| carbidopa/levodopa / Generic mfg. |
2008-006278-13: Motor function optimization in advanced Parkinson’s disease patients, combined with galantamine to prevent visual hallucinations. |
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| Ongoing | 4 | 10 | Europe | Reminyl Retard, Sinemet 125 mg, Reminyl Retard, Sinemet 125 mg | UMCG | patients with advanced (>5 years) Parkinson\'s disease and visual hallucinations. | | | | |
2010-019897-33: Brain activation by addition of L-Dopa to normal antipsychotic treatment in patients with schizophrenia |
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| Ongoing | 4 | 50 | Europe | Sinemet, Sinemet, Sinemet | erasmus mc, Erasmus MC | patients with psychotic symptoms, diagnosed with schizophrenia | | | | |
2013-004229-10: Placebo effect in Parkinson\'s disease El efecto placebo en la enfermedad de Parkinson |
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| Ongoing | 4 | 60 | Europe | Sinemet 25/250, Sinemet 25/250 | Raul de la Fuente-Fernandez, Complejo Hospitalario Universitario de Ferrol (CHUF) | Parkinson\'s disease Enfermedad de Parkinson | | | | |
ChiCTR2000039201: Pharmacology of levodopa/carbidopa versus levodopa/benserazide in patients with parkinson's disease |
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| Recruiting | 4 | 20 | | phase I: levodopa/carbidopa; phase II: levodopa/benserazide ;phase I: levodopa/benserazide; phase II: levodopa/carbidopa | The Affiliated Brain Hospital of Nanjing Medical University (Nanjing Brain Hospital); Brain Hospital of Nanjing Medical University, self-raised | Parkinson's disease | | | | |
2020-002754-24: Clinical study in early PD patients to investigate the effect of Opicapone 50mg or Levodopa 100 mg in the treatment of motor fluctuations. Estudio clínico en pacientes con EP temprana para investigar el efecto de Opicapone 50 mg o Levodopa 100 mg en el tratamiento de las fluctuaciones motoras. |
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| Ongoing | 4 | 100 | Europe | Capsule, hard, Tablet, Ongentys 50 mg hard capsules, Madopar 125 mg T, tablets, SINEMET 100 mg + 25 mg tablets | Bial - Portela & Ca, S.A., Bial - Portela & Ca, S.A. | Parkinson's Disease (PD) Enfermedad de Parkinson (EP), Parkinson's Disease (PD) Enfermedad de Parkinson (EP), Diseases [C] - Nervous System Diseases [C10] | | | | |
| Completed | 4 | 20 | US | Carbidopa Levodopa, Sinemet, L-DOPA, Placebo, Placebo tablet | Emory University, National Institute of Mental Health (NIMH) | Depression, Anhedonia | 10/23 | 10/23 | | |
| Recruiting | 4 | 70 | US | Carbidopa Levodopa, Sinemet, L-DOPA, Placebo, Placebo tablet | Emory University, National Institute of Mental Health (NIMH) | Anhedonia, Depression | 01/27 | 01/27 | | |
| Recruiting | 4 | 30 | US | Neurostimulation, Carbidopa 25/Levodopa 100Mg Tab | David Escobar, The Cleveland Clinic | Parkinson Disease | 06/28 | 06/28 | | |
| Recruiting | 2/3 | 60 | RoW | levodopa-carbidopa, Montelukast | Mostafa Bahaa | Parkinson Disease | 11/24 | 12/25 | | |
| Ongoing | 2 | 20 | Europe | SINEMET, RVG 08740, Tablet, SINEMET 125 | Centre for Human Drug Research, CHDR | Parkinson's Disease, Parkinson's Disease, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT05781711: Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease |
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| Recruiting | 2 | 60 | RoW | levodopa-carbidopa, Metformin | Tanta University, Eman Ibrahim Elberri, Faculty of Pharmacy, Tanta University, Fedaa Abd El-monem Kamal El-deen Kotkata Faculty of Pharmacy, Tanta University, Manal Ali Mahrous Hamouda Faculty of Pharmacy, Menufia University | Parkinson Disease | 09/24 | 11/25 | | |
