- |||||||||| levetiracetam / Generic mfg.
Journal: Neuronal intranuclear inclusion disease in a patient who exhibited abnormal behavior (Pubmed Central) - Jun 8, 2022
The acute-onset abnormal behavior was improved by levetiracetam. The present case indicates that patients with a high-intensity area in the corticomedullary junction should undergo a skin biopsy, even though they may present with non-specific symptoms such as acute-onset abnormal behavior.
- |||||||||| Journal: Do Thickening Agents Used in Dysphagia Diet Affect Drug Bioavailability? (Pubmed Central) - Jun 8, 2022
A good correlation was observed between in vitro and in vivo data, which was characterized by higher r values as the concentration of the thickening agents was increased, but not for all thickness levels studied, indicating an inability of this in vitro model to fully predict the in vivo response. These results suggest that regardless of the thickness level, the administration of levetiracetam with two commercial thickening agents commonly used in dysphagia for safe swallowing, do not affect the pharmacokinetic efficiency and thus, the bioavailability of the drug.
- |||||||||| carbamazepine / Generic mfg.
Journal: Acute lymphocytic leukemia in a patient with long-term carbamazepine exposure: Acute lymphoblastic leukemia that develops in a patient who has been using carbamazepine for a long time. (Pubmed Central) - Jun 8, 2022
In addition to causing thrombocytopenia, hypogammaglobulinemia, leukopenia, and neutropenia, it can have serious effects such as agranulocytosis, aplastic anemia, pure red cell aplasia, leukemia, or DRESS syndrome. The incidence of serious side effects from carbamazepine pharmacotherapy is low, and their exact mechanism of action is still unknown.
- |||||||||| levetiracetam / Generic mfg.
Retrospective data, Journal: Myoclonus in older Cavalier King Charles Spaniels. (Pubmed Central) - Jun 4, 2022
Myoclonus occurs in middle-aged to older CKCS and seems to be another epiphenomena of this breed. A link to epilepsy might be present.
- |||||||||| levetiracetam / Generic mfg., escitalopram / Generic mfg.
Preclinical, Journal: Spontaneous alternation and stereotypical behaviour in deer mice: response to escitalopram and levetiracetam. (Pubmed Central) - Jun 4, 2022
While levetiracetam increased the time spent engaging in normal rodent activity by Comp-H, but not Norm-N animals, neither of the interventions affected the expression of Comp-H behaviour or the alternation behaviour of deer mice. In conclusion, this work points to some degree of cognitive involvement in Comp-H expression, which should be explored to further our understanding of compulsive-like stereotypy.
- |||||||||| 19 Year Old Wrestler With Altered Mental Status (31A) - Jun 2, 2022 - Abstract #ACSM2022ACSM_1323;
CT 11/3: Interval development of increased sulcal crowding of the bilateral cerebral convexities concerning for mild diffuse cerebral edema. MRI 10/18: Subtle cortical edema is suggested diffusely that can be seen with encephalitis versus seizure activity.
- |||||||||| levetiracetam / Generic mfg.
Neurologic Condition - Swimming (31A) - Jun 2, 2022 - Abstract #ACSM2022ACSM_966;
The S-A was provided the opportunity to continue supervised dry land training during this time. Given the S-A’s consistent lack of prodromal symptoms and abnormal MRI he was diagnosed with a structural seizure disorder.
- |||||||||| levetiracetam / Generic mfg.
Journal: Silencing of amygdala circuits during sepsis prevents the development of anxiety-related behaviours. (Pubmed Central) - May 29, 2022
The transient and targeted silencing of this subpopulation only during the acute phase of sepsis with a viral pharmacogenetic approach, or with the anti-epileptic and neuroprotective drug levetiracetam, prevented the subsequent development of anxiety-related behaviours. Specific inhibition of brain anxiety and fear circuits during the sepsis acute phase constitutes a preventive approach to preclude the post-infection psychiatric outcomes.
