Sarcoma  >>  Phase 1
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287 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Sarcoma
KEYNOTE-505, NCT03126591: A Study of Olaratumab (LY3012207) Plus Pembrolizumab in Participants With Advanced or Metastatic Soft Tissue Sarcoma

Completed
1a/1b
38
Europe, US
Olaratumab, LY3012207, Pembrolizumab, MK3475
Eli Lilly and Company, Merck Sharp & Dohme LLC
Soft Tissue Sarcoma
05/21
02/23
TQB2858-Ib-02, CTR20220390: Single-arm, open-label, multi-center phase Ib clinical trial of TQB2858 injection for the treatment of advanced high-grade sarcoma

Active, not recruiting
1b
100
China
TQB2858 - Sino Biopharm
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd
Advanced high-grade sarcoma
 
 
TQB2450-Ib-02, CTR20190938: TQB2450 clinical study in combination with anlotinib in the treatment of soft tissue sarcoma

Ongoing
1b
30
China
benmelstobart (APL-502) - Apollomics, Focus V (anlotinib) - Advenchen, Sino Biopharm
Nanjing Shunxin Pharmaceutical Co., Ltd./ Chia Tai Tianqing Pharmaceutical Group Co., Ltd
Advanced soft tissue sarcoma
 
 
NCT02959164: Decitabine and Gemcitabine for Pancreatic Cancer and Sarcoma

Completed
1b
36
US
Decitabine, Dacogen, Gemcitabine, Gemzar
Mohammed Milhem, Holden Comprehensive Cancer Center, University of Iowa
Pancreatic Ductal Adenocarcinoma, Sarcoma
09/19
10/20
NCT03009201: Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery

Completed
1b
16
US
Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, hydroxydaunorubicin, Rubex, Laboratory Biomarker Analysis, Pharmacological Study, Ribociclib, Kisqali, LEE-011, LEE011
OHSU Knight Cancer Institute, Novartis Pharmaceuticals, Oregon Health and Science University
Advanced Soft Tissue Sarcoma, Locally Advanced Angiosarcoma, Locally Advanced Leiomyosarcoma, Locally Advanced Liposarcoma, Locally Advanced Malignant Peripheral Nerve Sheath Tumor, Locally Advanced Myxofibrosarcoma, Locally Advanced Undifferentiated Pleomorphic Sarcoma, Metastatic Angiosarcoma, Metastatic Epithelioid Sarcoma, Metastatic Fibrosarcoma, Metastatic Liposarcoma, Metastatic Malignant Peripheral Nerve Sheath Tumor, Metastatic Myxofibrosarcoma, Metastatic Soft Tissue Sarcoma, Metastatic Synovial Sarcoma, Metastatic Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma, Pleomorphic Rhabdomyosarcoma, Stage III Soft Tissue Sarcoma AJCC v7, Stage IV Soft Tissue Sarcoma AJCC v7, Undifferentiated (Embryonal) Sarcoma, Unresectable Leiomyosarcoma, Unresectable Liposarcoma, Unresectable Malignant Peripheral Nerve Sheath Tumor, Unresectable Soft Tissue Sarcoma, Unresectable Synovial Sarcoma, Unresectable Undifferentiated Pleomorphic Sarcoma
10/19
06/23
OV2-RRST-101, NCT05361954: Study to Assess the Safety and Preliminary Efficacy of STI-1386 Oncolytic Virus in Relapsed or Refractory Solid Tumors

Not yet recruiting
1b
36
NA
STI-1386, Seprehvec
Sorrento Therapeutics, Inc.
Cancer, Cancer of Pancreas, Sarcoma, Hepatic Metastasis, Solid Tumor
10/26
02/27
ChiCTR-PRCH-08000182: Early diagnosis of children tumour and screening and optimal the key markers of molecular staging of the tumour

Completed
1
60
 
Negative express of molecular marker ;Positive express of molecular marker
Pediatrics Collage, Chongqing Medical University; Chongqing Science and Technique Committee, Chongqing Science and Technique Committee
Children tumours include osteosarcoma, nerve blastoma, medulloblastoma
 
 
NCT00436735: Nelfinavir in Treating Patients With Metastatic, Refractory, or Recurrent Solid Tumors

Active, not recruiting
1
45
US
midazolam hydrochloride, nelfinavir mesylate, gene expression analysis, polymerase chain reaction, protein expression analysis, immunoenzyme technique, immunologic technique, laboratory biomarker analysis, mass spectrometry
National Cancer Institute (NCI)
Colorectal Cancer, Gastrointestinal Carcinoid Tumor, Head and Neck Cancer, Islet Cell Tumor, Lung Cancer, Metastatic Cancer, Neuroendocrine Carcinoma of the Skin, Ovarian Cancer, Pheochromocytoma, Sarcoma, Unspecified Adult Solid Tumor, Protocol Specific
 
 
ChiCTR-TRC-12002166: The comparison between CO2 injection and air injection in the endoscopic submucosal enucleation of gastrointestinal stromal tumors.

Completed
1
60
 
CO2 insufflation ;AIR insufflation
Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine; Xinhua Hospital, scientic fund of department
gastrointestinal stromal tumor
 
 
NCT00638898: Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor

Active, not recruiting
1
25
US
busulfan, BSF, BU, Misulfan, Mitosan, Myeloleukon, Myelosan, melphalan, Alkeran, CB-3025, L-PAM, L-phenylalanine mustard, L-Sarcolysin, Melfalan, topotecan hydrochloride, hycamptamine, Hycamtin, SKF S-104864-A, TOPO, laboratory biomarker analysis, filgrastim, G-CSF, granulocyte colony-stimulating factor, Neupogen, r-metHuG-CSF, Recombinant Methionyl Human Granulocyte Colony Stimulating Factor, autologous hematopoietic stem cell transplantation, pharmacological study, pharmacological studies, autologous bone marrow transplantation, ABMT, bone marrow transplantation, autologous, transplantation, autologous bone marrow
City of Hope Medical Center
Solid Tumor, Adult Central Nervous System Germ Cell Tumor, Adult Rhabdomyosarcoma, Childhood Central Nervous System Germ Cell Tumor, Childhood Soft Tissue Sarcoma, Ewing Sarcoma, Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Ovarian Mixed Germ Cell Tumor, Previously Untreated Childhood Rhabdomyosarcoma, Recurrent Adult Brain Tumor, Recurrent Adult Soft Tissue Sarcoma, Recurrent Childhood Brain Stem Glioma, Recurrent Childhood Cerebellar Astrocytoma, Recurrent Childhood Cerebral Astrocytoma, Recurrent Childhood Ependymoma, Recurrent Childhood Malignant Germ Cell Tumor, Recurrent Childhood Medulloblastoma, Recurrent Childhood Pineoblastoma, Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor, Recurrent Childhood Visual Pathway and Hypothalamic Glioma, Recurrent Childhood Visual Pathway Glioma, Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Recurrent Extragonadal Germ Cell Tumor, Recurrent Extragonadal Non-seminomatous Germ Cell Tumor, Recurrent Malignant Testicular Germ Cell Tumor, Recurrent Neuroblastoma, Recurrent Ovarian Germ Cell Tumor, Recurrent Wilms Tumor and Other Childhood Kidney Tumors, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
01/13
12/24
NCT01165632: Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma

