| pioglitazone / Generic mfg. |
NCT01799850: The Impact of Actos Treatment of Diabetes on Glucose Transporters in Muscle |
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| Completed | 4 | 12 | US | Pioglitazone, Actos or placebo, placebo, sugar pill | East Tennessee State University, Takeda Pharmaceuticals North America, Inc. | Diabetes Type 2 | 03/04 | 03/04 | | |
COMPLEMENT, NCT00672919: Pioglitazone Study of Triglyceride Changes in Subjects With Type 2 Diabetes After Conversion From Rosiglitazone. |
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| Completed | 4 | 305 | US | Pioglitazone, ACTOS®, AD-4833 | Takeda | Diabetes Mellitus | 08/04 | 08/04 | | |
NCT00384215: Insulin Glargine [rDNA Origin] Injection vs Pioglitazone as add-on Therapy in Patients Failing Monotherapy With Sulfonylurea or Metformin |
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| Completed | 4 | 352 | US | insulin glargine [rDNA origin] injection | Sanofi | Diabetes Mellitus, Type 2 | | 02/05 | | |
NCT00494312: Safety Study of Pioglitazone Compared To Glyburide on Liver Function |
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| Completed | 4 | 2120 | US | Pioglitazone, Actos, AD-4833, Glyburide | Takeda | Diabetes Mellitus, Liver | 06/05 | 06/05 | | |
NCT00816218: Molecular Mechanisms of Type 2 Diabetes Mellitus |
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| Completed | 4 | 39 | US | Pioglitazone, Actos | The University of Texas Health Science Center at San Antonio, Takeda | Type 2 Diabetes Mellitus | 07/06 | 11/08 | | |
NCT00754403: Efficacy of Pioglitazone and Fortamet Combination Therapy in Subjects With Type 2 Diabetes |
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| Completed | 4 | 312 | US | Pioglitazone and metformin, Actos, AD-4833XT, Fortamet, Metformin | Takeda | Diabetes Mellitus | 10/06 | 10/06 | | |
| Completed | 4 | 92 | Europe | pioglitazone, placebo | IKFE Institute for Clinical Research and Development, Takeda, Johannes Gutenberg University Mainz, Heidelberg University | Type 2 Diabetes Mellitus, Cardiovascular Disease | | 11/06 | | |
NCT00212290: Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes |
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| Completed | 4 | 140 | US | pioglitazone, nateglinide, placebo | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Insulin Resistance, Type 2 Diabetes Mellitus | | 12/06 | | |
| Completed | 4 | 60 | US | Actos plus standard diet, Actos plus structured diet, Metformin plus standard diet | Pennington Biomedical Research Center | Diabetes Mellitus | 12/06 | 12/06 | | |
NCT00314561: The Effect of Pioglitazone and Rosiglitazone on Atherosclerotic and Inflammatory Markers in Patients With Metabolic Syndrome |
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| Completed | 4 | 40 | RoW | Pioglitazone, Rosiglitazone | Korea University Anam Hospital | Metabolic Syndrome | | 12/06 | | |
NCT00571506: Effect of Thiazolidinedione Treatment Vascular Risk Markers |
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| Completed | 4 | 25 | US | Rosiglitazone, Avandia, Pioglitazone, Actos | University of Arkansas | Diabetes Mellitus, Type 2, Vascular Diseases | 08/07 | 08/07 | | |
NCT00402909: Safety and Efficacy of Nateglinide in Patients With Type 2 Diabetes Already Taking Insulin Glargine, Metformin and/or Pioglitazone or Rosiglitazone |
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| Completed | 4 | 28 | US | Nateglinide | Novartis Pharmaceuticals | Type 2 Diabetes | 08/07 | 08/07 | | |
NCT00402012: "TAKE TIME" Pioglitazone Reverses Defects in Mitochondrial Biogenesis in Patients With T2DM |
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| Completed | 4 | 24 | US | Pioglitazone, TZD | Pennington Biomedical Research Center, Takeda Pharmaceuticals North America, Inc. | Diabetes Mellitus, Type 2 | 12/07 | 12/07 | | |
NCT00926341: The Effects of Peroxisome Proliferators Activated Receptor-Gamma (PPAR-γ) Agonists on Certain Biochemical and Inflammatory Markers in Metabolic Syndrome |
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| Completed | 4 | 110 | RoW | Pioglitazone, Telmisartan | Aligarh Muslim University | Metabolic Syndrome | 06/08 | 09/08 | | |
NCT01432405: Effect Of Exenatide Treatment on Liver Fat Content in Patients With Diabetes |
