| memantine / Generic mfg. |
NCT02118727: Therapy in Amyotrophic Lateral Sclerosis (TAME) |
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| Completed | 2b | 89 | US | Memantine, Namenda, Placebo (for Memantine), Sugar pill manufactured to mimic memantine 10 mg | University of Kansas Medical Center, University of Missouri-Columbia | Amyotrophic Lateral Sclerosis, Frontal Temporal Dementia | 07/21 | 07/21 | | |
NCT02580305: SUVN-502 With Donepezil and Memantine for the Treatment of Moderate Alzheimer's Disease- Phase 2a Study |
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| Completed | 2a | 564 | US | SUVN-502, Masupirdine, Placebo, Donepezil, Namzaric, Memantine, Namenda XR® | Suven Life Sciences Limited | Alzheimer's Disease | 11/19 | 11/19 | | |
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ACTRN12614000619640: The effect of Memantine on cognition disorders induced by Electroconvulsive therapy (ECT) |
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| Recruiting | 2 | 40 | | | Mohammad Abbasinazari, Shahid Beheshti University of Medical Sciences | Post ECT cognition disorders | | | | |
NCT00000867: A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC) |
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| Completed | 2 | 120 | US | Memantine | National Institute of Allergy and Infectious Diseases (NIAID) | AIDS Dementia Complex, HIV Infections | | 07/01 | | |
| Terminated | 2 | 20 | Europe | Memantine, Ebixa, Placebo | Clinica Universidad de Navarra, Universidad de Navarra, H. Lundbeck A/S | Multiple Sclerosis | 03/08 | 03/08 | | |
MEMPDD, NCT00630500: Efficacy and Safety of Memantine for Parkinson's Disease Dementia (PDD) and Dementia With Lewy Bodies (DLB) |
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| Completed | 2 | 75 | Europe | Memantine, Placebo | Helse Stavanger HF, King's College London, Lund University | Dementia Associated With Parkinson's Disease, Dementia With Lewy Bodies | 02/09 | 03/09 | | |
NCT00409721: The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS) |
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| Completed | 2 | 42 | Canada | Memantine | University of Alberta, ALS Association | Amyotrophic Lateral Sclerosis | 12/10 | 12/10 | | |
| Completed | 2 | 299 | Europe | Memantine, Placebo | Merz Pharmaceuticals GmbH | Memory Disorder, Retention Disorder, Cognitive, Subjective Cognitive Impairment, Memory, Concentration or Attention Problems | 08/11 | 09/11 | | |
| Terminated | 2 | 9 | Europe | TRx0237, Placebo | TauRx Therapeutics Ltd | Alzheimer's Disease | 03/13 | 03/13 | | |
NCT00200538: Efficacy and Tolerability of Memantine in Frontotemporal Dementia (FTD) Patients |
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| Completed | 2 | 52 | Europe | memantine | Nantes University Hospital | Dementia | | | | |
2011-003466-33: Memantine as an adjunctive therapy to ongoing clozapine treatment: a proof-of-concept study Memantine toevoeging bij voortgezette behandeling met clozapine: een studie om het concept te bewijzen |
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| Completed | 2 | 52 | Europe | Memantine hydrochloride, EU/1/02/219/023, Film-coated tablet, Ebixa | Mental Health Services North Holland North, Mental Health Services North Holland North | Cognitive functioning, severity of psychopathology and treatment response (positive symptoms and negative symptoms of schizophrenia), depressive symptoms, social cognition, obsessive-compulsive symptoms, psychosocial functioning, quality of life and adverse effects in outpatients with refractory schizophrenia and a nonsatisfactory response to clozapine (duration of adequate clozapine treatment at least six months). Cognitief functioneren, ernst van psychopathologie en behandelrespons (positieve symptomen en negatieve symptomen van schizofrenie), depressieve symptomen, sociale cognitie, obsessief-compulsieve