Active, not recruiting
1
24
US
biopsy, biopsies, computed tomography, tomography, computed, therapeutic conventional surgery, radiation therapy treatment planning/simulation, radiation therapy, irradiation, radiotherapy, therapy, radiation, magnetic resonance imaging, MRI, NMR imaging, NMRI, nuclear magnetic resonance imaging, positron emission tomography, FDG-PET, PET, PET scan, tomography, emission computed, fluorine F 18 fluorodopa, (18)F-FDOPA, 18F-6- L-fluorodopa, 18F-DOPA, 18F-FDOPA
Mayo Clinic, National Cancer Institute (NCI)
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma, Adult Diffuse Astrocytoma, Adult Ependymoma, Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Adult Mixed Glioma, Adult Myxopapillary Ependymoma, Adult Oligodendroglioma, Adult Pilocytic Astrocytoma, Adult Pineal Gland Astrocytoma, Adult Subependymal Giant Cell Astrocytoma, Adult Subependymoma
11/13
12/24
NCT01586078: Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Patients With Brain Tumors

Recruiting
1
100
US
pioglitazone hydrochloride, Actos, pioglitazone, laboratory biomarker analysis, external beam radiation therapy, EBRT, 3-dimensional conformal radiation therapy, 3D-CRT, conformal radiation therapy, intensity-modulated radiation therapy, IMRT, management of therapy complications, complications of therapy, management of
Comprehensive Cancer Center of Wake Forest University, National Cancer Institute (NCI)
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Meningioma, Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma, Adult Choroid Plexus Tumor, Adult Craniopharyngioma, Adult Diffuse Astrocytoma, Adult Ependymoblastoma, Adult Ependymoma, Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Adult Grade I Meningioma, Adult Grade II Meningioma, Adult Medulloblastoma, Adult Meningeal Hemangiopericytoma, Adult Mixed Glioma, Adult Myxopapillary Ependymoma, Adult Oligodendroglioma, Adult Papillary Meningioma, Adult Pilocytic Astrocytoma, Adult Pineal Gland Astrocytoma, Adult Pineoblastoma, Adult Pineocytoma, Adult Subependymal Giant Cell Astrocytoma, Adult Subependymoma, Adult Supratentorial Primitive Neuroectodermal Tumor (PNET), Meningeal Melanocytoma, Nonmalignant Neoplasm, Recurrent Adult Brain Tumor, Tumors Metastatic to Brain
09/14
 
2011-003433-33: A Single Dose Study to Assess the Biocomparison of MK-8669 in Subjects

 
1
21
NA
ridaforolimus, MK-8669,
Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
Sarcoma
 
 
NCT01746238: Bevacizumab/Doxorubicin/Radiation for Sarcoma

Active, not recruiting
1
14
US
Bevacizumab, Avastin, Doxorubicin, Adriamycin, Radiation Therapy, XRT
Massachusetts General Hospital
Sarcoma
05/16
01/25
NCT02369185: Safety Study of BLZ-100 in Adult Subjects With Sarcoma Undergoing Surgery

Not yet recruiting
1
21
US
BLZ-100, Tumor Paint
Blaze Bioscience Inc., National Cancer Institute (NCI)
Sarcoma, Soft Tissue
06/16
09/16
NCT01957956: Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Completed
1
21
US
Laboratory Biomarker Analysis, Malignant Glioma Tumor Lysate-Pulsed Autologous Dendritic Cell Vaccine, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
Mayo Clinic, National Cancer Institute (NCI)
Giant Cell Glioblastoma, Glioblastoma, Gliosarcoma
11/16
11/16
ChiCTR-IIR-16009460: Bioequivalence test of Sunitinib Malate Capsules in Chinese healthy subjects

Recruiting
1
48
 
Sunitinib Malate Capsules produced by CSPC Ouyi Pharmaceutical Co., Ltd ;Sunitinib Malate Capsules produced by Pfizer Italia S.r.l.
The first hospital of Jilin university; Level of the institution：, CSPC Ouyi Pharmaceutical Co., Ltd
Gastrointestinal Stromal Tumors、renal cell carcinoma
 
 
NCT02432963: Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

Active, not recruiting
1
11
US
Laboratory Biomarker Analysis, Modified Vaccinia Virus Ankara Vaccine Expressing p53, MVA-p53 Vaccine, MVAp53 Vaccine, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475
City of Hope Medical Center, National Cancer Institute (NCI)
Adult Solid Neoplasm, Bladder Carcinoma, Colon Carcinoma, Estrogen Receptor Negative, Head and Neck Squamous Cell Carcinoma, Hepatocellular Carcinoma, HER2/Neu Negative, Melanoma, Non-Small Cell Lung Carcinoma, Pancreatic Carcinoma, Progesterone Receptor Negative, Rectal Carcinoma, Renal Cell Carcinoma, Soft Tissue Sarcoma, Triple-Negative Breast Carcinoma, TP53 Gene Mutation, Unresectable Solid Neoplasm
12/17
12/24
ChiCTR-TRC-08000171: Multicenter study on standardization of extensive resection in limb salvage management for osteosarcoma

Completed
1
800
 
The important vessel arround the knee joints will be separated by perform inner vagina vasorum exclusion, vagina vasorum and osteosarcoma will be resected as whole. ;The important vessel arround the knee joints will be separated by perform external vagina vasorum exclusion, vagina vasorum will be reserved, only osteosarcoma will be resected as whole.
Sun Yat-Sen University; Level of the institution：, Sun Yat-Sen University Clinical Research 5010 Program
osteosarcoma
 
 
NCT02444546: Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors

Completed
1
6
US
Laboratory Biomarker Analysis, Sargramostim, 23-L-Leucinecolony-Stimulating Factor 2, DRG-0012, Leukine, Prokine, rhu GM-CFS, Sagramostim, Sargramostatin, Wild-type Reovirus, Reolysin
Mayo Clinic, National Cancer Institute (NCI)
Childhood Astrocytoma, Childhood Atypical Teratoid/Rhabdoid Tumor, Diffuse Intrinsic Pontine Glioma, Glioma, Recurrent Childhood Anaplastic Oligodendroglioma, Recurrent Childhood Brain Neoplasm, Recurrent Childhood Glioblastoma, Recurrent Childhood Medulloblastoma, Recurrent Primitive Neuroectodermal Tumor, Refractory Brain Neoplasm
07/18
11/22
NCT02484391: CPI-613, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Granulocytic Sarcoma

