| amiloride hydrochloride / Generic mfg. |
2007-005655-42: STUDY TITLE: - Early Metabolic Changes with Thiazide or Beta blocker Therapy for Essential Hypertension – open label extension phase with the potassium sparing diuretic- Amiloride. |
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| Ongoing | 4 | 60 | Europe | Amiloride hydrochloride, Tablet, No trade name (Generic amiloride hydrochloride) | Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital | Essential hypertension | | | | |
CHIEF, ChiCTR-TRC-08000087: Randomised trial of initial low-dose CCB and ARB combination in Chinese hypertension patients (updated in February 5 2009) |
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| Completed | 4 | 24000 | | (Total Cholesterol concentration of participants: <4.0 or >6.1mmol/L). Amlodipine 2.5mg and compound amiloride half of a tablet. ;(Total Cholesterol concentration of participants <4.0 or >6.1mmol/L). Amlodipine 2.5mg and telmisartan 40mg. ;(Total Cholesterol concentration of participants: 4.0-6.1mmol/L). Amlodipine 2.5mg, telmisartan 40mg and simvastatin 10mg. ;(Total Cholesterol concentration of participants: 4.0-6.1mmol/L). Amlodipine 2.5mg and telmisartan 40mg, regular remedy of serum lipid decided by the doctors. ;(Total Cholesterol concentration of participants 4.0-6.1mmol/L). Amlodipine 2.5mg and compound amiloride half of a tabella and regular remedy of serum lipid decided by the doctors. ;(Total Cholesterol concentration of participants: 4.0-6.1mmol/L). Amlodipine 2.5mg, compound amiloride 2.5mg and simvastatin 10mg ;(Includes group 1, group 2, and group 5). Amlodipine 2.5mg, compound amiloride half of a tablet. ;(Includes group 3, group 4 and group 6). Amlodipine 2.5mg, telmisartan 40mg. | Fu Wai Hospital for Cardiovascular Disease; The Ministry of Science and Technology of the People's Republic of China, The Ministry of Science and Technology of the People's Republic of China | Hypertension | | | | |
ChiCTR-ONC-13003234: Amiloride as adjunctive treatment for drug-resistant adult epilepsy: a prospective, open-label study in China |
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| Completed | 4 | 30 | | Amiloride | Xijing Hospital, Fourth Military Medical University; Xijing Hospital, Fourth Military Medical University, self-financing | epilepsy | | | | |
2006-000637-35: double blind crossover compariosn of diuretics in young patients with low-renin hypertension |
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| Ongoing | 4 | 30 | Europe | Bendroflumethiazide, Amiloride, Frusemide, Spironolactone, Bendroflumethiazide, Amiloride, Frusemide, Spironolactone, Bendroflumethiazide, Amiloride, Frusemide, Spironolactone | Addenbrookes Hospital Cambridge University Hospitals NHS Foundation Trust | Low-renin hypertension | | | | |
2006-001202-84: Comparison of the action of amiloride and thiazide in the reduction of lithium-NDI in patients with affective disorders |
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| Ongoing | 4 | 50 | Europe | Amiloride, hydrochloorthiazide, Midamor, Hydrochloorthiazide, Midamor, Hydrochloorthiazide | Radboud University Nijmegen Medical Centre | Lithium-induced Nephrogenic Diabetes Insipidus | | | | |
2008-004746-81: Effect of amiloride on lithium-induced chronic nephropathy.Comparing discontinuation of lithium treatment to adding amiloride while continuing lithium treatment. |
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| Ongoing | 4 | 30 | Europe | amiloride (modamide), Modamide, Modamide | Parnassia-BAVO groep, St. Elisabeth Ziekenhuis, University Medical Center Utrecht | Renal failure due to long-term use of lithium salts in patients with bipolar disorders. | | | | |
2015-001946-26: Amilorid treatment of nephrotic edema Amilorid til kontrol af ødem ved nefrotisk syndrom, |
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| Ongoing | 4 | 40 | Europe | amiloride, C03DB01, Tablet | Aarhus University Hospital, Private fonds will be aplied | Childhood idiopathic nephrotic syndrome (NS) Idiopatisk nefrotisk syndrom, NS is characterized by leaking of protein from the kidneys into the urine. PLasma levels of protein decrease and weight gain and severe edema is observed NS viser sig ved at nyrerne bliver utætte og der tabes protein i urinen. Derfor bliver koncentrationen af protein lav i urinen og patienter oplever vægtøgning og svære hævelser., Not possible to specify | | | | |
| Ongoing | 4 | 1320 | Europe | Amlodipine, Lisinopril, Chlortalidone, Amiloride, Tablet | Cambridge University Hospitals NHS Foundation Trust and University of Cambridge | Cardiovascular Hemodynamics, Blood Preassure, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2020-000433-40: Treatment of stiffness in blood vessels in patients with familial cystic kidney disease Behandeling van stijfheid in bloedvaten bij patiënten met familiaire cystenieren |
