| methylprednisolone sodium succinate / Generic mfg. |
2018-000686-37: Early immune intervention in patients with recently diagnosed type 1 diabetes Vroege immuuninterventie bij recent vastgestelde type 1 diabetes |
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| | 4 | 42 | Europe | Prednisolone oral suspension, 97006815 / 0000002910, Capsule, hard, Powder for injection, Tablet, Solution for injection/infusion, Oral suspension, Proglicem (diazoxide), Solu-medrol (methylprednisolone), Prednisolone, Natriumchloride 0,9%, oplossing voor intraveneuze infusie | Leiden univerisity medical centre, Tjanka foundation, LUMC, Sanofi | Type 1 diabetes Type 1 diabetes, Insulin dependent diabetes Type 1 Suikerziekte, Diseases [C] - Hormonal diseases [C19] | | | | |
ChiCTR-TRC-11001454: Tacrolimus monotherapy follows intravenous methylprednisolone in adults with minimal change nephrotic syndrome: a prospective, multi-centered, open, randomized, controlled trial |
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| Completed | 4 | 120 | | Tacrolimus orally taken 0.5-1mg q12h for 36w, tape ;prednisone orally taken for 36w, 1.0 mg/kg.d, tape | Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University; Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University | minimal change disease in adults | | | | |
NCT03152474: Adrenal Cortical Function and Vitamin A Deficiency in Sepsis |
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| Completed | 4 | 300 | NA | Solumedrol 20mg, Methylprednisolone Sodium Succinate, Vitamin A 100,000 IU, Retinol, Placebo | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Sepsis | 01/00 | 01/00 | | |
NCT00048165: A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation |
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| Completed | 4 | 434 | US, Canada, Europe | Daclizumab, Zenapax, Methylprednisolone, Mycophenolate mofetil, Placebo, cyclosporine | Hoffmann-La Roche | Heart Transplantation | 08/02 | 08/02 | | |
NCT00755859: "Steroids and Azathioprine Versus Steroids Alone in IgAN" |
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| Completed | 4 | 206 | Europe | steroids plus azathioprine, solumedrol, deltacortene, azatioprina, steroids | A. Manzoni Hospital | IGA Nephropathy | 12/04 | 09/07 | | |
| Completed | 4 | 350 | US | Methotrexate, IV methylprednisolone | Biogen | Multiple Sclerosis, Relapsing-Remitting | 06/06 | 05/07 | | |
NCT00393367: Budesonide Inhalation Suspension for Acute Asthma in Children |
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| Completed | 4 | 179 | US | Budesonide inhalation suspension (0.5 mg/2mL) 2mg, albuterol (5mg/mL) 7.5 or 10mg, Pulmicort, Albuterol, Prednisolone, prednisone, or methylprednisolone, Prednisolone, prednisone, methylprednisolone, Albuterol, ipratropium bromide, Atrovent, Ipratropium bromide | Children's Hospital of Philadelphia | Asthma, Acute Asthma, Reactive Airway Exacerbation | 11/07 | 11/07 | | |
NCT00307606: Does a Single Steroid Injection Reduce the Formation of Postmastectomy Seroma |
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| Unknown status | 4 | 40 | Europe | Solu-medrol 125 mg | Herlev Hospital | Breast Neoplasms, Mastectomy | | 12/07 | | |
NCT00296244: Steroid Free Immunosuppression in Liver Transplantation |
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| Completed | 4 | 40 | US | Steroids, Methylprednisolone (Solumedrol), Prednisone, Basiliximab, Simulect, Tacrolimus, Prograf, Enteric-coated Mycophenolic acid (EC-MPA), Myfortic | Thomas Jefferson University, Novartis Pharmaceuticals | Liver Cirrhosis, Liver Transplant Disorder | 05/08 | 06/08 | | |
NCT00706680: Thymoglobulin in Calcineurin Inhibitor and Steroid Minimization Protocol |
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| Unknown status | 4 | 30 | Canada | Thymoglobulin, Thymo, Polyclonal ATG, Methyl Prednisone, SoluMedrol, Steroid, Prednisone, MMF, Cell Cept, Mycophenolate Mofetil, Mycopnlolic Acid, Myfortic, Cyclosporine, Neoral | University Health Network, Toronto, Genzyme, a Sanofi Company, Unity Health Toronto, St. Paul's Hospital, Canada | Diabetes, Graft Rejection | 02/09 | 06/09 | | |
NCT00596947: Prednisone Withdrawal Versus Prednisone Maintenance After Kidney Transplant |
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| Terminated | 4 | 18 | US | prednisone, Deltasone, Steroids, Methylprednisolone, Corticosteroids, rabbit antithymocyte globulin, RATG, Thymoglobulin, Polyclonal antibody, Tacrolimus, Prograf, Prednisone, Mycophenolate mofetil, mmf, CellCept | University of Pennsylvania | Transplants and Implants | 03/09 | 03/09 | | |
NCT01281748: Evaluation Of The Efficacy Of Corticosteroids In Patients With An Acute Exacerbation Of Chronic Obstructive Pulmonary Disease Receiving Ventilator Support |
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| Terminated | 4 | 83 | Europe | intravenous methylprednisolone, intravenous normal saline solution | Hospital Universitario Getafe, GRANT IP041233 FROM FONDO DE INVESTIGACION SANITARIA | COPD | 07/09 | 07/09 | | |