Completed
1
49
US
6,8-Bis(benzylthio)octanoic Acid, Alpha-Lipoic Acid Analogue CPI-613, CPI 613, CPI-613, Cytarabine, .beta.-Cytosine arabinoside, 1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone, 1-.beta.-D-Arabinofuranosylcytosine, 1.beta.-D-Arabinofuranosylcytosine, 2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-, Alexan, Ara-C, ARA-cell, Arabine, Arabinofuranosylcytosine, Arabinosylcytosine, Aracytidine, Aracytin, Aracytine, Beta-Cytosine Arabinoside, CHX-3311, Cytarabinum, Cytarbel, Cytosar, Cytosar-U, Cytosine Arabinoside, Cytosine-.beta.-arabinoside, Erpalfa, Starasid, Tarabine PFS, U 19920, U-19920, Udicil, WR-28453, Hematopoietic Cell Transplantation, HCT, Hematopoietic Stem Cell Transplantation, HSCT, stem cell transplantation, Mitoxantrone Hydrochloride, CL 232315, DHAD, DHAQ, Dihydroxyanthracenedione Dihydrochloride, Mitoxantrone Dihydrochloride, Mitoxantroni Hydrochloridum, Mitozantrone Hydrochloride, Mitroxone, Neotalem, Novantrone, Onkotrone, Pralifan
Wake Forest University Health Sciences, National Cancer Institute (NCI)
Granulocytic Sarcoma, Recurrent Adult Acute Myeloid Leukemia
10/18
02/22
NCT00268385: Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Active, not recruiting
1
83
US
Laboratory Biomarker Analysis, Pharmacological Study, Temozolomide, CCRG-81045, Gliotem, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temizole, Temodal, Temodar, Temomedac, TMZ, Vorinostat, L-001079038, MSK-390, SAHA, Suberanilohydroxamic Acid, Suberoylanilide Hydroxamic Acid, Zolinza
National Cancer Institute (NCI)
Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Adult Mixed Glioma, Recurrent Adult Brain Neoplasm
10/18
04/25
NCT01638533: Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver Dysfunction

Active, not recruiting
1
37
Canada, US
Pharmacological Study, Romidepsin, Antibiotic FR 901228, Depsipeptide, FK228, FR901228, Istodax, N-[(3S,4E)-3-Hydroxy-7-mercapto-1-oxo-4-heptenyl]-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoyl-L-valine, (4->1) Lactone, Cyclic
National Cancer Institute (NCI), Celgene Corporation
Glioma, Hematopoietic and Lymphoid Cell Neoplasm, Lymphoma, Metastatic Malignant Solid Neoplasm, Neuroendocrine Neoplasm, Recurrent Adult Soft Tissue Sarcoma, Recurrent Bladder Carcinoma, Recurrent Breast Carcinoma, Recurrent Chronic Lymphocytic Leukemia, Recurrent Colorectal Carcinoma, Recurrent Head and Neck Carcinoma, Recurrent Lung Carcinoma, Recurrent Malignant Solid Neoplasm, Recurrent Melanoma, Recurrent Pancreatic Carcinoma, Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma, Recurrent Prostate Carcinoma, Recurrent Renal Cell Carcinoma, Recurrent Thyroid Gland Carcinoma, Refractory Chronic Lymphocytic Leukemia, Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma, Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma, Stage III Breast Cancer AJCC v7, Stage III Colorectal Cancer AJCC v7, Stage III Cutaneous Melanoma AJCC v7, Stage III Lung Cancer AJCC v7, Stage III Pancreatic Cancer AJCC v6 and v7, Stage III Prostate Cancer AJCC v7, Stage III Renal Cell Cancer AJCC v7, Stage III Soft Tissue Sarcoma AJCC v7, Stage IIIA Breast Cancer AJCC v7, Stage IIIA Colorectal Cancer AJCC v7, Stage IIIA Cutaneous Melanoma AJCC v7, Stage IIIB Breast Cancer AJCC v7, Stage IIIB Colorectal Cancer AJCC v7, Stage IIIB Cutaneous Melanoma AJCC v7, Stage IIIC Breast Cancer AJCC v7, Stage IIIC Colorectal Cancer AJCC v7, Stage IIIC Cutaneous Melanoma AJCC v7, Stage IV Breast Cancer AJCC v6 and v7, Stage IV Colorectal Cancer AJCC v7, Stage IV Cutaneous Melanoma AJCC v6 and v7, Stage IV Lung Cancer AJCC v7, Stage IV Pancreatic Cancer AJCC v6 and v7, Stage IV Prostate Cancer AJCC v7, Stage IV Renal Cell Cancer AJCC v7, Stage IV Soft Tissue Sarcoma AJCC v7, Stage IVA Colorectal Cancer AJCC v7, Stage IVB Colorectal Cancer AJCC v7, Unresectable Solid Neoplasm
11/18
03/25
ChiCTR-OIC-17013872: To Evaluate the Efficacy of NY-ESO-1-specific T Cell Receptor (TCR) Affinity Enhancing Specific T Cell in bone and soft tissue sarcoma

Not yet recruiting
1
20
 
NY-ESO-1（TCR Affinity Enhancing Specific T cell Therapy）
Sun Yat-sen University Cancer Center; Sun Yat-sen University Cancer Center, Xiangxue Life Science Research Center Guangdong Xiangxue Precision Medical Technology Co., Ltd Guangzhou Xiangxue Pharmaceutical Co., Ltd
bone and soft tissue sarcoma
 
 
NCT05800106: A Bioequivalence Study of Sunitinib Malate Capsules.

Completed
1
24
RoW
Sunitinib malate capsules generic product, Sunitinib malate capsules reference product
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Gastrointestinal Stromal Tumors, Renal Cell Carcinoma, Pancreatic Neuroendocrine Tumor
01/19
01/19
ChiCTR1900021550: A phase I study for dose escalation of polyethylene glycol modified liposome adriamycin combined with cisplatin in the treatment of advanced osteosarcoma

Recruiting
1
21
 
Polyethylene glycol modified liposome doxorubicin combined with cisplatin
Sun Yat-sen University Cancer Center; Sun Yat-sen University Cancer Center, Shijiazhuang Pharmaceutical Group
osteosarcoma
 
 
NCT00089245 / 2020-001590-68: Radiolabeled MAB Therapy in Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer

Terminated
1
177
US
Iodine I 131 MOAB 8H9
Y-mAbs Therapeutics, Memorial Sloan Kettering Cancer Center
Brain and Central Nervous System Tumors, Neuroblastoma, Sarcoma
02/22
02/22
NCT01803152: Dendritic Cell Vaccine for Children and Adults With Sarcoma

Active, not recruiting
1
19
US
Dendritic Cells Vaccine, DC Vaccine, Lysate of Tumor, Lysate, Tumor Lysate, Gemcitabine, Gemzar, Imiquimod, Aldara, Leukapheresis, Pheresis
Macarena De La Fuente, MD
Sarcoma, Soft Tissue Sarcoma, Bone Sarcoma
09/19
07/24
VEGAS, NCT01953900: iC9-GD2-CAR-VZV-CTLs/Refractory or Metastatic GD2-positive Sarcoma and Neuroblastoma

Active, not recruiting
1
26
US
GD2 T cells, iC9-GD2-CAR-VZV-CTL, VZV vaccine, zostavax, Fludarabine, Fludara, Cyclophosphamide, Cytoxan
Baylor College of Medicine, National Cancer Institute (NCI), Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital Research Institute
Osteosarcoma, Neuroblastoma
10/19
10/34
NCT00902044: Her2 Chimeric Antigen Receptor Expressing T Cells in Advanced Sarcoma

Active, not recruiting
1
36
US
Autologous HER2-specific T cells, Fludarabine, Fludara, Cyclophosphamide, Cytoxan, Autologous CAR Positive T cells
Baylor College of Medicine, Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital Research Institute, Cancer Prevention Research Institute of Texas
Sarcoma
12/19
07/32
NCT02133183: Sapanisertib Before and After Surgery in Treating Patients With Recurrent Glioblastoma

