| doxycycline / Generic mfg. |
ACTRN12619000621112p: A study of the local anaesthetic lidocaine and the antibiotic doxycycline to help protect the blood vessel lining in patients undergoing heart surgery. |
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| Not yet recruiting | 4 | 60 | | | Hearty and Lung Institute of Western Australia, Spinnaker Foundation | Ischaemic Heart Disease; Valvular Heart Disease; Aortic Disease | | | | |
| Not yet recruiting | 4 | 100 | | | Dr. Andrew James Wood, Yet to be applied for | Chronic rhinosinusitis | | | | |
| Recruiting | 4 | 20 | | | Associate Professor Richard Douglas, N/A | CHRONIC SINUSITIS | | | | |
ACTRN12619000621112: A study of the local anaesthetic lidocaine and the antibiotic doxycycline to help protect the blood vessel lining in patients undergoing heart surgery. |
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| Recruiting | 4 | 60 | | | Hearty and Lung Institute of Western Australia, Spinnaker Foundation | Ischaemic Heart Disease, Valvular Heart Disease, Aortic Disease | | | | |
| Recruiting | 4 | 50 | | | Dr. Andrew James Wood, Linsell Richards Education Fund administered by the New Zealand Society of Otolaryngology-Head and Neck Society, Waikato Medical Research Foundation, Herbert and Gloria Keys Research Scholarship | Chronic rhinosinusitis | | | | |
ChiCTR-TQR-13003624: Evaluating Doxycycline and ceftriaxone as alternatives of Penicillin G for the treatment of early syphilis |
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| Completed | 4 | 504 | | one gram of Ceftriaxone administrated intramuscularly once a day for 10 days. ;100 milligrams dose of doxycycline administered orally, twice a day for 14 days. ;2.4 million units of benzathine penicillin G administered intramuscularly once a week for 2 weeks. | Institute of Dermatology, Chinese Academy of Medical Sciences; Institute of Dermatology, Chinese Academy of Medical Sciences, Science and Technology Agency of Jiangsu Province | early syphilis | | | | |
2004-004876-36: AN INVESTIGATION INTO THE ROLE OF MATRIX METALLOPROTEINASES (MMP’s) IN LOWER LIMB VASCULAR RESTENOSIS |
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| Ongoing | 4 | 150 | Europe | Doxycycline, Periostat, Periostat | Addenbrookes Hospital NHS Trust | Post angioplasty and post vein graft stenosis. | | | | |
2007-006658-24: A randomised controlled trial to compare the safety and effectiveness of doxycycline (200 mg/day) with prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid |
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| Ongoing | 4 | 210 | Europe | prednisolone, doxycycline, | University of Nottingham, Universitätsklinikum Schleswig-Holstein | BP is a serious condition with a significant associated morbidity and mortality rate. Widespread tense and haemorrhagic blisters, skin erosions and severe itching cause patients a great deal of distress and pain. It occurs mainly in the elderly. The mortality rate in treated patients is estimated to range from 20% - 40% at one year. | | | | |
2012-003146-32: Does a longer course of antibiotics reduce the incidence of wound infections after amputation surgery? |
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| Ongoing | 4 | 164 | Europe | HYDREX®, PINK CHLORHEXIDINE GLUCONATE 0.5% W/V IN 70% V/V DEB, VIDENE ALCOHOLIC TINCTURE - Povidone-Iodine 10% w/w, Augmentin Intravenous, Augmentin 625mg tablets, Doxycycline, Metronidazole 400mg Tablets, Metronidazole injections, Teicoplanin, Flucloxacillin powder for solution for injection/infusion, Flucloxacillin 500mg capsules, Benzylpenicillin, Gentamicin, HYDREX®, PINK CHLORHEXIDINE GLUCONATE 0.5% W/V IN 70% V/V DEB, VIDENE ALCOHOLIC TINCTURE 10% W/W CUTANEOUS SOLUTION, Augmentin Intravenous, Augmentin 625mg Tablets, Doxycycline, Flagyl, Flagyl injection, Targocid, Flucloxacillin, Flucloxacillin / Flucloxin, Crystapen, Genticin® Injectable, HYDREX®, PINK CHLORHEXIDINE GLUCONATE 0.5% W/V IN 70% V/V DEB, VIDENE ALCOHOLIC TINCTURE 10% W/W CUTANEOUS SOLUTION, Augmentin Intravenous, Augmentin 625mg Tablets, Doxycycline, Flagyl, Flagyl injection, Targocid, Flucloxacillin, Flucloxacillin / Flucloxin, Crystapen, Genticin® Injectable | Hull and East Yorkshire Hospital Trust | Incidence of Surgical Site infection following major lower limb amputation surgery | | | | |
2013-003378-28: The interaction of antibiotics, gut flora and viruses in healthy volunteers. |
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| Ongoing | 4 | 10 | Europe | Azithromycin \"Teva\", Azithromycin \"Teva\", Cefuroxim \"Actavis\", Cifin, Doxycycline \"2care4\", Azithromycin \"Teva\", Cefuroxim \"Actavis\", Cifin, Doxycycline \"2care4\" | Department of Medicine, Køge University Hospital, EU | Resistance to anitbiotics | | | | |
2014-002970-36: Oxygen deficiency of the human bowel Zuurstofgebrek van de darm in de mens |
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| Ongoing | 4 | 42 | Europe | Tranexmic acid, Doxycycline, TA, doxy, Gastroenteral solution, Cyklokapron, Doxycycline | Maastricht University Medical Center, MLDS | The participants enrolled in this study will all undergo major upper abdominal surgery (i.e. mostly Pylorus Preserving Pancreatico Duodenectomy or whipple procedure) mostly for pancreatic cancer, papillary carcinoma or pancreatitis. However, the indication for which the IMP is administered is intestinal ischemia and reperfusion. De deelnemers aan de studie ondergaan allen grote abdominale chirurgie (veelal Pylorus Preserving Pancreatico Duodenectomie of whipple procedure) meestal in het kader van pancreas of papilcarcinoom dan wel pancreatitis. Echter, de indicatie waarvoor het IMP wordt toegediend is darm ischemie en reperfusie., Oxygen deficiency of the human bowel Zuurstofgebrek van de darm oftewel het darminfarct, Diseases [C] - Digestive System Diseases [C06] | | | | |
ChiCTR-IPR-17012224: A multicenter, randomized, double-blind, double-mock test for the efficacy and safety of hydroxychloroquine in the treatment of rosacea |
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| Recruiting | 4 | 100 | | Hydroxychloroquine ;Doxycycline | Central South University Xiangya Hospital; Central South University Xiangya Hospital, Central South University Xiangya Hospital | Rosacea | | | | |
ACTRN12617000127303: Pilot trial evaluating the efficacy of different antibiotic treatments for the treatment of prosthetic joint infection in adults who have undergone joint replacement surgery.
