| amiloride hydrochloride / Generic mfg. |
| Completed | 2b | 445 | Europe | Amiloride, Riluzole, Fluoxetine, Placebo | University College, London, Medical Research Council, National Institute for Health Research, United Kingdom, MS Society, University of Edinburgh, Queen Mary University of London, Keele University, University of Sheffield, University of Leeds, University of Warwick | Secondary Progressive Multiple Sclerosis | 06/18 | 07/18 | | |
NCT00274391: Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis |
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| Completed | 2 | 24 | US | 7% NaCl, Amiloride HCl | University of North Carolina, Cystic Fibrosis Foundation | Cystic Fibrosis | | 04/04 | | |
NCT00394394: Antihypertensive Effectiveness of the Associations of Hydrochlorothiazide and Amiloride and Hydrochlorothiazide and Enalapril |
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| Completed | 2 | | RoW | Amiloride 2,5/d or Enalapril/d 10 mg | Hospital de Clinicas de Porto Alegre | Hypertension | | | | |
2012-004980-39: The Amiloride Clinical Trial in Optic Neuritis - does amiloride protect nerve cells from injury after an episode of optic nerve inflammation? |
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| Not yet recruiting | 2 | 46 | Europe | Amiloride, Capsule, Amiloride | University of Oxford, Multiple Sclerosis Society of Great Britain and Northern Ireland | Optic Neuritis, Inflammation of the nerve supplying the eye, one of the common first events in Multiple Sclerosis, a condition in which there is inflammation in multiple parts of the nervous system, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Completed | 2 | 46 | Europe | Amiloride, Midamor, Placebo | University of Oxford, Multiple Sclerosis Society of Great Britain and Northern Ireland | Optic Neuritis, Multiple Sclerosis | 11/15 | 11/15 | | |
2017-001288-18: ASIC channels and migraine disorders - Proof of concept study on the efficacy of Amiloride in prophylaxis of Migraine with Aura - APAM study Canaux ASIC et maladie migraineuse - Etude de preuve de concept sur l’efficacité de l’Amiloride dans la Prophylaxie de l’Aura Migraineuse – Etude APAM |
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| Not yet recruiting | 2 | 40 | Europe | Amiloride, Tablet, Modamide 5 mg cp | CHU de Nice, DGOS | Migraine with aura Migraine avec aura, Migraine with aura Migraine avec aura, Not possible to specify | | | | |
APAM, NCT04063540: Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura |
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| Unknown status | 2 | 40 | Europe | Amiloride, Placebos | Centre Hospitalier Universitaire de Nice | Migraine With Aura | 11/19 | 11/21 | | |
| Completed | 2 | 21 | US | Spironolactone, Amiloride | University of Alabama at Birmingham, National Institutes of Health (NIH) | Chronic Kidney Disease, Albuminuria | 07/21 | 07/21 | | |
