| doxycycline / Generic mfg. |
| Not yet recruiting | 2 | 40 | | | Dr Natalie Briggs, Waikato Medical Research Foundation | Rectal Cancer | | | | |
ACTRN12623000843651: A Clinical Trial of Ambroxol and Doxycycline in Moderate Severity Parkinson’s Disease |
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| Not yet recruiting | 2 | 240 | | | University of Sydney, University of Sydney | Parkinson’s Disease | | | | |
ACTRN12624001180505: Efficacy of tREating aSymptomatic infEctions To resTore fERtility: The RESETTER Study
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| Not yet recruiting | 2 | 440 | | | University of Western Australia, University of Western Australia | Infertility | | | | |
ACTRN12608000325303: Doxycycline in Lymphanioleiomyomatosis (LAM): a randomised double blind placebo controlled crossover trial |
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| Recruiting | 2 | 30 | | | Dr.Deborah Yates, LAM Fighting Fund, St.Vincents Hospital, LAM Australia | Lymphangioleiomyomatosis | | | | |
ACTRN12623000004662: A Phase II pilot study to determine protocol feasibility, and potential efficacy for disease modification of combined Doxycycline and Ambroxol in Dementia with Lewy Bodies |
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| Recruiting | 2 | 32 | | | University of Sydney, University of Sydney | Dementia with Lewy Bodies | | | | |
ACTRN12605000206628: Control of menstrual bleeding disturbances in women using Implanon contraception |
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| Recruiting | 2 | 500 | | | FPA Health, 328 Liverpool Rd Ashfield NSW 2131, National Institutes of Health | Breakthrough bleeding with Implanon progestogen-only contraception | | | | |
ACTRN12616001723471: A Trial to evaluate treatments for patients with haematological disease who also have low levels of immunoglobulins (antibodies) in the blood (hypogammaglobulinemia). |
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| Recruiting | 2 | 60 | | | Monash University, National Blood Authority | haematological malignancy, hypogammaglobulinemia | | | | |
ACTRN12618000260224: Anti-chlamydophila antibiotic combination therapy in the treatment of patients with Coronary Heart Disease |
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| Recruiting | 2 | 60 | | | Centre for Digestive Diseases, Cadrock Pty Ltd | Coronary Heart Disease, Chlamydophila pneumoniae infection | | | | |
| Recruiting | 2 | 300 | | | The University of Queensland, The Commonwealth of Australian represented by Department of Health , Anonymous donor, Cystic Fibrosis Foundation, The Unviersity of Queensland , Children's Hospital Foundation | Mycobacterium abscessus pulmonary disease, Mycobacterium abscessus | | | | |
NCT02257086: Spironolactone in Preventing Rash in Patients With Advanced Cancer Receiving Panitumumab and Cetuximab |
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| Active, not recruiting | 2 | 80 | US | spironolactone, Aldactone, SC 9420, SPL, placebo, PLCB, questionnaire administration, sunscreen, management of therapy complications, complications of therapy, management of, doxycycline, Doxycycline Monohydrate, Vibramycin, therapeutic hydrocortisone, Aeroseb-HC, Barseb HC, Cetacort, Cort-Dome, Cortef | Mayo Clinic, National Cancer Institute (NCI) | Dermatologic Complications, Malignant Neoplasm | 12/14 | | | |
2006-001774-24: INTESTINAL MICRO-ORGANISMS IN THE PATHOGENESIS OF NASH AND THE ROLE OF MODULATION OF ENTERIC BACTERIA IN TREATMENT. |
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| Ongoing | 2 | 40 | Europe | Doxycycline, Doxycycline, | Newcastle u Tyne Hospitals NHS Trust | Non alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH) | | | | |
2008-007178-39: Estudio unicéntrico de fase II, doble ciego, randomizado, comparando doxiciclina administrada oralmente frente a placebo en pacientes con pterigión.Single center, double blind, randomized clinical trial comparing orally administered doxycycline against placebo in pterygium patients. |