symptomen, psychosociaal functioneren, kwaliteit van leven en bijwerkingen bij ambulante patiënten met therapieresistente schizofrenie en onvoldoende respons na minimaal 6 maanden adquate behandeling met clozapine., Cognitive function, severity of psychopathology, depressive symptoms, obsessive-compulsive symptoms, social outcome and adverse effects in ambulatory patients with clozapine-resistant schizophrenia. Cognitieve functie, ernst van psychopathologie, depressieve symptomen, obsessief-compulsieve symptomen, sociale uitkomst en bijwerkingen bij ambulante patiënten met clozapineresistente schizofrenie., Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT01744444: Treatment of Pendular Nystagmus With Gabapentin and Memantine in Patients With Multiple Sclerosis |
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| Completed | 2 | 10 | Europe | Memantine, Gabapentin | Hospices Civils de Lyon | Pendular Nystagmus Patients With Multiple Sclerosis | 07/13 | 07/13 | | |
| Completed | 2 | 542 | US, Canada, Europe, RoW | RO4602522, Placebo, Donepezil, Memantine, Rivastigmine, Galantamine | Hoffmann-La Roche | Alzheimer's Disease | 06/15 | 06/15 | | |
2005-004109-27: A double-blind, placebo-controlled multi-centre trial of memantine in patients with Parkinsons’ disease dementia or dementia with Lewy bodies |
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| Ongoing | 2 | 20 | Europe | Ebixa, Ebixa, Ebixa | Neuropsychiatric clinic | Parkinsons disease (PD)and dementia with Lewy bodies (DLB) are both common disease of the elderly. The majority of patients who survive for more than 10 years with PD eventually develope dementia (PDD). The brain changes and clinical presentations of PDD and DLB are similar. The clinical characteristics are cognitive impairment with pronounced visuospatial and executive impairment, visual hallucinations, parkinsonism, fluctuations in cognition and REM sleep disorder. | | | | |
2007-000503-15: Experimental clinical open study, randomized, experimental group vs control group, for the evaluation of tolerability and the effects on magnetic resonance parameters and cognitive functions of memantine in patients at early stage of relapsing- remitting multiple sclerosis treated with interferon-beta. |
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| Ongoing | 2 | 120 | Europe | EBIXA, EBIXA | AZ. OSPEDALIERA GARIBALDI, S.LUIGI CURRO , ASCOLI TOMASELLI | patients at early stage of relapsing- remitting multiple sclerosis treated with interferon-beta. | | | | |
2007-002117-39: MEMANTINA (Ebixa X) PARA LA DISCAPACIDAD FUNCIONAL EN LA ESCLEROSIS LATERAL AMIOTRÓFICAMEMANTINE (Ebixa R) FOR FUNCTIONAL DISABILITY IN AMYOTROPHIC LATERAL SCLEROSIS . |
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| Ongoing | 2 | 80 | Europe | EBIXA, EBIXA | Jorge Matias-Guiu Guia | Esclerosis Lateral AmiotroficaAmyotrophic lateral Sclerosis | | | | |
2008-000490-37: Pharmacological treatment with memantine of oscilloscopy in patients suffering from multiple sclerosis: randomized,double blind placebo controlled study. |
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| | 2 | 40 | Europe | EBIXA, EBIXA | OSPEDALE S. RAFFAELE | multiple sclerosis | | | | |
2009-014810-87: Effect of Memantine 20 mg (Ebixa) and Donepezil 5 mg (Aricept) on motor cortex plasticity induced by paired associative stimulation using transcranial magnetic stimulation (TMS) in patients suffering from Mild Cognitive Impairment. A phase II monocentric, double-blind, randomised, placebo-controlled, parallel group study. |
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| | 2 | 60 | Europe | EBIXA, ARICEPT, EBIXA, ARICEPT | INSTITUT DE RECHERCHES INTERNATIONALES SERVIER | - Patients suffering from Mild Cognitive Impairment (memory problems, objective memory disorder, absence of other cognitive disorders or repercussions on daily life, normal general cognitive function and absence of dementia) | | | | |