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| Not yet recruiting | 4 | 54 | Europe | Amiloride, Tablet, Capsule, Amiloride, Sodium Chloride | Erasmus University Medical Centre Rotterdam, The Dutch Kidney Foundation | Autosomal dominant polycystic kidney disease Autosomaal dominante polycysteuze nierziekte, Cystic kidney disease Cystenieren, Not possible to specify | | | | |
| Recruiting | 4 | 1320 | Europe | Amlodipine, Lisinopril, Amiloride, Chlortalidone | Cambridge University Hospitals NHS Foundation Trust, Medical Research Council | Hypertension | 01/22 | 12/22 | | |
AMIND, NCT05044611: AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium |
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| Recruiting | 4 | 148 | Europe | Anhydrous Amiloride Hydrochloride, Placebo | Assistance Publique - Hôpitaux de Paris | Bipolar Disorder | 01/25 | 11/25 | | |
NCT04331691: Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension |
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| Recruiting | 4 | 118 | RoW | Spironolactone, Amiloride | Yonsei University | Resistant Hypertension | 08/24 | 12/24 | | |
| Recruiting | 4 | 54 | Europe | Sodium chloride (NaCl), Table salt, Placebo, Amiloride Hcl 5mg Tab, Amiloride | Erasmus Medical Center | Autosomal Dominant Polycystic Kidney | 12/24 | 12/24 | | |
ADD-AMI, NCT06416735: Natriuretic Effect of Amiloride in Relation to the Alpha Adducin Gene () RS4961 Variant |
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| Completed | 3 | 40 | Europe | Amiloride | Ospedale San Raffaele | Hypertension Essential, Salt Excess, Genetic Hypertension | 07/20 | 07/20 | | |
2019-002607-18: Clinical study on the efficacy of amiloride for the treatment of edema in nephrotic syndrome Klinische Studie über die Wirksamkeit von Amilorid zur Behandlung der Ödeme beim nephrotischen Syndrom |
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| Not yet recruiting | 3 | 36 | Europe | Furosemid-ratiopharm® 40 mgTabletten, Tablet, Modamide 5 mg tablet, Furosemid-ratiopharm® 40 mg Tabletten | University Hospital Tuebingen, Faculty of Medicine University of Tübingen | Nephrotic syndrome Nephrotisches Syndrom, Nephrotic syndrome Nephrotisches Syndrom, Diseases [C] - Symptoms and general pathology [C23] | | | | |
| Terminated | 3 | 20 | Europe | Amiloride, Furosemide | University Hospital Tuebingen | Nephrotic Syndrome, Edema, Sodium Retention | 11/22 | 11/22 | | |
| Active, not recruiting | 2/3 | 157 | US | Placebo - Cap, Amiloride Pill | University of Missouri-Columbia | Overweight and Obesity, Insulin Resistance | 06/24 | 06/24 | | |
2012-004980-39: The Amiloride Clinical Trial in Optic Neuritis - does amiloride protect nerve cells from injury after an episode of optic nerve inflammation? |
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| Not yet recruiting | 2 | 46 | Europe | Amiloride, Capsule, Amiloride | University of Oxford, Multiple Sclerosis Society of Great Britain and Northern Ireland | Optic Neuritis, Inflammation of the nerve supplying the eye, one of the common first events in Multiple Sclerosis, a condition in which there is inflammation in multiple parts of the nervous system, Diseases [C] - Nervous System Diseases [C10] | | | | |
2017-001288-18: ASIC channels and migraine disorders - Proof of concept study on the efficacy of Amiloride in prophylaxis of Migraine with Aura - APAM study Canaux ASIC et maladie migraineuse - Etude de preuve de concept sur l’efficacité de l’Amiloride dans la Prophylaxie de l’Aura Migraineuse – Etude APAM |
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| Not yet recruiting | 2 | 40 | Europe | Amiloride, Tablet, Modamide 5 mg cp | CHU de Nice, DGOS | Migraine with aura Migraine avec aura, Migraine with aura Migraine avec aura, Not possible to specify | | | | |
| Active, not recruiting | 1 | 12 | | | University of Otago, University of Otago | Bipolar affective disorder | | | | |
NCT04181008: Pharmacokinetics of Amiloride Nasal Spray in Healthy Volunteers |
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| Completed | 1 | 15 | US | Amiloride, Midamor | University of Utah, Center for Addiction and Mental Health | Pharmacokinetics | 08/22 | 03/23 | | |
| Recruiting | 1 | 50 | US | Placebo, Amiloride, Bendroflumethiazide | Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Heart Failure | 06/27 | 06/27 | | |
NCT05125237: Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Amiloride vs Triamterene |
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| Active, not recruiting | N/A | 146670 | US | Amiloride, Triamterene | Brigham and Women's Hospital, National Institute on Aging (NIA), Rutgers University, Johns Hopkins University | Hypertension | 07/23 | 12/23 | | |