Terminated
1
40
US
Laboratory Biomarker Analysis, Pharmacological Study, Sapanisertib, INK-128, INK128, MLN-0128, MLN0128, TAK-228, Therapeutic Conventional Surgery
National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma
01/20
10/23
CTR20192611: Phase I clinical study of TAEST16001 injection in patients with solid tumors

Completed
1
18
China
TAEST16001 - Guangzhou Xiangxue Pharma, Athenex
Guangdong Xiangxue Precision Medical Technology Co., Ltd.
Advanced malignant solid tumors, mainly soft tissue sarcomas
 
 
NCT01273168: Endoxifen in Adults With Hormone Receptor Positive Solid Tumors

Active, not recruiting
1
40
US
Z-Endoxifen
National Cancer Institute (NCI)
Hormone Receptor-Positive Breast, Gynecologic, Desmoid, Hormone Receptor-Positive Neoplasms
06/20
06/26
TRAMUNE, NCT03085225: Trabectedin Combined With Durvalumab in Patients With Advanced Pretreated Soft-tissue Sarcomas and Ovarian Carcinomas.

Checkmark From TRAMUNE trial in combination with trabectedin in locally advanced/unresectable soft-tissue sarcoma at ESMO 2020
Sep 2020 - Sep 2020: From TRAMUNE trial in combination with trabectedin in locally advanced/unresectable soft-tissue sarcoma at ESMO 2020
Completed
1
40
Europe
Combination of trabectedin with durvalumab
Institut Bergonié, AstraZeneca, PharmaMar
Ovarian Carcinoma, Soft Tissue Sarcoma
11/20
01/22
ChiCTR1900027033: Phase I dose escalation study of liposome doxorubicin combined with ifosfamide in the treatment of advanced soft tissue sarcoma

Recruiting
1
36
 
liposome doxorubicin combined with ifosfamide
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, CSPC Ouyi Pharmaceutical Co., Ltd.
soft tissue sarcoma
 
 
NCT01922076: Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

Completed
1
46
Canada, US
Adavosertib, AZD-1775, AZD1775, MK-1775, MK1775, Laboratory Biomarker Analysis, Pharmacological Study, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation
National Cancer Institute (NCI)
Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma, Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant, Glioblastoma, Gliosarcoma
12/20
09/22
ChiCTR1900028270: Phase I dose escalation research of liposomal doxorubicin combined with ifosfamide in the treatment of advanced soft tissue sarcoma

Not yet recruiting
1
18
 
Liposome adriamycin combined with ifosfamide
Union Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology; Union Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology, Shijiazhuang Pharmaceutical Group Co., Ltd.
sarcoma
 
 
OLATRASTS, NCT03985722: Olaratumab Plus Trabectedin in Advanced Soft-tissue Sarcoma Patients Soft-tissue Sarcoma Patients

Active, not recruiting
1
28
Europe
Olaratumab and Trabectedin, Lartruvo and Yondelis
Grupo Espanol de Investigacion en Sarcomas
Sarcoma, Soft Tissue
02/21
05/24
NCT02890758: Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803

Completed
1
14
US
Natural Killer (NK) Cells, ALT803, Cytokine
Brenda Cooper, MD
Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia, Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma, Hodgkin Lymphoma, Myeloproliferative Syndromes, Plasma Cell Myeloma, Colon Carcinoma, Adenocarcinoma of Rectum, Soft Tissue Sarcoma, Ewing's Sarcoma, Rhabdomyosarcoma
06/21
02/23
NCT03360708: Vaccine Therapy in Treating Patients With Recurrent Glioblastoma

Completed
1
20
US
Laboratory Biomarker Analysis, Malignant Glioma Tumor Lysate-Pulsed Autologous Dendritic Cell Vaccine
Mayo Clinic, National Cancer Institute (NCI)
Giant Cell Glioblastoma, Recurrent Glioblastoma, Recurrent Gliosarcoma
06/21
06/21
ChiCTR1800016649: Phase I+II clinical study protocol of recombinant human anti-PD-L1 monoclonal antibody (ZKAB001)

Not yet recruiting
1
21
 
Intravenous infusion ;Intravenous infusion ;Intravenous infusion
the Sixth People's Hospital; Zhaoke (Guang Zhou) Oncology Pharmaceutical Limited, Self-finacing
Osteosarcoma
 
 
OU-SCC-EXIST-001, NCT03206177: Paclitaxel/Carboplatin + Galunisertib for Patients With Carcinosarcoma of the Uterus or Ovary

Active, not recruiting
1
26
US
Galunisertib, Paclitaxel, Carboplatin
University of Oklahoma, Eli Lilly and Company
Carcinosarcoma, Ovarian
07/21
08/23
NCT02386826: INC280 Combined With Bevacizumab in Patients With Glioblastoma Multiforme

Completed
1
65
US
INC280, INCB28060, bevacizumab, Avastin
SCRI Development Innovations, LLC, Novartis
Glioblastoma Multiforme, Gliosarcoma, Colorectal Cancer, Renal Cell Carcinoma
07/21
08/23
NCT04316091: A Phase I Clinical Trial of Neoadjuvant Chemotherapy With/Without SPIONs/SMF for Patients With Osteosarcoma

Not yet recruiting
1
60
NA
neoadjuvant chemotherapy+SPIONs/SMF, neoadjuvant chemotherapy
Second Affiliated Hospital, School of Medicine, Zhejiang University, Leiden University Medical Center
Osteosarcoma
08/21
08/23
RADIOSARP, NCT02787642: A Study of Olaparib With Concomitant Radiotherapy in Locally Advanced/Unresectable Soft-tissue Sarcoma

Completed
1
41
Europe
Olaparib, Concomitant Radiotherapy
Institut Bergonié, National Cancer Institute, France
Soft-tissue Sarcoma
10/21
05/22
NCT02897375: Palbociclib With Cisplatin or Carboplatin in Advanced Solid Tumors

Completed
1
71
US
Carboplatin, Paraplatin, Cisplatin, CDDP, Cis-diamminedichloridoplatinum, Cisplatinum, Cismaplat, Neoplatin, Palbociclib, Ibrance, PD-0332991
Emory University, Pfizer, National Institutes of Health (NIH), National Cancer Institute (NCI)
Solid Neoplasm, Stage III Pancreatic Cancer, Stage IIIA Breast Cancer, Stage IIIA Non-Small Cell Lung Cancer, Stage IIIB Breast Cancer, Stage IIIB Non-Small Cell Lung Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer, Stage IV Non-Small Cell Lung Cancer, Stage IVA Pancreatic Cancer, Stage IVB Pancreatic Cancer, Sarcoma, Colorectal Cancer, Head and Neck Cancer, Cancer of Unknown Primary, Bladder Cancer, Ovarian Cancer
10/21
10/21
NCT02101905: Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

Active, not recruiting
1
29
US
Laboratory Biomarker Analysis, Lapatinib, GSK572016, GW 2016, GW2016, GW572016, Lapatinib Ditosylate, Tykerb, Pharmacological Study, Therapeutic Conventional Surgery
National Cancer Institute (NCI)
Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Oligodendroglioma, Gliosarcoma, Mixed Glioma, Recurrent Adult Brain Neoplasm, Recurrent Glioblastoma
10/21
10/24
ChiCTR1800018166: A clinical trial for CTC multi-antigen activated immune cells in the treatment of advanced osteosarcoma

