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| Not yet recruiting | 2 | 30 | | | South Eastern Sydney Local Health District, St George Hospital | Radiotherapy-related pain | | | | |
ACTRN12621001626853: A Phase II, prospective, open-label, dual-centre, single-arm feasibility study of Pregabalin for the management of uraemic pruritus in patients with End Stage Kidney Disease (ESKD) who are conservatively managed. |
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| Recruiting | 2 | 24 | | | University of Technology Sydney, University of Technology Sydney | Uraemic pruritis, End Stage Kidney Disease (ESKD) | | | | |
| Ongoing | 2 | 28 | Europe | LYRICA 75 mg hard capsules, -, Lyrica 75 mg, Lyrica 75 mg | Prof. Herta Flor, Head of the Institute of Clinical and Cognitive Neuroscience | The effect of pregabalin on the success to reduce the interference by tinnitus by an extinction training is tested in chronic tinnitus sufferers. | | | | |
2006-000499-33: Effects of Pregabalin on acid-induced oesophageal pain hypersensitivity in male and female healthy adult volunteers, as investigated in a single centre, placebo-controlled, double-blind, randomised, two-period, cross-over study. |
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| Ongoing | 2 | 16 | Europe | Pregabalin, PD 0144723 (CI-1008), | Queen Mary, University of London | This study will test the effects of Pregabalin in a validated model of visceral pain hypersensitivity (VPH) in healthy volunteers. The volunteers must be free of medical conditions. VPH is thought to contribute to the production of abdominal pain in patients with functional gastrointestinal disorders such as Irritable Bowel Syndrome. If the drug was effective in attenuating VPH in our model then it would be considered for use in patients with these disorders. | | | | |
2009-017728-13: A randomized controlled trial comparing pregabalin and placebo in patients with persistent globus sensation |
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| Ongoing | 2 | 90 | Europe | Lyrica, Lyrica | UZLeuven | Globus symptoms | | | | |
2013-004876-37: A study to assess the effectiveness and safety of PL37 in reducing pain intensity when given in addition to gabapentin or pregabalin in patients suffering from neuropathic pain of diabetic origin, for whom ongoing treatment with gabapentin or pregabalin does not provide complete or sufficient relief of their neuropathic pain. |
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| Ongoing | 2 | 40 | Europe | PL37, PL37, | Pharmaleads SA, Pharmaleads SA | Neuropathic pain develops as a result of damage to, or dysfunction of, the system that normally signals pain. It may arise from a heterogeneous group of disorders that affect the peripheral and central nervous systems. People with neuropathic pain may experience altered pain sensation, areas of numbness or burning, and continuous or intermittent evoked or spontaneous pain. In this study, neuropathic pain of diabetic origin is being investigated. | | | | |
2019-000755-14: Trial in healthy subjects to investigate the effect of analgesic drug on pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity. Studio su soggetti sani volto ad indagare gli effetti di farmaci analgesici sulla elaborazione del dolore mediante misure neurofisiologiche del'attività del midollo del midollo spinale e del tronco dell'encefalo |
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| Ongoing | 2 | 56 | Europe | pregabalin, lacosamide, tapentadol, [N03AX16], [N/A], [N02AX06], Capsule, hard, Film-coated tablet, Tablet, LYRICA - 75 MG CAPSULA RIGIDA - USO ORALE 100 CAPSULE IN BLISTER IN UNITA' SEPARABILI PERFORATO (PVC/ALU), VIMPAT - 100 MG - COMPRESSE RIVESTITE CON FILM - USO ORALE - BLISTER (PVC/PVDC/ALU) 14 COMPRESSE, PALEXIA - 50 MG COMPRESSE RIVESTITE CON FILM 10 COMPRESSE IN BLISTER PVC/PVDC/AL | UMBERTO I - POLICLINICO DI ROMA, Teva Pharmaceutical Industries LTD, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmbH | Healthy volunteers (intended indication: pain) soggetti sani (indicazione: dolore), Healthy volunteers (intended indication: pain) soggetti sani (indicazione: dolore), Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
