levetiracetam / Generic mfg. 
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  • ||||||||||  levetiracetam / Generic mfg., carbamazepine / Generic mfg.
    Effects of Anti-seizure Medication Exposure on Pcos-like Symptoms in Women with Epilepsy (Hall B, Level 3) -  Nov 29, 2022 - Abstract #AES2022AES_1252;    
    We used Student’s t-test for continuous variables of equal variances, chi-square test for categorical variables, and Fisher’s exact test for categorical variables with frequencies of less than 5. Significance was set at p< 0.05.
  • ||||||||||  Fycompa (perampanel) / Eisai, Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
    Practice Trends in Women with Epilepsy (Hall B, Level 3) -  Nov 29, 2022 - Abstract #AES2022AES_1220;    
    Based on available data, several organizations including the AAN (American Academy of Neurology) and the AES (American Epilepsy Society) recommend avoidance of valproate use in women of child bearing age group due to substantial risk of major congenital malformations and adverse neuro-cognitive outcomes and recommend use of folic acid supplementation. However, our study finds that there is a practice gap between recommendations and clinician practice trends illustrating the need for more clinician education and need for involvement of epileptologists in the care of these patients to ensure best outcomes.
  • ||||||||||  levetiracetam / Generic mfg.
    Seizures Characteristics of Individuals with Succinic Semialdehyde Dehydrogenase Deficiency: Results from a Multinational Longitudinal Study (Hall B, Level 3) -  Nov 29, 2022 - Abstract #AES2022AES_1152;    
    By correlations of neurophysiological, genetic, and biochemical data with the clinical outcomes, we have found the protective factors which are associated with epilepsy being better controlled. Additionally, by elucidating the details related to the timing of the decline of GABA and GHB levels in correlation with seizure onset, we have added information that further advances the efforts of developing novel therapeutic approaches for individuals with SSADHD.
  • ||||||||||  Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
    Effect of Anti-seizure Medication on Seizure-induced Brain Activation (Hall B, Level 3) -  Nov 29, 2022 - Abstract #AES2022AES_1143;    
    While LEV displayed reduced protection against MES seizures compared to CBM and PHT, no differences in cFOS immunoreactivity were seen between the ASMs suggesting that these ASMs provide little protection against activation of these brain regions during an MES seizure, and may indicate that CBT and PHT block seizures downstream of brain activation. All ASMs in the 6 Hz test displayed complete protection, but differences in cFOS levels between ASMs and VEH were noted, suggesting that these ASMs provide protection against brain region activation during a 6 Hz seizure.
  • ||||||||||  levetiracetam / Generic mfg.
    Reproductive Healthcare for People with Epilepsy: a Survey of Healthcare Providers (Hall B, Level 3) -  Nov 29, 2022 - Abstract #AES2022AES_1118;    
    Knowledge: Less than half of respondents are aware that only some antiseizure medications impact contraceptive efficacy (Table 1). About two-thirds to three-quarters of respondents believe that valproic acid is among ASMs with higher teratogenic risk and that levetiracetam is among ASMs with lower teratogenic risk.
  • ||||||||||  lacosamide / Generic mfg.
    Outcomes of Patients on Lacosamide Medication During Pregnancy (Hall B, Level 3) -  Nov 29, 2022 - Abstract #AES2022AES_1102;    
    Additionally, DNCs exhibited a decreasing trend during pregnancy, confirming that regular, optimized LCM dosage changes may be necessary to achieve the best possible maternal and fetal outcomes. Future analyses in larger cohort sizes are needed.
  • ||||||||||  Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
    The Pharmacokinetics of Cenobamate When Used as Monotherapy (Hall B, Level 3) -  Nov 29, 2022 - Abstract #AES2022AES_1009;    
    The following antiseizure medications (ASMs) were tested as covariates for statistically significant effects on the apparent clearance (CL/F) of cenobamate based on their use in the clinical studies of patients with focal seizures: carbamazepine, clobazam, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, topiramate, and valproate. Based on these findings, cenobamate monotherapy should result in plasma exposures comparable to those that have been demonstrated to be safe and effective when used as adjunctive therapy for the treatment of focal seizures.
  • ||||||||||  levetiracetam / Generic mfg.
    Beyond Epileptic Encephalopathies – Delineating the Mild End of the STXBP1 Spectrum (Hall B, Level 3) -  Nov 29, 2022 - Abstract #AES2022AES_965;    
    The unifying clinical features of this spectrum include learning impairments to mild developmental delay only, and this clinical subset appears to be linked to a unique variant spectrum, where individuals with novel missense variants in STXBP1 can present with mild neurodevelopmental differences. These findings hint at previously undescribed functional consequences of novel variants on the STXBP1 protein and informs prognostic counseling of those with STXBP1-related disorder.
  • ||||||||||  Seizalam (midazolam intramuscular) / Pfizer
    Time Is Brain: Improving Early Access to Antiseizure Medications During Status Epilepticus in the Pediatric Population () -  Nov 29, 2022 - Abstract #AES2022AES_884;    
    After the survey, a simplified status algorithm adding IN midazolam and including levetiracetam as first line was created...After presenting the study by Chamberlain et al, 11% chose fosphenytoin and 89% levetiracetam... With the usage of a simplified algorithm and order set for medications, we hope to decrease the time to treat status epilepticus at our institution.