NCT00462345: A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Therapies. |
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| Completed | 4 | 40 | RoW | rituximab, MabThera, Rituxan, Methotrexate, Corticosteroid or NSAID, Folate | Hoffmann-La Roche | Rheumatoid Arthritis | 07/09 | 07/09 | | |
| Completed | 4 | 119 | US | Solumedrol, Placebo | Minneapolis Heart Institute Foundation, Abbott Medical Devices | Atrial Fibrillation | 12/09 | 12/13 | | |
NCT00968578: Effects of Methylprednisolone After Total Knee Arthroplasty |
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| Completed | 4 | 48 | Europe | Methylprednisolone, Placebo | Hvidovre University Hospital, Lundbeck Foundation | Postoperative Pain, Postoperative Nausea and Vomiting, Sleeping Quality, Fatigue, Inflammatory Response | 12/09 | 12/09 | | |
BEFIRTH, NCT00538265: Benefit of Immunoprophylaxis on Fibrosis to Reduce Viral Load After Liver Transplantation |
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| Completed | 4 | 100 | Europe | tacrolimus, PROGRAF, tacrolimus, ATG, Thymoglobuline, ATG+mycophénolate mofétil+tacrolimus, Mycophénolate mofétil = Cellcept | University Hospital, Toulouse | Liver Transplantation | 01/10 | 01/11 | | |
2010-018289-21: Clinical, laboratory and ultrasound markers for the prediction of the response on the pulse-dose treatment by intravenous glucocorticoids in patients with endocrine orbitopathy |
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| Ongoing | 4 | 45 | Europe | Solu-Medrol, not applicable, Powder and solvent for solution for injection, Solu-Medrol | Insitute of Endocrinology | active severe endocrine orbitopathy | | | | |
| Unknown status | 4 | 152 | Europe | cyclosporine, Neoral, Myfortic, Solumedrol, Medrol, Simulect, Everolimus, Certican | University Hospital, Antwerp, Novartis Pharmaceuticals, Erasme University Hospital, University Hospital, Ghent, University of Liege, Universitair Ziekenhuis Brussel | Renal Transplantation | 04/10 | 04/15 | | |
| Completed | 4 | 49 | Europe | methylprednisolone, Group A, Group B, Placebo | Germans Trias i Pujol Hospital | Multiple Sclerosis | 11/10 | 01/11 | | |
| Completed | 4 | 48 | Europe | Methylprednisolone | Hvidovre University Hospital, Lundbeck Foundation | LOS, Postoperative Pain, Postoperative Nausea and Vomiting, Sleeping Quality, Fatigue, Inflammatory Response | 01/11 | 01/11 | | |
| Completed | 4 | 112 | Europe | Infliximab, Remicade, Methylprednisolone, Medrol, Solu-Medrol and Cadista., Methotrexate, Maxtrex, Folic acid, vitamin B9,vitamin Bc, or folacin | University of Leeds | Rheumatoid Arthritis | 02/11 | 02/11 | | |
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| Completed | 4 | 7500 | Europe | Solu-Medrol, Injection, Solu-Medrol | Population health Research Institute, Population Health Research Institute | cardiac surgery, cardiac surgery, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT01106547 / 2010-018448-15: The Effect of a Preoperative Single-dose Methylprednisolone on the Postoperative Rehabilitation After Abdominal Hysterectomy |
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| Completed | 4 | 55 | Europe | Methylprednisolone 125mg, Solu-medrol, Sodium Chloride 2 ml | Holbaek Sygehus | Hysterectomy, Methylprednisolone, Postoperative Pain | 09/11 | 10/11 | | |
| Terminated | 4 | 3 | US, Europe | Methylprednisolone, Medrol, Solu-Medrol, Prednisolone, Orapred, Prelone | Biogen, Elan Pharmaceuticals | Immune Reconstitution Inflammatory Syndrome, Leukoencephalopathy, Progressive Multifocal | 02/12 | 02/12 | | |
ChiCTR-TRC-10001162: Methylprednisolone for primary supratentorial intracerebral hemorrhage: a randomized double-blind, placebo-controlled trial in postoperativepatients |
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| Completed | 4 | 100 | | conventional medica treatment+placebo ;Methylprednisolone 80 mg via intravenous infusion once per 12 hours for 72 hours+conventional medical treatment | West China Hospital, Sichuan University; West China Hospital, Sichuan University, Self-funding | Postoperation acute primary supratentorial intracerebral hemorrhage | | | | |
| Completed | 4 | 40 | | Two doses of MP monthly for 3 months | Department of Endocrinology and Metabolism, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology; None, self-financing | Graves' ophthalmopathy | | | | |
ChiCTR-TRC-10001141: Methylprednisolone for primary intracerebral hemorrhage: a randomized double-blind, placebo-controlled trial |
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| Completed | 4 | 100 | | Methylprednisolone 80 mg via intravenous infusion once per 12 hours for 72 hours+conventional medical treatment ;Placebo+conventional medical treatment | West China Hospital, Sichuan University; Level of the institution：, Self-funding | Acute primary supratentorial intracerebral hemorrhage | | | | |