NCT04469959: Dopaminergic Dysfunction in Late-Life Depression |
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| Recruiting | 2 | 100 | US | L-Dopa, carbidopa/levodopa (Sinemet), 25/100 placebo capsules, Placebo | Vanderbilt University Medical Center, Emory University, University of Pittsburgh, University of Pittsburgh Medical Center, Rutgers University | Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa, Gait Impairment | 04/25 | 06/26 | | |
| Recruiting | 2 | 50 | RoW | carbidopa-levodopa, Pentoxifylline 400 MG | Mostafa Bahaa, Sahar Mohamed El-Haggar clinical pharmacy department, Tanta University, Sahar Kamal Hegazi clinical pharmacy department, Tanta University, Mohanad Omar Khrieba Clinical Pharmacy Department, Faculty of Pharmacy - Horus University | Parkinson Disease | 07/27 | 10/28 | | |
NCT05083260: NE3107 Activity and Safety in Patients With Parkinson's Disease Using Levodopa |
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| Completed | 1/2 | 46 | US | NE3107, placebo | BioVie Inc. | Parkinson Disease | 11/22 | 01/23 | | |
RES, NCT06219915: Neurobiological Drivers of Mobility Resilience: The Dopaminergic System - Placebo-Controlled Arm |
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| Completed | 1/2 | 13 | US | Carbidopa 25 mg, Carbidopa-Levodopa 25/100 mg, Sinemet, Placebo 1, Placebo 2 | University of Michigan, National Institute on Aging (NIA) | Parkinsonian Signs in Older Persons | 05/24 | 05/24 | | |
STIMO-PHARMA, NCT04052776: Acute Effects of Pharmacological Neuromodulation on Leg Motor Activity in Patients With SCI Treated With EES |
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| Completed | 1 | 3 | Europe | Buspirone, Levodopa-Carbidopa, Buspirone + Levodopa-Carbidopa, Placebo oral tablet | Centre Hospitalier Universitaire Vaudois, Ecole Polytechnique Fédérale de Lausanne | Spinal Cord Injuries, Drug Effect | 10/23 | 10/23 | | |
NCT05471609: Sustained Release Oral Formulation for Treatment of Parkinson's Disease |
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| Suspended | 1 | 6 | US | levodopa/carbidopa oral formulation A, levodopa/carbidopa oral formulation B, levodopa/carbidopa oral formulation C | University of Minnesota | Idiopathic Parkinson Disease | 06/25 | 06/25 | | |
NCT00624741: Compassionate Use Study of Pergolide in Patients With Parkinson's Disease |
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| No Longer Available | N/A | | US | Pergolide, Permax | Bausch Health Americas, Inc. | Parkinson Disease | | | | |
| Not yet recruiting | N/A | 30 | NA | Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, L-DOPA, l-3,4-dihydroxyphenylalanine, Sinemet, Citalopram, Celexa | Western University, Canada | Parkinson Disease, Depression | 01/22 | 01/22 | | |
SmIle, NCT06003608: Observational Small Intestine and Blood Fingerprint () Study in Parkinson's Disease |
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| Recruiting | N/A | 100 | Canada | Fluid biopsy capsule, Levodopa-Carbidopa Immediate Release | Nimble Science Ltd., MRM Health N.V. | Parkinson Disease | 08/24 | 09/24 | | |
| Recruiting | N/A | 120 | US | Anti-Parkinson medication, Carbidopa/levodopa, pramipexole, ropinirole, amantadine, tolcapone, entacapone, Deep Brain Stimulation | Beth Israel Deaconess Medical Center | Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Degeneration, Gait, Frontal, Huntington Disease | 06/25 | 06/25 | | |
| Recruiting | N/A | 40 | US | carbidopa/levodopa, as prescribed by treating physician, Parcopa, Sinemet | University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS) | Parkinson Disease | 02/25 | 02/25 | | |
