- |||||||||| levetiracetam / Generic mfg.
Enrollment open: LIBRA: Short Versus Long-term Levetiracetam in Brain Tumors (clinicaltrials.gov) - Jul 8, 2024
P3, N=604, Recruiting,
The combination of efgartigimod and methylprednisolone resulted in favorable outcomes, indicating that this is an optional treatment plan. Not yet recruiting --> Recruiting
- |||||||||| levetiracetam / Generic mfg.
Journal: Drug-Resistant Epilepsy: Experience From a Tertiary Care Center in Saudi Arabia. (Pubmed Central) - Jul 8, 2024
Conclusion The findings of this study confirm the challenges in diagnosing and managing patients with DRE and emphasize the necessity for careful and comprehensive patient evaluation. Further research is needed to investigate the effectiveness, safety, and accessibility of diagnostic and therapeutic resources for patients with DRE.
- |||||||||| levetiracetam / Generic mfg., pioglitazone / Generic mfg.
Journal: Brain Cell-based Genetic Subtyping and Drug Repositioning for Alzheimer Disease. (Pubmed Central) - Jul 1, 2024
Pathway analysis of priority genes demonstrated associations with neurodegeneration and suggested candidate drugs currently utilized in diabetes, hypertension, and epilepsy for repositioning in AD. Experimental validation utilizing human induced pluripotent stem cell (hiPSC)-derived astrocytes demonstrated the modifying effects of estradiol, levetiracetam, and pioglitazone on expression of APOE and complement C4 genes, suggesting potential repositioning for AD.
- |||||||||| verapamil / Generic mfg., acetazolamide / Generic mfg., levetiracetam / Generic mfg.
Journal: A Longitudinal Exploration of CACNA1A -related Hemiplegic Migraine in Children. (Pubmed Central) - Jul 1, 2024
However, verapamil ( n= 3) showed efficacy in preventing HM episodes (OR 2.68, CI 1.39-5.67)...Our data underscores the unpredictability of CACNA1A -related HM, highlighting the need for close surveillance for reoccurring HM events even in individuals with symptom-free periods. 24% of hemiplegic migraines (HM) in CACNA1A- related disorders are severe, involving cerebral edema and greater than 4 days to recover Timing and severity of HM are unpredictable, with large changes in severity between events, and age of onset ranging from 1-13 yearsEpilepsy occurred in 53% of individuals, with neither the timing nor severity of seizures correlated with HM.
- |||||||||| Journal: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports. (Pubmed Central) - Jun 27, 2024
The top 10 involved drugs are as follows: lamotrigine (23.5%), ibuprofen (12.9%), ceftriaxone (8.8%), amoxicillin and amoxicillin with beta-lactam inhibitors (8.8%), paracetamol (7.6%), carbamazepine (5.9%), azithromycin (4.1%), valproic acid (4.1%), omeprazole (3.5%), and levetiracetam (3.5%). (4) Our study was the first study in Russia aimed at the assessment of the structure of the drugs involved in SJS and TEN on the national level.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma
Journal: Serum perampanel levels in patients with seizures are not affected by hemodialysis. (Pubmed Central) - Jun 26, 2024
In 14 patients who started treatment between April 2020 and March 2023, perampanel serum levels did not decrease during hemodialysis, unlike other seizure medications. This shows that perampanel can be a good option for patients with seizures who need hemodialysis, with fewer side effects compared to other medications.
- |||||||||| phenobarbital / Generic mfg., levetiracetam / Generic mfg.
Review, Journal: Emergency Approach to Acute Seizures in Dogs and Cats. (Pubmed Central) - Jun 26, 2024
Typically, causes of seizures can be grouped into intracranial and extracranial causes, with the latter being easier to diagnose with commonly available tests. This review presents a systematic approach to the diagnosis and treatment of single seizures, cluster seizures, and status epilepticus in dogs and cats.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg., L-ornithine-L-aspartate / Generic mfg.
Journal: From seizures to cognitive dysfunction: A case report of Fahr syndrome in an Afghan patient. (Pubmed Central) - Jun 21, 2024
Onset of epilepsy after the first year of age, predominance of focal seizures with impaired awareness and generalized motor seizures, no pathognomonic underlying epileptic syndrome and infrequent occurrence of status epilepticus emerged as the main features of IQSEC2-related epilepsy phenotype. This case underscores the importance of raising awareness among physicians, especially in areas with limited medical resources, about the significance of prompt diagnosis and appropriate symptomatic treatment in enhancing patient prognosis and quality of life.
