| pioglitazone / Generic mfg. |
ACTRN12605000174684: Anti-inflammatory effects of pioglitazone in acute stroke - a double-blind placebo controlled trial |
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| Not yet recruiting | 4 | 45 | | | Dr R W Simpson | Acute stroke | | | | |
ACTRN12611000351910: The effect of Pioglitazone on Cardiovascular and Psychiatric status of non-Diabetic Metabolic Syndrome Patients |
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| Active, not recruiting | 4 | 140 | | | Osvah Pharmaceutical Company, Isfahan Cardiovascular Research Center | Metabolic Syndrome, Mental health screening indicators | | | | |
ChiCTR-TRC-08000111: A multicenter study of effects of early prevention on adult metabolic syndrome in Beijing region |
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| Recruiting | 4 | 600 | | Intervention on life habit + pioglitazone ;Intervention on life habit + dimethyldiguanide ;Intervention on life habit + placebo: 100 with dimethyldiguanide placebo tablet and 100 with pioglitazone placebo tablet | China-Japan Friendship Hospital; Beijing Municipal Health Bureau., Capital Medical Developmental Fund | Metablic Syndrome | | | | |
ChiCTR-TRC-08000099: Multicenter Research of Early Intervention for Adult Metabolic Syndrome in Beijing Region |
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| Completed | 4 | 600 | | Life style intervention + Metformin ;Life style intervention + placebo: Metformin placebo tablets are given in 100 patients, and Pioglitazone placebo tablets are given in another 100 patients ;Life style intervention + placebo | China-Japan Friendship Hospital of Ministry of Health of the People's Republic of China; Beijing Municipal Bureau of Public Health. B Zhonghuan Square, # 70, Zaolinqian Street, Xuanwu District, Beijing, Capital medical development fundation | Metabolic syndrome | | | | |
ChiCTR-TRC-10000879: Comparison of glycaemic control and beta-cell function among newly diagnosed type 2 diabetic patients treated with exenatide, insulin or rosiglitazone: a multicentre randomized parallel-group trial |
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| Completed | 4 | 414 | | Exenatide injection (Byetta) ;Premixed insulin analog (Humalog Mix 25) ;Pioglitazone (Ruitong) | The Third Affiliated Hospital of Sun Yat-Sen University; Peking University People's Hospital, Eli Lilly, 5010 Program of Sun Yat-Sen University, Ministry of Health | Type 2 diabetes | | | | |
| Completed | 4 | 2000 | | Intensive lifestyle intervention plus placebo ;Conventional lifestyle intervention plus pioglitazone ;Intensive lifestyle intervention plus pioglitazone ;Conventional lifestyle intervention plus placebo | People's Hospital, Peking University; Beijing Municipal Science & Technology Committee, Beijing Municipal Science & Technology Committee | Diabetes | | | | |
ChiCTR-OPC-17011571: Effects of pioglitazone on insulin sensitivity and function of pancreatic α and β cells in type 2 diabetic patients with different body weight |
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| Completed | 4 | 68 | | Pioglitazone ;Pioglitazone | Fuwai Hospital, Chinese Academy of Medical Sciences; Level of the institution：, Tekada, Pfizer | Type 2 Diabetes | | | | |
2004-003822-80: Modulation of Sympathetic Nerve Activity By Pioglitazone In Type 2 Diabetes Mellitus |
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| Ongoing | 4 | 16 | Europe | Actos (Pioglitazone), Actos (Pioglitazone) | The Leeds Teaching Hospitals NHS Trust | Type 2 diabetes mellitus | | | | |
2006-002084-49: Vascular function in impaired glucose tolerance - effect of pioglitazone |
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| Ongoing | 4 | 104 | Europe | Pioglitazone, Actos, Actos | Belfast City Hospital Trust | Impaired glucose tolerance | | | | |
2006-001982-41: An evaluation of the safety and effectiveness of combination therapy using the thiazolidinedione pioglitazone alongside insulin in type 2 diabetes mellitus. |
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| Ongoing | 4 | 40 | Europe | Actos Tablets, Actos, Actos | Bradford Teaching Hospitals NHS Foundation Trust | Type 2 Diabetes Mellitus | | | | |
