methylprednisolone sodium succinate / Generic mfg.  >>  Phase 2
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37 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
methylprednisolone sodium succinate / Generic mfg.
NCT02462252: Phase IIA Open Label Study to Evaluate Efficacy and Safety of BL-8040 Followed by (hATG), Cyclosporine and Methyprednisolone in Adult Subjects With Aplastic Anemia or Hypoplastic Myelodysplastic Syndrome

Completed
2a
11
US
BL-8040, horse anti-thymocyte globulin (hATG), ATGAM, Methylprednisolone, Medrol, Solu-Medrol, Depo-Medrol, Cyclosporine, Sandimmune, Cyclosporine A
BioLineRx, Ltd.
Aplastic Anemia, Hypoplastic Myelodysplastic Syndrome
11/20
11/20
NCT04046549: A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant

Completed
2a
25
US
Belatacept, VIB4920, Thymoglobulin, Methylprednisolone
Viela Bio (acquired by Horizon Therapeutics)
Allografts, Rejection; Transplant, Kidney, Transplant Rejection, Kidney Transplantation
07/22
03/23
NCT00136903: Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute Graft Versus Host Disease (GVHD)

Completed
2
32
US
Prochymal® - 2 Million cells/kg, Remestemcel-L, ex-vivo cultured adult human mesenchymal stem cells, hMSCs, Prochymal®- 8 Million cells/kg, Methylprednisolone, Prednisone, Cyclosporine, Tacrolimus, Mycophenolate Mofetil
Mesoblast, Inc.
Graft Vs Host Disease
07/06
07/08
SIERRA, NCT00282308: A Study to Evaluate the Effects of Rituximab on Immune Responses in Subjects With Active Rheumatoid Arthritis Receiving Background Methotrexate

Completed
2
103
US
Rituximab, Rituxan, MabThera, Methotrexate, Methylprednisone, C. albicans, Tetanus toxoid adsorbed booster vaccine, 23-valent pneumococcal polysaccharide vaccine, Keyhole limpet hemocyanin
Genentech, Inc.
Rheumatoid Arthritis
01/08
05/12
RUMBA, NCT00243412: A Study of the Safety and Efficacy of Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis Receiving Methotrexate

Completed
2
42
US
folate, methotrexate, methylprednisolone, Placebo, Rituximab
Genentech, Inc.
Rheumatoid Arthritis
02/09
02/09
NCT00298272: Safety and Tolerability of Rituxan With Methotrexate and Etanercept or Methotrexate and Adalimumab in Patients With Active Rheumatoid Arthritis

Terminated
2
54
US
IDEC-C2B8 (rituximab), Rituxan, Placebo, Methotrexate, Etanercept, Enbrel, Adalimumab, Humira, Methylprednisolone, Folate
Biogen, Hoffmann-La Roche, Genentech, Inc.
Rheumatoid Arthritis
04/09
07/11
NCT00423098 / 2006-002107-13: Efficacy and Safety of Enteric-coated Mycophenolate Sodium in Combination With Two Corticosteroid Regimens for the Treatment of Lupus Nephritis Flare

Completed
2
81
Europe, RoW
Mycophenolate sodium, Myfortic, Prednisone, Methylprednisolone
Novartis Pharmaceuticals
Lupus Nephritis
11/09
11/09
NCT00550342: Rituximab Treatment of Focal Segmental Glomerulosclerosis

Completed
2
10
US
rituximab, Rituxan
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Genentech, Inc., Indiana University
Focal Segmental Glomerulosclerosis (FSGS)
12/09
12/09
NCT01039103 / 2009-013884-21: Nanocort in Acute Exacerbation of Relapsing-Remitting Multiple Sclerosis (MS)

Terminated
2
15
Europe
PEG-liposomal prednisolone sodium phosphate, Nanocort, Methylprednisolone, Solu-Medrol
Galapagos NV
Acute Exacerbation of Remitting Relapsing Multiple Sclerosis, Clinically Isolated Syndrome
11/11
11/11
RESTORE, NCT01071083 / 2009-017490-38: Treatment Interruption of Natalizumab

Checkmark Interim Data AAN (MS)
Mar 2012 - Mar 2012: Interim Data AAN (MS)
Completed
2
175
US, Europe
natalizumab, interferon beta 1-a, methylprednisolone, IV placebo, glatiramer acetate
Biogen, Elan Pharmaceuticals
Relapsing Remitting Multiple Sclerosis
11/11
11/11
NCT00806598: Thymoglobulin and Cyclosporine in Patients With Aplastic Anemia or Myelodysplastic Syndrome

