| Xpovio (selinexor) / Karyopharm |
NCT03042819: Study of Selinexor and Doxorubicin in Advanced Soft Tissue Sarcomas |
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| Completed | 1b | 25 | Canada | Selinexor, Doxorubicin | University Health Network, Toronto, Karyopharm Therapeutics Inc | Soft Tissue Sarcoma | 11/19 | 06/21 | | |
NCT01896505: A Phase I Trial to Assess the Effects of Food and Formulation on PK of KPT-330 in Patients With Sarcoma |
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| Completed | 1 | 54 | Canada, US | KCP-330, Selinexor | Karyopharm Therapeutics Inc | Sarcoma | 10/16 | 10/16 | | |
NCT03880123: Selinexor in Combination With Ixazomib for the Treatment of Advanced Sarcoma |
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| Withdrawn | 1 | 0 | US | Selinexor, KPT-330, Ixazomib, Ninlaro | Matthew Ingham, Karyopharm Therapeutics Inc, Takeda | Liposarcoma, Malignant Peripheral Nerve Sheath Tumors, Alveolar Soft Part Sarcoma, Ewing Sarcoma, Sarcoma | 11/20 | 11/20 | | |
| Recruiting | 1 | 14 | Europe | Selinexor, Gemcitabine | Grupo Espanol de Investigacion en Sarcomas | Sarcoma,Soft Tissue | 11/25 | 05/26 | | |
NCT04811196: A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients |
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| Active, not recruiting | 1 | 56 | Canada | Selinexor, KPT-330, XPOVIO | University Health Network, Toronto | Soft Tissue Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST), Leiomyosarcoma, Endometrial Stromal Sarcoma | 02/25 | 02/25 | | |
NCT04216329: Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma |
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| Active, not recruiting | 1 | 6 | US | Selinexor, Temozolomide, Generic Radiation therapy (RT) | National Cancer Institute (NCI) | Gliosarcoma, Newly Diagnosed, Glioblastoma | 09/23 | 07/26 | | |
NCT05952687: Trial of Idasanutlin and Selinexor Therapy for Children With Progressive/Relapsed AT/RT or Extra-CNS Malignant Rhabdoid Tumors |
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| Withdrawn | 1 | 52 | NA | Idasanutlin, RO5503781, Selinexor, KPT-330 | St. Jude Children's Research Hospital | Rhabdoid Tumor, Atypical Teratoid/Rhabdoid Tumor, Atypical Teratoid/Rhabdoid Tumor of CNS, CNS Tumor | 09/25 | 08/32 | | |
