| pregabalin / Generic mfg. |
| Not yet recruiting | 4 | 80 | | | King Edward Memorial Hospital, Australia and New Zealand College of Anaesthetists Research Grant | 1. To describe the transfer of gabapentin and pregabalin in to breast milk in lactating women immediately post-partum. | | | | |
| Recruiting | 4 | 90 | | | Professor Michael Paech, Pfizer Global Pharmaceuticals | Prevention of Postoperative Pain | | | | |
ACTRN12615000413527: Optimizing post operative outcomes in Total Knee Arthroplasty (TKR) through improved pain and fatigue management: a randomized placebo controlled trial. |
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| Recruiting | 4 | 104 | | | ORIQL , Orthopaedic Research Institute of Queensland (ORIQL) | Knee Osteoarthritis, Post Operative Management of Total Knee Arthroplasty | | | | |
ChiCTR-TRC-12002171: Auxiliary treatment of the calcium channel alpha2-garma subunit inhibitors for postherpetic neuralgia: a randomized, double-blind controlled trial |
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| Completed | 4 | 156 | | placebo ;pregabalin 225mg/d ;pregabalin 375mg/d ;gabapentin 900mg/d | Department of pain, the first affiliated hospital of Nanchang University; None, none | postherpetic neuralgia | | | | |
2009-010557-12: Comparison of Lidocaine 5% plasters and Pregabalin for the treatment of the painful condition called Complex Regional Pain Syndrome. |
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| Ongoing | 4 | 20 | Europe | Lidocaine 5% Plaster, pregabalin, Medicated plaster, Capsule, hard, Versatis 5% Medicated Plaster, Lyrica | The Pennine Acute Hospitals NHS Trust, The Pennine Acute Hospitals NHS Trust | Complex regional pain syndrome type 1., Complex Regional Pain Syndrome, also called as Reflex Sympathetic Dystrophy or Sudeck's atrophy is a chronic painful condition often affecting an arm or leg with skin changes and swelling, Diseases [C] - Nervous System Diseases [C10] | | | | |
ACTRN12614000554662: A Prospective Study of the Effects of Pregabalin versus Placebo on the incidence and intensity of pain after video-assisted thoracoscopic surgery. |
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| Active, not recruiting | 4 | 95 | | | Dr Alex Konstantatos, Pfizer Pharmaceuticals Investigator initiated funding | post thoracotomy pain syndrome | | | | |
ChiCTR-TTRCC-13003121: Efficient Assessment of Pregabalin Combined With Morphine Using in Patients With Neuropathic Cancer Pain |
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| Completed | 4 | 60 | | morphine-pregabalin combination followed by morphine-placebo ;morphine-placebo combination followed by morphine-pregabalin | The First Affiliated Hospital of Guangxi Medical University; The First Affiliated Hospital of Guangxi Medical University, Postgraduate Innovative Research Grant of Guangxi Zhuang Autonomous Region | Cancer pain | | | | |
2014-005701-20: Het verschuiven van pijn modulatie naar pijnstilling: mechanisme-specifieke farmacologische preventie van post-sternotomie pijn: de MASTER studie |
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| Ongoing | 4 | 300 | Europe | Capsule, Cymbalta, Lyrica | Leiden University Medical Center, LUMC | chronic pain chronische pijn, chronic pain chronische pijn, Body processes [G] - Physiological processes [G07] | | | | |
2004-004953-24: A double-blind placebo-controlled two period crossover study of pregabalin and aprepitant in the electrical hyperalgesia model of central sensitisation in healthy volunteers |
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| Ongoing | 4 | 32 | Europe | Pregabalin, Aprepitant, Parecoxib, Lyrica, Emend, Dynastat, Lyrica, Emend, Dynastat | Department of Anesthesiology, University Hospital Erlangen | The primary aim of the present study is therefore to investigate the effects of oral pregabalin and aprepitant on experimentally-induced central sensitization in the electrical hyperalgesia model, using dosing titration regimens utilised in the clinic. Furthermore, as a hypothesis-generating part of the study, we propose to investigate the effect of a COX-2 inhibitor parecoxib in combination with either aprepitant or pregabalin. | | | | |
2006-004464-31: Ahdistuksen vaikutukset neuropaattisessa kivussa ja pregabaliinin ahdistusta moduloiva vaikutus funktionaalisella magneettikuvauksella (fMRI) tutkittuna |
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| Ongoing | 4 | 20 | Europe | LYRICA | Eija Kalso | neuropaattinen kipuahdistuneisuus | | | | |