Completed
2
53
US
Thymoglobulin, ATG, Antithymocyte globulin, Cyclosporine, CYA, Sandimmune, Cyclosporine A, Methylprednisolone, Duralone®, Medralone®, Medrol®, M-Prednisol®, Solu-Medrol®, G-CSF, Neupogen®, Granulocyte - Colony Stimulating Factor
M.D. Anderson Cancer Center, Genzyme, a Sanofi Company
Myelodysplastic Syndrome, Aplastic Anemia
06/12
06/12
DARA-GEN501, NCT00574288 / 2007-003783-22: Daratumumab (HuMax®-CD38) Safety Study in Multiple Myeloma

Checkmark From GEN501 and SIRIUS trials for MM at ASH 2017 [screenshot]
Dec 2017 - Dec 2017: From GEN501 and SIRIUS trials for MM at ASH 2017 [screenshot]
Checkmark From SIRIUS and GEN501 trials in multiple myeloma at EHA 2016
Jul 2016 - Jul 2016: From SIRIUS and GEN501 trials in multiple myeloma at EHA 2016
Checkmark MM
More
Completed
2
104
US, Europe
Part 1: Daratumumab, HuMax-CD38, Part 2: Daratumumab, Methylprednisolone, Dexamethasone
Janssen Research & Development, LLC
Multiple Myeloma
01/15
04/17
2015-002127-26: Comparison between treatment with belimumab and methylprednisolone in Graves’hyperthyroidism (GD) and active orbitopathy (GO). Confronto tra terapia dell’ipertiroidismo di Graves’ (GD) ed orbitopatia basedowiana (GO) attiva con belimumab vs metilprednisolone

Ongoing
2
40
Europe
BENLYSTA, SOLU MEDROL, L04AA26, D07AA01, Powder and solvent for solution for injection, BENLYSTA - 120 MG - POLVERE PER CONCENTRATO PER SOLUZIONE PER INFUSIONE - USO ENDOVENOSO - FLACONCINO (VETRO) 120 MG 1 FLACONCINO, SOLU MEDROL - 500 MG/8 ML POLVERE E SOLVENTE PER SOLUZIONE INIETTABILE 1 FLACONE DI POLVERE DA 500 MG+ FIALA SOLVENTE DA 8 ML
FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO, Glaxo Smith&Kline GSK International
GRAVES' ORBITOPATHY ORBITOPATIA BASEDOWIANA, GRAVES' ORBITOPATHY ORBITOPATIA BASEDOWIANA, Diseases [C] - Hormonal diseases [C19]
 
 
NCT02763761: An Investigational Study of Infliximab With Prednisone or Methylprednisolone Versus Prednisone Combination Treatment in Immune Related or Severe Diarrhea in Patients Treated With Yervoy and/or Opdivo

Withdrawn
2
0
US
Infliximab + Prednisone, Methylprednisolone + Prednisone
Bristol-Myers Squibb
Renal Cell Carcinoma, Melanoma, Lung Cancer
03/17
03/17
NCT00565773: Belatacept Post Depletional Repopulation to Facilitate Tolerance

Completed
2
40
US
Belatacept, LEA29Y, Nulojix, Sirolimus, Rapamycin, Alemtuzumab, Campath, Lemtrada
Allan D Kirk, MD, PhD, Bristol-Myers Squibb, Duke University
Organ Transplantation
07/17
07/17
REACH1, NCT02953678: A Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease (REACH-1)

Checkmark REACH1 trial in steroid refractory acute GVHD
Dec 2018 - Dec 2018: REACH1 trial in steroid refractory acute GVHD
Checkmark REACH 1 trial in steroid refractory acute GVHD [screenshot]
Jun 2018 - Jun 2018: REACH 1 trial in steroid refractory acute GVHD [screenshot]
Checkmark Data from REACH1 study
More
Completed
2
71
US
Ruxolitinib, Jakafi, INCB018424, Prednisone or methylprednisolone
Incyte Corporation
Graft-versus-host Disease (GVHD)
01/18
08/19
NCT02500550 / 2015-002821-20: Safety and Efficacy of Two Doses of ATIR101, a T-lymphocyte Enriched Leukocyte Preparation Depleted of Host Alloreactive T-cells, in Patients With a Hematologic Malignancy Who Received a Hematopoietic Stem Cell Transplantation From a Haploidentical Donor