Not yet recruiting
1
20
 
CTC multi-antigen activated immune cells
Shanghai 6th People's Hospital; Shanghai 6th People's Hospital, Shanghai Shen Kang Hospital Development Center
osteosarcoma
 
 
NCT02076906: MR-guided High Intensity Focused Ultrasound (HIFU) on Pediatric Solid Tumors

Active, not recruiting
1
14
US
Magnetic Resonance High Intensity Focused Ultrasound, MR-HIFU, HIFU, Philips Sonalleve
AeRang Kim
Relapsed Pediatric Solid Tumors, Refractory Pediatric Solid Tumors, Rhabdomyosarcoma, Ewing Sarcoma, Osteosarcoma, Neuroblastoma, Wilms Tumor, Hepatic Tumor, Germ Cell Tumor, Desmoid Tumor
12/21
11/24
NCT03043391: Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children

Completed
1
8
US
Polio/Rhinovirus Recombinant (PVSRIPO)
Istari Oncology, Inc., Solving Kids' Cancer, The Andrew McDonough B+ Foundation, Duke University
Malignant Glioma, Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma, Anaplastic Oligodendroglioma, Glioblastoma, Gliosarcoma, Atypical Teratoid/Rhabdoid Tumor of Brain, Medulloblastoma, Ependymoma, Pleomorphic Xanthoastrocytoma of Brain, Embryonal Tumor of Brain
03/22
03/22
2021-001488-25: A clinical trial to look at the safety and potential efficacy of FHD-609 in people with advanced synovial sarcoma Un ensayo clínico para estudiar la seguridad y la posible eficacia de FHD-609 en personas con sarcoma sinovial avanzado

Not yet recruiting
1
70
Europe
-, FHD-609, Lyophilisate for solution for infusion
Foghorn Therapeutics Inc., Foghorn Therapeutics Inc.
Advanced Synovial Sarcoma (SS) Sarcoma Sinovial (SS) Avanzado, Synovial Sarcoma (SS) Sarcoma Sinovial (SS), Diseases [C] - Cancer [C04]
 
 
2019-004310-33: A Phase I Trial of Memory T Cells Expressing an ANTI-NKG2D Chimeric Antigen Receptor in Children, Adolescents and Young Adults with Advanced Sarcoma Ensayo fase I de células T de memoria que expresan un receptor de antígeno quimérico ANTI-NKG2D en niños, adolescentes y adultos jóvenes con sarcoma avanzado

Not yet recruiting
1
18
Europe
CART45RA-NKG2D Cells, Suspension for injection
Dr. Antonio Pérez Martínez, Asociación Española Contra el Cancer
Advanced Sarcoma Sarcoma avanzado, Advanced Sarcoma Sarcoma avanzado, Diseases [C] - Immune System Diseases [C20]
 
 
NCT04318964: TAEST16001 in the Treatment of Soft Tissue Sarcoma

Active, not recruiting
1
12
RoW
TAEST16001 cells
Sun Yat-sen University, Guangdong Xiangxue Precision Medical Technology Co., Ltd.
Soft Tissue Sarcoma
04/22
05/24
NCT02658981: Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18)

Completed
1
63
US
Anti-LAG-3 Monoclonal Antibody BMS 986016, Anti-PD-1, BMS-936558, Nivolumab, Pharmacological Study, Laboratory Biomarker Analysis, Anti-CD137, urelumab
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI), Bristol-Myers Squibb
Glioblastoma, Gliosarcoma, Recurrent Brain Neoplasm
04/22
10/23
NCT04864821: Clinical Study of CD276 Targeted Autologous Chimeric Antigen Receptor T Cell Infusion in Patients With CD276 Positive Advanced Solid Tumor

Not yet recruiting
1
24
NA
Targeting CD276 CAR T cells
PersonGen BioTherapeutics (Suzhou) Co., Ltd., The First Affiliated Hospital of Zhengzhou University
Osteosarcoma, Neuroblastoma, Gastric Cancer, Lung Cancer
05/22
05/23
M032-HSV-1, NCT02062827: Genetically Engineered HSV-1 Phase 1 Study for the Treatment of Recurrent Malignant Glioma

Active, not recruiting
1
29
US
M032 (NSC 733972)
University of Alabama at Birmingham, National Cancer Institute (NCI)
Recurrent Glioblastoma Multiforme, Progressive Glioblastoma Multiforme, Anaplastic Astrocytoma or Gliosarcoma
09/22
09/24
NCT04900766: A Study of Mitoxantrone Hydrochloride Liposome Injection in Subjects With Advanced Bone and Soft Tissue Sarcoma

Terminated
1
31
RoW
Mitoxantrone Hydrochloride Liposome Injection
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Unresectable or Metastatic Bone and Soft Tissue Sarcoma
02/23
02/23
NCT06413095: PBI-MST-01 (NCT04541108) Substudy MSD-03: Intratumoral Microdosing of Pembrolizumab Alone and With MK-0482 or MK-4830 in HNSCC or STS

Completed
1
13
US
Pembrolizumab, Keytruda, MK-3475, MK-0482 + Pembrolizumab, MK-4830 + Pembrolizumab
Presage Biosciences, Merck Sharp & Dohme LLC
Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma
06/23
06/23
NCI-2018-00438, NCT03552471: Mirvetuximab Soravtansine and Rucaparib Camsylate in Treating Participants With Recurrent Endometrial, Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Active, not recruiting
1
25
US
Laboratory Biomarker Analysis, Mirvetuximab Soravtansine, IMGN853, M9346A-sulfo-SPDB-DM4, Pharmacokinetic Study, PHARMACOKINETIC, PK Study, Rucaparib Camsylate, 8-Fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic Acid Salt, C0-338, Rubraca, Rucaparib Phosphate
Ohio State University Comprehensive Cancer Center, ImmunoGen, Inc., Clovis Oncology, Inc.
BRCA1 Gene Mutation, BRCA2 Gene Mutation, Folate Receptor Alpha Positive, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma, Recurrent Uterine Corpus Carcinoma, Recurrent Uterine Serous Carcinoma, Recurrent Uterine Carcinosarcoma, Platinum Resistant Ovarian Cancer
06/22
12/23
NCT03960060: A Study of CCT301-59 CAR T Therapy in Adult Subjects With Recurrent or Refractory Solid Tumors

Active, not recruiting
1
18
RoW
CCT301-59
Shanghai PerHum Therapeutics Co., Ltd., Shanghai Zhongshan Hospital
Solid Tumor, Soft Tissue Sarcoma, Gastric Cancer, Pancreatic Cancer, Bladder Cancer
06/22
06/23
NCT01858168: Phase I Study of Olaparib and Temozolomide for Ewings Sarcoma or Rhabdoomyosarcoma

Active, not recruiting
1
93
US
Olaparib, AZD2281, Temozolomide, Temodal, SCH52365, Temodar, Irinotecan, Camptosar
Massachusetts General Hospital
Ewing Sarcoma, Rhabdomyosarcoma
11/24
12/24
NCT04714983: DNX-2440 for Resectable Colorectal Liver Metastasis