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| Completed | 4 | 24 | US | Exenatide, Byetta, Pioglitazone, Actos | Baylor College of Medicine | Type 2 Diabetes Mellitus | 07/08 | 06/09 | | |
NCT00494559: The Effect of Pioglitazone on Neointima Volume and Inflammatory Markers |
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| Completed | 4 | 240 | RoW | Pioglitazone, Actos, Placebo | Korea University Anam Hospital | Diabetes Mellitus, Coronary Artery Stenosis | 07/08 | 07/15 | | |
NCT00579813: Mechanisms Underlying Metabolic Syndrome in Obesity |
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| Completed | 4 | 70 | US | Pioglitazone, Actos | Philip Kern, National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Metabolic Syndrome, Insulin Resistance, Prediabetes | 01/09 | 01/11 | | |
| Withdrawn | 4 | 120 | Europe | pioglitazone, simvastatin, pioglitazone + simvastatin | University of Leipzig, Institut für Gesundheits- und Praxismanagement GmbH | Glucose Metabolism Disorders | | 05/09 | | |
NCT00770367: Pioglitazone and Serum Asymmetric Dimethylarginine (ADMA) in Patients With Diabetes |
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| Completed | 4 | 36 | US | Pioglitazone then Placebo, Actos, Glustin, Zactos, Placebo then Pioglitazone | Medical University of South Carolina, Takeda Pharmaceuticals North America, Inc. | Diabetes | 12/09 | 06/10 | | |
T2DMCT, NCT01589445: Efficacy Study of Pioglitazone and Metformin and Association Between Pioglitazone Response and Peroxisome Proliferator-activated Receptor Gamma Gene Variants in Bangladeshi Type 2 Diabetes Mellitus Subjects |
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| Completed | 4 | 77 | RoW | Pioglitazone hydrochloride, GLUCOZON, 30 mg tablet, once, daily, Coded as B001(Preparation Date:Jun 08), Aristopharma LTD.,Bangladesh, Metformin hydrochloride, GLUCOMET, 850 mg tablet, once, daily, Coded as B002 (Preparation date: Jun 08) | University of Dhaka, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders, University of Dundee | Type 2 Diabetes Mellitus | 12/09 | 06/10 | | |
NCT00231894: Pioglitazone as a Treatment for Lipid and Glucose Abnormalities In Patients With Schizophrenia |
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| Completed | 4 | 56 | US | Pioglitazone, Actos, Life style diet group, Placebo | Nathan Kline Institute for Psychiatric Research | Diabetes, Schizophrenia, Insulin Resistance, Cognitive Impairment | 01/10 | 01/10 | | |
| Completed | 4 | 43 | US | Pioglitazone, ACTOS, Exenatide, BYETTA, Pioglitazone and Exenatide | The University of Texas Health Science Center at San Antonio | Type 2 Diabetes, Healthy, Impaired Glucose Tolerance | 07/10 | 07/10 | | |
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| Completed | 4 | 24 | US | Pioglitazone, Actos (brand name for pioglitazone), Placebo | University of Vermont, Takeda | Diabetes Mellitus, Type 2 | 11/10 | 11/10 | | |
NCT00879970: Thiazolidinedione Intervention With Vitamin D Evaluation |
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| Terminated | 4 | 1332 | US, Canada, Europe, RoW | pioglitazone, rosiglitazone, placebo, Vitamin D, Placebo | GlaxoSmithKline, Population Health Research Institute | Diabetes Mellitus, Type 2 | 11/10 | 11/10 | | |
NCT00545233: A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus COPEGUS (Ribavirin) With or Without Pioglitazone in Treatment-Naive Patients With Chronic Hepatitis C and Insulin Resistance. |
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| Completed | 4 | 155 | US | peginterferon alfa-2a [Pegasys], Pegasys, ribavirin [Copegus], Copegus, Pioglitazone, Actos | Hoffmann-La Roche | Hepatitis C, Chronic | 12/10 | 12/10 | | |
NCT00775164: Pioglitazone Therapy in Obese Children With Insulin Resistance: A Randomized, Controlled Pilot Study |
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| Withdrawn | 4 | 0 | US | pioglitazone, ACTOS, Metformin, Glucophage XR | University of Minnesota | Obesity, Insulin Resistance | 12/10 | 02/11 | | |
NCT00708175: Efficacy of Pioglitazone on Bone Metabolism in Postmenopausal Women With Impaired Fasting Glucose. |
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| Completed | 4 | 156 | US | Pioglitazone, ACTOS®, Placebo | Takeda | Bone Metabolism | 01/11 | 02/11 | | |