Checkmark AIR-008 study for GVHD
Jan 2018 - Jan 2018: AIR-008 study for GVHD
Checkmark Safety data readout from CR-AIR-008 trial for GVHD in patients with hematologic malignancies post-HSCT
Dec 2016 - Dec 2016: Safety data readout from CR-AIR-008 trial for GVHD in patients with hematologic malignancies post-HSCT
Completed
2
15
Europe, Canada, RoW
ATIR101, Haploidentical hematopoietic stem cell transplantation (HSCT), TBI regime, Non-TBI regime
Kiadis Pharma
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome
07/18
12/18
INCREASE, NCT03387046: A Pilot Study in Participants With Relapsing Remitting Multiple Sclerosis (RR-MS)

Terminated
2
7
Europe
D-aspartate, Placebo, IFN beta-1a, Methylprednisolone
Merck KGaA, Darmstadt, Germany
Multiple Sclerosis, Relapsing-Remitting
01/19
01/19
NOBILITY, NCT02550652 / 2015-002022-39: A Study to Evaluate the Safety and Efficacy of Obinutuzumab Compared With Placebo in Participants With Lupus Nephritis (LN)

Checkmark Efficacy and safety data from NOBILITY trial for lupus nephritis
Nov 2020 - Nov 2020: Efficacy and safety data from NOBILITY trial for lupus nephritis
Checkmark Safety and efficacy data from trial for lupus nephritis at ASN/ACR 2019
Nov 2019 - Nov 2019: Safety and efficacy data from trial for lupus nephritis at ASN/ACR 2019
Checkmark Safety and efficacy data from NOBILITY trial in lupus nephritis
More
Completed
2
126
Europe, US, RoW
Mycophenolate Mofetil/Mycophenolic Acid, Obinutuzumab, Gazyva, GA101, RO5072759, Placebo, Methylprednisolone, Prednisone
Hoffmann-La Roche
Lupus Nephritis
01/19
08/23
2018-002790-22: Efficacy evaluation of tocilizumab in the treatment Graves' Orbitopathy Valutazione dell’efficacia di tocilizumab nel trattamento dell’orbitopatia basedowiana

Not yet recruiting
2
64
Europe
Roactemra, SOLU MEDROL, Tocilizumab, SOLU MEDROL, Concentrate for solution for infusion, Powder and solvent for solution for injection, ROACTEMRA - 20 MG/ML CONCENTRATO PER SOLUZIONE PER INFUSIONE - USO ENDOVENOSO - FLACONCINO (VETRO) 4ML 1 FLACONCINO, SOLU MEDROL - 500 MG/8 ML POLVERE E SOLVENTE PER SOLUZIONE INIETTABILE 1 FLACONE DI POLVERE DA 500 MG+ FIALA SOLVENTE DA 8 ML
FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO, Roche S.p.A.
Active moderate-severe Graves' Orbitopathy Orbitopatia basedowiana di grado moderato-severo in fase attiva, Garcves' Orbitopathy in the zacute inflammatory phase Oftalmopatia di Basedow in fase infiiammatoria acuta, Diseases [C] - Hormonal diseases [C19]
 
 
NCT02294357: Weekly 70 mg/m2 Carfilzomib for Multiple Myeloma Patients Refractory to 27 mg/m2 Carfilzomib

Terminated
2
45
US
Carfilzomib, Kyprolis, Dexamethasone, Decadron, Dexamethasone acetate, Prednisone, Deltasone, Cortan, Methylprednisolone, Medrol, Methylprednisolone acetate, Lenalidomide, Revlimid, Pomalidomide, Pomalyst
Oncotherapeutics, Amgen
Multiple Myeloma
09/20
09/20
NCT01319981: Hyper-CVAD With Liposomal Vincristine in Acute Lymphoblastic Leukemia