Suspended
1
30
US
DNX-2440
DNAtrix, Inc., H. Lee Moffitt Cancer Center and Research Institute
Liver Metastases, Liver Metastasis Colon Cancer, Colorectal Cancer, Breast Cancer, Gastric Cancer, Periampullary Cancer, Melanoma, Renal Cell Cancer, Sarcoma, Squamous Cell Carcinoma, Gastrointestinal Stromal Tumors
07/26
12/26
NCT04006769: Entacapone Combination With Imatinib for Treatment of GIST

Completed
1
5
RoW
Entacapone, Comtan, Comtess, Imatinib Mesylate, Gleevec
Xiangya Hospital of Central South University
Gastrointestinal Stromal Tumor, Malignant
08/22
08/22
NCT05001204: 68Ga-NOTA-RM26 PET/CT for the Detection of Gastrointestinal Stromal Tumor

Recruiting
1
30
RoW
68Ga-NOTA-RM26
Peking Union Medical College Hospital
Gastrointestinal Stromal Tumors
08/22
08/22
NCT03829436: TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Completed
1
38
US
Part 1 TPST-1120, Experimental, Part 2 TPST-1120 + nivolumab, Experimental + Opdivo, Part 3 TPST-1120, Part 4 TPST-1120 + nivolumab
Tempest Therapeutics
Hepatocellular Carcinoma, Metastatic Castration Resistant Prostate Cancer, Renal Cell Carcinoma, Non-small Cell Lung Cancer, Colorectal Cancer, Squamous Cell Carcinoma of Head and Neck, Triple-Negative Breast Cancer, Urothelial Carcinoma, Cholangiocarcinoma, GastroEsophageal Cancer, Pancreatic Cancer, Sarcoma
09/22
09/22
TQB2858-Ⅰ-05, CTR20213001: Phase I clinical trial to evaluate the tolerability and pharmacokinetics of TQB2858 injection in subjects with advanced malignant tumors

Terminated
1
163
China
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Alveolar soft tissue sarcoma
 
 
NCT03478462: Dose Escalation Study of CLR 131 in Children, Adolescents, and Young Adults With Relapsed or Refractory Malignant Tumors Including But Not Limited to Neuroblastoma, Rhabdomyosarcoma, Ewings Sarcoma, and Osteosarcoma

Active, not recruiting
1
30
Canada, US, RoW
CLR 131, I-131-CLR1404
Cellectar Biosciences, Inc.
Pediatric Solid Tumor, Pediatric Lymphoma, Pediatric Brain Tumor, DIPG, Neuroblastoma, Ewing Sarcoma, Rhabdomyosarcoma, Osteosarcoma
09/22
12/24
SJDAWN, NCT03434262: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Completed
1
68
US
Gemcitabine, Gemzar®, ribociclib, LEE011, LEE-011, KISQALI®, sonidegib, LDE225, LDE-225, ODOMZO®, trametinib, TMT212, TMT-212, MEKINIST(TM), filgrastim, G-CSF
St. Jude Children's Research Hospital, Novartis Pharmaceuticals
Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Ganglioglioma, Anaplastic Meningioma, Anaplastic Oligodendroglioma, Pleomorphic Xanthoastrocytoma, Anaplastic, Atypical Teratoid/Rhabdoid Tumor, Brain Cancer, Brain Tumor, Central Nervous System Neoplasms, Choroid Plexus Carcinoma, CNS Embryonal Tumor With Rhabdoid Features, Ganglioneuroblastoma of Central Nervous System, CNS Tumor, Embryonal Tumor of CNS, Ependymoma, Glioblastoma, Glioma, Glioma, Malignant, Medulloblastoma, Medulloblastoma; Unspecified Site, Medulloepithelioma, Neuroepithelial Tumor, Neoplasms, Neoplasms, Neuroepithelial, Papillary Tumor of the Pineal Region (High-grade Only), Pediatric Brain Tumor, Pineal Parenchymal Tumor of Intermediate Differentiation (High-grade Only), Pineoblastoma, Primitive Neuroectodermal Tumor, Recurrent Medulloblastoma, Refractory Brain Tumor, Neuroblastoma. CNS, Glioblastoma, IDH-mutant, Glioblastoma, IDH-wildtype, Medulloblastoma, Group 3, Medulloblastoma, Group 4, Glioma, High Grade, Neuroepithelial Tumor, High Grade, Medulloblastoma, SHH-activated and TP53 Mutant, Medulloblastoma, SHH-activated and TP53 Wildtype, Medulloblastoma, Chromosome 9q Loss, Medulloblastoma, Non-WNT Non-SHH, NOS, Medulloblastoma, Non-WNT/Non-SHH, Medulloblastoma, PTCH1 Mutation, Medulloblastoma, WNT-activated, Ependymoma, Recurrent, Glioma, Recurrent High Grade, Glioma, Recurrent Malignant, Embryonal Tumor, NOS, Glioma, Diffuse Midline, H3K27M-mutant, Embryonal Tumor With Multilayered Rosettes (ETMR), Ependymoma, NOS, WHO Grade III, Ependymoma, NOS, WHO Grade II, Medulloblastoma, G3/G4, Ependymoma, RELA Fusion Positive
09/22
05/24
NCT02536183: A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors

Terminated
1
2
US
Magnetic resonance high intensity focused ultrasound, MR-HIFU, Lyso-thermosensitive liposomal doxorubicin, LTLD; ThermoDox
AeRang Kim
Pediatric Cancer, Solid Tumors, Rhabdomyosarcoma, Ewing Sarcoma, Soft Tissue Sarcomas, Osteosarcoma, Neuroblastoma, Wilms Tumor, Hepatic Tumor, Germ Cell Tumors
10/22
10/22
NCT05061537: Study of PF-07263689 in Participants With Selected Advanced Solid Tumors

Terminated
1
13
US
PF-07263689, Sasanlimab
Pfizer
Renal Cell Cancer, Melanoma, Non-Small-Cell Lung Cancer, Hepatocellular Cancer, Bladder Cancer, Sarcoma, Head and Neck Cancer, Colorectal Cancer, Ovarian Cancer, Squamous Cell Carcinoma
10/22
10/22
NCT05943990: Study of GSK3845097 in Previously Treated Participants With Advanced Synovial Sarcoma and Myxoid/Round Cell Liposarcoma

Terminated
1
5
Europe, Canada, US, RoW
GSK3845097, Cyclophosphamide, Fludarabine
GlaxoSmithKline
Neoplasms
10/22
10/22
NCT04661852: Cabozantinib With Topotecan-Cyclophosphamide

Completed
1
12
US
Cabozantinib, COMETRIQ™, Topotecan, Hycamtin®, Cyclophosphamide, Neosar®, Cytoxan®, Myeloid growth factor, Filgrastim, Pegfilgrastim
Dana-Farber Cancer Institute
Relapsed Ewing Sarcoma, Refractory Ewing Sarcoma, Relapsed Osteosarcoma, Refractory Osteosarcoma
10/22
10/22
NCT01376505: Vaccine Therapy in Treating Patients With Metastatic Solid Tumors