| Recruiting | 2 | 70 | RoW | Duloxetine, Pregablin | National Cancer Institute, Egypt | Drug Effect | 03/21 | 04/21 | | |
| Recruiting | 2 | 230 | RoW | Pregabalin 150mg, Placebo oral tablet | InCor Heart Institute | Postoperative Pain | 12/21 | 11/23 | | |
NCT05083793: the Effect of Pregabalin on Postoperative Pain and Opioid Consumption in Spine Surgery |
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| Enrolling by invitation | 2 | 90 | RoW | Pregabalin 150mg, Pregabalin, Placebo | Assiut University | Postoperative Pain | 01/22 | 01/22 | | |
NCT04660773: PHOTOTHERAPY VERSUS PREGABALIN IN TREATMENT OF REFRACTORY UREAMIC PRURITIS |
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| Recruiting | 2 | 40 | RoW | NB UVB phototherapy, Pregabalin | Alexandria University | Refractory Uremic Pruritis | 03/22 | 03/22 | | |
2019-000942-36: The effects of lacosamide, pregabalin and tapentadol on biomarkers of peripheral pain processing |
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| Not yet recruiting | 2 | 60 | Europe | lacosamide, Pregabalin, Tapentadol, [N02AX06], [N/A], [N03AX16], Tablet, Capsule, Vimpat 100 mg film coated tablets, Lyrica 75 mg hard capsules, Palexia 50 mg film-coated tablets | Aarhus University, UMBERTO I - POLICLINICO DI ROMA, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmbH, Teva Pharmaceutical Industries LTD | Healthy volunteers (intended indication: pain), Study in healthy volunteers to examine drug effects on biomarkers in experimental pain, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
2019-001204-37: The effects of lacosamide, pregabalin and tapentadol on biomarkers of pain processing |
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| Not yet recruiting | 2 | 56 | Europe | lacosamide, pregabalin, tapentadol, [N02AX06], [N03AX16], [N/A], Film-coated tablet, Capsule, Tablet, Vimpat 100mg film coated tablets, Lyrica 75 mg hard capsules, Palexia 50 mg film-coated tablets | Institute of Neuroscience (IoNS), Université catholique de Louvain, UMBERTO I - POLICLINICO DI ROMA, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under Grant Agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmBH, Teva Pharmaceutical Industries LTD | Healthy subjects (intended indication: pain), Study in healthy subjects to examine drug effects on biomarkers in experimental pain, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
2019-000908-15: The effects of lacosamide, pregabalin and tapentadol on pain processing |
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| Not yet recruiting | 2 | 36 | Europe | lacosamide, Pregabalin, Tapentadol, Tablet, Capsule, Vimpat 100 mg film coated tablets, Lyrica 75 mg hard capsules, Palexia 50 mg film-coated tablets | Aarhus University, Innovatice Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement, Eli Lilly and Company LTD, Esteve Pharmaceutical Industries LTD, Grünenthal GmbH, Teva Pharmaceutical Industries LTD | Healthy volunteers (intended indication: pain), Study in healthy volunteers to examine drug effects on biomarkers in experimental pain, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
NCT05529004: A 6 Months Double Blind Trial to Prevent PONV in Laparoscopic Cholecystectomy |
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| Not yet recruiting | 2 | 100 | NA | Oral Capsule pregapalin, general anesthesia, laparoscope device | Al Safwa University College | Postoperative Nausea and Vomiting | 10/22 | 04/23 | | |
PGB-LOF, NCT04218240: Combining Pregabalin (LYRICA®) With Lofexidine (LUCEMYRATM) to Treat OPIOID Withdrawal |
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| Completed | 2 | 90 | US | Pregabalin 200 MG capsules, lyrica, Placebo oral tablet, Lofexidine 0.18Mg Tab, lucemyra | University of Pennsylvania | Opioid Withdrawal | 03/23 | 03/23 | | |
NCT05763550: To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Herpetic Neuralgia |
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| Completed | 2 | 331 | RoW | HSK16149 20mg BID, HSK16149 40mg BID, Pregabalin 150mg | Haisco Pharmaceutical Group Co., Ltd. | Herpetic Neuralgia | 06/23 | 08/23 | | |