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| Ongoing | 2 | 98 | Europe | VIBRACINA CAPSULAS, VIBRACINA CAPSULAS | Center for Biomedical Research of La Rioja (CIBIR) | Pacientes con pterigión primario no intervenido.Patients suffering from untreated primary pterygium. | | | | |
2011-001589-16: MINOPTIC - A prospective, double-masked, placebo-controlled study on efficacy and safety of minicycline in the treatment of optic neuritis |
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| Ongoing | 2 | 150 | Europe | Minocyclin-ratiopharm 100 mg, | HUCH Eye Hospital, Finnish Academy, KELA, Mary and Georg c: Ehrnrooth Foundation, The Evald and Hilda Nissi Foundation, The Eye and Tissue Bank Foundation, EVO-funding | optic neuritis | | | | |
| Active, not recruiting | 2 | 34 | Europe | Doxycycline | International Extranodal Lymphoma Study Group (IELSG) | Marginal Zone Lymphoma of Ocular Adnexal | 05/16 | 09/25 | | |
2016-000871-26: Uso della doxiciclina nel trattamento del tumore al seno in stadio precoce Use of doxycycline for the treatment of the early-stage breast cancer |
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| Not yet recruiting | 2 | 130 | Europe | BASSADO, NA, Tablet, BASSADO - 100 MG COMPRESSE 10 COMPRESSE | AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA, Fondazione Pisana per la Scienza | Breast cancer - Stage 1-2 to or Stage 3 that is candidate for primary surgery Carcinoma mammario - Stage 1-2 o Stage 3 candidato alla chirurgia, Early breast cancer Carcinoma mammario in stadio precoce, Diseases [C] - Cancer [C04] | | | | |
NCT03076281: Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery |
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| Active, not recruiting | 2 | 7 | US | Metformin Hydrochloride, 1,1-Dimethylbiguanide Hydrochloride, 1115-70-4, 91485, Cidophage, Dimefor, Glucoformin, Glucophage, Glifage, Doxycycline, 17086-28-1, Doxycycline Monohydrate, Metformin +Doxycycline | Sidney Kimmel Cancer Center at Thomas Jefferson University | Larynx, LIP, Oral Cavity, Pharynx | 12/18 | 08/20 | | |
2019-000585-38: Chronic Endometritis and Recurrent Miscarriage - The CERM trial |
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| Ongoing | 2 | 3062 | Europe | Doxycycline Capsules 100mg, Capsule, Doxycycline Capsules 100mg | University Hospitals Coventry and Warwickshire NHS Trust, The Efficacy and Mechanism Evaluation (EME) programme - National Institute for Health Research, University Hospitals Coventry and Warwickshire NHS Trust, Warwick Clinical Trials Unit, The University of Warwick | Chronic Endometritis and Recurrent Miscarriage, In some women the lining of the womb (endometrium) is inflamed (endometritis) possible due to infection and researchers have found a link between this and miscarriage., Body processes [G] - Reproductive physiologi cal processes [G08] | | | | |
NCT04551755: Safety and Efficacy of Ivermectin and Doxycycline in Treatment of Covid-19 |
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| Not yet recruiting | 2 | 188 | NA | Ivermectin and Doxycycline, Placebo | Bangladesh Medical Research Council (BMRC) | Covid19 | 11/20 | 12/20 | | |
NCT02874430: Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer |
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| Active, not recruiting | 2 | 27 | US | Metformin Hydrochloride, 1,1-Dimethylbiguanide Hydrochloride, 1115-70-4, 91485, Cidophage, Dimefor, Glifage, Glucoformin, Glucophage, N,N-Dimethylimidodicarbonimidic Diamide Monohydrochloride, Riomet, Siofor, Doxycycline, 17086-28-1, Doxycycline Monohydrate | Sidney Kimmel Cancer Center at Thomas Jefferson University | Breast Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Uterine Corpus Cancer, Uterine Corpus Carcinosarcoma | 12/20 | 06/23 | | |
NCT04723069: Efficacy and Safety of Fuke Qianjin Capsule in Patients With Pelvic Inflammatory Diseases |
