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185 Diseases |  |
81 Trials |
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81 Trials |  |
6476 News |  |
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- | levetiracetam / Generic mfg.
Journal: The Postpartum Period Can Worsen Myelin Oligodendrocyte Glycoprotein Antibody-associated Encephalomyelitis: A Case Report. (Pubmed Central) - Sep 8, 2022
A 28-year-old woman with MOG antibody-associated encephalomyelitis had 2 pregnancies; her disease worsened during both postpartum periods despite continuing prednisolone and levetiracetam...This is the first case report of MOG antibody-associated demyelinating disease that worsened postpartum despite continuous medication. Furthermore, we observed the placental transfer of MOG antibodies for the first time.
- || levetiracetam / Generic mfg.
Review, Journal: Levetiracetam for bipolar disorder: Consideration from a systematic review. (Pubmed Central) - Sep 7, 2022
Furthermore, we observed the placental transfer of MOG antibodies for the first time. No abstract available
- levetiracetam / Generic mfg., omeprazole / Generic mfg.
Severe Immune-Mediated Liver Injury Following COVID-19 Vaccination Necessitating Liver Transplantation in a Patient With Cirrhosis (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_3997;
We wish to raise awareness of ILI as a potential complication of C19V but not to discourage vaccination. Figure: Liver biopsy: marked portal and lobular inflammation with interface hepatitis and lymphoplasmacytic infiltrates
- | levetiracetam / Generic mfg.
Preclinical, Journal: Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain. (Pubmed Central) - Sep 3, 2022
Synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane protein that binds levetiracetam and is involved in neurotransmission via an unknown mechanism...Interestingly, in all areas examined, the binding capacity returned to control levels 12 weeks after the SE comparable to the chronic phase. These data show that lithium-pilocarpine-induced epileptogenesis involves both loss and gain of synapses in the in a time-dependent manner.
- || levetiracetam / Generic mfg.
Clinical, Review, Journal: Efficacy of Levetiracetam in neonatal seizures: a systematic review. (Pubmed Central) - Aug 31, 2022
Levetiracetam has shown to have promising anti-epileptic properties for the management of neonatal seizure with better efficacy and less or no side effects. There is a need to conduct more randomized controlled trials seeking the role of LEV in the acute management of neonatal seizures and also for assessing its neuroprotective role and neurodevelopmental outcome in these neonates.
- | levetiracetam / Generic mfg.
Observational data, Journal: A multicentre observational study of the use of antiseizure medication in patients with aneurysmal subarachnoid haemorrhage in the PROMOTE-SAH study. (Pubmed Central) - Aug 31, 2022
Forty percent of patients received an ASM and the most commonly used agent was levetiracetam...There may be an association with poorer outcomes in patients with lower grade aSAH. This finding requires further exploration.
- | levetiracetam / Generic mfg.
Retrospective data, Journal: Vitamin B6 decreases the risk of levetiracetam discontinuation in children with epilepsy: A retrospective study. (Pubmed Central) - Aug 31, 2022
Levetiracetam side effects significantly impact the tolerability of this ASM in children with epilepsy. Our results suggest that vitamin B6 supplementation can significantly reduce the odds of discontinuing LEV due to its behavioral side effects.
- | levetiracetam / Generic mfg.
Journal: Levetiracetam-induced gingival hyperplasia. (Pubmed Central) - Aug 31, 2022
After one-month of stopping the drug, the lesions cleared. This case highlights the importance of maintaining good oral hygiene and periodic dental review in patients on antiseizure medications.
- | Retrospective data, Journal: Non-lesional late-onset epilepsy in the elderly Japanese patients: Presenting characteristics and seizure outcomes with regard to comorbid dementia. (Pubmed Central) - Aug 31, 2022
In conclusion, the NLLOE among Japanese patients aged ≥ 65 years has variable presenting characteristics, and comorbid dementia is diagnosed in one-third of cases. Seizure-free status for ≥ 12 months may be attained in more than two-thirds of treated patients, but comorbid dementia is associated with significantly worse response to antiseizure therapy.
- | levetiracetam / Generic mfg.
Reimbursement, Retrospective data, Journal: Prescription trends in anti-seizure medications for adult patients with epilepsy in Japan: A retrospective cohort study using the database of health insurance claims between 2015 and 2019. (Pubmed Central) - Aug 31, 2022
Newer ASMs became more widely prescribed throughout the study period in populations with both prevalent and incident epilepsies, as well as the subpopulation with focal epilepsy. The advantages of newer ASMs such as better safety profiles may have led to the increasing proportions of prescriptions and newer ASMs may increase the treatment options for patients.