- |||||||||| Fycompa (perampanel) / Eisai
Journal: Optimization of therapy in patients with epilepsy and psychiatric comorbidities: key points. (Pubmed Central) - May 29, 2022
However, a number of ASMs, in particular levetiracetam, topiramate, and perampanel, may contribute to psychiatric disorders, including depression, aggressive behaviour and even psychosis...Although most of these can be safely used at therapeutic doses, bupropion, some tricyclic antidepressants, maprotiline, and clozapine may alter seizure threshold and facilitate epileptic seizures...Prevalence of non-adherence in PWE and psychiatric comorbidities is reported to reach values even higher than 70%. A careful evaluation of all these aspects contributes to optimize therapy with positive impact on seizure control, psychiatric wellbeing and quality of life.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Clinical, Journal: Adult phenotype of KCNQ2 encephalopathy. (Pubmed Central) - May 26, 2022
Most adult patients have severe ID. Motor, language and behavioural problems are an issue of continuous concern.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Review, Journal: A review of the pharmacotherapeutic considerations for managing epilepsy in people with autism. (Pubmed Central) - May 25, 2022
Alongside this, there is evidence to support a move toward precision medicine in specific genetic syndromes such as Tuberous Sclerosis Complex and other genetic seizure disorders. The first-line treatments that should be considered for focal seizures include carbamazepine, lamotrigine, and levetiracetam.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
Journal: De novo variant of CSNK2B causes Poirier-Bienvenu neurodevelopmental syndrome: two case report (Pubmed Central) - May 25, 2022
Our study further proves that the pathogenic variant of CSNK2B is related to epilepsy with developmental disorder, and enrich is the CSNK2B gene variant spectrum. The pathogenesis of CSNK2B has great clinical heterogeneity, with great difference in severity of nervous system injury and different prognosis, and agenesis of corpus callosum may be one of its clinical phenotypes.
- |||||||||| Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech
A RARE CASE OF ENCEPHALITIS IN AN ADOLESCENT BOY FOLLOWING THE FIRST DOSE OF BNT162B2 MRNA COVID-19 VACCINE () - May 19, 2022 - Abstract #ESPID2022ESPID_1239;
Learning Points/ Temporal correlation, absence of autoimmune or infectious causes and positive Abs against Sars-CoV2 S1 without Abs against nucleocapsid suggest a possible relationship of this case to the vaccine. Although further studies are required to clarify the pathogenesis of COVID-19 vaccination-related adverse events, the benefit of Covid-19 vaccination outweighs the risk of such rare side effects.
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Clinical, Journal: Vitamin D Status in Children on Anticonvulsant Therapy. (Pubmed Central) - May 19, 2022
Vitamin D deficiency is common with anticonvulsant therapy, especially in those having CP. In Kerala, the hot, dry season from March to May is protective.
- |||||||||| levetiracetam / Generic mfg.
Journal: WHAT IS THE THERAPEUTIC REFERENCE RANGE FOR LEVETIRACETAM? (Pubmed Central) - May 18, 2022
In the first version of the 2017 update, it was changed to 20-40 mg/L; however, 5 months later, in an erratum version, it was changed back to 10-40 mg/L. Here, the authors agree with the range to 10-40 mg/L, but discuss to what extent a wider interval may be proposed for certain patients.
- |||||||||| levetiracetam / Generic mfg.
Review, Journal: Pharmacological treatment of tremor in multiple sclerosis; a systematic review. (Pubmed Central) - May 18, 2022
Here, the authors agree with the range to 10-40 mg/L, but discuss to what extent a wider interval may be proposed for certain patients. Further well-designed comparative clinical trials with a large sample size can improve clinical management of tremor in patients with MS.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Review, Journal: NEXMIF mutations in intellectual disability and epilepsy: A report of 2 cases and literature review. (Pubmed Central) - May 18, 2022
She took the medicine of levetiracetam and lamotrigine, and the seizures were under control...He was given topiramate and adrenocorticotrophic hormone (ACTH)...During the follow-up period, the seizures were reduced with vigabatrin...Most of the variants reported so far were loss-of-function resulted in the reduced protein expression of NEXMIF. The degree of NEXMIF loss appears to correlate with the severity of the phenotype.
- |||||||||| levetiracetam / Generic mfg.
