| Xiaflex (collagenase clostridium histolyticum) / Asahi Kasei, SOBI, Endo |
NCT01450397: MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex |
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| Completed | 4 | 5 | US | XIAFLEX, Collagenase | Hospital for Special Surgery, New York, Auxilium Pharmaceuticals, Inc. | Dupuytren's Disease | 01/12 | 02/12 | | |
2012-000516-28: The efficacy of CCH in the thumb and first webspace in Dupuytren's Disease De effectiviteit van CCH bij de ziekte van Dupuytren in de duim en eerste webcontractuur |
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| Ongoing | 4 | 15 | Europe | Xiapex, Powder for injection, Xiapex | University Medical Centre Groningen, Pfizer Ltd | Dupuytren's Disease De ziekte van Dupuytren, Dupuytren's Disease causing contractures of fingers and thumb De ziekte van Dupuytren veroorzaakt contracturen aan vingers en duim, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
NCT01226121: Safety and Efficacy of Delayed Manipulation After Xiaflex Treatment in Subjects With Dupuytren's Contracture |
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| Terminated | 4 | 37 | US | Clostridial collagenase injectable | Indiana Hand to Shoulder Center, Stony Brook University | Dupuytren's Disease | 12/12 | 12/12 | | |
| Completed | 4 | 52 | US, Europe, RoW | Collagenase clostridium histolyticum, XIAFLEX, XIAPEX, AA4500 | Endo Pharmaceuticals | Dupuytren's Disease | 10/13 | 10/13 | | |
NCT01265420: Efficacy and Safety of Xiaflex Injection for Treatment of Dupuytren's Contracture of the Thumb |
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| Completed | 4 | 7 | US | Injectable clostridial collagenase, Xiaflex | Indiana Hand to Shoulder Center | Dupuytren's Contracture | 02/14 | 02/14 | | |
| Unknown status | 4 | 50 | Europe | xiapex, clostridium histolyticum, percutaneous needle fasciotomy, PNF | Oslo University Hospital | Dupuytrens Contracture | 04/16 | 01/21 | | |
2016-005215-41: Kämmenen kalvokutistuman hoitostrategiat: satunnaistettu, kontrolloitu monikeskustutkimus Kämmenen kalvokutistuman hoitostrategiat: satunnaistettu, kontrolloitu monikeskustutkimus |
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| Ongoing | 4 | 278 | Europe | Powder and solvent for solution for injection, Xiapex | Olli Leppänen, Olli Leppänen | Dupuytren kontraktuura, kämmenen kalvokutistuma, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2016-004251-76: Is collagenase injection as effective as surgery for the treatment of moderate Dupuytren’s Contracture in adult patients? |
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| Ongoing | 4 | 710 | Europe | Xiapex, Powder and solvent for solution for injection, Xiapex | University Hospitals of Leicester NHS Trust | Dupuytren's contracture, Dupuytren’s Contracture is a common problem of the hand caused by fibrous tissue build up, which forces the finger to bend down into the palm leading to an inability to straighten the finger., Diseases [C] - Musculoskeletal Diseases [C05] | | | | |
NCT03767452: Additional Xiaflex® Treatment in Patients With Peyronie's Disease Recurrence, Worsening, or Incomplete Response |
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| Unknown status | 4 | 20 | US | Xiaflex® 0.58 mg | Manhattan Medical Research Practice, PLLC, Endo Pharmaceuticals | Peyronie's Disease | 12/19 | 02/20 | | |
NCT03815331: Xiaflex® Plus Testosterone Treatment Pilot Study Protocol |
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| Completed | 4 | 20 | US | Xiaflex®, Aveed | Men's Health Boston | Peyronie's Disease (PD) | 12/20 | 12/20 | | |
NCT03000114: Collagenase Injection vs Percutaneous Needle Aponeurotomy for Dupuytren's Disease |
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| Unknown status | 4 | 334 | Canada | Percutaneous Needle Aponeurotomy, Percutaneous Needle Fasciotomy, XIAFLEX, collagenase clostridium histolyticum | University of Calgary | Dupuytren Contracture, Dupuytren's Disease of Finger | 01/21 | 01/21 | | |
| Completed | 4 | 80 | Europe | Xiapex, Xiaflex, Needle aponeurotomy, Percutaneous needle fasiotomy | University Hospital, Akershus | Dupuytren Contracture | 04/22 | 04/22 | | |
NCT05309525: Effect of Oral TXA on Buttock Bruising Post CCH Injections in Adult Females |
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| Completed | 4 | 17 | US | Collagenase Clostridium Histolyticum-Aaes, QWO, Lysteda 650 MG Oral Tablet | Luxurgery | Cellulite | 09/22 | 10/22 | | |
NCT05108558: Efficacy of a Novel CCH Protocol for PD Among Prior Non-responders |
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| Recruiting | 4 | 40 | US | CCH administration, Collagenase Clostridium Histolyticum, Control - Crossover to CCH, RestoreX | Charitable Union for the Research and Education of Peyronie's Disease | Peyronie's Disease | 12/25 | 09/28 | | |
NCT05777031: Safety and Efficacy of Collagenase Clostridium Histolyticum After Prior Intralesional PRP for Peyronie's Disease |
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| Recruiting | 4 | 22 | US | Collagenase Clostridium Histolyticum (CCH), Xiaflex | University of Miami, Endo Pharmaceuticals | Peyronie Disease, Sexual Dysfunctions, Psychological, Genital Diseases, Male | 07/24 | 01/25 | | |
NCT03406338: Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease |
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| Active, not recruiting | 4 | 60 | Europe | Fasciectomy, Surgery, Collagenase Clostridium Histolyticum, Non-surgical treatment | Region Skane | Dupuytren Disease of Finger | 09/24 | 09/27 | | |
| Active, not recruiting | 4 | 302 | Europe | Percutaneous needle fasciotomy (PNF), Percutaneous needle aponeurotomy, Collagenase Clostridium Histolyticum (CCH) 2.9 MG/ML [Xiaflex], [Xiapex], Limited fasciectomy (LF), Limited aponeurectomy | Tampere University, Central Finland Hospital District, Helsinki University Central Hospital, Turku University Hospital, Tampere University Hospital, Kuopio University Hospital, Oulu University Hospital, Medcare Oy, Finnish Institute for Health and Welfare, Orton Orthopaedic Hospital | Dupuytren Contracture | 05/26 | 05/31 | | |
iSCRIP, NCT04786106: Investigation of Surgery, Collagenase, and Restorex for the Improvement of Peyronie's |
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| Active, not recruiting | 4 | 40 | US | Collagenase Clostridium Histolyticum 0.9 MG [Xiaflex] (CCH), Xiaflex, Penile Plication Surgery, Incision and Grafting (I&G) Surgery, RestoreX Penile Traction Device | Charitable Union for the Research and Education of Peyronie's Disease, Endo Pharmaceuticals | Peyronie's Disease | 02/27 | 02/27 | | |