| Completed | 4 | 39 | Europe | Pioglitazone and Metformin, ACTOS®, AD-4833, Glibenclamide and Metformin, Diabeta, Glynase, Micronase, Daonil, Semi-Daonil, Euglucon | Takeda | Diabetes Mellitus | 05/11 | 05/11 | | |
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NCT01040819: Does Pioglitazone Increase the Production of 15-EPI-Lipoxin A4? |
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| Completed | 4 | 25 | US | Pioglitazone, Actos | Baylor College of Medicine | Type 2 Diabetes Mellitus | 10/11 | 12/11 | | |
NCT01588470: Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM) |
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| Completed | 4 | 130 | NA | pioglitazone, Actos | The University of Texas Health Science Center at San Antonio, Takeda Pharmaceuticals North America, Inc. | Type 2 Diabetes, Coronary Heart Disease | 12/11 | 12/11 | | |
NCT01472497: Effects of Pioglitazone in Hypertensive Patients |
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| Completed | 4 | 16 | Japan | Pioglitazone, actos | Tottori University Hospital | Hypertension, Insulin Resistance | 12/11 | 03/12 | | |
| Completed | 4 | 60 | US | Pioglitazone, ACTOS, Placebo | The University of Texas Health Science Center at San Antonio | Type 2 Diabetes | 12/11 | 12/11 | | |
NCT01882907: Safety and Efficacy Study to Compare Vildagliptin to Pioglitazone as Adding on Metformin in Type 2 Diabetes |
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| Completed | 4 | 287 | RoW | vildagliptin, Galvus, Pioglitazone, Actos | Pusan National University Hospital | Type 2 Diabetes | 03/13 | 03/13 | | |
NCT00835120: Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance |
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| Completed | 4 | 34 | US | Pioglitazone, Actos | University Hospitals Cleveland Medical Center, National Alliance for Research on Schizophrenia and Depression, Takeda Pharmaceuticals North America, Inc. | Metabolic Syndrome, Bipolar Depression, Insulin Resistance | 04/13 | 04/13 | | |
| Completed | 4 | 37 | US | Pioglitazone, Actos, Sugar Pill, Placebo | Stanford University, National Institutes of Health (NIH), National Institute of Mental Health (NIMH) | Major Depressive Disorder, Insulin Resistance | 01/14 | 06/14 | | |
| Completed | 4 | 176 | US | Pioglitazone study drug, Actos (brand name), manufactured by Takeda Pharmaceuticals., Placebo, Pioglitazone Open Label | University of Florida, The University of Texas at San Antonio | Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus | 12/14 | 12/14 | | |
NCT00815399: Pioglitazone Versus Metformin in Type 2 Diabetes |
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| Completed | 4 | 150 | Europe | Pioglitazone, Metformin | University of Campania "Luigi Vanvitelli" | Type 2 Diabetes | 03/15 | 04/15 | | |
NCT01947790: Pioglitazone Regress Left Ventricular Mass in Type 2 Diabetes With Ischeamia Heart Disease |
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| Completed | 4 | 120 | RoW | pioglitazone group, Metformin group | Xiang Guang-da | LVM, Type 2 Diabetic Patients With IHD, Endothelial Function | 07/15 | 07/15 | | |
NCT01717040: Pioglitazone for the Treatment of Bipolar Depression |
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| Terminated | 4 | 37 | US | Pioglitazone, Actos, Placebo, Sugar Pill | University Hospitals Cleveland Medical Center, The Depressive and Bipolar Disorder Alternative Treatment Foundation | Bipolar Disorder, Insulin Resistance | 03/16 | 03/16 | | |
NCT01972724: Efficacy of Pioglitazone in Participants With Inadequately Controlled Type 2 Diabetes Mellitus Treated With Stable Triple Oral Therapy |
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| Completed | 4 | 114 | RoW | Pioglitazone, ACTOS, Metformin, Sulfonylurea | Takeda | Type II Diabetes Mellitus | 10/16 | 10/16 | | |
NCT02365233: Fatty Liver Study in Patients With Type II Diabetes |
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| Terminated | 4 | 5 | US | DPP4 inhibitor, sitagliptin100 mg daily, saxagliptin 5 mg daily, Pioglitazone, Pioglitazone 15 mg daily, Lantus insulin, Lantus insulin (0.35U/kg of body weight once daily) | The University of Texas Medical Branch, Galveston | Type II Diabetes, Nonalcoholic Fatty Liver | 12/16 | 12/16 | | |