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| Completed | 2 | 198 | RoW | Control Group, Traditional Chinese Medicine (TCM), Test Group | University of Karachi, Zhuzhou Qianjin Pharmaceutical Co., Ltd., 801, Zhuzhou, China, Center for bioequivalence studies and Clinical Research (CBSCR), ICCBS, University of Karachi | Pelvic Inflammatory Disease | 03/22 | 03/22 | | |
NCT03968562: Assessment of Suppression of Cutaneous Allergic Responses and Pruritus by Topical Doxycycline |
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| Active, not recruiting | 2 | 25 | US | 2% Doxycycline Cream in Generic Aquaphor or Generic Aquaphor | State University of New York - Downstate Medical Center | Hives | 05/22 | 05/22 | | |
NCT02203682: Doxycycline Treatment in Mild Thyroid-Associated Ophthalmopathy |
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| Recruiting | 2 | 100 | RoW | Doxycycline hyclate, Placebo | Sun Yat-sen University | Graves Ophthalmopathy, Graves Disease, Thyroid-associated Ophthalmopathy, Thyroid Diseases, Endocrine System Diseases, Eye Diseases, Hereditary, Hyperthyroidism, Autoimmune Diseases, Immune System Diseases | 07/22 | 07/22 | | |
NCT01917721: Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease |
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| Recruiting | 2 | 50 | US | Doxycycline, Placebo, IVIG and Remicade | Hawaii Pacific Health | Kawasaki Disease, Coronary Aneurysm | 11/22 | 11/22 | | |
NCT03397004: Doxycycline for Hereditary Hemorrhagic Telangiectasia |
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| Active, not recruiting | 2 | 30 | Canada | Doxycycline Hyclate, capsule, Placebo | Unity Health Toronto, Barrow Neurological Institute, Duke University, Feinstein Institute for Medical Research, University of Pittsburgh, Sunnybrook Health Sciences Centre | Hereditary Hemorrhagic Telangiectasia (HHT) | 12/22 | 12/24 | | |
NCT02366884: Clinical Evaluation of a New Form of Cancer Therapy (Atavistic Chemotherapy) Based on the Principles of Atavistic Metamorphosis (2011) |
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| Recruiting | 2 | 250 | RoW | Anti-Bacterial Agents, Anti-Fungal Agents, Anti-Protozoal Agents | Dr. Frank Arguello Cancer Clinic, Instituto de Ciencia y Medicina Genomica, Torreon, Coah. Mexico www.institutodeciencia.com | Neoplasms | 12/22 | 12/23 | | |
NCT05492019: Effect of Doxycycline in Levodopa Treated Parkinson's Disease Patients |
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| Recruiting | 2 | 60 | RoW | Doxycycline, Brand name- Doxin, Placebo | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Parkinson Disease | 01/23 | 01/23 | | |
2020-000050-10: Finding the best treatment for lung disease from infection with Mycobacterium abscessus. |
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| Not yet recruiting | 2 | 300 | Europe | Amikacin, Tigecycline, Imipenem and Cilastatin, Cefoxitin, Azithromycin, Clofazimine, Ethambutol, Clarithromycin, Linezolid, Trimethoprim and Sulfamethoxazole, Doxycycline, Moxifloxacin, Bedaquiline, Rifabutin, Solution for injection, Powder for solution for infusion, Film-coated tablet, Powder for oral suspension, Capsule, Tablet, Capsule, hard, Clofazimine "Lamprene", Trimethoprim and Sulfamethoxazole "SAD" | University of Queensland, Medical Research Futures Fund, Cystic Fibrosis Foundation, Anonymous Donor, Thoracic Society of Australia and New Zealand, The University of Queensland, Children's Hospital Foundation | Mycobacterium abscessus pulmonary disease, Nontuberculous mycobacterium (NTM) are a group of bacteria. These bacteria can cause significant lung damage in both healthy people and those with underlying lung disease., Diseases [C] - Respiratory Tract Diseases [C08] | | | | |
NCT06252194: Comparative Study of Metformin Versus Doxycycline in Moderate to Severe Adult Acne Vulgaris Patients. |
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| Recruiting | 2 | 120 | RoW | Metformin and doxycycline | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Acne Vulgaris | 03/24 | 03/24 | | |