| Completed | 4 | 44 | US | plasmapheresis, Bortezomib, Velcade, Rituximab, Rituxan, Methylprednisolone, Medrol | University of Cincinnati, Millennium Pharmaceuticals, Inc. | HLA Sensitization | 11/12 | 11/12 | | |
NCT00915473: Greater Occipital Nerve Block for Migraine Prophylaxis |
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| Completed | 4 | 70 | US | bupivicaine, Marcain, Marcaine, Sensorcaine, Vivacaine, normal saline, methylprednisolone, Medrol, Solu-Medrol, lidocaine, xylocaine | Mayo Clinic, National Center for Advancing Translational Sciences (NCATS) | Migraine Headache | 01/13 | 01/13 | | |
| Completed | 4 | 90 | RoW | Etomidate, etomidate lipuro, BRAUN, Midazolam, Dormicum,Roche, methylprednisolone, Prednol-L, Mustafa Nevzat | Istanbul University | Adrenocortical Deficiency, Hemodynamic Instability | 03/13 | 03/13 | | |
2013-001196-20: EFFICACY OF STEROIDS IN THE TREATMENT OF DYSTHYROID OPTIC NEUROPATHY EFFICACIA DEGLI STEROIDI NEL TRATTAMENTO DELL'OTTICOPATIA DISTIROIDEA ACUTA |
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| Ongoing | 4 | 70 | Europe | SOLUMEDROL, 83-43-2, Powder and solution for solution for injection, SOLUMEDROL | FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO MILANO, FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO | GRAVES' ORBITOPATHY ORBITOPATIA DI GRAVES, GRAVES' ORBITOPATHY ORBITOPATIA DI GRAVES, Diseases [C] - Immune System Diseases [C20] | | | | |
NCT02571517 / 2011-000337-36: Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe Bronchiolitis |
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| Completed | 4 | 94 | Europe | Glucocorticoids, SOLU-MODERIN 125 mg, METHYLPREDNISOLONE SODIUM SUCCINATE, ESTILSONA Gotas, Placebo, glucose 5% solution, Plast-Apyr Glucosado 5% | Fundació Sant Joan de Déu | Bronchiolitis, Viral | 12/13 | 12/13 | | |
| Completed | 4 | 14 | Europe | prednisone, placebo | Bispebjerg Hospital | Exercise Performance in Copd Patients | 12/13 | 12/13 | | |
| Completed | 4 | 122 | Europe | Etanercept, Abatacept, Rituximab, Adalimumab, Certolizumab Pegol, Infliximab, Golimumab | Julia Brown | Rheumatoid Arthritis | 11/15 | 11/15 | | |
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2005-002391-14: Pulsed Intravenous Methylprednisolone for Ocular Pemphigoid- A Pilot Study |
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| Ongoing | 4 | 20 | Europe | Solu-Medrone, Solu-Medrone | Moorfields Eye Hospital NHS Foundation Trust | ocular mucous membrane pemphigoid | | | | |
2006-000607-42: Treatment of borderline changesin protocol biopsy 3 months after renal transplantation |
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| Ongoing | 4 | 30 | Europe | SOLU-MEDROL inj. | Institute for clinical and experimental Medicine | Patients with transplanted kidney and stabilised graft function | | | | |
2006-005803-33: ÉTUDE PILOTE OBSERVATIONNELLE CHEZ DES PATIENTES SOUFFRANT D’UN CANCER DU SEIN ET RECEVANT UNE CHIMIOTHÉRAPIE ÉMÉTISANTE TRAITÉES PAR UNE DOSE UNIQUE DE ALOXI® (PALONOSÉTRON) 0,25 MG ASSOCIÉE À UNE CORTICOTHÉRAPIE |
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| Ongoing | 4 | 150 | Europe | ALOXI, SOLU-MEDROL, ALOXI, SOLU-MEDROL | THERABEL LUCIEN PHARMA | The prevention of acute or delayed Chemotherapy-Induced Nausea and Vomiting (CINV) by the combination of palonosetron 250 microgrammes and methylprednisolone 80 mg in patients receiving a first administration of a first line of emetogenic chemotherapy to treat their non metastatic breast cancer. | | | | |
2007-006780-70`ACTRN12621000229875: METYYLIPREDNISOLONIN IMEYTYMINEN VAIKEAA KOLIITTIA SAIRASTAVILLASuonensisäistä ja suun kautta tapahtuvaa annostelua vertaileva lääkeainepitoisuusmäärityksiin perustuva tutkimus |
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| Ongoing | 4 | 10 | Europe | Medrol, Solu-Medrol | Tampereen yliopistollinen sairaala, Clinical Project Grant reviewed by Royal Adelaide Hospital Research Committee | needle fear, haemodialysis patients | | | | |
2008-007413-76: Metyyliprednisolonin farmakokinetiikka ja -dynamiikka lasten avosydänleikkausten yhteydessä |
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| Ongoing | 4 | 105 | Europe | Solu-Medrol | Pertti Suominen | Lasten ja nuorten sairaalassa (HUS) hoidettavat 1-12 kk ikäiset avosydänleikkaukseen tulevat potilaat, joilla on sydänvikanan TOF, AVSD tai VSD.Lasten ja nuorten sairaalassa (HUS) hoidettavat korkeintaan 28 päivän ikäiset avosydänleikkaukseen tulevat potilaat, joilla on sydänvikana TGA, HLHS tai IAA. | | | | |
2009-013441-28: POMEVAR : PreOperative Methylprednisolone in EndoVascular Aortic Repair- a randomized, double-blind, placebocontrolled trial. |
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| Completed | 4 | 150 | Europe | Solu-medrol, Solu-medrol | Copenhagen University Hospital, Rigshospitalet | Asymptomatic abdominal aortic aneurysms | | 04/13 | | |