Completed
1
65
US
HER-2 vaccine, Synthetic peptides of HER-2 comprising B cell epitopes with a Promiscuous T cell epitope of Measles Virus., Extension HER-2 vaccine trial at OBD
Robert Wesolowski
Malignant Solid Tumour, Breast Cancer, Malignant Tumor of Colon, GIST, Ovarian Cancer
11/22
11/22
NCT00102648: Lonafarnib and Temozolomide in Treating Patients With Glioblastoma Multiforme That Is Recurrent or Did Not Respond to Previous Treatment With Temozolomide

Active, not recruiting
1
35
US
Lonafarnib, 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide, Sarasar, SCH 66336, SCH-66336, SCH66336, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Malignant Supratentorial Neoplasm, Recurrent Glioblastoma, Recurrent Gliosarcoma
12/22
12/22
NCI-2018-00926, NCT03450122: Modified T Cells, Chemotherapy, and Aldesleukin With or Without LV305 and CMB305 in Treating Participants With Advanced or Recurrent Sarcoma

Checkmark Initiation of pivotal monotherapy trial
Mar 2018 - Mar 2018: Initiation of pivotal monotherapy trial
Completed
1
15
US
Aldesleukin, 125-L-Serine-2-133-interleukin 2, Proleukin, r-serHuIL-2, Recombinant Human IL-2, Recombinant Human Interleukin-2, Autologous NY-ESO-1-specific CD8-positive T Lymphocytes, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, Dendritic Cell-targeting Lentiviral Vector ID-LV305, DCvex-NY-ESO-1, ID-LV305
M.D. Anderson Cancer Center
HLA-A*0201 Positive Cells Present, NY-ESO-1 Positive Tumor Cells Present, Recurrent Myxoid Liposarcoma, Recurrent Synovial Sarcoma
12/22
12/22
NCT04659733: Phase I Clinical Trial of Anlotinib in Progressive, Recurrent, and Refractory Sarcoma in Children

Not yet recruiting
1
36
NA
Anlotinib hydrochloride
Yizhuo Zhang
Sarcoma
12/22
12/22
NCT02709226: Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Completed
1
17
US
Radiation
National Cancer Institute (NCI)
Astrocytoma, Grade IV, Giant Cell Glioblastoma, Glioblastoma Multiforme, Gliosarcoma
12/22
07/23
AMPLIFY-201, NCT04853017: A Study of ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors

Active, not recruiting
1
25
US
ELI-002 2P
Elicio Therapeutics
Minimal Residual Disease, KRAS G12D, KRAS G12R, NRAS G12D, NRAS G12R, Pancreatic Ductal Adenocarcinoma, Colorectal Cancer, Non-small Cell Lung Cancer, Ovarian Cancer, Cholangiocarcinoma, Bile Duct Cancer, Gallbladder Carcinoma
01/23
03/26
NCT05410483: A Dose-finding Trial of Hyperthermic Intraperitoneal Docetaxel

Recruiting
1
30
RoW
Docetaxel
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hyperthermic Intraperitoneal Chemotherapy
02/23
02/23
NCT04837677: A Study of PRT1419 in Patients With Advanced Solid Tumors

Completed
1
26
US
PRT1419
Prelude Therapeutics
Sarcoma, Melanoma, Lung Cancer, Breast Cancer, Esophageal Cancer, Cervical Cancer, Head and Neck Cancer
02/23
02/23
NCT03361436: Eribulin and Radiation Therapy in Treating Patients With Retroperitoneal Liposarcoma That Can Be Removed by Surgery

Active, not recruiting
1
15
US
Eribulin Mesylate, B1939 Mesylate, E7389, ER-086526, Halaven, Halichondrin B Analog, Intensity-Modulated Radiation Therapy, IMRT, Intensity Modulated RT, Intensity-Modulated Radiotherapy, Radiation, Intensity-Modulated Radiotherapy, Laboratory Biomarker Analysis, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Therapeutic Conventional Surgery
OHSU Knight Cancer Institute, Eisai Inc., Oregon Health and Science University
Liposarcoma, Malignant Abdominal Neoplasm, Malignant Retroperitoneal Neoplasm, Malignant Scrotal Neoplasm, Malignant Solid Neoplasm, Malignant Spermatic Cord Neoplasm
02/23
04/33
NCT02736565: Pbi-shRNA™ EWS/FLI1 Type 1 LPX in Subjects With Advanced Ewing's Sarcoma

Completed
1
7
US
pbi-shRNA™ EWS/FLI1 Type 1 Lipoplex, Lipoplex
Gradalis, Inc.
Ewing's Sarcoma, Ewing Family of Tumors, Ewing's Tumor Metastatic, Ewing's Sarcoma Metastatic, Ewing's Tumor Recurrent, Rare Diseases, Sarcoma
08/19
08/20
NCI-2018-00615, NCT03670069: Itacitinib in Treating Patients With Refractory Metastatic/Advanced Sarcomas

Terminated
1
27
US
Itacitinib, 1334298-90-6, 3-Azetidineacetonitrile, INCB039110, Laboratory Biomarker Analysis
Fred Hutchinson Cancer Center, Incyte Corporation
Metastatic Leiomyosarcoma, Metastatic Synovial Sarcoma, Metastatic Undifferentiated Pleomorphic Sarcoma, Advanced Myxoid Liposarcoma, Advanced Soft Tissue Sarcoma, Metastatic Myxoid Liposarcoma, Metastatic Round Cell Liposarcoma, Metastatic Soft Tissue Sarcoma, Refractory Leiomyosarcoma, Refractory Myxoid Liposarcoma, Refractory Round Cell Liposarcoma, Refractory Soft Tissue Sarcoma, Refractory Synovial Sarcoma, Refractory Undifferentiated Pleomorphic Sarcoma, Advanced Leiomyosarcoma, Advanced Synovial Sarcoma, Advanced Undifferentiated Pleomorphic Sarcoma, Metastatic Chondrosarcoma
03/23
05/24
NCT04802070 / 2017-002257-11: Study of Adoptive Immunotherapy in Relapsed and Non-resectable Sarcomas After Multimodal Treatment.

Completed
1
7
Europe
Autologous CIK
Prof. Franca Fagioli
Sarcoma
03/23
03/23
NCT04537715: Study to Describe the Interaction Between Tazemetostat and Itraconazole and Between Tazemetostat and Rifampin in Participants With Advanced Cancer

Completed
1
42
Europe, US
Tazemetostat, EPZ-6438, Tazverik, Itraconazole, Sporanox, Rifampin, RIF, Rifampicin, Rifadin, Rimactane
Epizyme, Inc.
All Malignancies, Advanced Malignancies, Hematologic Malignancy, Solid Tumor, Follicular Lymphoma (FL), Non-Hodgkin Lymphoma (NHL), Diffuse Large B-Cell Lymphoma (DLBCL), Epithelioid Sarcoma (ES), Synovial Sarcoma, Renal Medullary Carcinoma, Mesothelioma, Rhabdoid Tumor
04/23
04/23
GEN-602-CT-101, NCT03775525: Study Evaluating GZ17-6.02 in Patients With Advanced Solid Tumors or in Combination With Capecitabine in Metastatic Hormone Receptor Positive Breast Cancer