| Recruiting | 2 | 50 | US | Doxycycline Hyclate, Antibiotic - tetracycline compound, Placebo, Inactive substance | University of Iowa | Exudative Macular Degeneration, Wet Age-related Macular Degeneration | 12/23 | 03/24 | | |
| Recruiting | 2 | 130 | US | Trimethoprim/sulfamethoxazole (TMP/SMZ), Cephalexin, Doxycycline, Sodium hypochlorite, Placebo capsules, Placebo Sodium hypochlorite | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Eczema, Dermatitis, Skin Diseases, Genetic, Dermatitis, Atopic, Skin Diseases | 01/27 | 01/27 | | |
NCT06201793: Minocyclin in Ulcerative Colitis as Added on Therapy |
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| Recruiting | 2 | 46 | RoW | Mesalazine, Minocycline | Mostafa Bahaa, Amira Fawzy Mohamed Mashaly, Clinical Pharmacy Demonstrator, Faculty of Pharmacy- Horus University, Sahar Kamal Hegazi clinical pharmacy department, Tanta University, Mounir Hussein Bahgat Internal Medicine Department Mansoura University | Inflammatory Bowel Diseases | 01/27 | 08/28 | | |
NCT05205993: Εffectiveness of Intrauterine Antibiotic Administration for Treatment of Chronic Endometritis |
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| Recruiting | 2 | 90 | Europe | Intrauterine infusion, Oral administration | Genesis Athens Clinic, National and Kapodistrian University of Athens | Chronic Endometritis | 01/24 | 04/24 | | |
TODOS, NCT03637400: Short and Long Term Outcomes of Doxycycline Versus Trimethoprim-Sulfamethoxazole for Skin and Soft Tissue Infections Treatment |
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| Recruiting | 2 | 462 | US | TMP-SMX, Trimethoprim/sulfamethoxazole, DOXY, Doxycycline | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, National Institute of Allergy and Infectious Diseases (NIAID), Washington University School of Medicine, University of California, Los Angeles | Methicillin-resistant Staphylococcus Aureus, Skin Infection | 04/24 | 11/25 | | |
NCT05411484: Investigation of Laser Assisted Drug Delivery of NanoDOX® |
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| Recruiting | 2 | 20 | US | NanoDOX® Hydrogel, Doxycycline application, CO2 Ablative Fractional Laser, laser treatment | Massachusetts General Hospital, NanoSHIFT LLC | Wounds and Injury | 11/24 | 11/24 | | |
| Not yet recruiting | 2 | 200 | RoW | Doxycycline, Placebo, Anti Tuberculosis Drug, Adjunctive corticosteroid | National University Hospital, Singapore, National Medical Research Council (NMRC), Singapore | Tuberculosis, Meningeal, Tuberculosis; Meningitis (Etiology), Tuberculosis, Central Nervous System, Tuberculosis; Meningoencephalitis (Etiology) | 11/27 | 12/27 | | |
TALF-TB, NCT06477185: Characterization of Tuberculosis Associated Lung Fibrosis and Respiratory Impairment, and Prevention Using Doxycycline |
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| Not yet recruiting | 2 | 200 | RoW | Doxycycline, Placebo | Makerere University, Makerere University Lung Institute | Tuberculosis, Pulmonary | 12/26 | 12/27 | | |
NCT03508232: Doxycycline to Protect Heart Muscle After Heart Attacks |
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| Recruiting | 2 | 170 | Canada | Placebo, Doxycycline Hyclate, Doxycycline | University of Alberta, Royal Alexandra Hospital | ST Segment Elevation Myocardial Infarction, Heart Failure | 12/24 | 12/24 | | |
| Not yet recruiting | 2 | 50 | Europe | Doxycyclin, Doxyclin | Swiss Group for Clinical Cancer Research | Breast Cancer | 03/28 | 12/28 | | |
COCOON, NCT06120140: Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib |
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| Recruiting | 2 | 300 | Europe, US, RoW | Amivantamab, JNJ-61186372, Lazertinib, JNJ-73841937, Doxycycline, Minocycline, Clindamycin, Chlorhexidine, Noncomedogenic skin moisturizer | Janssen Research & Development, LLC | Carcinoma, Non-Small-Cell Lung | 07/25 | 03/26 | | |
| Recruiting | 2 | 250 | US | Doxycycline, Placebo | Weill Medical College of Cornell University, National Heart, Lung, and Blood Institute (NHLBI), University of California, Los Angeles, University of Iowa, University of Michigan | Emphysema, HIV | 02/27 | 02/27 | | |