2006-002286-40: Chronic Pain Management after HerniorraphyPregabaline versus Placebo |
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| Ongoing | 4 | 135 | Europe | Lyrica®, - Lyrica 75 mg hard capsules Pregabalin - Lyrica 150 mg hard capsules Pregabalin - Lyrica 300 mg hard capsules Pregabalin, - Lyrica 75 mg hard capsules Pregabalin - Lyrica 150 mg hard capsules Pregabalin - Lyrica 300 mg hard capsules Pregabalin | Pfizer bv | Patients suffering from chronic pain of neuropathic character after open hernia repair. | | | | |
2007-007697-39: EVALUACION DE LOS EFECTOS DE LA PREGABALINA EN EL TEMBLOR ESENCIAL: ENSAYO CLÍNICO CRUZADO, RANDOMIZADO A DOBLE CIEGO Y CONTROLADO CON PLACEBO |
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| Ongoing | 4 | 16 | Europe | Lyrica, Lyrica | Instituto de Investigación del Hospital de la Santa Creu i Sant Pau | Temblor esencial | | | | |
2007-006182-32: Ensayo clínico controlado y aleatorizado para evaluar el efecto de los gabapentinoides sobre el dolor agudo postoperatorio en pacientes quemados |
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| Ongoing | 4 | 132 | Europe | Neurontín, Lyrica, Enantyum, Neurontín, Lyrica, Enantyum | Anaesthesiology Department. Universitary Hospital Vall d\'Hebron, Barcelona. | Postoperative pain in burned patients with a burn excision area between 2 and 12 % of total body surface area. | | | | |
2009-010266-28: Een gerandomiseerde dubbelblinde, placebogecontroleerde, klinische parallelle groep studie van pregabaline in patiënten met chronische pancreatitis |
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| Ongoing | 4 | 30 | Europe | Lyrica®, Lyrica® | Afdeling heelkunde, Universitair Medisch Centrum Sint Radboud | chronische pancreatitis | | | | |
2011-004371-36: Effects of pregabalin on slow wave sleep and glucose tolerance in patients with diabetic polyneuropathy. An exploratory study. Efecto de la pregabalina sobre el sueño de ondas lentas y sobre la tolerancia a la glucosa en pacientes con neuropatía diabética. Un estudio exploratorio |
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| Ongoing | 4 | 24 | Europe | Lyrica 75 mg capsulas duras, Lyrica 150 mg capsulas duras, Lyrica 300 mg capsulas duras, Lyrica 75 mg capsulas duras, Lyrica 150 mg capsulas duras, Lyrica 300 mg capsulas duras | Instituto de Investigaciones del Sueño, Instituto de Investigacioens del Sueño | Patients with diabetic polyneuropathy (DPN) Pacientes con polineuropatía diabética (DPN). | | | | |
2012-004062-17: Treatment of Generalized Anxiety Disorder comorbid with Major Depressive Disorder. Αντιμετώπιση της ΓενικευμÎνης Αγχώδους ΔιαταÏαχής ΣυνυπάÏχουσα με Μείζων Καταθλιπτική ΔιαταÏαχή. |
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| Ongoing | 4 | 60 | Europe | Pregabalin, Lyrica, Lyrica | Aristotle University of Thessaloniki, Aristotle University of Thessaloniki | Generalized Anxiety Disorder comorbid with major depressive disorder. ΓενικευμÎνη Αγχώδης ΔιαταÏαχής ΣυνυπάÏχουσα με Μείζων Καταθλιπτική ΔιαταÏαχή. | | | | |
2015-004515-20: Individual pain management in day surgery Päiväkirurgisten potilaiden kivun hoito perustuen arvioon riskistä kunkin potilaan kohdalla |
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| Ongoing | 4 | 60 | Europe | Lyrica, Lyrica | Vesa Kontinen, Academic research, no funding | Leikkauksen jälkeinen kipu. | | | | |
2009-015316-17: Perioperativ administrasjon av pregabalin ved laparoskopisk living donor nefrektomi (L-LDN) - et adjuvans til peroral analgetisk behandling - en randomisert kontrollert studie |
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| Ongoing | 4 | 80 | Europe | Pregabalin, Capsule*, Lyrica | Oslo Universitetssykehus - Rikshospitalet | Hensikten med studien er å undersøke om perioperativ administrasjon av pregabalin vil redusere postoperativ smerte og forbruket av intravenøse opioider postoperativt sammenliknet med dagens standardbehandling som består av paracetamol, corticosteroider og ketobemidon. I tillegg vil vi se nærmere på eventuelle bivirkninger, spesielt sederende effekt og effekt på kognitiv funksjon. | | | | |
2018-003617-17: Localized neuropathic pain: topical treatment versus systemic treatment |
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| Not yet recruiting | 4 | 591 | Europe | Cutaneous patch, Capsule, hard, Lidocaïne Grünenthal 700 mg pleister (Versatis), Capsaicine (Qutenza) 179 mg huidpleister, Pregabaline (Lyrica) 75 mg harde capsules | Antwerp University Hospital (UZA), Belgian Health Care Knowledge Center (KCE) | Patients suffering from localized neuropathic pain (LNP), Patients suffering from localized neuropathic pain (LNP), Diseases [C] - Nervous System Diseases [C10] | | | | |