2010-020329-42: EFFECTS OF PREVENTIVE TREATMENT WITH STEROIDS ON COAGULATION DYSFUNCTION INDUCED BY EXTRACORPOREAL CIRCULATION |
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| Completed | 4 | 50 | Europe | SOLUMEDROL, SOLUMEDROL | AZIENDA OSPEDALIERA OSPEDALE POLICLINICO CONSORZIALE | All patients were candidates for cardiac surgery intervention in extracorporeal circulation | | | | |
2011-000899-33: Rituximab treatment in patients with tjyroid associated that do not respond to intravenous steroids or relapse after intravenous steroid treatment |
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| Ongoing | 4 | 50 | Europe | mabthera, metotrexate, Solu-Medrol, Prednisolon, Mabthera, metotrexate, Solu-Medrol, Prednisolon, Mabthera, metotrexate, Solu-Medrol, Prednisolon | Department of Endocrinology, Sahlgrenska University Hospital | Thyroid associated opthalmopathy | | | | |
2012-002628-34: Inflammation of the optic nerve and early treatment with prednisolone. Synsnervebetændelse og tidlig behandling med binyrebarkhormon. |
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| Completed | 4 | 200 | Europe | Solu-Medrol, Solu-Medrol | Thor Petersen, Aarhus University Hospital Research Fund, Skleroseforeningen (The Danish Multiple Sclerosis Society) | Optic neuritis. Synsnervebetændelse. | | 07/15 | | |
2012-004451-37: pain management after videoscopic pulmonary surgery with pills, local analgesic and with or without adrenocortical hormone. Smertebehandling efter kikkert-lungekirurgi med piller, smertekateter og med eller uden binyrebarkhormon. |
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| Ongoing | 4 | 100 | Europe | Solu-Medrol, Solu-Medrol | Per F. Jensen, Rigshospitalet | Pain after thoracoscopic surgery Smerter efter video-assisteret thorakoskopisk kirurgi | | | | |
NCT02584738: Nebulized Magnesium Sulfate as an Adjunct to Standard Therapy in Asthma Exacerbation |
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| Unknown status | 4 | 152 | RoW | Nebulized Magnesium Sulfate, MgSO4, Nebulized isotonic saline, Standard treatment, Nebulized Salbutamol, Ipratropium bromide, Methylprednisolone or Prednisolone, Corticosteroid therapy | Hospital General Naval de Alta Especialidad - Escuela Medico Naval | Asthma | 01/16 | 01/18 | | |
| Completed | 4 | 122 | Europe | methylprednisolone sodium succinate, Solu-medrol Product Code 52245, placebo saline | Hvidovre University Hospital | Delirium - Postoperative, Stress, Physiological | 05/16 | 05/16 | | |
ChiCTR-OPB-15006526: Quantitative assessment of TCR repertoire after standardized treatment in Graves' Ophthalmopathy |
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| Recruiting | 4 | 10 | | high-dose intravenous methylprednisolone pulse (IVMP) therapy | First Affiliated Hospital of Xi’an Jiaotong University Health Science Center; First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, National Natural Science Foundation of China | Graves‘ Ophthalmopathy | | | | |
NCT02576249: Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis |
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| Completed | 4 | 29 | US | Ropivacaine, Naropin, Normal saline, Sodium Chloride, Methylprednisolone, Depo-Medrol | Mayo Clinic | Osteoarthritis | 07/16 | 10/16 | | |
SCOUT, NCT02169219: Pilot Study of Short-Course Glucocorticoids and Rituximab for Treatment of ANCA-Associated Vasculitis |
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| Completed | 4 | 20 | US | Glucocorticoids, Prednisone, Rituximab, Rituxan | Massachusetts General Hospital, Genentech, Inc. | Granulomatosis With Polyangiitis, Microscopic Polyangiitis | 08/16 | 11/17 | | |
NCT03667157: Liver Function After Intravenous Methylprednisolone Administration |
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| Completed | 4 | 68 | NA | every week IVMP therapy, very high doses IVMP therapy | Medical University of Warsaw | Graves Disease, Graves Ophthalmopathy, Liver Diseases, Liver Failure, Liver Injury, Liver Dysfunction, Liver Insufficiency, Acute Liver Failure, Acute Liver Injury, Acute Liver Injury, Drug Induced, Methylprednisolone Adverse Reaction, Glucocorticoids Toxicity, Dysthyroid Orbitopathy, Dysthyroid Ophthalmopathy | 10/16 | 10/16 | | |
NCT02645565: Comparison of Low Dose Versus High Dose Cyclophosphamide as Induction Therapy in the Treatment of Lupus Nephritis |
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| Completed | 4 | 75 | RoW | Cyclophosphamide, Endoxan, Azathioprine, Imuran, Methylprednisolone, prednisolone,steroid | Jawaharlal Institute of Postgraduate Medical Education & Research | Lupus Nephritis | 12/16 | 12/16 | | |
NCT02552342: Corticosteroid Therapy for Severe Community-Acquired Pneumonia |