NCT02246075: Study of the Safety of Two Doses of Investigational Study Drug EVP-6124 in Subjects With Alzheimer's Disease Currently Receiving Memantine |
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| Withdrawn | 2 | 0 | US | EVP-6124, encenicline | FORUM Pharmaceuticals Inc, Quintiles, Inc. | Alzheimer's Disease, Dementia, Cognition | 10/16 | | | |
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2017-004125-32: A randomised, double blind, placebo controlled trial to evaluate the safety, efficacy and pharmakokinetics of Pleconaril as an add on to AchEI/memantine for treatment of patients with Alzheimer’s disease |
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| Ongoing | 2 | 120 | Europe | pleconaril, Capsule, hard | Apodemus Aktiebolag, Apodemus AB | Alzheimer's disease, Alzheimer's disease, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Unknown status | 2 | 150 | RoW | MLC901, Neuroaid II (MLC901), Placebo, MLC901 matched Placebo | National University Hospital, Singapore | Alzheimer Disease | 06/18 | 06/19 | | |
2014-003080-38: GOAT - Glutamatergic medication in the treatment of Obsessive Compulsive Disorder (OCD) and Autism Spectrum Disorder (ASD) |
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| Completed | 2 | 100 | Europe, RoW | Ebixa 5 mg film-coated tablets, Ebixa 10 mg film-coated tablets, Film-coated tablet, Ebixa 5 mg film-coated tablets, Ebixa 10 mg film-coated tablets | Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, European Union, Framework Programme 7 (FP7) European Union/European Commission | Obsessive Compulsive Disorders (OCD) Autism Spectrum Disorders (ASD), OCD: repetitive thoughts/impulses/images and behaviours/mental actsASD: deficits in social interaction/communication, and restricted, repetitive and stereotyped patterns of behaviour/interests/activ, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT03560245: A Study of Bryostatin in Moderately Severe to Severe Alzheimer's Disease Subjects Not On Memantine |
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| Completed | 2 | 108 | US | Bryostatin, Placebo | Neurotrope Bioscience, Inc., Worldwide Clinical Trials | Alzheimer Disease | 07/19 | 07/19 | | |
ARIQUELI-ME, NCT02630888: Efficacy of Memantine add-on in the Treatment of Bipolar Disorder (Type I) Nonresponders or Partial Responders Patients |
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| Unknown status | 2 | 44 | RoW | Memantine, Namenda, Ebixa, Placebo, Non active drug | University of Sao Paulo | Bipolar Disorder | 04/20 | 09/20 | | |
NCT04538066: Bryostatin Treatment of Moderately Severe Alzheimer's Disease |
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| Completed | 2 | 117 | US | Bryostatin 1, Placebo | Neurotrope Bioscience, Inc., National Institutes of Health (NIH), National Institute on Aging (NIA) | Alzheimer Disease | 11/22 | 11/22 | | |
NCT05538507: Efficacy of Chinese Traditional Medicine "Smart Soup" in Cognition and Behavior Regulation in Alzheimer's Disease |
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| Recruiting | 2 | 180 | RoW | smart soup, traditional chinese medicine, Donepezil, donepezil pill, Memantine, Memantine Pill, Placebo | Peking Union Medical College Hospital, Tongji University | Alzheimer Disease, Mild Cognitive Impairment | 06/24 | 06/24 | | |
NCT05063851: The Use of Memantine for Prevention of Alzheimer's Disease |
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| Recruiting | 2 | 32 | US | Memantine Hydrochloride Tablets, Placebo | University of Virginia | Alzheimer Disease | 12/25 | 12/25 | | |
NCT01555697: Biomarker Strategies for Medication-Enhanced Cognitive Training in Schizophrenia |
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| Completed | 1/2 | 80 | US | Memantine, Namenda, Placebo | University of California, San Diego | Schizophrenia | 06/19 | 06/19 | | |
