, the treatment choices do not necessarily follow the recommended guidelines to select conventional AEDs, at low strengths, at initiation. To facilitate use of levetiracetam for treatment of CSE in pediatrics, it should be included as a second-line agent in addition to phenytoin in the next update of the National Institute for Health and Care Excellence and other United Kingdom clinical guidelines.
- |||||||||| Neuropsychiatric Manifestations of COVID-19: A Case Report () - May 5, 2022 - Abstract #APA2022APA_990;
We present a case of a 32 y/o Hispanic female, with no PPHx and PMHx of Diabetes Mellitus Type 1 & a positive COVID-19 infection, who initially presented to the ER, brought in by ambulance, due to an overdose of 20 metformin pills...It was recommended that the patient be started on Seroquel 25 mg PO & Melatonin 6 mg PO at bedtime to assist with sleep...Keppra and Ativan were given for the management of seizures...However, it soon became apparent that SARS-CoV-2 was a catalyst to the development of the neuropsychiatric manifestations. This case goes to prove that practicing clinicians should maintain a low threshold of suspicion of neuropsychiatric manifestations when dealing with patients with a history SARS-CoV-2.
- |||||||||| Lennox-Gastaut Syndrome: A Case Report and Literature Review () - May 5, 2022 - Abstract #APA2022APA_525;
Therefore, it is important to understand the complexity in trying to provide symptomatic relief to LGS patients. Despite seeing the majority of cases lead to moderate - to - severe cognitive impairment within the first 5 years, targeting LGS and its surrounding neurocognitive problems individually and holistically, can improve the lives of the patients, but also in the lives of their families.
- |||||||||| lorazepam / Generic mfg., levetiracetam / Generic mfg.
Blue Lotus-Associated Epilepsy and Amnesia in Active Duty Servicemember () - May 5, 2022 - Abstract #APA2022APA_383; Blue Lotus is easily obtained, undetectable by routine drug screen, and has the potential to provoke seizures, retrograde amnesia, and akathisia in an otherwise young and healthy individual. Recognizing these devastating drug complications is critical for medical providers to provide appropriate care.
- |||||||||| Antipsychotic Induced Hypothermia () - May 5, 2022 - Abstract #APA2022APA_360;
Clinicians should be aware of APD induced hypothermia and monitor body temperature particularly during initiation of APD use. Mild hypothermia can be easily missed leading to severe hypothermia.
- |||||||||| levetiracetam / Generic mfg.
Journal: A Case of Possible Levetiracetam Induced Aseptic Meningitis vs Viral Meningitis. (Pubmed Central) - May 5, 2022 Applying the Naranjo Scale yields a score of 4, which indicates possible levetiracetam-induced meningitis in this adult patient. Providers should be cognizant when prescribing antiepileptics to assess and monitor for aseptic meningitis that may appear with atypical symptoms.
- |||||||||| phenytoin / Generic mfg., levetiracetam / Generic mfg.
Journal: Association between anti-seizure medication and outcomes in infants. (Pubmed Central) - Apr 30, 2022 First-line treatment of neonatal seizures with phenobarbital is associated with a lower rate of treatment failure than levetiracetam. There was no significant difference in second-line treatment failure.
- |||||||||| levetiracetam / Generic mfg.
Retrospective data, Journal: Rational therapy with lamotrigine or levetiracetam: Which one to select? (Pubmed Central) - Apr 29, 2022 Implementation of appropriate personalized treatment plans in patients with epilepsy is of paramount significance. Rational selection of appropriate drug(s) is the mainstay of this process.
- |||||||||| levetiracetam / Generic mfg., haloperidol / Generic mfg.
Journal: McLeod syndrome with a novel XK frameshift mutation: A case report. (Pubmed Central) - Apr 29, 2022 We describe a family with MLS caused by a novel frameshift mutation in the XK gene. The causes of the mild clinical presentation in the proband's mother require further investigation.
- |||||||||| levetiracetam / Generic mfg.
Review, Journal: Levetiracetam Mechanisms of Action: From Molecules to Systems. (Pubmed Central) - Apr 24, 2022 This puts it as a possible multitarget drug with clinical applications other than for epilepsy. According to the above, the objective of this work was to carry out a comprehensive and integrative review of LEV in relation to its clinical uses, structural properties, therapeutical targets, and different molecular, genetic, and systemic action mechanisms in order to consider LEV as a candidate for drug repurposing.