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| Unknown status | 4 | 610 | RoW | methylprednisolone, Solu-Medrol, Normal saline, sodium chloride | Peking Union Medical College Hospital, The Second Hospital of Hebei Medical University, Tianjin Medical University General Hospital, Cangzhou Central Hospital, Cangzhou People's Hospital, Affiliated Hospital of Hebei University, Nantong University, The First Affiliated Hospital of Anhui Medical University, Northern Jiangsu Province People's Hospital, First Affiliated Hospital of Wenzhou Medical University, Zhejiang University, Taishan Medical University Affiliated Hospital, Tianjin Third Central Hospital, Jinhua Central Hospital, Navy General Hospital, Beijing | Community Acquired Pneumonia | 05/17 | 05/17 | | |
ChiCTR-IPR-16009576: A randomized, single-blind, controlled clinical trial design to evaluate the effectiveness and safety of methylprednisolone in patients with early post-operative hyperbilirubinemia after liver transplantation from donation after citizen’s death |
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| Recruiting | 4 | 60 | | Methylprednisolone 1mg/Kg iv qd + Ursodeoxycholic Acid 250mg po tid for 5 days ;Ursodeoxycholic Acid 250mg po tid for 5 days | Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University; The First Affiliated Hospital, Sun Yat-sen University, Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University | Early post-operative hyperbilirubinemia after liver transplantation | | | | |
NCT02375867: Steroids in Fulminant Hepatitis A in the Pediatric Age Group |
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| Completed | 4 | 33 | RoW | prednisolone, Hostacortin-H, methylprednisolone, Solumedrol | National Liver Institute, Egypt, Quesna Central Hospital, Ministry Of Health, Egypt | Fulminant Hepatic Failure | 08/17 | 09/17 | | |
| Unknown status | 4 | 60 | Europe | Solu-medrol or placebo administration, Solu-medrol 500mg IV BE145214, Solu-medrol 500mg IV H02AB04, Solu-medrol 500mg IV SUB14562MIG, Solu-medrol 500mg IV 277S102F12 | Erasme University Hospital, Jean Paul Van Vooren | C.Surgical Procedure, Cardiac | 09/17 | 09/17 | | |
NCT02847494: Corticosteroids for Acute Migraine in the Emergency Department |
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| Completed | 4 | 220 | US | metoclopramide, Dexamethasone, methylprednisolone acetate | Montefiore Medical Center | Migraine | 09/17 | 09/17 | | |
2014-005186-73: The impact of intense exercise on uptake and excresion of glucocorticoides in relation to doping analysis Intens trænings indvirkning på glukokortikoiders optagelse og udskillelse i relation til doping analyse |
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| Completed | 4 | 24 | Europe | Medrol, Solu-Medrol, Locoid, Tablet, Concentrate and solvent for solution for injection/infusion, Cream, Medrol, Solu-medrol, Locoid | Bispebjerg University Hospital, WADA | Impact of intense exercise on pharmacokinetics of glucocorticoids in relation to doping analysis Intens trænings indvirkning på glykokortikoiders farmakokinetik i relation til doping analyse, Uptake and excresion of glucocorticoids optagelse og udskillelse af glukokortikoider, Body processes [G] - Physiological processes [G07] | | | | |
2017-000622-35: Different dosis of corticosteroids in mandibular third molar surgery. En randomiserede undersøgelse af forskellige doser af kortikosteroid på smerte, hævelse og gabeevne efter kirurgisk fjernelse af visdomstænder i underkæben. |
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| Ongoing | 4 | 52 | Europe | Methylprednisolone, SUB08872MIG, Concentrate and solvent for solution for injection, Solu-medrol® | Aalborg University Hospital, None | The purpose is to investigate the postoperative morbidity after removal of mandibular third molar with different doses of methylprednisolone., The purpose is to investigate the postoperative morbidity after removal of mandibular third molar with different doses of methylprednisolone., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Surgical Procedures, Operative [E04] | | | | |
| Completed | 4 | 33 | | | Putz Laurie, CHU UCL Namur | neuromuscular relaxation, microsurgery of vocal cord. | | | | |
ChiCTR-IPR-17013049: Effects of via methylprednisolone inhibits mast cell degranulation on postoperative cognitive dysfunction in elderly patients |
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| Not yet recruiting | 4 | 100 | | Preoperative intravenous injection of methylprednisolone ;Preoperative intravenous injection of the same amount of saline | The First Affiliated Hospital, University of South China; The First Affiliated Hospital, University of South China, Private expenses | postoperative cognitive dysfunction | | | | |
| Completed | 4 | 318 | Europe | Prednisolone | Chronic Obstructive Pulmonary Disease Trial Network, Denmark | Lung Diseases, Obstructive, Blood Eosinophil Count, Glucocorticoids, COPD, Pulmonary Disease, Chronic Obstructive | 09/18 | 01/19 | | |
