| Xiaflex (collagenase clostridium histolyticum) / Asahi Kasei, SOBI, Endo |
2012-000516-28: The efficacy of CCH in the thumb and first webspace in Dupuytren's Disease De effectiviteit van CCH bij de ziekte van Dupuytren in de duim en eerste webcontractuur |
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| Ongoing | 4 | 15 | Europe | Xiapex, Powder for injection, Xiapex | University Medical Centre Groningen, Pfizer Ltd | Dupuytren's Disease De ziekte van Dupuytren, Dupuytren's Disease causing contractures of fingers and thumb De ziekte van Dupuytren veroorzaakt contracturen aan vingers en duim, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2016-005215-41: Kämmenen kalvokutistuman hoitostrategiat: satunnaistettu, kontrolloitu monikeskustutkimus Kämmenen kalvokutistuman hoitostrategiat: satunnaistettu, kontrolloitu monikeskustutkimus |
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| Ongoing | 4 | 278 | Europe | Powder and solvent for solution for injection, Xiapex | Olli Leppänen, Olli Leppänen | Dupuytren kontraktuura, kämmenen kalvokutistuma, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
2016-004251-76: Is collagenase injection as effective as surgery for the treatment of moderate Dupuytren’s Contracture in adult patients? |
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| Ongoing | 4 | 710 | Europe | Xiapex, Powder and solvent for solution for injection, Xiapex | University Hospitals of Leicester NHS Trust | Dupuytren's contracture, Dupuytren’s Contracture is a common problem of the hand caused by fibrous tissue build up, which forces the finger to bend down into the palm leading to an inability to straighten the finger., Diseases [C] - Musculoskeletal Diseases [C05] | | | | |
NCT05309525: Effect of Oral TXA on Buttock Bruising Post CCH Injections in Adult Females |
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| Completed | 4 | 17 | US | Collagenase Clostridium Histolyticum-Aaes, QWO, Lysteda 650 MG Oral Tablet | Luxurgery | Cellulite | 09/22 | 10/22 | | |
NCT05108558: Efficacy of a Novel CCH Protocol for PD Among Prior Non-responders |
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| Recruiting | 4 | 40 | US | CCH administration, Collagenase Clostridium Histolyticum, Control - Crossover to CCH, RestoreX | Charitable Union for the Research and Education of Peyronie's Disease | Peyronie's Disease | 12/25 | 09/28 | | |
NCT05777031: Safety and Efficacy of Collagenase Clostridium Histolyticum After Prior Intralesional PRP for Peyronie's Disease |
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| Recruiting | 4 | 22 | US | Collagenase Clostridium Histolyticum (CCH), Xiaflex | University of Miami, Endo Pharmaceuticals | Peyronie Disease, Sexual Dysfunctions, Psychological, Genital Diseases, Male | 01/25 | 01/25 | | |
NCT03406338: Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease |
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| Active, not recruiting | 4 | 60 | Europe | Fasciectomy, Surgery, Collagenase Clostridium Histolyticum, Non-surgical treatment | Region Skane | Dupuytren Disease of Finger | 09/24 | 09/27 | | |
NCT06649539: Delayed Dose Collagenase Clostridium Histolyticum (CCH) Protocol for Men With Peyronie's Disease |
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| Recruiting | 4 | 40 | US | Collagenase Clostridium Histolyticum, Xiaflex, CCH, RestoreX, Sildenafil, Viagra | Charitable Union for the Research and Education of Peyronie's Disease, Endo Pharmaceuticals | Peyronie Disease | 10/29 | 10/29 | | |
| Active, not recruiting | 4 | 302 | Europe | Percutaneous needle fasciotomy (PNF), Percutaneous needle aponeurotomy, Collagenase Clostridium Histolyticum (CCH) 2.9 MG/ML [Xiaflex], [Xiapex], Limited fasciectomy (LF), Limited aponeurectomy | Tampere University, Central Finland Hospital District, Helsinki University Central Hospital, Turku University Hospital, Tampere University Hospital, Kuopio University Hospital, Oulu University Hospital, Medcare Oy, Finnish Institute for Health and Welfare, Orton Orthopaedic Hospital | Dupuytren Contracture | 05/26 | 05/31 | | |