Active, not recruiting
1
127
US
GZ17-6.02, Capecitabine, Xeloda
Genzada Pharmaceuticals USA, Inc., Translational Drug Development
Advanced Cancer, Gastric Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer Metastatic, Colo-rectal Cancer, Solid Tumor, Solid Carcinoma, Solid Carcinoma of Stomach, Cancer of Stomach, Lymphoma, Sarcoma, Cutaneous T Cell Lymphoma, Head and Neck Squamous Cell Carcinoma, Basal Cell Carcinoma, Cutaneous T-cell Lymphoma, Cutaneous Squamous Cell Carcinoma
05/23
12/23
NCT05100628: A Study of NOX66 Plus Doxorubicin in Anthracycline-naïve, Adult Patients With Soft Tissue Sarcoma

Terminated
1
10
US
NOX66, Doxorubicin
Noxopharm Limited
Metastatic Soft-tissue Sarcoma
05/23
05/23
NCT02962167: Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT

Completed
1
34
US
Modified Measles Virus, MV-NIS, Modified Measles Virus Lumbar Puncture, MV-NIS LP
Sabine Mueller, MD, PhD, No More Kids With Cancer, The Matthew Larson Foundation for Pediatric Brain Tumors, Vyriad, Inc., Mayo Clinic
Medulloblastoma, Childhood, Recurrent, Atypical Teratoid/Rhabdoid Tumor, Medulloblastoma Recurrent
05/23
05/23
NCT04052334: Lymphodepletion Plus Adoptive Cell Therapy With High Dose IL-2 in Adolescent and Young Adult Patients With Soft Tissue Sarcoma

Completed
1
9
US
TIL, Tumor-infiltrating lymphocytes, Interleukin-2, IL-2, Fludarabine, Fludara, Cyclophosphamide, Cytoxan, Neosar
H. Lee Moffitt Cancer Center and Research Institute, Iovance Biotherapeutics, Inc., The V Foundation for Cancer Research, National Cancer Institute (NCI)
Sarcoma
05/23
05/24
NCT06048705: Study of GSK3901961 In Previously Treated Advanced (Metastatic OR Unresectable) Synovial Sarcoma/ Myxoid/Round Cell Liposarcoma, and Previously Treated Metastatic Non-Small Cell Lung Cancer

Terminated
1
7
Europe, Canada, US, RoW
GSK3901961, Cyclophosphamide, Fludarabine
GlaxoSmithKline
Neoplasms
06/23
06/23
ALS-6000-101, NCT04969835: A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours

Recruiting
1
80
Europe, US
AVA6000
Avacta Life Sciences Ltd
Pancreatic Cancer, Colorectal Cancer, Non-small Cell Lung Cancer, Head and Neck Cancer, Cancer of Unknown Primary Site, Ovarian Cancer, Breast Cancer, Soft Tissue Sarcoma, Bladder Cancer, Oesophageal Cancer, Prostate Cancer, Biliary Tract Cancer
05/23
06/23
NCT05043649: Camsirubicin + Pegfilgrastim to Determine MTD in ASTS

Terminated
1
14
US
Camsirubicin
Monopar Therapeutics
Advanced Soft-tissue Sarcoma
10/23
05/24
NCT06114173: Efficacy and Safety Study of Cardunilizumab in Soft Tissue Sarcoma

Active, not recruiting
1
15
RoW
Cardunilizumab, PD-1/CTLA-4 Bispecific Antibody
Xiangya Hospital of Central South University
Sarcoma, Soft Tissue
06/23
11/24
NCT06171282: A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Bone and Soft Tissue Tumors

Recruiting
1
9
RoW
Recombinant oncolytic herpes simplex virus type Ⅰ (R130), Oncolytic virus Injection
Shanghai Yunying Medical Technology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Osteosarcoma, Sarcoma, Soft Tissue Sarcoma, Bone Tumor
07/25
07/26
NCT04521686: Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations

Active, not recruiting
1
200
Europe, Japan, US, RoW
LY3410738, Gemcitabine, LY188011, Cisplatin, Durvalumab
Eli Lilly and Company, Loxo Oncology, Inc.
Cholangiocarcinoma, Chondrosarcoma, Glioma, Any Solid Tumor
07/23
05/25
NCT04556669: Anti-PD-L1 Armored Anti-CD22 CAR-T/CAR-TILs Targeting Patients With Solid Tumors

Recruiting
1
30
RoW
Autologous aPD-L1 armored anti-CD22 CAR T cells
Hebei Senlang Biotechnology Inc., Ltd.
Solid Tumor, Adult, Cervical Cancer, Sarcoma, NSCLC
08/23
08/25
NCT02869217: Study of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid Tumors

Checkmark From P1 trial at ESMO 2019 [screenshot]
Sep 2019 - Sep 2019: From P1 trial at ESMO 2019 [screenshot]
Checkmark Data presentation from P1 trial in solid tumors
Jun 2019 - Jun 2019: Data presentation from P1 trial in solid tumors
Hourglass Nov 2016 - Mar 2017 : Initiation of trial in synovial sarcoma
Active, not recruiting
1
22
Canada
Cyclophosphamide, TBI-1301, Fludarabine
University Health Network, Toronto, Takara Bio Inc.
NY-ESO-1 Expressing Solid Tumors in HLA-A2 Positive Patients, Synovial Sarcoma, Melanoma, Esophageal Cancer, Ovarian Cancer, Lung Cancer, Bladder Cancer, Liver Cancer
09/24
09/24
SALA-002-EW16, NCT03600649: Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related Sarcomas

Active, not recruiting
1
50
US
Seclidemstat, LSD1 Inhibitor, SP-2577, Cyclophosphamide, Topotecan
Salarius Pharmaceuticals, LLC, National Pediatric Cancer Foundation
Ewing Sarcoma, Myxoid Liposarcoma, Sarcoma,Soft Tissue, Desmoplastic Small Round Cell Tumor, Extraskeletal Myxoid Chondrosarcoma, Angiomatoid Fibrous Histiocytoma, Clear Cell Sarcoma, Primary Pulmonary Myxoid Sarcoma, Myoepithelial Tumor, Sclerosing Epithelioid Fibrosarcoma, Fibromyxoid Tumor
09/25
12/25
NCT01430351: Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy

Active, not recruiting
1
144
US
Mefloquine, Memantine Hydrochloride, Ebixia, Namenda, Metformin Hydrochloride, APO-Metformin, Cidophage, Dimefor, Glifage, Glucoformin, Glucophage, Glucophage ER, Metformin HCl, Riomet, Siofor, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma, Supratentorial Glioblastoma
09/25
09/25
NCT03896568: MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

Recruiting
1
36
US
Oncolytic Adenovirus Ad5-DNX-2401, Ad5-Delta24RGD, DNX-2401, DNX2401, Oncolytic Ad5-Delta 24RGD, Oncolytic Adenovirus Ad5-Delta 24RGD, Therapeutic Conventional Surgery
M.D. Anderson Cancer Center, DNAtrix, Inc.
IDH1 wt Allele, Recurrent Anaplastic Astrocytoma, Recurrent Glioblastoma, Recurrent Gliosarcoma, Recurrent Malignant Glioma
09/27
09/27
 

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