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| Completed | 4 | 60 | | | John Hunter Hospital , John Hunter Hospital | Prosthetic joint infection | | | | |
ChiCTR1900024825: A multicenter, randomized, double-blinded, controlled trial for comparing the efficacy and safety of intravenous Sulbactam plus Ceftazidime with cefoperazone-sulbactam (2:1) among the HABP/VABP patients with infections due to carbapenem-resistant Acinetobacter baumannii |
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| Recruiting | 4 | 60 | | Sulbactam in combination with Ceftazidime and doxycycline Infected patients who meet the inclusion criteria will receive 4.0g ceftazidime plus 8.0g sulbactam per day by intravenous infusion together and followed by doxycycline 0.2g per day for 7 to 14 days. Intervention: Drug: Sulbactam Drug: ceftazidime D ;Cefoperazone-sulbactam (2:1) in combination with doxycycline Infected patients who meet the inclusion criteria will receive Sulperazon (cefoperazone-sulbactam, 2 vs 1) 12.0g per day by intravenous infusion and followed by doxycycline 0.2g per day for 7 to 14 days. Intervention: Drug: cefoperazone-Sulba | Yongchuan Hospital of Chongqing medical University; Xinchuangyi Pharmaceutical and Clinical Research CO.LTD, Xiangbei Welman pharmaceutical Co., Ltd. | Hospital acquired bacterial pneumonia (HABP) Ventilator-associated bacterial pneumonia (VABP) | | | | |
| Recruiting | 4 | 200 | RoW | Doxycycline Tablets, Doxycycline, Rivaroxaban 15Mg Tab, Hydroxychloroquine and Azithromycin | Yaounde Central Hospital | COVID-19 | 05/21 | 09/21 | | |
NCT04035070: Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria |
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| Not yet recruiting | 4 | 51 | RoW | co-amoxiclav-clindamycin solution, MTAD, BioPure MTAD, 2.5% sodium hypochlorite | Cairo University | Necrotic Pulp | 06/21 | 06/21 | | |
ChiCTR1900027896: CD38 and CD138 in the diagnosis and treatment of intrauterine adhesions |
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| Not yet recruiting | 4 | 180 | | Doxycycline therapy ;observation ;Doxycycline therapy | Chongqing Health Center for Women and Children; Chongqing Health Center for Women and Children, Chongqing health commission and Chongqing bureau of science and technology | intrauterine adhesions | | | | |
COVIVER-OUT PLUS, NCT04729140: An Outpatient Clinical Trial Using Ivermectin and Doxycycline in COVID-19 Positive Patients at High Risk to Prevent COVID-19 Related Hospitalization |
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| Recruiting | 4 | 150 | US | Ivermectin Tablets, Doxycycline Tablets, Placebo | Max Health, Subsero Health | Covid19 | 12/21 | 03/22 | | |
ChiCTR2000040227: A randomised controlled trial of combination dydrogesterone and antibiotic or antibiotic alone for therapy in women with chronic endometritis |
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| Recruiting | 4 | 206 | | Women were given dysdrogesterone and antibiotic, oral dysdrogesterone 20mg daily from the 15th day of menstruation for a total of 10 days, combined with oral doxycycline 200 mg daily for 14 days. Antibiotic was given once CE was diagnosed by CD138 positive. ;Oral doxycycline 200 mg daily for 14 days. Antibiotic was given once CE was diagnosed by CD138 positive. | Affiliated Hospital of North Sichuan Medical College; Affiliated Hospital of North Sichuan Medical College, Science ＆ Technology Department of of Sichuan Province Key Research Project, 2018SZ0264 | Chronic endometritis | | | | |
| Recruiting | 4 | 500 | RoW | Naïve patients - ACO therapy, Naïve patients - LNDL therapy, Naïve patients - MNDL therapy, Treatment-experienced patients- LNDL therapy, Treatment-experienced patients- MNDL therapy | National Liver Institute, Egypt, Future pharmaceutical industries | Helicobacter Pylori | 02/22 | 03/22 | | |
NCT05040334: Role of Prophylactic Antibiotics in Preventing Pelvic Infection After Surgical Evacuation |
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| Recruiting | 4 | 138 | RoW | Group 1: Antibiotic receiving group, Group 2 :placebo receiving group | Cairo University | Antibiotics Causing Adverse Effects in Therapeutic Use | 04/22 | 05/22 | | |
NCT06090565: Cefixime Plus Doxycycline Compared to Ceftriaxone Plus Azithromycin for Treatment of Gonorrhoea |
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| Completed | 4 | 161 | RoW | Cefixime, Cefixime (ATC code J01DD08), Doxycyclin, Doxyhexal (ATC code J01AA02), Ceftriaxon, Ceftriaxone (ATC code J01DD04), Azithromycin, Sumamed (ATC code J01FA10) | Bulovka Hospital, Örebro University, Sweden | Gonorrhea | 06/22 | 12/22 | | |
dPEP-KE, NCT04050540: Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP |
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| Active, not recruiting | 4 | 449 | RoW | Doxycycline | University of Washington, Kenya Medical Research Institute, Kenya National AIDS & STI Control Programme, University of California, San Francisco, National Institute of Allergy and Infectious Diseases (NIAID) | HIV Infections, HIV/AIDS, Neisseria Gonorrheae Infection, Chlamydia Trachomatis Infection, Syphilis Infection | 10/22 | 06/24 | | |