- |||||||||| phenytoin / Generic mfg.
Journal: Phenytoin-Induced Severe Thrombocytopenia: A Case Report. (Pubmed Central) - Jun 20, 2024
It should be recognized early, particularly in patients with a high risk of hemorrhage or concurrently with medications that increase phenytoin epoxide. Regularly consecutive complete blood count tests may be essential in order to detect an early decrease in platelet count in these patients.
- |||||||||| phenytoin / Generic mfg., ketamine / Generic mfg., levetiracetam / Generic mfg.
Journal: Status Epilepticus: An Update on Pharmacological Management. (Pubmed Central) - Jun 19, 2024
Midazolam, propofol, pentobarbital, and ketamine are continuous intravenous infusions of anesthetic medications utilized in the refractory SE (RSE) period. The most efficacious pharmacotherapeutic treatments for RSE and superrefractory status epilepticus are not clearly defined.
- |||||||||| Aduhelm (aducanumab) / Neurimmune, Eisai, verubecestat (MK-8931) / Merck (MSD)
MODEL-AD Pre-Clinical Testing Core: A Precision Medicine Pipeline for Preclinical Testing of Alzheimer (201 ABC (Pennsylvania Convention Center)) - Jun 19, 2024 - Abstract #AAIC2024AAIC_5710;
Conclusion : Based on our experience executing rigorous screening strategies with QC checkpoints provide insight to the challenges of conducting translational studies in animal models. The PTC pipeline, an NIA resource, is accessible to the research community for investigators to nominate compounds for testing (https://stopadportal.synapse.org/), thus enabling unbiased studies that support clinical translation.
- |||||||||| levetiracetam / Generic mfg., doxycycline / Generic mfg.
Anti-epilepsy drug therapy in a dox-regulatable TDP-43 mouse model of ALS-FTD with seizures. (Exhibit (Pennsylvania Convention Center); In-Person) - Jun 19, 2024 - Abstract #AAIC2024AAIC_4531;
Daily levetiracetam administration was not effective in significantly reducing disease severity. Future studies will examine the effect of orthogonal approaches, such as AAV encoded chemogenetics, and characterize downstream mediators of TDP-43 -induced hyperexcitability, which may serve as more potent and specific therapeutic targets.
- |||||||||| levetiracetam / Generic mfg., diazepam / Generic mfg.
A disease modification drug screening platform targeting neuronal hyperexcitability and seizures in Alzheimer (Exhibit (Pennsylvania Convention Center); In-Person) - Jun 19, 2024 - Abstract #AAIC2024AAIC_3678;
EOAD-associated risk genes do not equally influence age-related seizure susceptibility or impact ASM efficacy; seizures in AD may require precision medicine interventions. Further ASM profiling focused on attenuating neuronal hyperexcitability may uncover novel disease-modifying strategies for AD.
- |||||||||| levetiracetam / Generic mfg.
High Frequency Oscillations in Epileptic and Non-Epileptic Alzheimer (Exhibit (Pennsylvania Convention Center); In-Person) - Jun 19, 2024 - Abstract #AAIC2024AAIC_980;
LEV resulted in region-specific increases in HFOs in both NEAD and EAD. Thus, HFOs can function as a biomarker of hyperexcitability in AD; however, their contribution to the epileptic phenotype in AD requires further investigation.
- |||||||||| levetiracetam / Generic mfg.
Journal: Factors influencing serum concentrations of levetiracetam in dogs with epilepsy. (Pubmed Central) - Jun 18, 2024
Thus, HFOs can function as a biomarker of hyperexcitability in AD; however, their contribution to the epileptic phenotype in AD requires further investigation. Our data suggest that a dosage of 99-216?mg/kg/day of levetiracetam is needed to achieve a serum concentration known to be therapeutically effective in humans, especially when administered concomitantly with phenobarbital.
- |||||||||| levetiracetam / Generic mfg.