Review, Journal: Synaptic Vesicle Glycoprotein 2A: Features and Functions. (Pubmed Central) - May 17, 2022
Following the development of molecules derived from the structure of the anti-epileptic drug levetiracetam, which selectively binds to SV2A, several radiolabeled markers have been synthetized to allow the study of SV2A distribution with positron emission tomography (PET)...Here, we summarize the current knowledge of the SV2A protein and we discuss uncertain aspects of SV2A biology and physiology. As SV2A expression is ubiquitous, but likely more strongly related to a certain type of neurotransmission in particular circumstances, a more extensive knowledge of the protein would greatly facilitate the analysis and interpretation of neuroimaging results by allowing the evaluation not only of an increase or decrease of the protein level, but also of the type of neurotransmission involved.
- |||||||||| levetiracetam / Generic mfg.
Trial completion: LEV-AD: Levetiracetam for Alzheimer's Disease-Associated Network Hyperexcitability (clinicaltrials.gov) - May 16, 2022
P2a, N=34, Completed,
As SV2A expression is ubiquitous, but likely more strongly related to a certain type of neurotransmission in particular circumstances, a more extensive knowledge of the protein would greatly facilitate the analysis and interpretation of neuroimaging results by allowing the evaluation not only of an increase or decrease of the protein level, but also of the type of neurotransmission involved. Active, not recruiting --> Completed
- |||||||||| Journal: Therapeutic Basis of Generic Substitution of Antiseizure Medications. (Pubmed Central) - May 12, 2022
Generic ASMs are interchanged with little consideration of differences in therapeutic equivalence and other clinical factors. This article describes key issues on generic substitution of ASMs and highlights critical pharmacotherapeutic issues associated with generic ASMs.
- |||||||||| levetiracetam / Generic mfg., clobazam / Generic mfg.
Journal: Delineating the Epilepsy Phenotype of NGLY1 Deficiency. (Pubmed Central) - May 12, 2022
Some of the more common seizure types (epileptic spasms, myoclonic, and atonic seizures) can be subtle and require counseling to ensure early recognition and treatment to ensure the best possible outcomes. Despite transient liver enzyme abnormalities in this disorder, hepatically metabolized medications were well tolerated.
- |||||||||| levetiracetam / Generic mfg.
Journal: Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures. (Pubmed Central) - May 12, 2022
Cumulative doses of levetiracetam 100 mg/kg were well tolerated and associated with substantial decrease in seizure burden in several cases. Levetiracetam remains a promising first-line treatment for neonatal seizures; additional randomized controlled trials evaluating the effects of high-dose levetiracetam on seizure burden and long-term outcomes are warranted.
- |||||||||| levetiracetam / Generic mfg., paracetamol / Generic mfg.
Journal: Myoclonic status epilepticus after severe hyperthermia in a patient with coronavirus disease 2019. (Pubmed Central) - May 12, 2022
This case demonstrates that severe hyperthermia can cause cortical injury significant enough to trigger MSE and should be treated emergently using the most aggressive measures available. Providers should have a low threshold for electroencephalography in intubated patients with a recent history of hyperpyrexia.
- |||||||||| flunarizine / Generic mfg., levetiracetam / Generic mfg.
Journal: Alternating Hemiplegia of Childhood associated with a pathogenic variant of the ATP1A3 gene (Pubmed Central) - May 12, 2022
The diagnosis of AHC is complex and is frequently confused with epilepsy, so it is important to correctly perform the diffe rential diagnosis, including anamnesis, tests such as EEG, and careful observation of clinical events that, with the current access to audiovisual technology, becomes more accurate. The genetic analysis is a great diagnostic tool that, when performed in time, avoids other unnecessary tests and therapies.
- |||||||||| levetiracetam / Generic mfg.
Preclinical, Journal: Effect of levetiracetam on the gene expression of placental transporters in a murine model. (Pubmed Central) - May 10, 2022
The repression of the Rfc transcript by LEV at GD 18 suggests that the protein expression would be abolished contributing to the observed intrauterine growth restriction (IUGR). Furthermore, the significant increase in mRNA of xCt, Snat4, Oatp4a1, and Lat1 might be a compensatory mechanism for fetal survival at GD 18.
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