NCT04864717: Doxycycline vs Isotretinoin for Acneiform Eruptions of TKI |
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| Recruiting | 4 | 98 | Canada | Doxycycline 100mg po once daily x 6 months, Isotretinoin 40 mg po once daily x 6 months | Lady Davis Institute | Acneiform Eruptions, Cancer, Treatment-Related | 12/22 | 12/22 | | |
NCT05018923: Tetracycline Versus Doxycycline for HP Rescue Therapy |
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| Recruiting | 4 | 242 | RoW | Rabeprazole, Bismuth potassium citrate, Metronidazole, Doxycycline, Tetracycline | Shanghai Zhongshan Hospital | Helicobacter Pylori Infection | 12/22 | 12/22 | | |
ChiCTR2000037071: Multi-center clinical study of refractory syphilis for standardized diagnosis and treatment |
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| Not yet recruiting | 4 | 538 | | Treat with Penicillin ;Treat with Doxycycline ;Treat with Ceftriaxone | Shanghai Skin Disease Hospital; Shanghai Skin Disease Hospital, Three-year project of Shenkang | Syphilis | | | | |
ChiCTR2300072790: Clinical study of antibiotics combined with antioxidants in the treatment of infertility patients with chronic endometritis after repeated transplantation failure |
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| Completed | 4 | 100 | | doxycycline 100 mg Bid + metronidazole 400 mg Bid + cefdinir 100 mg tid for 14 days ;doxycycline 100 mg Bid + metronidazole 400 mg Bid + cefdinir 100 mg tid + vitamin E 500 mg Bid + vitamin C 500 mg Bid for 14 days | People's Hospital of Guangxi Zhuang Autonomous Region; People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Zhuang Autonomous Region Health and Family Planning Commission | Reproductive endocrine | | | | |
NCT03980223: Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men |
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| Active, not recruiting | 4 | 637 | US | Doxycycline Hyclate Delayed-Release 200 mg | University of California, San Francisco, University of Washington, National Institute of Allergy and Infectious Diseases (NIAID), Mayne Pharma International Pty Ltd, San Francisco Department of Public Health | Gonorrhea, Chlamydia, Syphilis | 05/23 | 05/23 | | |
NCT06050824: A Comparative Study Between Concomitant Versus Load Therapy in Eradication of Helicobacter Pylori Infection |
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| Completed | 4 | 200 | RoW | Comparing Load and Concomitant therapy, Clarithromycin - pantoprazole - Metronidazole - Amoxycyllin | Helwan University | H. Pylori Infection | 07/23 | 07/23 | | |
NCT05448937: Lesion Sterilization And Tissue Repair Versus Zinc Oxide And Eugenol For Treatment of Necrotic Primary Molars |
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| Not yet recruiting | 4 | 60 | NA | Lesion sterilization and tissue repair, zinc oxide and eugenol pulpectomy | Cairo University | Necrotic Primary Molars | 08/23 | 09/23 | | |
| Recruiting | 4 | 80 | Europe | Azithromycin, Doxycycline | Medical University of Vienna | Dry Eye Syndromes, Meibomian Gland Dysfunction | 08/23 | 08/23 | | |
| Recruiting | 4 | 50 | US | Doxycycline 40 MG ( 20mg twice daily), Doxycycline 200 MG ( 100 mg twice daily), Placebo | University of California, San Francisco | Ocular Rosacea, Antimicrobial Resistance | 10/25 | 12/25 | | |
| Recruiting | 4 | 80 | RoW | Doxycycline, Tinadizole, Esomeprazole, levofloxacine, Levofloxacin 500mg, Amoxicilline, Esomeprazol | Damascus Hospital | Helicobacter Pylori Infection | 12/23 | 05/24 | | |
CCCA, NCT04207931: Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (): a Multicenter Prospective Study |
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| Recruiting | 4 | 250 | US | Topical steroid class I-II, Clobetasol, Betamethasone Dipropionate, or Fluocinonide, Triamcinolone Acetonide, Kenaolog, Doxycyline, Doxy-100, Targadox, Oracea, Minoxidil, Rogaine | Wake Forest University Health Sciences, The Skin of Color Society | Central Centrifugal Cicatricial Alopecia (CCCA) | 09/24 | 12/24 | | |
| Enrolling by invitation | 4 | 135 | US | Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, metronidazole, moxifloxacin, rifampin, trimethoprim-sulfamethoxazole, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem, meropenem, oritavancin, oxacillin, penicillin, piperacillin-tazobactam, tigecycline, vancomycin | West Virginia University | Endovascular Infection, Bone and Joint Infection, Skin and Soft Tissue Infection, Pulmonary Infection, Gastrointestinal Infection, Genitourinary Infection | 08/24 | 08/24 | | |
NCT06188442: Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM |
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| Not yet recruiting | 4 | 300 | RoW | DoxyODPrEP, doxycycline on demand PrEP, DoxyPEP, doxycycline PEP | Chinese University of Hong Kong | Sexually Transmitted Diseases, Bacterial, Syphilis, Gonorrhea, Chlamydia | 10/26 | 03/27 | | |
NCT02864550: Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex With Men (DaDHS) |