| Completed | 4 | 316 | US | Alemtuzumab, Campath, rabbit antithymocyte globulin, Thymoglobulin, Belatacept, Nulojix, Tacrolimus, Prograf, various, Mycophenolate mofetil, Cellcept, various, Myfortic, early cessation of steroids, prednisone, various | University of Cincinnati | Renal Transplantation | 12/18 | 12/19 | | |
| Unknown status | 4 | 100 | NA | External beam radiotherapy, intravenous corticosteroids (methylprednisolone) | University of British Columbia | Graves Ophthalmopathy | 12/18 | 12/19 | | |
NCT02077556: Effect of Everolimus on the Pharmacokinetics of Tacrolimus in Renal Transplant Patients |
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| Completed | 4 | 14 | RoW | Everolimus, Certican, Mycophenolate mofetil, CellCept, Tacrolimus, Prograf, Methylprednisolone, Solu-Medrol, Prednisolone, Predonine | National Taiwan University Hospital | Drug Interaction Potentiation | 01/19 | 01/19 | | |
2018-004205-12: Methylprednisolone injection in treatment of birch pollen induced allergic rhinitis |
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| Not yet recruiting | 4 | 60 | Europe | Depo-medrol, Injection, Depo-Medrol® Injektionsvätska, suspension 40 mg/ml | Region Skåne, Region Skåne | Seasonal birch pollen induced allergic rhinitis, Pollen allergy, Body processes [G] - Circulatory and Respiratory Physiological Phenomena [G09] | | | | |
NCT03792945: Comparison of the Efficacy of Corticosteroid Injection and ESWT in Patients With CTS |
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| Completed | 4 | 72 | RoW | local injection, local corticosteroid injection, extracorporeal shock wave therapy, physiotheraphy | Ahi Evran University Education and Research Hospital | Carpal Tunnel Syndrome, Tenosynovitis | 04/19 | 05/19 | | |
| Recruiting | 4 | 120 | | Cyclophosphamide+methylprednisolone ;Methylprednisolone | Shanghai Changzheng Hospital; Shanghai Changzheng Hospital, Second Military Medical University | thyroid associated ophthalmopathy | | | | |
NCT03190642: Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery |
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| Completed | 4 | 180 | Canada | Methylprednisolone, Solumedrol | Jean Charles Doucet, Nova Scotia Health Authority | Post-operative Edema, Steroid Use | 07/19 | 12/19 | | |
| Completed | 4 | 80 | RoW | Methylprednisolone eyedrops | Tanta University | Epiphora Due to Insufficient Drainage | 09/19 | 09/19 | | |
2018-004083-62: Effect of intramuscular corticosteroid injection on the post-operative swelling, trismus and pain following lower third molar surgery Alsó bölcsességfog eltávolításnál a műtét előtt közvetlenül a rágóizomba juttatott szteroid hatásai a műtét következményeként kialakuló duzzanatra, szájzárra és fájdalomra |
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| Not yet recruiting | 4 | 30 | Europe | Powder and solution for solution for injection, Solu-Medrol | Semmelweis University, Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, Oro-Maxillofacial Surgery and Stomatology | post-operative swelling, trismus, pain posztoperatív duzzanat, szájzár, fájdalom, post-operative swelling, trismus, pain műtét következményeként kialakuló duzzanat, szájzár, fájdalom, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Dentistry [E06] | | | | |
ACTRN12612000252819: A Randomised Controlled trial of intravenous immunoglobulin (IVIg) compared with pulse methyl-prednisolone for the treatment of chronic active antibody mediated rejection |
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| Terminated | 4 | 50 | | | Dr William Mulley, National Blood Authority | chronic active antibody mediated rejection of the renal allograft | | | | |
NCT03635957: Study of Pegloticase (KRYSTEXXA®) Plus Methotrexate in Patients With Uncontrolled Gout |
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| Completed | 4 | 14 | US | Pegloticase, Methotrexate (MTX), Standard Gout Flare Prophylaxis, Infusion Reaction (IR) Prophylaxis, Folic Acid | Amgen | Gout | 10/19 | 10/20 | | |
NCT04653415: Large Doses of Methylprednisolone Combined With Gabapentin in Total Knee Arthroplasty |
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| Completed | 4 | 160 | Europe | Gabapentin 300mg, Methylprednisolone 125 mg, Tablet, Normal Saline 10 mL Injection | Jagiellonian University | Arthroplasty Complications, Knee Osteoarthritis, Pain, Postoperative, Perioperative Complication | 01/20 | 05/20 | | |
ChiCTR1900024125: Effect of intravenous injection of different doses of methylprednisolone on maternal fever rate and maternal and infant outcome in labor analgesia |
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| Recruiting | 4 | 300 | | Intravenous preinjection of NS ;intravenous injection of methylprednisolone 10mg ;intravenous injection of methylprednisolone 20mg | Zhujiang Hospital of Southern Medical University; Zhujiang Hospital of Southern Medical University, self-financing | Fever after labor analgesia | | | | |