2007-003152-10: Influence du traitement par glitazones sur les Phospholipases A2 et sur l\'effet des Lipoprotéines de haute densité (HDL) sur la réactivité artérielle, au cours du diabète de type 2 |
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| Ongoing | 4 | 60 | Europe | PIOGLITAZONE, ROSIGLITAZONE, PIOGLITAZONE, ROSIGLITAZONE | CHU DIJON | Diabète de type 2 | | | | |
2006-004296-35: An investigation into the modulation of obesity associated monocyte/macrophage function, vascular inflammation and insulin resistance by PPAR agonist treatment |
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| Ongoing | 4 | 80 | Europe | Actos, Supralip 160, Actos, Supralip 160 | The Royal Group of Hospitals, Belfast Health and Social Care Trust, Queen\'s University Belfast | The proposed study will investigate early indicators of cardiovascular disease and diabetes in healthy, obese men without a family history of diabetes and whether these are changed by treatment with the common PPAR agonists fenofibrate andpioglitazone. | | | | |
2006-007027-14: Influence du traitement par Pioglitazone sur l\'Ostéoprotégérine dans le diabète de tye II |
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| Ongoing | 4 | 104 | Europe | Actos 30 mg, Actos 45 mg, Actos 30 mg, Actos 45 mg | INSERM | Diabète de type II | | | | |
2007-007884-26: Pioglitatsonin käyttö potilailla, joilla krooninen rasvamaksasairaus ja tuore tyypin 2 diabetes |
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| Ongoing | 4 | 10 | Europe | Actos, Actos | HUS, HYKS, Diabetesklinikka | K76.9 RasvamaksaE11 Tyypin 2 diabetes | | | | |
2007-007075-16: The effect of peroxisome proliferator activator receptor γ agonist pre-treatment on pegylated interferon-α2a and ribavirin efficacy in hepatitis C patients, previously resistant to treatment with pegylated interferon and ribavirin - a randomized-controlled trial - |
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| Ongoing | 4 | 50 | Europe | Copegus, Actos, Pegasys, Actos, Pegasys | VU university medical center | Chronic hepatitis C infection | | | | |
2009-011106-42: Aditive effects of omega-3 polyunsaturated fatty acids and pioglitazone in the treatment of type 2 diabetes mellitus |
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| Ongoing | 4 | 60 | Europe | ACTOS 15 MG POR TBL NOB 28X15MG, Epax 1050TG, ACTOS 15 MG POR TBL NOB 28X15MG, Epax 1050TG | Institute for Clinical and Experimental Medicine | The project deals with hummoral and metabolic aspects of insulin resistance (IR), which is assumed to be the basic metabolic disorder which leads to the development of type 2 diabetes mellitus (T2D) and metabolic syndrome. Study population will be patients with T2D treated by metformin. | | | | |
| Ongoing | 4 | 100 | Europe | Actos, Actos | Nottingham University | Asthma | | | | |
2009-016678-34: Exploring the Relationship Between Insulin Resistance and Interferon Resistance: Options to Overcome HCV Non-Response to Pegylated Interferon |
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| Ongoing | 4 | 22 | Europe | Actos, ViraferonPeg, Actos, ViraferonPeg, Actos, ViraferonPeg | Imperial College London | HCV infected patient who do not response to Pegylated Interferon. This study is trying to explore the relationship between insulin resistance and Interferon Resistance and the possible rule of Pioglitazone treatment to improve Interferon sensetivity. | | | | |
2015-002104-91: A Randomised Controlled Trial for People with Established Type 2 Diabetes during Ramadan: Canagliflozin (Invokana™) vs. standard dual therapy regimen: The ‘Can Do Ramadan’ Study. The ‘Can Do Ramadan’ Trial |
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| Ongoing | 4 | 116 | Europe | Canagliflozin, Gliclazide, Glimepiride, Glibenclamide, Glipizide, Repaglinide, Pioglitazone, Film-coated tablet, Tablet, Invokana, The sulphonylurea - Gliclazide, Repaglinide, Prandin, Actos | University of Leicester | Type 2 Diabetes Mellitus, Diabetes, Body processes [G] - Metabolic Phenomena [G03] | | | | |