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| Active, not recruiting | 4 | 52 | Canada | Doxycycline, Placebo | British Columbia Centre for Disease Control | Syphilis, Sexually Transmitted Infections | 05/24 | 12/24 | | |
ChiCTR2200059531: Transcriptome changes of rosacea patients before and after doxycycline by single-cell sequencing |
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| Not yet recruiting | 4 | 12 | | Doxycycline ;None | The Second Affiliated Hospital of Xi'an Jiaotong University; The Second Affiliated Hospital of Xi'an Jiaotong University, National Natural Science Foundation of China | Rocasea | | | | |
NCT06422221: An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures |
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| Not yet recruiting | 4 | 150 | Europe | Clindamycin, Doxycycline | University of Santiago de Compostela, Hospital Clinico Universitario de Santiago | Bacteremia, Endocarditis | 01/25 | 06/25 | | |
NCT06468462: Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSM |
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| Not yet recruiting | 4 | 2900 | NA | WHO-recommended periodic presumptive treatment, WHO PPT, Doxycycline post-exposure prophylaxis, doxyPEP | University of Washington, Aurum Institute, Nyanza Reproductive Health Society, Partners for Health and Development in Africa, National Institute of Allergy and Infectious Diseases (NIAID) | Gonorrhea Male, Chlamydia (Male), Syphilis Male | 01/28 | 07/28 | | |
| Recruiting | 4 | 40 | US | Doxycycline, DOX | Emory University, Centers for Disease Control and Prevention | Sexually Transmitted Diseases | 09/24 | 09/24 | | |
ChiCTR2300075084: A prospective, randomized controlled study comparing vonoprazan-based triple therapy with amoxicillin and doxycycline as first-line treatment for Helicobacter pylori infection. |
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| Recruiting | 4 | 180 | | Bismuth-Containing Quadruple Therapy ;triple therapy | The First Affiliated Hospital, Ningbo University; The First Affiliated Hospital, Ningbo University, Investigator Initiated Trial Foundation of the First Affiliated Hospital, Ningbo University | Helicobacter pylori infection | | | | |
| Recruiting | 4 | 177 | RoW | Doxycycline 7 days, Doxycycline 3 days, Azithromycin 3 days | University of Oxford, Shoklo Malaria Research Unit, Chiangrai Prachanukroh Hospital | Scrub Typhus | 10/24 | 10/24 | | |
ChiCTR2200066299: Comparison of the effect of two antibiotic treatment regimens on the cure rate of chronic endometritis: a prospective randomized controlled trial |
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| Recruiting | 4 | 182 | | oral doxycycline 200 mg daily for 14 days ;Oral levofloxacin 500 mg and tinidazole 1000 mg daily for 14 days | Affiliated Hospital of North Sichuan Medical College; Affiliated Hospital of North Sichuan Medical College, None | Chronic endometritis | | | | |
NCT05874570: Doxycycline for Helicobacter Pylori Rescue Treatment |
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| Recruiting | 4 | 368 | RoW | Esomeprazole, Bismuth Potassium Citrate, Tetracycline, Doxycycline, Metronidazole | Shanghai Jiao Tong University School of Medicine | Helicobacter Pylori Infection | 12/24 | 12/24 | | |
| Active, not recruiting | 4 | 240 | US | PrEP discontinuation intervention, Offering of on-demand oral PrEP, emtricitabine/tenofovir disoproxil, Truvada, Offering of STI PEP, doxycycline, Injectable PrEP, Apretude, Cabotegravir | Emory University, National Institute of Mental Health (NIMH) | HIV, STI | 02/25 | 02/25 | | |
NCT05980871: Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline |
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| Recruiting | 4 | 300 | RoW | Doxycycline, Ceftriaxone, benzathine penicillin G | National Taiwan University Hospital | Early Syphilis | 03/25 | 03/25 | | |
NCT04297592: Antibiotic Prophylaxis in High-Risk Arthroplasty Patients |
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| Enrolling by invitation | 4 | 4618 | US | Cephalexin, Keflex, Doxycycline, Cefadroxil, Duricef | Mayo Clinic | Infections Joint Prosthetic, Overweight or Obesity, MSSA Colonization, MRSA, Chronic Kidney Diseases, Diabetes, Autoimmune Diseases, Inflammatory Disease, Tobacco Use | 06/26 | 06/26 | | |
ChiCTR2300072703: A prospective, randomized, controlled, open-label clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus doxycycline plus rifampicin in Chinese adults with uncomplicated brucellosis |
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| Recruiting | 4 | 194 | | oral sitafloxacin (100mg daily, for 6weeks) ;doxycycline (100 mg po b.i.d.) plus rifampin (10 mg /kg q.d.) for 6 weeks | Qilu Hospital, Shandong University; Qilu Hospital, Shandong University, Self-financing | brucellosis | | | | |
NCT04582383: Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne |
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| Recruiting | 4 | 400 | US | Spironolactone, Doxycycline Hyclate | University of Pennsylvania | Acne | 07/25 | 07/26 | | |