Burning mouth syndrome exquisite response to levetiracetam therapy () - Jun 18, 2024 - Abstract #AHS2024AHS_199;
Our data suggest that a dosage of 99-216?mg/kg/day of levetiracetam is needed to achieve a serum concentration known to be therapeutically effective in humans, especially when administered concomitantly with phenobarbital. At this point, she was on oxcarbazepine 150
- |||||||||| levetiracetam / Generic mfg.
Journal: Evaluation of [11C]UCB-A positron emission tomography in human brains. (Pubmed Central) - Jun 17, 2024
However, its slow kinetics require a long scan duration, which is impractical with the short half-life of carbon-11. Consequently, the slow kinetics and complicated quantification methods may restrict its use in humans.
- |||||||||| Zavzpret (zavegepant nasal spray) / Pfizer, Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Review, Journal: An update on pharmacotherapy for trigeminal neuralgia. (Pubmed Central) - Jun 13, 2024
Third-generation anticonvulsants, new calcitonin gene-related peptide blockers for migraine, and older drugs such as ketamine and cannabinoids may be promising adjuvants or monotherapeutic options...Combination therapy might allow for lower doses of carbamazepine or oxcarbazepine, thus reducing the number and severity of potential adverse events but the potential for pharmacokinetic drug-drug interactions must be considered. Drug therapy for trigeminal neuralgia involves acute or abortive treatments, often administered in hospital versus long-term preventive therapy, usually involving oral agents.
- |||||||||| levetiracetam / Generic mfg.
Trial completion date, Trial primary completion date: NEOLEV3: A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures (clinicaltrials.gov) - Jun 12, 2024
P2, N=133, Recruiting,
Drug therapy for trigeminal neuralgia involves acute or abortive treatments, often administered in hospital versus long-term preventive therapy, usually involving oral agents. Trial completion date: Dec 2026 --> Dec 2027 | Trial primary completion date: Jul 2026 --> Jul 2027
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma, Diacomit (stiripentol) / Biocodex, Meiji Seika, Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Journal, Adverse events: An analysis of suicidal and self-injurious behavior reports with antiseizure medications in the FDA adverse event database. (Pubmed Central) - Jun 6, 2024
These drugs included diazepam, brivaracetam, gabapenetin, and pregabalin. Although several limitations are present with the FAERS database, it is imperative to closely monitor patient comorbidities for increased risk of suicidality with the use of several ASMs.
- |||||||||| levetiracetam / Generic mfg.
Journal: Subcutaneous Bolus Infusions of Undiluted Levetiracetam for End-of-Life Patients: Two Cases. (Pubmed Central) - Jun 5, 2024
Amongst others reducing patient discomfort, increasing freedom of movement, and accessibility to essential seizure prophylaxis by eliminating the need for a syringe driver, thereby helping accommodate many patients wish to die in their own home. However, pharmacokinetics, efficacy, and safety, including the optimum dilution and administration time of the subcutaneous preparation remains to be determined in clinically controlled trials.
- |||||||||| ketamine / Generic mfg., levetiracetam / Generic mfg., fosphenytoin / Generic mfg.
Review, Journal: Emergent Management of Status Epilepticus. (Pubmed Central) - Jun 3, 2024
If seizures persist, second-line treatments such as phenytoin and fosphenytoin, valproate, or levetiracetam are warranted...For cases of refractory and super-refractory status epilepticus, IV anesthetics, including ketamine and ?-aminobutyric acid-mediated (GABA-ergic) medications, are necessary...Antiseizure medication should be initiated quickly to achieve seizure cessation. There is a need to explore newer generations of antiseizure medications and nonpharmacologic modalities to treat status epilepticus.
- |||||||||| brivaracetam / Generic mfg.
Preclinical, Review, Journal: Narrative Review of Brivaracetam: Preclinical Profile and Clinical Benefits in the Treatment of Patients with Epilepsy. (Pubmed Central) - May 30, 2024
P3
Brivaracetam (BRV) is an ASM that was developed in a major drug discovery program aimed at identifying selective, high-affinity synaptic vesicle protein 2A (SV2A) ligands, the target molecule of levetiracetam. Evidence from daily clinical practice highlights BRV effectiveness and tolerability in specific epilepsy patient populations with high unmet needs: the elderly (??65
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