NCT06199440: Azithromycin Versus Doxycycline on Restistin Level in Periodontitis Patients With Type 2 Diabetes |
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| Completed | 1/2 | 15 | RoW | Group I, Group II, Group III | King Abdulaziz University | Periodontal Diseases, Type 2 Diabetes | 03/23 | 03/23 | | |
ACTRN12622000386730: Therapies to prevent progression of COVID-19 in outpatients: The 'Primary Care Australian COVID-19 Therapeutics' (PACT) Trial |
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| Completed | 1/2 | 300 | | | AProf Dr Karin Ried, Lumina Medical Research | COVID-19 | | | | |
| Terminated | 1/2 | 12 | US | Lefamulin, Xenleta, Doxycycline | University of Washington, Nabriva Therapeutics AG | Mycoplasma Genitalium Infection | 11/23 | 11/23 | | |
| Recruiting | 1/2 | 60 | RoW | Sitagliptin 100mg, Doxycyclin | Mostafa Bahaa | Diabetes Mellitus, Type 2 | 03/25 | 04/25 | | |
| Recruiting | 1/2 | 19 | US | Doxycycline Injection [Doxy], Doxycycline Hyclate | Massachusetts Eye and Ear Infirmary | Neurofibromatosis Type 2 | 09/24 | 12/24 | | |
ChiCTR2400085250: A single-center, dose-escalation, and cohort-expanding single-arm, open-label Phase I/IIa clinical study evaluating the safety, tolerability, and initial efficacy of doxycycline in patients with intrahepatic cholangiocarcinoma that progresses after standard treatment |
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| Recruiting | 1/2 | 50 | | This phase is a single-arm, open design and is intended to determine the MTD and/or RP2D of doxycycline by dose climbing (200mg/ day, 400mg/ day, 600mg/ day, 800mg/ day). Doxycycline: Continuous oral administration, twice a day, half a dose each time, 12 hours between the two times, after meals, or according to the previous low dose of PK/PD adjustment mode of administration. The "3+3" dose climbing principle was adopted, with the initial dose of 200mg/ day and the incremental dose of 400mg/ day, 600mg/ day and 800mg/ day. Whether to proceed to the next dose group test after completion of each dose group is determined according to the following rules: (1) If no dose limiting toxicity (DLT) occurs in all three patients, the next dose group is increased. (2) If DLT occurs in ≥2 patients, decrease to the previous dose group. (3) If 1 out of 3 patients developed DLT, 3 more patients were added to the dose group for testing. If 1/6 patients develop DLT, increase to the next dose group. If ≥2/6 patients develop DLT, decrease to the previous dose group. (4) When the dose is reduced to the previous dose group, if there are only 3 patients in this dose group, 3 more patients are added for the test. If this dose has been tested in 6 patients, the trial is over and this dose is the maximum tolerated dose (MTD).; This stage is to preliminarly observe the efficacy of doxycycline in the treatment of patients with intrahepatic cholangiocarcinoma who are unresponsive or resistant to chemotherapy combined with PD-1 monoclonal antibody. RP2D was determined based on the safety, tolerability, and initial antitumor effects observed in the Phase I clinical trial, combined with the concentrations used in our team's previous in vitro cell inhibition trial. Enrolled patients were given RP2D dose of doxycycline every 21 days, and the treatment effect was evaluated according to mRECIST criteria. The survival status of the subjects was collected by telephone follow-up or interview every 35 +3 days until the subjects died, withdrew informed consent, lost follow-up or terminated the study. 38 subjects were planned to be enrolled. | The Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital); The Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital), National Natural Science Foundation of China | Advanced intrahepatic cholangiocarcinoma | | | | |
| Active, not recruiting | 1/2 | 30 | US | Doxycycline | University of California, Davis | Acne Vulgaris | 01/27 | 01/27 | | |