- || lamotrigine liquid oral suspension / OWP Pharma, Enbrel (etanercept) / Pfizer, Amgen
Retrospective data, Review, Journal: Pharmacotherapies for Central Post-Stroke Pain: A Systematic Review and Network Meta-Analysis. (Pubmed Central) - Aug 30, 2022
Our study confirmed that pamidronate, prednisone, and guideline-recommended anticonvulsants were effective for reducing pain intensity for CPSP. Pamidronate and prednisone showed better effect than other pharmacotherapies, which warrants further investigation.
- || levetiracetam / Generic mfg., dexmedetomidine / Generic mfg.
It’s easier to pronounce than dexmedetomidine or levetiracetam? Sorry, couldn’t think of much else. (Twitter) - Aug 30, 2022
- || Review, Journal: Neurosyphilis presenting as autoimmune limbic encephalitis: A case report and literature review. (Pubmed Central) - Aug 28, 2022
The present case was diagnosed with neurosyphilis presenting as ALE, but meanwhile, in most case, neurosyphilis presenting as LE developed at a slower progressive rate, and it had a broader or restricted involvement on brain MRI than ALE based on the literature review. Therefore, an appropriate differential diagnosis of LE can be obtained by identifying clinical differences between the 2 conditions.
- || levetiracetam / Generic mfg.
PK/PD data, Preclinical, Journal: Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL-AD preclinical testing core study. (Pubmed Central) - Aug 27, 2022
Overall, this study highlights the importance of PK/PD relationships in preclinical studies to inform clinical study design. Significant sex differences in pharmacokinetics of levetiracetam were observed in 5XFAD mice.Plasma concentrations of 10 mg/kg levetiracetam dose in 5XFAD overlapped with human plasma concentration used in the clinic.Drug- and dose-related differences in gene expression relevant to human brain regions and pathways were also similar to brain region-specific changes in 18F-fluorodeoxyglucose uptake.
- | Journal: Evaluation of Serum and Rapid Serum Separator Collection Tubes for Therapeutic Drug Assays. (Pubmed Central) - Aug 27, 2022
Evaluation of the stability and accuracy of commonly monitored drugs revealed that the majority were not affected by exposure to gel separator material under conditions similar to outpatient clinic storage, courier transport and laboratory storage. Expanding the collection requirements for appropriate drugs to include gel separator tubes decreases the number of specimens drawn and the complexity of laboratory workflows.
- | levetiracetam / Generic mfg., fosphenytoin / Generic mfg.
Journal: Treatment of Toxin-Related Status Epilepticus With Levetiracetam, Fosphenytoin, or Valproate in Patients Enrolled in the Established Status Epilepticus Treatment Trial. (Pubmed Central) - Aug 26, 2022
Alcohol withdrawal and cocaine/opioid use were the most common toxin-related precipitants. Toxin-related benzodiazepine-refractory status epilepticus was successfully treated with a single dose of second-line antiseizure medication in 42% of the patients.
- || levetiracetam / Generic mfg.
PK/PD data, Journal: Effect of Nonadherence on Levetiracetam Pharmacokinetics and Remedial Dose Recommendations Using Monte Carlo Simulations. (Pubmed Central) - Aug 26, 2022
The appropriate remedial dosage regimen for one and two consecutive missed doses of LEV have been proposed. These remedial regimens, however, should be applied with clinicians' judgment based on the clinical status of the patients.
- || Review, Journal: Drug Dosing in Critically Ill Adult Patients with Augmented Renal Clearance. (Pubmed Central) - Aug 26, 2022
The potential need for increased dosing frequency in patients with ARC was also found for both enoxaparin and levetiracetam. In conclusion, ARC has been shown to influence the probability of target attainment in several medications requiring dosing changes to mitigate the risk of therapeutic failure.
- || lamotrigine liquid oral suspension / OWP Pharma
Review, Journal: Antiseizure medication-induced obsessive-compulsive disorder and tic disorder: a pragmatic review. (Pubmed Central) - Aug 26, 2022
Monitoring for medication-induced obsessive compulsions or tics should be undertaken when prescribing antiseizure medication for treatment of mood disorders or epilepsy. Further research identifying the causal relationship between antiseizure medication and de novo onset of obsessive-compulsive symptoms, obsessive-compulsive disorder and tic disorder is required.
- | phenytoin / Generic mfg.
