| Dapivirine Vaginal Ring (dapivirine) / International Partnership for Microbicides, J&J |
NCT00700284: Feasibility Study of a Vaginal Ring for Delivery of TMC120 (Dapivirine) |
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| Completed | 1 | 12 | Europe | placebo vaginal ring, TMC120 (dapivirine) vaginal ring | International Partnership for Microbicides, Inc., Tibotec Pharmaceutical Limited | HIV Infections | 01/05 | 01/05 | | |
NCT00332995: Safety and Feasibility Study of Dapivirine (TMC120) Vaginal Ring in Belgium |
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| Completed | 1 | 13 | Europe | dapivirine (TMC120) vaginal ring | International Partnership for Microbicides, Inc., Tibotec Pharmaceutical Limited | HIV Infections | | 08/05 | | |
NCT00469768: A Pharmacokinetic Study of Dapivirine Vaginal Rings in Belgium |
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| Completed | 1 | 24 | Europe | dapivirine reservoir intravaginal ring, dapivirine matrix intravaginal ring, placebo intravaginal ring | International Partnership for Microbicides, Inc. | HIV Infections | | 08/07 | | |
NCT01144013: Safety and Pharmacokinetic Trial in Healthy HIV-Negative Women to Assess the Delivery of Dapivirine From a Vaginal Ring |
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| Completed | 1 | 16 | Europe | dapivirine, placebo | International Partnership for Microbicides, Inc. | HIV Infections | 04/10 | 04/10 | | |
NCT02920827: Safety and Pharmacokinetic Trial in Healthy HIV-Negative Women to Assess the Delivery of Dapivirine From a Vaginal Ring |
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| Completed | 1 | 16 | Europe | Dapivirine Vaginal Ring, Placebo vaginal ring | International Partnership for Microbicides, Inc. | HIV Infections | 04/10 | 04/10 | | |
NCT01144676: A Safety Study to Assess the Delivery of Dapivirine From a Matrix Vaginal Ring |
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| Completed | 1 | 45 | Europe | dapivirine, placebo | International Partnership for Microbicides, Inc. | HIV Infections | 09/10 | 09/10 | | |
NCT01363037: Safety and Pharmacokinetics of Dapivirine/Maraviroc Vaginal Ring |
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| Completed | 1 | 48 | US | Dapivirine Vaginal Ring, Maraviroc Vaginal Ring, Placebo Vaginal Ring, Dapivirine-Maraviroc Vaginal Ring | International Partnership for Microbicides, Inc. | HIV Infections | 08/12 | 08/12 | | |
NCT01731574: DDI Potential: Dapivirine Vaginal Ring and Miconazole Nitrate |
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| Completed | 1 | 36 | Europe | dapivirine, miconazole | International Partnership for Microbicides, Inc. | HIV | 10/13 | 10/13 | | |
| Completed | 1 | 40 | US, Europe | dapivirine ring | International Partnership for Microbicides, Inc. | Pharmacokinetics | 03/14 | 05/14 | | |
NCT02858024: A Trial In Healthy HIV-Negative Women To Assess The Effect Of Menses And Tampon Use On The Pharmacokinetics Of Dapivirine, Delivered By Dapivirine Vaginal Ring-004, Containing 25 Mg Of Dapivirine |
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| Completed | 1 | 16 | NA | Dapivirine Vaginal Ring-004 and no tampons, Treatment A, Dapivirine Vaginal Ring-004 with tampons, Treatment B, Dapivirine Vaginal Ring-004 with no menses, Treatment E, Dapivirine Vaginal Ring-004 and same ring inserted after menses, Treatment C, Dapivirine Vaginal Ring-004 and new ring inserted after menses, Treatment D | International Partnership for Microbicides, Inc. | HIV | 04/16 | 04/16 | | |
NCT02847286: To Assess the Drug-drug Interaction Potential Between Dapivirine Vaginal Ring-004, Containing 25 mg of Dapivirine, and Clotrimazole 10 mg/g (1%) |
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| Completed | 1 | 36 | NA | Dapivirine Ring-004, Treatment A, Dapivirine Ring-004 for 28 days along with clotrimazole, Treatment B, Clotrimazole, Treatment C | International Partnership for Microbicides, Inc. | HIV- Prevention | 11/16 | 11/16 | | |
NCT02658227: Pharmacokinetic Study of the Dapivirine Vaginal Ring in Lactating Women |
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| Recruiting | 1 | 16 | US | Dapivirine, Dapivirine Vaginal Ring | International Partnership for Microbicides, Inc. | HIV Infections | 08/17 | 08/17 | | |
| Completed | 1 | 24 | US | 200 mg of DPV + 320 mg LNG, Dapivirine, 200 mg of DPV, Dapivirine/Levonorgestrel | International Partnership for Microbicides, Inc., National Institutes of Health (NIH) | HIV Prevention | 08/17 | 08/17 | | |
NCT02808949: Pharmacokinetic Study of the Dapivirine Vaginal Ring in Lactating Women |
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| Completed | 1 | 16 | US | Dapivirine, Dapivirine vaginal ring | International Partnership for Microbicides, Inc. | Human Immunodeficiency Virus | 03/18 | 03/18 | | |
NCT03234400: A Phase 1, Randomized Pharmacokinetics and Safety Study of Extended Duration Dapivirine Vaginal Rings |
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| Completed | 1 | 49 | US | Dapivirine Vaginal Ring, 25 mg, Dapivirine Vaginal Ring, 100 mg, Dapivirine Vaginal Ring, 200 mg | International Partnership for Microbicides, Inc., National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) | HIV-1-infection | 10/18 | 01/19 | | |
NCT03467347: PK Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel |
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| Completed | 1 | 25 | US | VR: 200 mg DPV + 320 mg LNG | International Partnership for Microbicides, Inc., Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Division of AIDS, US National Institute of Allergy and Infectious Diseases, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) | Healthy, Contraception, Contraceptive Usage, Women | 08/19 | 10/19 | | |
NCT05416021: Relative Bioavailability Trial of Dapivirine Ring-004 and Ring-008 |
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| Active, not recruiting | 1 | 110 | RoW | dapivirine | International Partnership for Microbicides, Inc. | HIV Infections | 04/24 | 04/24 | | |