- |||||||||| phenytoin / Generic mfg., levetiracetam / Generic mfg., midazolam hydrochloride / Generic mfg.
Review, Journal: Status epilepticus in pregnancy: a literature review and a protocol proposal. (Pubmed Central) - Apr 22, 2022 Levetiracetam and phenytoin represent the most suitable second-line agents...For refractory SE, anesthetic drugs are needed, with propofol and midazolam as preferred drugs...Termination of pregnancy, via delivery or abortion, is recommended in case of failure of general anesthetics. Further studies are needed to identify the safest and most effective treatment protocol.
- |||||||||| riluzole / Generic mfg., levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal: The effect of lamotrigine and other antiepileptic drugs on respiratory rhythm generation in the pre-Bötzinger complex. (Pubmed Central) - Apr 19, 2022 Moreover, our study adds further insight into sodium-dependent changes occurring during hypoxia and the contribution of cellular properties to the respiratory rhythm generation in the pre-Bötzinger complex. It raises the question of whether sodium channel blocking AEDs could, in conditions of extreme hypoxia, contribute to SUDEP, an important issue that warrants further studies.
- |||||||||| levetiracetam / Generic mfg.
Journal: Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy. (Pubmed Central) - Apr 19, 2022 The recording results showed that levetiracetam could significantly inhibit the abnormal discharge of patients. Compared with sodium valproate, high-dose levetiracetam is a drug with a rapid effect, good effect, and long action time.
- |||||||||| Review, Journal: Antiseizure Medications for Adults With Epilepsy: A Review. (Pubmed Central) - Apr 15, 2022
For focal epilepsy, oxcarbazepine and lamotrigine are first-line therapy, while levetiracetam can be also considered if there is no history of psychiatric disorder...ASDs with cytochrome P450 enzyme-inducing properties (eg, carbamazepine, phenytoin) may worsen comorbid coronary and cerebrovascular disease by causing hyperlipidemia and accelerating the metabolism of concomitant drugs used for their treatment...Epilepsy affects approximately 65 million people worldwide and is associated with increased rates of bodily injuries and mortality when not optimally treated. For focal and generalized epilepsy, selection of ASDs should consider the seizure and epilepsy types and epilepsy syndrome, as well as the patient's age and sex, comorbidities, and potential drug interactions.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo
Journal: Antiseizure Medication Concentrations During Pregnancy: Results From the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) Study. (Pubmed Central) - Apr 14, 2022 Additionally, compared with dose-normalized concentrations from control participants, pregnancy dose-normalized median (SE) concentrations decreased significantly by week of gestational age: carbamazepine, -0.14 (0.06) μg/L/mg (P = .02); carbamazepine unbound, -0.04 (0.01) μg/L/mg (P = .01); lacosamide, -0.23 (0.07) μg/L/mg (P < .001); lamotrigine, -0.20 (0.02) μg/L/mg (P < .001); levetiracetam, -0.06 (0.03) μg/L/mg (P = .01); oxcarbazepine, -0.14 (0.04) μg/L/mg (P < .001); oxcarbazepine unbound, -0.11 (0.03) μg/L/mg (P < .001); and zonisamide, -0.53 (0.14) μg/L/mg (P < .001) except for topiramate (-0.35 [0.20] μg/L/mg per week) and carbamazepine-10,11-epoxide (0.02 [0.01] μg/L/mg). Study results suggest that therapeutic drug monitoring should begin early in pregnancy and that increasing doses of these anticonvulsants may be needed throughout the course of pregnancy.
- |||||||||| Fycompa (perampanel) / Eisai, Diacomit (stiripentol) / Biocodex, Meiji Seika
Journal, Adverse events: A pharmacovigilance study on antiepileptic medications in a paediatric hospital in Italy. (Pubmed Central) - Apr 13, 2022 Half of the ADRs occurred with polytherapy, which often included valproic acid and stiripentol. It is to be hoped that such active pharmacovigilance through the collaboration of hospital pharmacists and physicians will serve to improve the management of treatment.
|