Completed
2
31
US
Rituximab, Rituxan, Imatinib, Imatinib Mesylate, Gleevec, ST1571, NSC-716051, Cyclophosphamide, Cytoxan, Neosar, Doxorubicin, Adriamycin, Rubex, Mesna, Mesnex, VSLI, Liposomal Vincristine, Vincristine Sulfate Liposomes Injection, Marqibo, Solu-Medrol, Methylprednisolone, Depo-Medrol, Medrol, Methotrexate, Ara-C, Cytarabine, Cytosar, DepoCyt, Cytosine Arabinosine Hydrochloride, G-CSF, Filgrastim, Neupogen, Pegfilgrastim, Neulasta, Dexamethasone, Decadron
M.D. Anderson Cancer Center, Spectrum Pharmaceuticals, Inc
Leukemia
11/20
11/20
NCT02133924: Multicenter Study Of Natalizumab Plus Standard Steroid Treatment For High Risk Acute Graft-Versus-Host Disease

Checkmark Data from trial for acute GVHD
Sep 2020 - Sep 2020: Data from trial for acute GVHD
Completed
2
76
US
natalizumab, Tysabri, steroids, Prednisone, methylprednisolone equivalent IV
John Levine, Biogen
Acute Graft Versus Host Disease
12/20
11/21
NCT02495077: Effects of Inhibiting Early Inflammation in Kidney Transplant Patients

Completed
2
290
Canada, US
Infliximab, Remicade®, Methylprednisolone, Solu-Medrol, Mycophenolate Mofetil, MMF, CellCept®, Tacrolimus, FK-506, FR-900506, Prograf®, Thymoglobulin®, Antithymocyte Globulin [Rabbit], Rabbit ATG, Acetaminophen, Tylenol®, Loratadine, Claritin®, Placebo for Infliximab, Prednisone, Diphenhydramine, Benadryl
National Institute of Allergy and Infectious Diseases (NIAID), Clinical Trials in Organ Transplantation, Rho Federal Systems Division, Inc.
Kidney Transplant
07/21
07/21
2021-000641-41: Sirolimus vs Corticosteroids in Treatment of Thyroid Eye Disease

Not yet recruiting
2
70
Europe
Powder and solvent for solution for injection, Tablet, Solu-Medrol, Rapamune
Helse Bergen HF, Haukeland University Hospital, HelseVest
Thyroid Eye Disease (TED) in patients with Graves' Diease., Thyroid Eye Disease (TED) in patients with Graves' Diease., Diseases [C] - Eye Diseases [C11]
 
 
NCT03388008: Belatacept Pilot Study in Lung Transplantation Immunosuppression in Lung Transplantation

Completed
2
27
US
Belatacept, Nulojix, Tacrolimus, Prograf, ATG, Thymoglobulin, Mycophenolate Mofetil, Cellcept, Myfortic, Methylprednisolone, Solumedrol, Prednisone
Washington University School of Medicine, National Heart, Lung, and Blood Institute (NHLBI), Bristol-Myers Squibb
Lung Transplant Rejection, Antibody-mediated Rejection
08/22
08/22
NCT04903054: Selective CD28 Blockade in Renal Transplant Recipients

Withdrawn
2
54
US
Lulizumab, BMS-931699, anti-CD28 domain antibody (anti-CD28 dAb), Tacrolimus, Prograf®, Thymoglobulin®, antithymocyte globulin, Methylprednisolone, corticosteroid, Mycophenolate Mofetil, MMF, CellCept®, Prednisone
National Institute of Allergy and Infectious Diseases (NIAID), Bristol-Myers Squibb, PPD
Kidney Transplantation, Renal Transplant Recipients
09/22
09/22
NCT03292861: The Effect and Safety Profile of Thymoglobulin® in Primary Cardiac Transplant Recipients

Enrolling by invitation
2
60
US
Thymoglobulin, Mycophenolate Mofetil, Tacrolimus, Sirolimus, Corticosteroids
Cedars-Sinai Medical Center, Genzyme, a Sanofi Company
Heart Transplantation
10/24
10/25
NCT03913559: Inotuzumab Ozogamicin for Children With MRD Positive CD22+ Lymphoblastic Leukemia

Recruiting
2
32
US
Inotuzumab ozogamicin, Besponsa, CMC-544, Methotrexate, Trexall®, Hydrocortisone, Cortisol, Cytarabine, Ara-C, Diphenhydramine, Benadryl, Acetaminophen, Tylenol, Methylprednisolone, Solu-Medrol
St. Jude Children's Research Hospital, Pfizer
Acute Lymphoblastic Leukemia
12/24
01/25
NCT05643638: A Study of CYP-001 in Combination With Corticosteroids in Adults With High-risk aGvHD