NCT03704584: Corticosteroid(CS) + Lido or Corticosteroid(CS) Alone |
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| Terminated | 4 | 62 | US | Treatment Group: Corticosteroid injection, depo-medrol, kenalog, Control Group (corticosteroid alone), Methylprednisolone acetate injectable suspension, Treatment Group: Lidocaine, Xylocaine | Emory University | Tenosynovitis | 01/20 | 01/20 | | |
PIRAT, NCT02523768 / 2009-018189-36: Prevention in Recipients With Primary IgA Nephropathy of Recurrence After Kidney Transplantation: ATG-F Versus Basiliximab as Induction Immunosuppressive Treatment |
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| Terminated | 4 | 117 | Europe | ATG-F, Simulect | Centre Hospitalier Universitaire de Saint Etienne | Glomerulonephritis, IgAN | 01/20 | 02/20 | | |
NCT02378298: Rituximab (RTX) Therapy in Patients With Active TAO |
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| Active, not recruiting | 4 | 26 | Europe | Rituximab, Mabthera, Rituxan, Zytux, L01XC02, Iv Methylprednisolone, Solumedrol, peroral methylprednisolone and Methotrexate, Prednisolone | Göteborg University, Sahlgrenska University Hospital, Sweden | Ophthalmopathy, Thyroid-Associated | 02/20 | 12/24 | | |
NCT04263402: The Efficacy of Different Hormone Doses in 2019-nCoV Severe Pneumonia |
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| Unknown status | 4 | 100 | RoW | Methylprednisolone | Tongji Hospital | 2019-nCoV Severe Pneumonia | 06/20 | 07/20 | | |
NCT04411667: Study of SOC Plus IVIG Compared to SOC Alone in the Treatment of COVID-19 |
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| Completed | 4 | 34 | US | Octagam, IVIG | George Sakoulas, MD, Octapharma | Sars-CoV2 | 06/20 | 06/20 | | |
| Completed | 4 | 174 | Europe | Methylprednisolone, solu-medrol, Dexamethasone | Rigshospitalet, Denmark | Complication, Postoperative | 08/20 | 09/20 | | |
NCT03876041: Evaluation of Corticosteroid in Systemic Inflammatory Response Syndrome |
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| Completed | 4 | 60 | RoW | solumedrol, methylprednisolone, Dexamethasone phosphate, dexamethasone | Assiut University | Systemic Inflammatory Response Syndrome | 09/20 | 11/20 | | |
| Completed | 4 | 70 | Europe | Methylprednisolone, Placebo | Leiden University Medical Center, Netherlands Brain Foundation, Innovatiefonds Zorgverzekeraars | Cluster Headache, Episodic, Greater Occipital Nerve Injection | 08/21 | 08/21 | | |
ChiCTR2000028818: Clinical efficacy of different treatment routes of methylprednisolone in rescure treatment of sudden deafness: a randomized controlled trial |
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| Not yet recruiting | 4 | 170 | | Apply methylprednisolone 48mg/d throughout the day for 7 days, then gradually reduce the amount for 3 days for a total of 10 days. At the same time, 40 mg / mL methylprednisolone was injected into the tympanic cavity every 2 days during the treatment period, a total of 5 times. ;The whole body was treated with methylprednisolone 48mg/d for 7 days, then gradually reduced for 3 days for a total of 10 days. | The First Affiliated Hospital, Sun Yat-Sen University; The First Affiliated Hospital, Sun Yat-Sen University, project of Guangzhou sciences revolution plan | Idopathic sudden sensorineural hearing loss | | | | |
NCT02580630: Achilles Tendinopathy Treated With Training and Injections |
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| Completed | 4 | 100 | Europe | Reduction in running and jumping, Impact reduction, Training, Heavy slow resistance training, Ultrasound guided injection with Glucocorticosteroid, Glucocorticosteroid, Ultrasound guided injection with local anaestethic, local anaestethic | Bispebjerg Hospital, The Danish Rheumatism Association | Achilles Tendinopathy | 12/20 | 12/20 | | |
| Completed | 4 | 152 | US | Pegloticase, KRYSTEXXA®, methotrexate, MTX, placebo, folic acid, gout flare prophylaxis regimen, fexofenadine, acetaminophen, methylprednisolone | Amgen | Gout | 03/21 | 04/22 | | |
NCT01941589: Corticosteroids+5-aminosalicylic Acid Compared to Corticosteroids in the Treatment of Moderate-severe Ulcerative Colitis |
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| Completed | 4 | 149 | Europe, RoW | oral 5-ASA+/-topical 5-ASA+IV corticosteroids / PO Methylprednisolone, rafassal, pentasa, asacol, hydrocortisone, solu-cortef, methylprednisolone, corticosteroids only | Sheba Medical Center | Ulcerative Colitis | 04/21 | 04/21 | | |
| Unknown status | 4 | 60 | US | Tacrolimus Extended Release Oral Tablet [Envarsus], Envarsus XR, Mycophenolate Mofetil, Cellcept, MMF, Mycophenolic Acid Oral Product, Myfortic, MPA, Tacrolimus, Prograf, FK506, Methylprednisolone, Prednisone, Deltasone, Rabbit Anti-Human T-Lymphocyte Globulin Injectable Solution [Thymoglobulin], Thymoglobulin, rATG | Simon Tremblay, PharmD, PhD, Veloxis Pharmaceuticals | Kidney Transplantation, Immunosuppression | 07/21 | 06/22 | | |