iSCRIP, NCT04786106: Investigation of Surgery, Collagenase, and Restorex for the Improvement of Peyronie's |
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| Active, not recruiting | 4 | 40 | US | Collagenase Clostridium Histolyticum 0.9 MG [Xiaflex] (CCH), Xiaflex, Penile Plication Surgery, Incision and Grafting (I&G) Surgery, RestoreX Penile Traction Device | Charitable Union for the Research and Education of Peyronie's Disease, Endo Pharmaceuticals | Peyronie's Disease | 02/27 | 02/27 | | |
ACTRN12607000216415: A Placebo Controlled Study of the Safety and Efficacy of AA4500 in the Treatment of Subjects With Dupuytren’s Contracture Followed by an Open-Label Extension Phase |
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| Not yet recruiting | 3 | 60 | | | Auxilium Pharmaceuticals, Inc., Auxilium Pharmaceuticals, Inc. | Dupuytren's contracture | | | | |
ACTRN12607000217404: An Open-Label Study of the Safety and Efficacy of AA4500 in the Treatment of Subjects With Dupuytren’s Contracture |
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| Not yet recruiting | 3 | 240 | | | Auxilium Pharmaceuticals, Inc., Auxilium Pharmaceuticals, Inc. | Dupuytren's contracture | | | | |
STRIDE, NCT06151197: Study to Assess EN3835 in the Treatment of Plantar Fibromatosis (Also Known as Ledderhose Disease) |
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| Recruiting | 3 | 418 | US, RoW | EN3835, Placebo | Endo Pharmaceuticals | Plantar Fibromatosis, Ledderhose Disease | 11/25 | 11/25 | | |
NCT04874870: Effectiveness of Splinting After Collagenase Injection |
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| Completed | 3 | 80 | US | Collagenase Clostridium Histolyticum 0.9 MG [Xiaflex], Xiaflex, Xiaflex + Hand-Based Custom Orthosis | Foundation for Orthopaedic Research and Education, EndoPharmceuticals | Dupuytren Contracture, Dupuytren's Disease | 12/23 | 12/23 | | |
NCT05254457: Long-Term Safety, Efficacy, and Durability of EN3835 in the Treatment and Retreatment of Plantar Fibromatosis |
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| Completed | 3 | 145 | US | EN3835 | Endo Pharmaceuticals | Plantar Fibromatosis | 03/24 | 03/24 | | |
2018-003637-14: Local injection of collagenase for difficult-to-treat scar strictures of the gastrointestinal tract. |
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| Not yet recruiting | 2 | 10 | Europe | Xiapex, Powder and solution for solution for injection, Xiapex 0,9 mg powder and solution for injection | Ghent University Hospital, BSGIE | refractory iatrogenic gastrointestinal strictures, difficult-to-treat gastrointestinal strictures, Diseases [C] - Digestive System Diseases [C06] | | | | |
APHRODITE, NCT05419505: Study of Different Interventions to Reduce Bruising Following CCH-Aaes Treatment for Cellulite of the Buttocks |
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| Completed | 2 | 91 | US | CCH-aaes, Collagenase clostridium histolyticum-aaes, QWO®, Antifibrinolytic Agent | Endo Pharmaceuticals | Edematous Fibrosclerotic Panniculopathy, Cellulite | 01/23 | 06/23 | | |
NCT02948842: Clostridium Histolyticum Collagenase Injection for Urethral Disease |
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| Completed | 2 | 5 | US | Clostridium Histolyticum Collagenase, XIAFLEX®, Saline, Injectable normal saline | University of South Florida | Urethral Stricture | 03/23 | 04/23 | | |
NCT06169319: A Study to Assess EN3835 in the Treatment of Plantar Fasciitis (PFA) |
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| Completed | 2 | 231 | US | EN3835, Placebo | Endo Pharmaceuticals | Plantar Fasciitis | 09/24 | 09/24 | | |
| Withdrawn | N/A | 800 | US | Collagenase Clostridium Histolyticum, Xiaflex, Duolith SD1 T-TOP | Mayo Clinic | Peyronie Disease, Penile Curvature, Erectile Dysfunction | 12/24 | 12/24 | | |
NCT06065436: Concurrent Low Intensity Shockwave Therapy on Collagenase Clostridium Histolyticum for Peyronie's Disease |
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| Recruiting | N/A | 60 | US | Collagenase Clostridium Histolyticum, Xiaflex, Storz Duolith LiSWT | Mayo Clinic | Peyronie Disease, Erectile Dysfunction | 12/25 | 12/25 | | |