ChiCTR-OPC-17011930: Clinical research of Pioglitazone Hydrochloride and Metformin Hydrochloride Tablets in the treatment of polycystic ovary syndrome |
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| Completed | 4 | 30 | | Take Pioglitazone Hydrochloride and Metformin Hydrochloride Tablets | Shanghai Changhai Hospital; Shanghai Changhai Hospital, Self financing | polycystic ovary syndrome | | | | |
NCT03646292: Comparison of The Effects of Thiazolidinediones(TZD), Sodium- Glucose Cotransporter 2 Inhibitors(SGLT2i) Alone and TZD / SGLT2i Combination Therapy on Non-alcoholic Fatty Liver Disease in Type 2 Diabetic Patients With Fatty Liver |
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| Recruiting | 4 | 60 | RoW | Pioglitazone, Empagliflozin, Combination of pioglitazone and empagliflozin | Yonsei University | NAFLD - Nonalcoholic Fatty Liver Disease, Type2 Diabetes | 02/21 | 02/21 | | |
ChiCTR1900028606: A randomized controlled trial for pioglitazone/metformin fixed-dose combination compared with uptitrated metformin alone in patients with type 2 diabetes inadequately controlled with metformin |
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| Not yet recruiting | 4 | 304 | | Pioglitazone Hydrochloride and Metformin Hydrochloride Tablets ;Metformin Hydrochloride Tablets | Beijing Hospital; Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Diabetes | | | | |
| Recruiting | 4 | 1506 | RoW | Pioglitazone 45 mg | Dasman Diabetes Institute, Ministry of Health, Kuwait, Texas Diabetes Institute, Kuwait University | Covid19, Type 2 Diabetes | 06/21 | 06/21 | | |
| Completed | 4 | 8 | Europe | Pioglitazone 30 mg, standard of care | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | Type 2 Diabetes | 11/21 | 01/22 | | |
NCT02315287: Comparison of Lobeglitazone With Pioglitazone as Initial Triple Therapy for Diabetes Management |
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| Recruiting | 4 | 190 | RoW | Pioglitazone, Actos, Lobeglitazone, Duvie | Seoul National University Bundang Hospital | Type 2 Diabetes | 12/21 | 12/21 | | |
NCT04584242: Clinical Trials to Compare the Effects of Pioglitazone and Evogliptin on Hepatic Fibrosis in Patients With Chronic Hepatitis B With Significant Hepatic Fibrosis With Type 2 Diabetes |
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| Recruiting | 4 | 40 | RoW | gluconon tab 15mg, suganon tab 5mg | Yonsei University | Chronic Hepatitis B With Significant Hepatic Fibrosis With Type 2 Diabetes | 05/22 | 05/22 | | |
| Completed | 4 | 57 | Europe | Liraglutide, Pioglitazone | University of Leeds | Diabetes Mellitus, Type 2 | 10/22 | 10/22 | | |
| Active, not recruiting | 4 | 26 | Europe | Acetazolamide, Diamox, ATC code: S01EC01, Placebo | University Hospital, Antwerp | Obstructive Sleep Apnea | 04/23 | 08/24 | | |
NCT05519813: Effects of Pioglitazone Combined With Metformin on Gonadal and Metabolic Profiles in Chinese Nonobese PCOS Patients. |
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| Active, not recruiting | 4 | 60 | RoW | Metformin, Pioglitazone Hydrochloride And Metformin Hydrochloride Tablets | Bing He | Polycystic Ovary Syndrome | 01/23 | 03/23 | | |
NCT05473806: Effects of Pioglitazone and Evogliptin on Hepatic Fibrosis in Patients With Chronic Hepatitis B With Type 2 Diabetes |
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| Active, not recruiting | 4 | 28 | RoW | Pioglitazone 15 Mg Oral Tablet, Gluconon tablet 15mg, Evogliptin 5mg, SUGANON tablet 5mg | Seung Up Kim | Hepatitis B, Chronic, Fibrosis, Liver, Diabetes Mellitus, Type 2 | 01/23 | 02/23 | | |
NCT06164665: Effects of Pioglitazone on Exogenous Carbohydrate Oxidation During Steady-State Exercise at High Altitude |
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| Completed | 4 | 9 | US | Pioglitazone 15mg, Actos, Placebo | United States Army Research Institute of Environmental Medicine | High Altitude | 07/23 | 07/23 | | |
NCT04976283: Effect of Oral Anti-diabetic Medication on Liver Fat in Subjects With Type II Diabetes and Non-alcoholic Fatty Liver |