LEPTO3, NCT04211649: Comparing Two Antibiotic Therapy Periods (3 Versus 7 Days) in Patients With Mild Leptospirosis and Seen at the Hospital in 5 French Overseas Departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte) |
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| Recruiting | 4 | 220 | RoW | 3 days of antibiotherapy | University Hospital Center of Martinique, University Hospital of Guadeloupe, Centre Hospitalier de Cayenne, Centre Hospitalier Universitaire de la Réunion, Hôpital de Mayotte | Mild Leptospirosis | 07/25 | 08/25 | | |
NCT05840159: A Study of Doxycycline to Treat Chlamydial Infection |
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| Recruiting | 4 | 664 | US, RoW | Doxycycline, Placebo | National Institute of Allergy and Infectious Diseases (NIAID), Infectious Diseases Clinical Research Consortium | Chlamydial Infection | 12/25 | 12/25 | | |
| Recruiting | 4 | 4447 | RoW | Rabeprazole, Bismuth potassium citrate, Metronidazole, Clarithromycin, Levofloxacin, Amoxicillin, Doxycycline, Tetracycline | Shanghai Zhongshan Hospital | Helicobacter Pylori Infection | 06/26 | 06/26 | | |
ChiCTR2300073060: Clinical efficacy and safety of doxycycline combined with probiotics in the treatment of rosacea: a multicenter, randomized, controlled, double-blind clinical trial |
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| Not yet recruiting | 4 | 240 | | Oral Doxycycline 0.05 g Qd for 8 weeks and probiotics A 2 packs Qd for 16 weeks. ;Oral Doxycycline 0.05 g Qd for 8 weeks and probiotics B 2 packs Qd for 16 weeks. ;Oral Doxycycline 0.05 g Qd for 8 weeks and probiotics mimetic 2 packs Qd for 16 weeks. | Xiangya Hospital Central South University; Xiangya Hospital Central South University, self-financing | Rosacea | | | | |
ChiCTR2200061961: A randomized, double-blind, placebo-controlled clinical study to assess the efficacy of oral doxycycline for recurrence prevention after hysteroscopic resection of multiple endometrial polyps in the reproductive age group |
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| Not yet recruiting | 4 | 76 | | Doxycycline ;Placebo | Tianjin Medical University General Hospital; Tianjin Medical University General Hospital, Clinical Medicine Research Program, Tianjin Medical University General Hospital | endometrial polyp | | | | |
NCT04762134: Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO) |
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| Recruiting | 4 | 560 | Canada | Doxycycline Hyclate | Jonathan Troy Grennan, Canadian Institutes of Health Research (CIHR) | Bacterial Sexually Transmitted Diseases | 12/26 | 06/27 | | |
ChiCTR1900028700: Study for registration of exposure of doxycycline at early pregnancy and safety of maternity and offspring |
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| Recruiting | 4 | 1000 | | NA | Women's Hospital, School of Medicine Zhejiang University; Women's Hospital, School of Medicine Zhejiang University, Self-financing | pregnancy | | | | |
ACTRN12619000073101: Comparison of Efficacy of Oral Azithromycin Versus Oral Doxycycline in the Treatment of Moderate Acne Vulgaris and Determination of the Effects of These Treatments on Patients' Quality of Life Among University Students. |
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| Recruiting | 3/4 | 200 | | | Sultan Qaboos University , Sultan Qaboos University | moderate acne | | | | |
2008-003951-54: Intraveneous induction theraphy followed by oral theraphy against exclusive oral theraphy: randomized trial for the treatment of Whipple's disease |
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| Not yet recruiting | 3 | 60 | Europe | Powder for solution for infusion, Tablet, Ceftriaxon, Trimethoprim, Sulfamethoxazol, Doxycyclin, Hydroxychloroquinsulfat | Charité University Medicine Berlin | ICD 10 K90.8 Sonstige intestinale Malabsorption - Whipple disease | | | | |
2010-022233-28: Fatal familial insomnia: preventive treatment with doxycycline of at risk individuals Insonnia Fatale Familiare: trattamento preventivo con doxiciclina in soggetti a rischio |
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| Ongoing | 3 | 30 | Europe | Tablet, BASSADO | IST. DI RICERCHE FARMACOLOG. M. NEGRI, Telethon | Subjects born between 1958 and 1969 belonging to the Treviso FFI family, tested previously for Prion D178N/129M mutation Soggetti nati dal 1958 al 1969 appartenenti alla Famiglia FFI di Treviso preventivamente testati geneticamente per la mutazione Prion D178N/129M., Diseases [C] - Nervous System Diseases [C10] | | | | |
2007-005553-34: Efficacité et tolérance de la doxycycline dans le traitement des maladies humaines à prions : un essai randomisé en double aveugle versus placebo |
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| Ongoing | 3 | 188 | Europe | Doxycycline, Doxycycline, Doxycycline | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP) | Maladies humaines à Prions (ESST) | | | | |
2010-021150-19: Doxycycline versus minocycline in the treatment of rosacea: a randomised controlled trial. |