Recruiting
2
60
US, RoW
CYP-001: Cymerus induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (MSCs), Placebo, Corticosteroids
Cynata Therapeutics Limited
Graft Versus Host Disease, Acute
04/25
12/26
POSTERITY, NCT05039619 / 2021-000097-29: A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants

Recruiting
2
40
Europe, Canada, US, RoW
Obinutuzumab, Gazyva, Placebo, Mycophenolate Mofetil, Acetaminophen/paracetamol, Diphenhydramine hydrochloride (HCl), Methylprednisolone, Prednisone
Hoffmann-La Roche, Genentech, Inc.
Lupus Nephritis
03/26
03/29
NCT04918147: Elotuzumab in Immunoglobulin G4-Related Disease (IgG4-RD)

Terminated
2
8
US
elotuzumab, BMS-901608, Empliciti®, placebo for elotuzumab, normal saline, methylprednisolone, Solu-Medrol®, diphenhydramine, Benadryl®, acetaminophen, Tylenol®, famotidine, H2 blocker, prednisone, corticosteroid
National Institute of Allergy and Infectious Diseases (NIAID), Autoimmunity Centers of Excellence, Bristol-Myers Squibb, Rho Federal Systems Division, Inc.
IgG4 Related Disease, IgG4-RD
01/24
01/24
NCT01154387: Evaluating Safety and Efficacy of TOL101 Induction Versus Anti-Thymocyte Globulin to Prevent Kidney Transplant Rejection

Unknown status
1/2
85
US
Anti-Thymocyte Globulin, Thymoglobulin, TOL101, Steroids, Tacrolimus, Mycophenolate mofetil (MMF)
Tolera Therapeutics, Inc
End Stage Renal Disease, Renal Transplant
06/13
06/13
NCT03721965 / 2018-002253-30: Safety and Efficacy of Itacitinib in Combination With Corticosteroids for Treatment of Graft-Versus-Host Disease in Pediatric Subjects

Terminated
1/2
2
Europe, US
Itacitinib, INCB039110, Corticosteroids, prednisone, methylprednisolone
Incyte Corporation
Acute Graft-versus-host Disease
02/20
02/20
NCT02464657: Study of Idarubicin, Cytarabine, and Nivolumab in Patients With High-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Completed
1/2
44
US
Nivolumab, BMS-936558, Opdivo, Idarubicin, Idamycin, Cytarabine, Ara-C, Cytosar, DepoCyt, Cytosine Arabinosine Hydrochloride, Solu-medrol, Methylprednisolone, Depo-Medrol, Medrol, Dexamethasone, Decadron
M.D. Anderson Cancer Center, Bristol-Myers Squibb
Leukemia, Acute Myeloid Leukemia, Myelodysplastic Syndrome
05/20
05/20
NCT04066114: Treg Modulation With CD28 and IL-6 Receptor Antagonists

Completed
1/2
10
US
lulizumab pegol, BMS-931699, antithymocyte globulin (rabbit), ATG (rabbit), Thymoglobulin®, methylprednisolone, Solu-Medrol ®, tocilizumab, Actemra®, Prednisone, prednisone tablets, Rayos®, everolimus, Zortress®, belatacept, Nulojix®, mycophenolate mofetil, MMF, CellCept®, mycophenolic acid, Myfortic®
National Institute of Allergy and Infectious Diseases (NIAID), Bristol-Myers Squibb, Clinical Trials in Organ Transplantation
Living-Donor Kidney Transplant, Kidney Transplant Recipients
09/23
09/23
NCT03952637: A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis

Recruiting
1/2
45
US
AAV9-GLB1, Abdominal ultrasound, Rituximab, Sirolimus, Methylprednisolone, Prednisone, Audiology assessment with ABR, Bone density scan (DEXA), Electrocardiogram (EKG), Echocardiogram, Electroencephalogram (EEG) awake and extended overnight, Laboratory tests, Lumbar puncture, Brain MRI/MRS/fMRI, Neurocognitive testing, Neurology exam, PICC or other Central line placement, Skeletal survey, Skin biopsy, Speech and modified barium swallow study, Ophthalmology exam
National Human Genome Research Institute (NHGRI), Sio Gene Therapies
Lysosomal Diseases, Gangliosidosis, GM1
01/28
01/28

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