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| Recruiting | 4 | 123 | RoW | Pioglitazone, Zolid, Empagliflozin, Diampa, Pioglitazone + Empagliflozin, Zolid + Diampa | Getz Pharma | Diabetes Mellitus, Type 2, NASH - Nonalcoholic Steatohepatitis, NAFLD | 05/23 | 11/23 | | |
| Recruiting | 4 | 20 | RoW | Pioglitazone 45 mg, pioglitazone hydrochloride | University of Campinas, Brazil | Myocardial Reperfusion Injury | 06/24 | 12/24 | | |
| Recruiting | 4 | 120 | US, RoW | Pioglitazone 45 mg, Placebo | The University of Texas Health Science Center at San Antonio | Type 1 Diabetes Mellitus | 12/24 | 01/25 | | |
NCT04370093: Pathogenesis of Uric Acid Nephrolithiasis: Role of Pioglitazone/Weight Loss |
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| Recruiting | 4 | 54 | US | Pioglitazone 45 mg, Weight Loss, Pioglitazone + Weight Loss | University of Texas Southwestern Medical Center | Nephrolithiasis, Uric Acid | 06/25 | 07/25 | | |
EPIDOTE, NCT03499704: A Study to Evaluate the Effect of add-on Pioglitazone or Dapagliflozin in Participants With Type 2 Diabetes Mellitus Inadequately Controlled by DPP-4 Inhibitor and Metformin Therapy |
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| Active, not recruiting | 4 | 133 | RoW | Pioglitazone + Alogliptin, SYR-322-4833, Alogliptin, Metformin, Dapagliflozin | Celltrion Pharm, Inc. | Diabetes Mellitus, Type 2 | 01/24 | 06/24 | | |
NCT06243536: The Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients |
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| Not yet recruiting | 4 | 60 | RoW | Semaglutide, standard of care, Metformin, Sulfonylureas, Sodium-glucose cotransporter-2 inhibitors, pioglitazone | University Hospital "Sestre Milosrdnice", University of Zagreb School of Medicine | Type 2 Diabetes, Overweight, Disordered Eating Behaviors | 12/24 | 12/24 | | |
NCT06399835: Enavogliflozin vs. Pioglitazone on Glucose and Atherosclerosis |
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| Recruiting | 4 | 120 | RoW | Enavogliflozin, Envlo Tab., Pioglitazone, Actos Tab. | Seoul National University Bundang Hospital, Daewoong Pharmaceutical Co. LTD. | Type 2 Diabetes | 06/26 | 12/26 | | |
NCT05813249: Semaglutide in Nonalcoholic Fatty Liver Disease |
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| Completed | 4 | 180 | RoW | Rybelsus Oral Product, Ozempic Injectable Product, Wegovy, Tocopherol and/or Actos | Zagazig University | Non-alcoholic Fatty Liver Disease | 02/24 | 04/24 | | |
NCT03471117: Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients |
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| Recruiting | 4 | 28 | US | Pioglitazone, Placebo | The University of Texas at Arlington, University of Texas, Southwestern Medical Center at Dallas | Chronic Kidney Diseases | 04/25 | 04/25 | | |
NCT05942963: Efficacy of Empagliflozin and Pioglitazone in Diabetic Patients With NAFLD |
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| Not yet recruiting | 4 | 240 | RoW | Empagliflozin 10 MG, Pioglitazone 15mg, Metformin | Jinnah Postgraduate Medical Centre | Non-Alcoholic Fatty Liver Disease, Type2diabetes | 04/24 | 04/24 | | |
ChiCTR2200062954: Pioglitazone in spontaneous subarachnoid hemorrhage: A multicentre, double-blind, randomised trial |
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| Not yet recruiting | 4 | 400 | | Pioglitazone treatment ;Placebo treatment | 904th Hospital of Joint Logistic Support Force; 904th Hospital of Joint Logistic Support Force, Natural Science Foundation of Jiangsu Province; Wuxi key demonstration project | Spontaneous subarachnoid hemorrhage | | | | |
NCT05305287: Quantifying Hepatic Mitochondrial Fluxes in Humans |
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| Recruiting | 4 | 60 | US | Pioglitazone, Actos, Placebo | The University of Texas Health Science Center at San Antonio, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Non-Alcoholic Fatty Liver Disease, Type 2 Diabetes, Mitochondrial Metabolism Disorders | 03/27 | 03/27 | | |
| Recruiting | 4 | 78 | US | Pioglitazone, Actos, Placebo, Placebo tablet | The University of Texas Health Science Center at San Antonio | Type 2 Diabetes Mellitus in Obese, Heart Failure With Preserved Ejection Fraction | 04/28 | 01/29 | | |