Journal: Exposure to phenytoin associates with a lower risk of post-COVID cognitive deficits: a cohort study. (Pubmed Central) - Aug 25, 2022
These findings provide pharmacoepidemiological support for the hypothesis that receptor-interacting protein kinase signaling is involved in post-COVID cognitive deficits. These results should prompt empirical investigations of receptor-interacting protein kinase inhibitors in the prevention of post-COVID cognitive deficits.
- | levetiracetam / Generic mfg., sumatriptan succinate / Generic mfg.
Journal, Combination therapy: Value of Combination Therapy With Antiepileptic Drugs (AEDs) for Migraine to Prevent Ischemic Stroke in Young Women. (Pubmed Central) - Aug 25, 2022
Significant differences were found in Group B when compared with Groups A and C with respect to the use of combination hormonal contraception, smoking, a family history of migraine, and seizures. The results of this study suggested that combination treatment with levetiracetam and sumatriptan was more effective in preventing migraines and reducing the risk of stroke in young women than sumatriptan monotherapy.
- | Journal: Neonatal seizures treatment based on conventional multichannel EEG monitoring: an overview of therapeutic options. (Pubmed Central) - Aug 25, 2022
Traditionally, the first-line treatments are phenobarbital and phenytoin, followed by midazolam and lidocaine, but their efficacy is limited...: Therapy for neonatal seizures should be prompt and tailored, based on semeiology, mirror of the underlying cause, and cEEG features. Further research should focus on antiseizure medications that directly act on the etiopathogenetic mechanism responsible for seizures and are therefore more effective in seizure control.
- | Diacomit (stiripentol) / Biocodex, Meiji Seika, Fintepla (low-dose fenfluramine) / UCB
Journal: Treatment-Refractory Dravet Syndrome: Considerations for Novel Medications. (Pubmed Central) - Aug 24, 2022
Management of seizures in DS changed in recent years with the approval of cannabidiol and stiripentol in 2018 and fenfluramine in 2020. This continuing education article summarizes available efficacy and safety data involving cannabidiol, stiripentol, and fenfluramine and provides a practical review of dosing strategies, pharmacokinetics, and monitoring interventions relevant to their use.
- | levetiracetam / Generic mfg.
Preclinical, Journal: Levetiracetam Attenuates Adolescent Stress-induced Behavioral and Electrophysiological Changes Associated With Schizophrenia in Adult Rats. (Pubmed Central) - Aug 24, 2022
This continuing education article summarizes available efficacy and safety data involving cannabidiol, stiripentol, and fenfluramine and provides a practical review of dosing strategies, pharmacokinetics, and monitoring interventions relevant to their use. These findings suggest that levetiracetam attenuates the adverse outcomes associated with schizophrenia caused by stress during adolescence.
- || Review, Journal: Polycystic ovary syndrome and the new antiepileptic drugs: A systematic review. (Pubmed Central) - Aug 24, 2022
These findings suggest that levetiracetam attenuates the adverse outcomes associated with schizophrenia caused by stress during adolescence. The anticonvulsants are probably safer, but the risk of developing PCOS associated with the antiepileptics cannot be established, since there are insufficient studies.
- | lacosamide / Generic mfg., levetiracetam / Generic mfg.
Journal: Reponse of second-line treatment in focal status epilepticus: A tertiary hospital experience. (Pubmed Central) - Aug 24, 2022
Our findings further support the notion that early termination of SE with a first or second ASM confers a better functional outcome. The large difference in response between the first ASM and consecutive ones suggests that the sum of different ASMs might be the key to resolving focal SE.
- ||| levetiracetam / Generic mfg.
Journal, Adverse events: Systemic photosensitivity due to levetiracetam: report of a previously undescribed adverse effect. (Pubmed Central) - Aug 24, 2022
The large difference in response between the first ASM and consecutive ones suggests that the sum of different ASMs might be the key to resolving focal SE. No abstract available
- || sodium valproate / Generic mfg., levetiracetam / Generic mfg.
Clinical, Journal: Efficacy of levetiracetam, lamotrigine and sodium valproate on seizure attacks and EEG disorders in patients with juvenile myoclonic epilepsy: A double blind randomized clinical trial. (Pubmed Central) - Aug 22, 2022
According to our study, lamotrigine could not be a suitable treatment option for JME patients as a mono therapy. Levetiracetam can be a good alternative to sodium valproate, especially in women of childbearing age.
- || levetiracetam / Generic mfg., midazolam hydrochloride / Generic mfg., fosphenytoin / Generic mfg.
Review, Journal: Status epilepticus: review on diagnosis, monitoring and treatment. (Pubmed Central) - Aug 22, 2022
Phenytoin/fosphenytoin, levetiracetam and valproic acid are evidence choices for second line treatment...Midazolam is usually the best initial choice and barbiturates should be considered for refractory cases...EEG monitoring is crucial for diagnosis of nonconvulsive SE, after initial control of convulsive SE and treatment control. Institutional protocols are advised to improve care.