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| Ongoing | 3 | 80 | Europe | doxycycline (Efracea), minocycline, Efracea, capsules met gereguleerde afgifte, hard 40 mg, Minocycline 100 PCH, omhulde tabletten 100 mg, Efracea, capsules met gereguleerde afgifte, hard 40 mg, Minocycline 100 PCH, omhulde tabletten 100 mg | Academical medical Center, Department of dermatology | Patients with moderate to severe, papulopustular rosacea. | | | | |
2012-002199-15: The effect of long term antibiotic therapy on exacerbation (flare-up) frequency in patients with Stable Chronic Obstructive Pulmonary Disease (COPD). |
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| Ongoing | 3 | 222 | Europe | Doxycycline, Doxycycline 100, Doxycycline 100 | Imperial College London, National Institute for Health Research | COPD Chronic Obstructive Pulmonary Disease | | | | |
2016-001830-91: A NON RANDOMISED, NON BLINDED REAL WORLD STUDY OF THE SAFETY, TOLERABILITY AND EFFECTIVENESS OF METABOLIC MEDICINES FOR THE TREATMENT OF CANCER COMPARED AGAINST HISTORICAL CONTROLS |
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| Not yet recruiting | 3 | 207 | Europe | Metformin, Atorvastatin, Doxycycline, Mebendazole, Modified-release tablet, Tablet, Capsule, hard, Metformin, Atorvastatin, Doxycycline, Mebendazole | Health Clinics Limited | Cancer, Cancer, Diseases [C] - Cancer [C04] | | | | |
2017-001392-22: Randomized double-blind study on the benefit of spironolactone for treating acne of adult woman Etude randomisée en double-aveugle sur l'intérêt de la spironolactone dans le traitement de l'acné de la femme adulte |
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| Not yet recruiting | 3 | 200 | Europe | spironolactone, Doxycycline, SPIRONOLACTONE, Capsule, Tablet, Spironolactone Arrow 75mg, Doxycycline Sandoz 100mg | CHU de Nantes, Ministère de la santé - DGOS | Acne vulgaris of adult woman Acné vulgaris de la femme adulte, Acne vulgaris of adult woman Acné vulgaris de la femme adulte, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2017-001621-41: Treatment with doxycycline and tauroursodeoxycholic acid (Doxy/TUDCA) plus standard supportive therapy in cardiac amyloidosis caused by transthyretin Trattamento con con doxiciclina e acido taurodesossicolico (Doxy-TUDCA) in aggiunta alla terapia standard in pazienti affetti da amiloidosi cardiaca da transtiretina |
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| Not yet recruiting | 3 | 102 | Europe | Doxiciclina, Acido tauroursodesossicolico, [NA], Tablet, Capsule, hard, BASSADO - 100 MG COMPRESSE 10 COMPRESSE, TAURO - 250 MG CAPSULE RIGIDE 20 CAPSULE | FONDAZIONE I.R.C.C.S. POLICLINICO SAN MATTEO, Società Italiana per L'Amiloidosi ONLUS | Cardiac amyloidosis caused by transthyretin Amiloidosi cardiaca da transtiretina, Cardiac amyloidosis caused by transthyretin Amiloidosi cardiaca causata da transtiretina, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2020-002029-28: Doxycycline Versus Placebo in COVID-19 + Patients without hospitalization criteria:Prospective, multicenter, randomized, double-blind, prospective study. |
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| Not yet recruiting | 3 | 330 | Europe | Granudoxy, Tablet, Granudoxy 100mg | CHU Nantes, Pierre Fabre, CHU de Nantes, Laboratoire Bailleul, Nantes métropole, Fondation grand Ouest Banque populaire | COVID-19 disease, Patients COVID-19 + without hospitalization criteria, Diseases [C] - Virus Diseases [C02] | | | | |
NCT04636125: Prospective Evaluation of Oral Antibiotics for Treatment of Shoulder PJI |
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| Enrolling by invitation | 3 | 100 | US | Doxycycline 100 MG Oral Tablet | Rothman Institute Orthopaedics | Periprosthetic Infection, Oral Antibiotics, Revision Total Shoulder Arthroplasty | 09/21 | 09/21 | | |
| Recruiting | 3 | 100 | RoW | Nitazoxanide, Alenia, nitclean, parazoxanide, Levofloxacin, Tavanic, levoxin, venaxan., Doxycyclin, Vibramycin, Doxymycin, Omeprazole, Omepak, Pepzole, Gasec, Risek. | Tanta University | Dyspepsia | 12/22 | 12/22 | | |
NCT03481972: A Study of Doxycycline and Tauroursodeoxycholic Acid (Doxy/TUDCA) Plus Standard Supportive Therapy Versus Standard Supportive Therapy Alone in Cardiac Amyloidosis Caused by Transthyretin |
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| Completed | 3 | 102 | Europe | Doxycycline and tauroursodeoxycholic acid, Standard of care therpay, Standard of care | IRCCS Policlinico S. Matteo | TTR Cardiac Amyloidosis | 01/23 | 06/23 | | |
| Enrolling by invitation | 3 | 308 | US | Bactrim, Cefadroxil, Doxycycline Hcl, Clindamycin | Rothman Institute Orthopaedics | Joint Infection | 01/23 | 01/23 | | |
NCT04649502: Metformin for the Treatment of Hidradenitis Suppurativa (HS) |
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| Completed | 3 | 62 | Europe | Metformin | K.R. van Straalen | Hidradenitis Suppurativa | 01/23 | 08/23 | | |
FASCE, NCT03334682: Randomized Double-blind Study on the Benefit of Spironolactone for Treating Acne of Adult Woman. |