  • ||||||||||  levetiracetam / Generic mfg., clobazam / Generic mfg.
    syngap1-related Disorder Genotype-phenotype Analysis Through Digital Registry () -  Nov 29, 2022 - Abstract #AES2022AES_845;    
    Our retrospective analysis of database-derived medical records data regarding SYNGAP1-related disorder reveal an overall picture of developmental delay and ultimately intellectual disability as often the first diagnosis, followed by onset of epilepsy in the majority of individuals. These results can inform development of targeted clinical trial outcomes and highlight a window of opportunity for prevention or early identification of seizures between the diagnosis of developmental delay and the onset of epilepsy.
  • ||||||||||  levetiracetam / Generic mfg.
    Adverse Effects of Levetiracetam in Newly Diagnosed and Treated Focal Epilepsy () -  Nov 29, 2022 - Abstract #AES2022AES_802;    
    There were no significant differences in total AEP scores across ASMs. Patients with a baseline diagnosis of depression (adjusted marginal score ratio [aMSR]=1.25, 95% CI: 1.11-1.41, p< 0.001) or anxiety (aMSR=1.15, 95 % CI: 1.05-1.27, p=0.004) had significantly increased total AEP scores, irrespective of ASM use.
  • ||||||||||  Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
    Real World Evaluation of Serum Sodium Levels in Patients With Focal Seizures Treated With Eslicarbazepine Acetate () -  Nov 29, 2022 - Abstract #AES2022AES_658;    
    The most common concomitant baseline ASMs were levetiracetam and lacosamide, and the most common comorbidities were bipolar disorder and chronic pulmonary disease. In both epilepsy and focal epilepsy groups, mean serum sodium values in patients treated with ESL aged ≥ 4 years did not change from baseline in a real-world clinical setting over a period of 12 months.
  • ||||||||||  phenobarbital / Generic mfg., levetiracetam / Generic mfg.
    Retrospective data, Journal:  Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. (Pubmed Central) -  Nov 20, 2022   
    Our study suggests a potential noninferiority and a more acceptable safety profile for LEV, which may thus be a reasonable option as first-line ASM for neonatal seizures in place of PB. Treatment should be initiated as early as possible since higher seizure frequencies predispose to less favorable responses.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  Suspected benzodiazepine withdrawal-associated seizures in 3 young dogs undergoing mechanical ventilation. (Pubmed Central) -  Nov 19, 2022   
    Young dogs managed with benzodiazepines to facilitate MV may have acute onset of generalized seizures following cessation, which can be successfully managed with short-term benzodiazepine therapy. The 3 cases in this series demonstrated a positive outcome and were successfully managed following acute onset of generalized seizure activity post-MV.
  • ||||||||||  levetiracetam / Generic mfg.
    Journal:  First-line levetiracetam versus enzyme-inducing antiseizure medication in glioma patients with epilepsy. (Pubmed Central) -  Nov 19, 2022   
    The 3 cases in this series demonstrated a positive outcome and were successfully managed following acute onset of generalized seizure activity post-MV. In this study it was demonstrated that LEV had a significantly better effectiveness (i.e. less often ASM treatment failure for any reason or due to adverse effects) compared to EIASMs, supporting the current neuro-oncology guideline recommendations to avoid EIASMs in glioma patients.
  • ||||||||||  levetiracetam / Generic mfg.
    Review, Journal:  The Association Between Alzheimer's Disease and Epilepsy: A Narrative Review. (Pubmed Central) -  Nov 18, 2022   
    However, diagnosis of seizures in AD is complicated by the difficulty in identifying non-motor focal seizures in patients with cognitive decline, problems with obtaining histories, low sensitivity of standard scalp electroencephalogram (EEG) methods, nonspecific cerebrospinal fluid (CSF) and radiological findings. This article has reviewed and summarised the existing literature on the association between AD and epilepsy pertaining to epidemiology, pathophysiological links, risk factors, modalities for diagnosis, and treatment strategies.
  • ||||||||||  phenobarbital / Generic mfg., levetiracetam / Generic mfg., midazolam hydrochloride / Generic mfg.
    Review, Journal:  Isolated ictal apnea in neonatal age: Clinical features and treatment options. A systematic review. (Pubmed Central) -  Nov 18, 2022   
    This article has reviewed and summarised the existing literature on the association between AD and epilepsy pertaining to epidemiology, pathophysiological links, risk factors, modalities for diagnosis, and treatment strategies. Not homogeneous data and paucity of isolated IA currently reported in literature limits agreement about definition, management and treatment of entity, however an ever-growing attention is needed, and EEG/aEEG, despite their possible controversies in the diagnosis, should be performed to investigate unexplained forms of apnea.
  • ||||||||||  Clinical, Observational data, Journal:  A Multicenter, Cross-Sectional, Observational Study on Epilepsy and its Management Practices in India. (Pubmed Central) -  Nov 16, 2022   
    No serious adverse drug reactions or new safety concerns were identified. Findings from this large, cross-sectional, observational, multicenter study indicate that first-generation AEDs sodium valproate and phenytoin continued to be used in a substantial number of patients on monotherapy and combination therapy in India, even though an increasing trend toward use of second-generation AEDs was noted in clinical practice.
  • ||||||||||  levetiracetam / Generic mfg., carbamazepine / Generic mfg., oxcarbazepine / Generic mfg.
    Journal:  Association of HLA Alleles with Antiepileptic Drug-Induced Mild Cutaneous Reactions: A Case-Control Study of a Northeast Han Chinese Population. (Pubmed Central) -  Nov 16, 2022   
    We failed to find statistically significant differences in HLA alleles between the cADRs group and the control group when considering all the drugs included in our study together or when considering oxcarbazepine (OXC), carbamazepine (CBZ), and levetiracetam (LEV) alone (P > 0.05). Our findings indicated that there was no correlation between HLA alleles and AED-induced mild cADRs in the Northeast Han Chinese population.