- || Review, Journal: Mini Review on Forced Degradation Studies on Anti-Epileptic Drugs and Beyond. (Pubmed Central) - Aug 22, 2022
A systematic method for the forced degradation studies on anti-epileptic drugs such as "Topiramate, Vigabatrin, Lacosamide, Tiagabine, Levetiracetam and Zonisamide" is discussed. This review helps researchers to get an idea about stability-indicating methods of development and validation for newer antiepileptic drugs and the characteristics of drug products that degrade under specific degradation conditions.
- ||| Retrospective data, Review, Journal, Adverse events: Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis. (Pubmed Central) - Aug 22, 2022
Use of levetiracetam and valproic acid may result in subclinical hypothyroidism. The anti-seizure drug with the least disruptive effect on thyroid hormone levels was found to be lamotrigine.
- | levetiracetam / Generic mfg.
Journal: Efflux dynamics of the antiseizure drug, levetiracetam, through the P-glycoprotein channel revealed by advanced comparative molecular simulations. (Pubmed Central) - Aug 22, 2022
Comparative results for the control drugs, zosuquidar and verapamil, confirmed their established P-gp inhibitory activity...Our findings also stressed the contribution of nonpolar interactions with P-gp channel lining as well as with membrane lipid molecules to hamper the ASM efflux by the transmembrane exporter. Appropriate structural engineering of the ASMs is thus recommended to address drug-resistant epilepsy.
- ||| levetiracetam / Generic mfg.
P3 data, Journal: Safety and efficacy of prophylactic levetiracetam for prevention of epileptic seizures in the acute phase of intracerebral haemorrhage (PEACH): a randomised, double-blind, placebo-controlled, phase 3 trial. (Pubmed Central) - Aug 22, 2022
P3
Levetiracetam might be effective in preventing acute seizures in intracerebral haemorrhage. Larger studies are needed to determine whether seizure prophylaxis improves functional outcome in patients with intracerebral haemorrhage.
- ||| levetiracetam / Generic mfg.
Our neurologists are proponents of very early use of levetiracetam in seizures including status. (Twitter) - Aug 20, 2022
- ||| levetiracetam / Generic mfg.
Clinical: As with most prolonged prophylactic therapies, the keppra is to make the team happy, not necessarily protect patient (Twitter) - Aug 17, 2022
- || Review, Journal: Pharmacological Management of Core Symptoms and Comorbidities of Autism Spectrum Disorder in Children and Adolescents: A Systematic Review. (Pubmed Central) - Aug 16, 2022
This review has successfully summarized the pharmacological advancements made in the past decade to manage ASD. Although there is still no pharmacological cure for ASD core symptoms or additional drugs that have obtained regulatory approval for use in ASD, the availability of promising pharmacological agents are under evaluation and study.
- || levetiracetam / Generic mfg.
Keppra turned my son into a lunatic that tried to physically have an altercation with his twin every time he saw him. He also screamed at me, you can't make me take a shower! Needless to say, I am not a fan of keppra. (Twitter) - Aug 16, 2022
- |||| levetiracetam / Generic mfg.
Clinical: So far this might be the neurocritical care study of the year. 50 ICH patients randomized Keppra (LVT) or placebo, most between 5–20 ml. All with cEEG. WAY fewer seizures in the LVT group! 1/ https://t.co/gvjR6pol25 (Twitter) - Aug 16, 2022
- bleomycin / Generic mfg.
A FATAL CASE OF ACCELERATED BLEOMYCIN-INDUCED PNEUMONITIS IN A PATIENT WITH STAGE IV NONSEMINOMATOUS GERM CELL TUMOR (Convention Center Exhibit Hall: Poster Area) - Aug 16, 2022 - Abstract #CHEST2022CHEST_2594;
Although its occurrence may be sporadic, some factors may increase the risk of such a pulmonary reaction. More studies are required to understand the acuity of onset of toxicity symptoms.
- esmolol / Generic mfg., levetiracetam / Generic mfg., amiodarone / Generic mfg.
New Onset Atrial Flutter With Hemodynamic Instability In The Setting Of Traumatic Brain Injury (Hall C) - Aug 15, 2022 - Abstract #ASA2022ASA_985;
Heart remained fluctuated between 50-160 and blood pressure ranged from SBP of 90-220. Atrial flutter unresponsive to esmolol, metoprolol and patient was started on amiodarone drip in the ICU pending TEE and cardioversion.