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| Completed | 3 | 158 | Europe | spironolactone, Doxycycline | Nantes University Hospital | Acne Vulgaris | 02/23 | 07/23 | | |
DOXYVAC, NCT04597424: Combined Prevention of Sexually Transmitted Infections (STIs) in Men Who Have Sex With Men and Using Oral Tenofovir Disoproxil Fumarate/ Emtricitabine (TDF/FTC) for HIV Pre-Exposure Prophylaxis (PrEP) |
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| Active, not recruiting | 3 | 556 | Europe | Experimental: doxycycline, Bexsero® vaccine | ANRS, Emerging Infectious Diseases | Unsafe Sex, Risk-Taking | 02/23 | 09/23 | | |
NCT03491995: A Unique Regimen for Treatment of Helicobacter Pylori Infection |
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| Recruiting | 3 | 600 | RoW | Quadruple therapy, Moxiflox, Downoprazol, Nanazoxid, Doxymycin, Classic treatment, Downoprazol, Emox, Klacid | Sherief Abd-Elsalam | Helicobacter Infections | 04/23 | 04/23 | | |
2022-004192-16: Study to evaluate the efficacy of autovaccines versus antibiotic treatment in hip or knee prosthesis infections. Estudio para evaluar la eficacia de las autovacunas frente a tratamiento antibiótico en infecciones de protésis de cadera o rodilla. |
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| Not yet recruiting | 3 | 20 | Europe | AUTOVACCUNA, amoxycillin, cotrimoxazole, doxycycline, metronidazole, ciprofloxacin, amoxicillin-clavulanic acid, linezolid, fluconazole, clindamycin, Sublingual spray, emulsion, Capsule, Tablet, AUTOVACUNA 300 FTU/mL, suspension for sublingual spraying, amoxycillin, cotrimoxazole, doxycycline, metronidazole, ciprofloxacin, amoxicillin-clavulanic acid, linezolid, fluconazole, clindamycin | idival, IDIVAL | Patients with chronic infections of hip and knee prostheses, without the possibility of curative treatment of the infection. Pacientes con infecciones crónicas de prótesis de cadera y rodilla, sin posibilidad de tratamiento curativo de la infección., Patients with hip or knee prosthesis infections. Pacientes con infecciones de prótesis de cadera o rodilla, Diseases [C] - Bacterial Infections and Mycoses [C01] | | | | |
NCT04128176: Efficacy and Safety of Rituximab Combined With Omalizumab in Patients With Bullous Pemphigoid |
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| Not yet recruiting | 3 | 15 | US | Rituximab combined with Omalizumab, Xolair | University of California, Davis | Bullous Pemphigoid | 05/23 | 11/23 | | |
| Completed | 3 | 232 | RoW | Vonoprazan, Clarithromycin, Amoxycillin, Esomeprazole, Levofloxacin, Doxycicline, Nitazoxanide | Ain Shams University | Helicobacter Pylori Eradication | 06/23 | 06/23 | | |
MVOR-1, NCT05296629: A Randomized, Double-Blind Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea. |
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| Completed | 3 | 323 | US | DFD-29, Doxycycline, Placebo | Journey Medical Corporation, Dr. Reddy's Laboratories Limited | Papulopustular Rosacea | 06/23 | 06/23 | | |
MVOR-2, NCT05343455: A Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea |
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| Completed | 3 | 330 | Europe, US | DFD-29, Doxycycline, Placebo | Journey Medical Corporation, Dr. Reddy's Laboratories Limited | Papulopustular Rosacea | 06/23 | 06/23 | | |
| Recruiting | 3 | 200 | Europe | BPG, Doxycycline | Assistance Publique - Hôpitaux de Paris | Syphilis | 12/23 | 12/23 | | |
NCT05708625: Intralesional Voriconazole, or Intralesional Cryotherapy, or Oral Doxycycline in the Treatment of Cutaneous Leishmaniasis |
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| Recruiting | 3 | 136 | RoW | Intralesional Sodium stibogluconate, SSG, Intralesional Cryotherapy, Intralesional Voriconazole, Vfend, Oral doxycycline | Zagazig University | Leishmaniasis, Cutaneous | 12/23 | 03/24 | | |
NCT05157412: Role of Doxycycline in Chronic Rhinosinusitis With Nasal Polyps |
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| Not yet recruiting | 3 | 60 | NA | Doxycycline 100 mg Oral Tablet, doxycycline, Prednisolone 20 mg, prednisolone | Assiut University | Nasal Polyps, Chronic Rhinosinusitis With Nasal Polyps | 01/24 | 03/24 | | |
| Recruiting | 3 | 624 | Europe, US, RoW | D-PLEX, Standard of Care (SoC) | PolyPid Ltd. | Surgical Site Infection, Colon Surgery, Abdominal Surgery, Post-Op Infection | 07/24 | 09/24 | | |
| Recruiting | 3 | 72 | US | Precision Medicine Approach, ReCODE, Hormones and Medications tailored to lab tests, combined with devices that support stress management and brain exercises, Standard-of-Care, Academy of Neurology practice guidelines, Lifestyle including diet, exercise, stress management | Alzheimer's Prevention and Reversal Project, Inc., Four Winds Foundation | Mild Cognitive Impairment, Dementia, Mild | 03/25 | 09/25 | | |
ETHNIC, NCT06447480: Randomized Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients |
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| Not yet recruiting | 3 | 420 | Europe | ISOtretinoin 5 MG, Topical cream | Centre Hospitalier Universitaire de Nice | Acne Vulgaris | 09/26 | 09/27 | | |