2021-004737-37: The effect of corticosteroids on early recovery after major surgery in elderly patients_CORTERAS STUDY |
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| Not yet recruiting | 4 | 674 | Europe | Concentrate and solvent for solution for injection/infusion, Solu-medrol | Ziekenhuis Oost-Limburg, Ziekenhuis Oost-Limburg | major surgery• off-pump coronary bypass surgery• on-pump coronary bypass surgery• Aortic Valve Replacement Mini Access Surgery• laparoscopic hemicolectomies• thoracoscopic lung resections• femoral popliteal and tibial bypass surgery• laparoscopic radical prostatectomies, major surgery (cardial, abdominal, vascular surgery), Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
| Completed | 4 | 92 | US | Dexamethasone | Johns Hopkins All Children's Hospital | Asthma Childhood | 12/21 | 05/22 | | |
NCT01838174: A Trial of Neuroprotection With ACTH in Acute Optic Neuritis |
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| Terminated | 4 | 37 | US | ACTHAR Gel (ACTH), ACTH, IV methylprednisolone (steroids), methylprednisolone | University of Colorado, Denver, Mallinckrodt, University of Pennsylvania | Multiple Sclerosis | 01/22 | 01/22 | | |
| Completed | 4 | 1 | US | Methylprednisolone Injectable Product, Prednisone, Doxycycline Injection, Doxy | Vanderbilt University Medical Center, Orthopedic Research and Education Foundation | Adhesive Capsulitis, Adhesive Capsulitis of Unspecified Shoulder, Frozen Shoulder | 02/22 | 02/22 | | |
NCT04622917: Methylprednisolone Injections Treating Birch Pollen Induced Allergic Rhinitis. |
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| Completed | 4 | 44 | Europe | MethylPREDNISolone 40 Mg/mL Injectable Suspension, Depo-Medrol, NaCl 9 MG/ML Injectable Solution, Sodium Chloride | Karolinska Institutet | Rhinitis, Allergic, Seasonal, Hay Fever, Pollen Allergy, Allergic Rhinitis | 06/22 | 05/23 | | |
| Terminated | 4 | 89 | US | Low Dose Corticosteroids, prednisone, methylprednisolone, Solumedrol, High Dose Corticosteroids | Rutgers, The State University of New Jersey | COPD | 03/20 | 03/20 | | |
ChiCTR2000037658: A randomized controlled, open-label, phase II study aimed to evaluate the efficacy and safety of topical or systemic glucocorticoid therapy for grade 2 immune-related pneumonitis |
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| Recruiting | 4 | 40 | | Inhalation budesonide 2mg 3 times per day ;intravenous methylprednisolone 1~2mg/kg | Shanghai Pulmonary Hospital; Shanghai Pulmonary Hospital, Shanghai Shenkang Hospital Development Center | Lung Cancer | | | | |
NCT06041451: Early and Late Prognosis in Patients With Guillain-Barre Syndrome |
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| Recruiting | 4 | 450 | RoW | Intravenous Immunoglobulins, Human, Methylprednisolone 500 MG Injection | First Affiliated Hospital of Wenzhou Medical University | Guillain-Barre Syndrome | 12/22 | 01/25 | | |
NCT05824390: A Randomized, Controlled Clinical Study of Rituximab in Treatment of Primary IgA Nephropathy |
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| Active, not recruiting | 4 | 116 | RoW | rituximab group, ACEi and / or ARB | XIEJINGYUAN, Dongfang Hospital Affiliated to Tongji University, Shanghai Pudong New Area People's Hospital, Ruijin Hospital North Shanghai Jiao Tong University School of Medicine, Ningbo Municipal Yinzhou District No.2 Hospital, Third Affiliated Hospital, Sun Yat-Sen University, Xiamen Hongai Hospital, Sir Run Run Shaw Hospital | IgA Nephropathy | 10/23 | 10/23 | | |
NCT05604859: Evaluate the Efficacy and Safety of Various Treatment Schemes for Severe Fever With Thrombocytopenia Syndrome(SFTS) |
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| Recruiting | 4 | 350 | RoW | Methylprednisolone, intravenous immunoglobulin, Tocilizumab, Low molecular weight heparin, conventional treatment | Qin Ning | Severe Fever With Thrombocytopenia Syndrome | 12/23 | 06/24 | | |
| Recruiting | 4 | 200 | RoW | GlucoCorticoid, Rituximab, Cyclophosphamide | Wang Mo | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, ANCA-Associated Glomerulonephritis | 12/23 | 12/25 | | |
NCT05329740: Glucocorticoids for Post-operative Patients With Acute Type A Aortic Dissection (The GLAD Trial) |
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| Completed | 4 | 212 | RoW | Methylprednisolone Injection | Shanghai Zhongshan Hospital | Methylprednisolone, Glucocorticoid, Aortic Dissection, Organ Dysfunction | 11/23 | 11/23 | | |
GLUCO-TAVR, NCT06076824: Glucocorticoid Treatment in Transaortic Valve Replacement to Reduce the Incidence of Conduction Disturbances (). |
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| Recruiting | 4 | 100 | Europe | Methylprednisolone, Placebo, Saline solution | Hospital General Universitario de Alicante | Heart Block, Aortic Stenosis, Bundle-Branch Block | 09/24 | 09/24 | | |
