| carbidopa/levodopa / Generic mfg. |
NCT00590122: Parcopa Versus Carbidopa-levodopa in a Single Dose Cross-over Comparison Study |
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| Completed | 4 | 20 | US | Parcopa, carbidopa-levodopa (Sinemet) | Baylor College of Medicine, UCB Pharma | Parkinson's Disease | 10/08 | 11/08 | | |
2009-017416-33: Standardized clinical trial on the application of Levodopa (LD) / Carbidopa (CD) to patients with Parkinson disease vs LD / CD and Entacapon (EN) vs LD / CD and Tolcapon (TO) concerning the parameters motor function, pharmacokinetics of LD, plasma level of homocystein and serum level of cortisol. |
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| Completed | 4 | 24 | Europe | Tolcapon, Entacapon, Levodopa/Carbidopa, TO, EN, LD/CD, Coated tablet, Tasmar, Comtess, Isicom | Clinical research lab for neurodegeneration, Dept. of Neurology, St. Josef-Hospital, Ruhr-University | Male and female patients with Parkinson´s disease meeting UKPDS criteria | | | | |
| Completed | 4 | 150 | RoW | Levodopa/Carbidopa(200mg/50mg), Dopaminergic Agonists | Sandoz | Impulse Control Disorder | 12/14 | 12/14 | | |
2008-006278-13: Motor function optimization in advanced Parkinson’s disease patients, combined with galantamine to prevent visual hallucinations. |
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| Ongoing | 4 | 10 | Europe | Reminyl Retard, Sinemet 125 mg, Reminyl Retard, Sinemet 125 mg | UMCG | patients with advanced (>5 years) Parkinson\'s disease and visual hallucinations. | | | | |
2010-019897-33: Brain activation by addition of L-Dopa to normal antipsychotic treatment in patients with schizophrenia |
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| Ongoing | 4 | 50 | Europe | Sinemet, Sinemet, Sinemet | erasmus mc, Erasmus MC | patients with psychotic symptoms, diagnosed with schizophrenia | | | | |
2013-004229-10: Placebo effect in Parkinson\'s disease El efecto placebo en la enfermedad de Parkinson |
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| Ongoing | 4 | 60 | Europe | Sinemet 25/250, Sinemet 25/250 | Raul de la Fuente-Fernandez, Complejo Hospitalario Universitario de Ferrol (CHUF) | Parkinson\'s disease Enfermedad de Parkinson | | | | |
| Completed | 4 | 39 | Europe | placebo, control group, citalopram, citalopram group, sinemet plus, sinemet group | Hospital de Granollers | Stroke | 03/17 | 10/19 | | |
NCT02513485: Inflammation-related Alterations in Neurocircuitry: Reversal With Levodopa |
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| Completed | 4 | 57 | US | Levodopa+carbidopa, Sinemet, Placebo | Emory University, National Institute of Mental Health (NIMH) | Depression | 02/20 | 08/20 | | |
ChiCTR2000039201: Pharmacology of levodopa/carbidopa versus levodopa/benserazide in patients with parkinson's disease |
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| Recruiting | 4 | 20 | | phase I: levodopa/carbidopa; phase II: levodopa/benserazide ;phase I: levodopa/benserazide; phase II: levodopa/carbidopa | The Affiliated Brain Hospital of Nanjing Medical University (Nanjing Brain Hospital); Brain Hospital of Nanjing Medical University, self-raised | Parkinson's disease | | | | |
2020-002754-24: Clinical study in early PD patients to investigate the effect of Opicapone 50mg or Levodopa 100 mg in the treatment of motor fluctuations. Estudio clínico en pacientes con EP temprana para investigar el efecto de Opicapone 50 mg o Levodopa 100 mg en el tratamiento de las fluctuaciones motoras. |
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| Ongoing | 4 | 100 | Europe | Capsule, hard, Tablet, Ongentys 50 mg hard capsules, Madopar 125 mg T, tablets, SINEMET 100 mg + 25 mg tablets | Bial - Portela & Ca, S.A., Bial - Portela & Ca, S.A. | Parkinson's Disease (PD) Enfermedad de Parkinson (EP), Parkinson's Disease (PD) Enfermedad de Parkinson (EP), Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT03761030: L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older Adults |
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| Terminated | 4 | 51 | US | L-DOPA, carbidopa/levodopa (Sinemet), Placebo Oral Tablet, Placebo | New York State Psychiatric Institute, National Institute of Mental Health (NIMH) | Major Depressive Disorder, Dysthymia, Depression | 09/21 | 09/21 | | |
| Terminated | 4 | 5 | US | Carbidopa/levodopa, L-DOPA, Sinemet, Placebo, Placebo tablet | New York State Psychiatric Institute, National Institute of Mental Health (NIMH), Vanderbilt University Medical Center, Columbia University, Emory University | Depression, Cognitive Impairment, Gait Impairment | 10/21 | 10/21 | | |
NCT04650217: Levodopa and Exercise for Older Adults With Depression and Psychomotor Slowing |
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| Terminated | 4 | 1 | US | Carbidopa/levodopa, sinemet, Placebo, Placebo tablet, Exercise training, lifestyle counseling, psychotherapy, Control | New York State Psychiatric Institute, National Institute of Mental Health (NIMH), Columbia University | Depressive Disorder | 12/21 | 12/21 | | |
| Completed | 4 | 20 | US | Carbidopa Levodopa, Sinemet, L-DOPA, Placebo, Placebo tablet | Emory University, National Institute of Mental Health (NIMH) | Depression, Anhedonia | 10/23 | 10/23 | | |
| Recruiting | 4 | 70 | US | Carbidopa Levodopa, Sinemet, L-DOPA, Placebo, Placebo tablet | Emory University, National Institute of Mental Health (NIMH) | Anhedonia, Depression | 01/27 | 01/27 | | |
| Recruiting | 4 | 30 | US | Neurostimulation, Carbidopa 25/Levodopa 100Mg Tab | David Escobar, The Cleveland Clinic | Parkinson Disease | 06/28 | 06/28 | | |