CHRONOS-2, NCT05074147: Comparison Between Two Durations of Antibiotherapy for Non-surgically-treated Diabetic Foot Osteomyelitis |
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| Not yet recruiting | 3 | 280 | Europe | Reduction in the duration of antibiotic therapy 3 weeks or 6 weeks | Tourcoing Hospital | Osteomyelitis - Foot | 11/24 | 11/26 | | |
Rocky-Z, NCT05398055: Efficacy of Azithromycin Plus Doxycycline Versus Doxycycline Plus Placebo in Patients With Rocky Mountain Spotted Fever |
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| Recruiting | 3 | 86 | RoW | Azithromycin + Doxycycline, A, Placebo + Doxycycline, B | Hospital General de Mexicali | Rocky Mountain Spotted Fever | 12/25 | 12/25 | | |
Doxy-TB, NCT05473520: Doxycycline Host-directed Therapy to Improve Lung Function and Decrease Tissue Destruction in Pulmonary Tuberculosis |
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| Recruiting | 3 | 150 | RoW | Doxycycline, Placebo | National University Hospital, Singapore, Tan Tock Seng Hospital, Hospital Queen Elizabeth, Malaysia, National University of Singapore | Tuberculosis | 04/26 | 01/27 | | |
ACTRN12622000359730p: Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Immunoglobulin Stopping or Extension (RATIONALISE) |
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| Not yet recruiting | 2/3 | 300 | | | Monash University, National Health and Medical Research Council | haematological malignancy; hypogammaglobulinemia | | | | |
ACTRN12622000359730: Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Immunoglobulin Stopping or Extension (RATIONALISE) |
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| Recruiting | 2/3 | 300 | | | Monash University, National Health and Medical Research Council | haematological malignancy, hypogammaglobulinemia | | | | |
NCT03474458 / 2017-002210-31: A Trial of Doxycycline vs. Standard Supportive Therapy in Newly-diagnosed Cardiac AL Amyloidosis Patients Undergoing Bortezomib-based Therapy |
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| Terminated | 2/3 | 19 | Europe, Canada, RoW | Doxycycline, Standard of care therapy | IRCCS Policlinico S. Matteo | Cardiac AL Amyloidosis | 05/22 | 05/22 | | |
NCT05897034: Combination Therapy Between Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active Men |
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| Not yet recruiting | 2/3 | 100 | NA | Doxycyclin, Pentoxifylline, Nitazoxanide 500Mg Oral Tablet | Tanta University, Marwa Ahmed El-Samongy | Sexually Transmitted Diseases | 06/24 | 06/28 | | |
| Recruiting | 2/3 | 300 | Europe, Canada, RoW | Amikacin, Tigecycline, Imipenem, Cefoxitin, Azithromycin, Clarithromycin, Clofazimine, Ethambutol, Linezolid, co-trimoxazole, Doxycycline, Moxifloxacin, Bedaquiline, Rifabutin | The University of Queensland, Australian Government Department of Health and Ageing, Children's Hospital Foundation, Cystic Fibrosis Foundation, Newcastle University, Griffith University, Erasmus Medical Center, Monash University, University of Copenhagen, Hôpital Cochin, South Australian Health and Medical Research Institute, University of Melbourne, James Cook University, Queensland, Australia, Murdoch Childrens Research Institute | Pulmonary Disease Due to Mycobacteria (Diagnosis) | 06/24 | 08/24 | | |
| Not yet recruiting | 2/3 | 72 | RoW | Doxycyclin, vibramycin, Azithromycin, Zithromax | Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Mahidol Oxford Tropical Medicine Research Unit | Infectious Disease, Therapeutics | 08/25 | 08/26 | | |
RATIONALISE, NCT05678621: Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Immunoglobulin Stopping or Extension |
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| Recruiting | 2/3 | 300 | RoW | trimethoprim-sulfamethoxazole (co-trimoxazole), amoxycillin/clavulanic acid and ciprofloxacin, Immunoglobulins | Monash University | Haematological Malignancy, Hypogammaglobulinemia | 04/27 | 04/27 | | |
| Not yet recruiting | 2 | 40 | | | Dr Natalie Briggs, Waikato Medical Research Foundation | Rectal Cancer | | | | |
ACTRN12623000843651: A Clinical Trial of Ambroxol and Doxycycline in Moderate Severity Parkinson’s Disease |
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| Not yet recruiting | 2 | 240 | | | University of Sydney, University of Sydney | Parkinson’s Disease | | | | |
ACTRN12608000325303: Doxycycline in Lymphanioleiomyomatosis (LAM): a randomised double blind placebo controlled crossover trial |
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| Recruiting | 2 | 30 | | | Dr.Deborah Yates, LAM Fighting Fund, St.Vincents Hospital, LAM Australia | Lymphangioleiomyomatosis | | | | |
ACTRN12623000004662: A Phase II pilot study to determine protocol feasibility, and potential efficacy for disease modification of combined Doxycycline and Ambroxol in Dementia with Lewy Bodies |
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| Recruiting | 2 | 32 | | | University of Sydney, University of Sydney | Dementia with Lewy Bodies | | | | |