- |||||||||| levetiracetam / Generic mfg.
Journal: The Postpartum Period Can Worsen Myelin Oligodendrocyte Glycoprotein Antibody-associated Encephalomyelitis: A Case Report. (Pubmed Central) - Sep 8, 2022 A 28-year-old woman with MOG antibody-associated encephalomyelitis had 2 pregnancies; her disease worsened during both postpartum periods despite continuing prednisolone and levetiracetam...This is the first case report of MOG antibody-associated demyelinating disease that worsened postpartum despite continuous medication. Furthermore, we observed the placental transfer of MOG antibodies for the first time.
- |||||||||| levetiracetam / Generic mfg.
Preclinical, Journal: Spatio-Temporal Alterations in Synaptic Density During Epileptogenesis in the Rat Brain. (Pubmed Central) - Sep 3, 2022 Synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane protein that binds levetiracetam and is involved in neurotransmission via an unknown mechanism...Interestingly, in all areas examined, the binding capacity returned to control levels 12 weeks after the SE comparable to the chronic phase. These data show that lithium-pilocarpine-induced epileptogenesis involves both loss and gain of synapses in the in a time-dependent manner.
- |||||||||| levetiracetam / Generic mfg.
Clinical, Review, Journal: Efficacy of Levetiracetam in neonatal seizures: a systematic review. (Pubmed Central) - Aug 31, 2022 Levetiracetam has shown to have promising anti-epileptic properties for the management of neonatal seizure with better efficacy and less or no side effects. There is a need to conduct more randomized controlled trials seeking the role of LEV in the acute management of neonatal seizures and also for assessing its neuroprotective role and neurodevelopmental outcome in these neonates.
- |||||||||| levetiracetam / Generic mfg.
Journal: Levetiracetam-induced gingival hyperplasia. (Pubmed Central) - Aug 31, 2022 After one-month of stopping the drug, the lesions cleared. This case highlights the importance of maintaining good oral hygiene and periodic dental review in patients on antiseizure medications.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma, Enbrel (etanercept) / Pfizer, Amgen
Retrospective data, Review, Journal: Pharmacotherapies for Central Post-Stroke Pain: A Systematic Review and Network Meta-Analysis. (Pubmed Central) - Aug 30, 2022 Our study confirmed that pamidronate, prednisone, and guideline-recommended anticonvulsants were effective for reducing pain intensity for CPSP. Pamidronate and prednisone showed better effect than other pharmacotherapies, which warrants further investigation.
- |||||||||| Review, Journal: Neurosyphilis presenting as autoimmune limbic encephalitis: A case report and literature review. (Pubmed Central) - Aug 28, 2022
The present case was diagnosed with neurosyphilis presenting as ALE, but meanwhile, in most case, neurosyphilis presenting as LE developed at a slower progressive rate, and it had a broader or restricted involvement on brain MRI than ALE based on the literature review. Therefore, an appropriate differential diagnosis of LE can be obtained by identifying clinical differences between the 2 conditions.
- |||||||||| levetiracetam / Generic mfg.
PK/PD data, Preclinical, Journal: Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL-AD preclinical testing core study. (Pubmed Central) - Aug 27, 2022 Overall, this study highlights the importance of PK/PD relationships in preclinical studies to inform clinical study design. Significant sex differences in pharmacokinetics of levetiracetam were observed in 5XFAD mice.Plasma concentrations of 10 mg/kg levetiracetam dose in 5XFAD overlapped with human plasma concentration used in the clinic.Drug- and dose-related differences in gene expression relevant to human brain regions and pathways were also similar to brain region-specific changes in 18F-fluorodeoxyglucose uptake.
- |||||||||| Journal: Evaluation of Serum and Rapid Serum Separator Collection Tubes for Therapeutic Drug Assays. (Pubmed Central) - Aug 27, 2022
Evaluation of the stability and accuracy of commonly monitored drugs revealed that the majority were not affected by exposure to gel separator material under conditions similar to outpatient clinic storage, courier transport and laboratory storage. Expanding the collection requirements for appropriate drugs to include gel separator tubes decreases the number of specimens drawn and the complexity of laboratory workflows.
- |||||||||| Review, Journal: Drug Dosing in Critically Ill Adult Patients with Augmented Renal Clearance. (Pubmed Central) - Aug 26, 2022
The potential need for increased dosing frequency in patients with ARC was also found for both enoxaparin and levetiracetam. In conclusion, ARC has been shown to influence the probability of target attainment in several medications requiring dosing changes to mitigate the risk of therapeutic failure.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Review, Journal: Antiseizure medication-induced obsessive-compulsive disorder and tic disorder: a pragmatic review. (Pubmed Central) - Aug 26, 2022 Monitoring for medication-induced obsessive compulsions or tics should be undertaken when prescribing antiseizure medication for treatment of mood disorders or epilepsy. Further research identifying the causal relationship between antiseizure medication and de novo onset of obsessive-compulsive symptoms, obsessive-compulsive disorder and tic disorder is required.
- |||||||||| phenytoin / Generic mfg.