- | levetiracetam / Generic mfg.
Journal: The optimized biocatalytic synthesis of (S)-methyl 2-chlorobutanoate by Acinetobacter sp. lipase. (Pubmed Central) - Aug 14, 2022
) reached more than 95%, with a yield of over 86%. Therefore, this lipase can efficiently resolve racemic methyl 2-chlorobutanoate and obtain (S)-methyl 2-chlorobutanoate, which presents great potential in the industrial production of levetiracetam.
- | levetiracetam / Generic mfg.
Journal: Associations of levetiracetam use with the safety and tolerability profile of chemoradiotherapy for patients with newly diagnosed glioblastoma. (Pubmed Central) - Aug 13, 2022
LEV is not associated with reduced tolerability of chemoradiotherapy in patients with glioblastoma regarding hematologic toxicity and fatigue. Antiemetic properties of LEV may be beneficial during maintenance temozolomide.
- | levetiracetam / Generic mfg.
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: Levetiracetam in Early Psychosis (clinicaltrials.gov) - Aug 12, 2022
P2, N=48, Completed, Sponsor: NYU Langone Health
Antiemetic properties of LEV may be beneficial during maintenance temozolomide. Recruiting --> Completed | N=32 --> 48 | Trial completion date: Mar 2022 --> Nov 2021 | Trial primary completion date: Mar 2022 --> Nov 2021
- | levetiracetam / Generic mfg.
Journal: A Randomized Controlled Trial on the Study of Effectiveness and Safety of Hormonal (ACTH) Treatment Alone versus Hormonal (ACTH) with Levetiracetam for Epileptic Spasms. (Pubmed Central) - Aug 11, 2022
Conclusion There was no difference in children treated with ACTH alone versus ACTH and LEV in terms of control of spasms and subsequent epilepsy rates. The relapse rate is less, and developmental outcome is better in ACTH with LEV group but statistically not significant.
- Early Recurrence of Ventricular Tachycardia and the Impact of Radiofrequency Ablation on Success of ICD Therapy (Zone 3, Science and Technology Hall, Level 200) - Aug 11, 2022 - Abstract #AHA2022AHA_4570;
The relapse rate is less, and developmental outcome is better in ACTH with LEV group but statistically not significant. Abstract is embargoed at this time.
- Use of Cardiac Computed Tomography (CT) Imaging Biomarker Variables for the Prediction of Incident Heart Failure: Multi-Ethnic Study of Atherosclerosis (Zone 2, Science and Technology Hall, Level 200) - Aug 11, 2022 - Abstract #AHA2022AHA_4076;
Abstract is embargoed at this time. Abstract is embargoed at this time.
- || levetiracetam / Generic mfg.
Review, Journal: Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review. (Pubmed Central) - Aug 11, 2022
Collaborative research between different institutions and researchers are warranted and needed to improve our understanding of the pathophysiology and management of this condition. In this review, we propose a practical treatment algorithm for HT based on currently available evidence.
- | levetiracetam / Generic mfg.
Journal: Differences between men and women in response to antiseizure medication use and the likelihood of developing treatment resistant epilepsy. (Pubmed Central) - Aug 9, 2022
This study assessed sex differences in response to antiseizure medications using the development of TRE as a proxy for effectiveness. Women newly exposed to levetiracetam were 27% more likely to develop TRE than men, independent of age.
- levetiracetam / Generic mfg.
Pulse-chase proteomics of the APP knock-in mouse models of Alzheimer’s disease reveals synaptic dysfunction originates in presynaptic terminals (Grand Horizon B (Marriott Marquis Chicago)) - Aug 9, 2022 - Abstract #ACSFall2022ACS_Fall_3713;
Our preliminary studies demonstrated that levetiracetam selectively normalizes SV endocytosis machinery abundance and restores non-amyloidogenic processing of APP which is anti-correlated to our disease progression observations in APP KI mice. Thus we have uncovered a potential mechanism that may explain the therapeutic benefits of levetiracetam as well as targets for future therapeutic intervention.
- | sodium valproate / Generic mfg., levetiracetam / Generic mfg.
Journal: Subcutaneous Levetiracetam and Sodium Valproate Use in Palliative Care Patients. (Pubmed Central) - Aug 6, 2022
Subcutaneous sodium valproate was given for a median duration of 3.5 days, with no reported seizure recurrences in 83% of patients and one report of a localized skin reaction. This analysis suggests that subcutaneous levetiracetam and sodium valproate can effectively control seizures in palliative care populations, with minimal localized reactions.