NCT04221165: Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer |
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| Completed | 2 | 49 | Canada | Opioids, PAiN - multimodal analgesia | Lawson Health Research Institute, Ontario Institute for Cancer Research | Head and Neck Cancer, Radiation-Induced Mucositis | 09/23 | 09/23 | | |
| Not yet recruiting | 2 | 112 | Europe | Prospective data and sample collection, Ketorolac 10 Mg Oral Tablet, Pregabalin 75mg | Jules Bordet Institute, KU Leuven, University of Milan | Early-stage Breast Cancer, Estrogen-receptor-positive Breast Cancer | 07/26 | 12/26 | | |
NCT05660538: Evaluation of Efficacy and Safety of VX-548 for Painful Diabetic Peripheral Neuropathy (DPN) |
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| Completed | 2 | 192 | US | VX-548, Suzetrigine, Pregabalin, Placebo (matched to VX-548), Placebo (matched to pregabalin) | Vertex Pharmaceuticals Incorporated | Diabetic Peripheral Neuropathy | 10/23 | 10/23 | | |
JMKX0623-201, NCT06221241: Evaluate the Efficacy and Safety of JMKX000623 in Participants With Diabetic Peripheral Neuropathic Pain |
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| Recruiting | 2 | 220 | RoW | JMKX000623, Pregabalin, Placebo | Jemincare | Diabetic Peripheral Neuropathic Pain | 03/25 | 04/25 | | |
HSK16149-207, NCT06490484: Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Diabetic Peripheral Neuropathic Pain Who Had an Inadequate Response to Pregabalin |
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| Recruiting | 2 | 90 | RoW | HSK16149 20mg BID, Crisugabalin, Pregabalin 150mg BID, Pregabalin | Haisco Pharmaceutical Group Co., Ltd. | Diabetic Peripheral Neuropathic Pain | 07/24 | 07/24 | | |
NCT06417580: Effect of Pregabalin Gel in Controlling Cervical Dentin Hypersensitivity |
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| Not yet recruiting | 2 | 18 | NA | Placebo Treatment, Nitrate Potassium Treatment, Pregabalin Treatment | Jesuína Lamartine Nogueira Araújo | Dentin Sensitivity | 09/24 | 09/24 | | |
| Suspended | 2 | 50 | US | Pregabalin, Lyrica, Placebo | New York State Psychiatric Institute, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Use Disorder | 12/24 | 12/24 | | |
NCT06614322: SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy. |
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| Not yet recruiting | 2 | 190 | US | Pregabalin, Duloxetine, Placebo | University of Rochester, Beth Israel Deaconess Medical Center | Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN), Chemotherapy Induced Peripheral Neuropathy (CIPN), Idiopathic Peripheral Neuropathy | 06/28 | 06/28 | | |
UH3, NCT05995535: Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid Withdrawal |
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| Recruiting | 2 | 150 | US | LFX/PGB, Lucemyra, lyrica, LFX/PLA-PGB, placebo pregabalin | University of Pennsylvania | Opiate Withdrawal Syndrome, Opioid Use | 08/26 | 08/26 | | |
POSTCOVID, NCT05967052: Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or Complex Rehabilitation |
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| Recruiting | 2 | 132 | Europe | Pregabalin, Independent walking training, Placebo, Gradual movement therapy in the ward, Telerehabilitation, Psychotherapy | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland, Medical Research Agency, Poland | Chronic Fatigue Syndrome, COVID-19, Long Haul | 03/28 | 03/28 | | |
NCT04622202: Pre-emptive Pregabalin on Attenuating Maternal Anxiety And Stress Response To Intubation During Caesarean Section |
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| Recruiting | 1/2 | 74 | RoW | Pregabalin 150mg, Lyrica, multivitamin, Placebo | Zagazig University | Anxiety State, Sedation | 02/21 | 03/21 | | |
NCT05442931: Comparison Between Pregabalin and Magnesium Sulfate in Hypotensive Anaesthesia |
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| Recruiting | 1/2 | 60 | RoW | Pregabalin 150mg, Lyrica 150mg, Magnesium Sulfate, Magnisol 1gm/ 5ml, Nitroglycerin, Nitronal, surgeon satisfaction, surgeon satisfaction Likert's scale | Minia University | Functional Endoscopic Sinus Surgery | 10/22 | 10/22 | | |