Journal: Exposure to phenytoin associates with a lower risk of post-COVID cognitive deficits: a cohort study. (Pubmed Central) - Aug 25, 2022 These findings provide pharmacoepidemiological support for the hypothesis that receptor-interacting protein kinase signaling is involved in post-COVID cognitive deficits. These results should prompt empirical investigations of receptor-interacting protein kinase inhibitors in the prevention of post-COVID cognitive deficits.
- |||||||||| levetiracetam / Generic mfg., sumatriptan succinate / Generic mfg.
Journal, Combination therapy: Value of Combination Therapy With Antiepileptic Drugs (AEDs) for Migraine to Prevent Ischemic Stroke in Young Women. (Pubmed Central) - Aug 25, 2022 Significant differences were found in Group B when compared with Groups A and C with respect to the use of combination hormonal contraception, smoking, a family history of migraine, and seizures. The results of this study suggested that combination treatment with levetiracetam and sumatriptan was more effective in preventing migraines and reducing the risk of stroke in young women than sumatriptan monotherapy.
- |||||||||| Journal: Neonatal seizures treatment based on conventional multichannel EEG monitoring: an overview of therapeutic options. (Pubmed Central) - Aug 25, 2022
Traditionally, the first-line treatments are phenobarbital and phenytoin, followed by midazolam and lidocaine, but their efficacy is limited...: Therapy for neonatal seizures should be prompt and tailored, based on semeiology, mirror of the underlying cause, and cEEG features. Further research should focus on antiseizure medications that directly act on the etiopathogenetic mechanism responsible for seizures and are therefore more effective in seizure control.
- |||||||||| Diacomit (stiripentol) / Biocodex, Meiji Seika, Fintepla (low-dose fenfluramine) / UCB
Journal: Treatment-Refractory Dravet Syndrome: Considerations for Novel Medications. (Pubmed Central) - Aug 24, 2022 Management of seizures in DS changed in recent years with the approval of cannabidiol and stiripentol in 2018 and fenfluramine in 2020. This continuing education article summarizes available efficacy and safety data involving cannabidiol, stiripentol, and fenfluramine and provides a practical review of dosing strategies, pharmacokinetics, and monitoring interventions relevant to their use.
- |||||||||| Review, Journal: Polycystic ovary syndrome and the new antiepileptic drugs: A systematic review. (Pubmed Central) - Aug 24, 2022
These findings suggest that levetiracetam attenuates the adverse outcomes associated with schizophrenia caused by stress during adolescence. The anticonvulsants are probably safer, but the risk of developing PCOS associated with the antiepileptics cannot be established, since there are insufficient studies.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg.
Journal: Reponse of second-line treatment in focal status epilepticus: A tertiary hospital experience. (Pubmed Central) - Aug 24, 2022 Our findings further support the notion that early termination of SE with a first or second ASM confers a better functional outcome. The large difference in response between the first ASM and consecutive ones suggests that the sum of different ASMs might be the key to resolving focal SE.
- |||||||||| levetiracetam / Generic mfg., midazolam hydrochloride / Generic mfg., fosphenytoin / Generic mfg.
Review, Journal: Status epilepticus: review on diagnosis, monitoring and treatment. (Pubmed Central) - Aug 22, 2022 Phenytoin/fosphenytoin, levetiracetam and valproic acid are evidence choices for second line treatment...Midazolam is usually the best initial choice and barbiturates should be considered for refractory cases...EEG monitoring is crucial for diagnosis of nonconvulsive SE, after initial control of convulsive SE and treatment control. Institutional protocols are advised to improve care.
- |||||||||| Review, Journal: Mini Review on Forced Degradation Studies on Anti-Epileptic Drugs and Beyond. (Pubmed Central) - Aug 22, 2022
A systematic method for the forced degradation studies on anti-epileptic drugs such as "Topiramate, Vigabatrin, Lacosamide, Tiagabine, Levetiracetam and Zonisamide" is discussed. This review helps researchers to get an idea about stability-indicating methods of development and validation for newer antiepileptic drugs and the characteristics of drug products that degrade under specific degradation conditions.
- |||||||||| levetiracetam / Generic mfg.
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: Levetiracetam in Early Psychosis (clinicaltrials.gov) - Aug 12, 2022 P2, N=48, Completed, Antiemetic properties of LEV may be beneficial during maintenance temozolomide. Recruiting --> Completed | N=32 --> 48 | Trial completion date: Mar 2022 --> Nov 2021 | Trial primary completion date: Mar 2022 --> Nov 2021
- |||||||||| levetiracetam / Generic mfg.
Review, Journal: Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review. (Pubmed Central) - Aug 11, 2022 Collaborative research between different institutions and researchers are warranted and needed to improve our understanding of the pathophysiology and management of this condition. In this review, we propose a practical treatment algorithm for HT based on currently available evidence.
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg.
Journal: Subcutaneous Levetiracetam and Sodium Valproate Use in Palliative Care Patients. (Pubmed Central) - Aug 6, 2022 Subcutaneous sodium valproate was given for a median duration of 3.5 days, with no reported seizure recurrences in 83% of patients and one report of a localized skin reaction. This analysis suggests that subcutaneous levetiracetam and sodium valproate can effectively control seizures in palliative care populations, with minimal localized reactions.
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