ChiCTR-IPR-17012328: The clinical observation of Zheng Qing Fen Tong Ning in treating herpetic neuralgia |
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| Not yet recruiting | 4 | 100 | | Pregabalin ;gabapentin ;Pregabalin Capsules and Zhengqingfengtongning sustained release patches ;Gabapentin capsules and Zhengqingfengtongning sustained release patches | The First Affiliated Hospital of Nanchang University; The First Affiliated Hospital of Nanchang University, At their own expense | herpes zoster neuralgia | | | | |
2017-001439-37: The Effect of Pregabalin on the required dose of the anesthetic vaporSevoflurane to achieve immobility |
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| Ongoing | 4 | 75 | Europe | Capsule, hard, Lyrica | Medical University of Vienna, Department of Anaesthesia, General Critical Care and Pain Management, Medical University of Vienna | This study aims to investigate the effect of clinically used doses ofPregabalin on the minimum alveolar concentration of sevoflurane toprovide more information to clinicians using this adjunctive drug in theperioperative setting., This study aims to investigate the effect of clinically used doses ofPregabalin on sevoflurane requirements to provide more information toclinicians using this drug in the perioperative setting., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
ChiCTR2000031236: Effect of local infiltration using ropivacaine combined with celebrex and pregabalin on the pain control of spinal surgery |
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| Recruiting | 4 | 90 | | Local subcutaneous infiltration at 0.75% ropivacaine suture, 2h preoperative celebrex (400 mg), prerabalin (150 mg), then daily celebrex (200 mg, bid), prerabalin (75 mg, bid) ;Local subcutaneous infiltration was observed with 0.75% ropivacaine suture ;normal saline | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Natural Science Foundation of Chongqing | Pain management of spinal surgery | | | | |
ChiCTR1800019880: Efficacy and Safety of Hydromorphone in Subjects With Herpes Zoster Associated Pain: A Randomized Controlled Trial |
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| Recruiting | 4 | 200 | | Oral pregabalin treatment for herpes zoster-associated pain ;Hydromorphone patient-controlled intravenous analgesia combined with oral pregabalin treatment for herpes zoster-associated pain | Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School; Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Self-financing | herpes zoster-associated pain | | | | |
ChiCTR2100046045: Clinical efficacy evaluation and prevention of adverse reactions in a randomized trial of a combination of three drugs in the treatment of cancerous pudendal neuralgia |
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| Completed | 4 | 51 | | Celecoxib combined with OxyContin and Pregabalin ;OxyContin and Pregabalin | Jilin Province People's Hospital; Jilin Province People's Hospital, Jilin Province Health and Health Technology Innovation Project (2020Z023) | Cancerous pudendal neuralgia | | | | |
ChiCTR1900027120: Effect of preoperative oral pregabalin for acute postoperative pain in patients undergoing temporal craniotomy |
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| Recruiting | 4 | 80 | | preoperative oral placebo ;preoperative oral placebo 150mg | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | postoperative pain | | | | |
ChiCTR2000035554: The effects of pregabalin versus gabapentin combined with NSIADs on the pain of spinal surgery: a randomized controlled trial. |
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| Recruiting | 4 | 140 | | Gabapentin combined with Celebrex ;Pregabalin and Celebrex ;Gabapentin combined with Parecoxib ;Pregabalin combined with Parecoxib | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Natural Science Foundation of Chongqing | Degenerative diseases and injuries of the spine | | | | |
ChiCTR1900028026: A single-center, prospective, randomized, controlled clinical trial: a clinical study for the safety and efficacy of pregabalin in the treatment of central - mediated abdominal pain syndrome |
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| Recruiting | 4 | 60 | | Pinaverium bromide 50mg p.o. t.i.d. ;Pinaverium bromide 50mg p.o. t.i.d. and Pregabalin 75mg p.o. t.i.d. ;Pregabalin 75mg p.o. t.i.d. | Qilu Hospital of Shandong University; Qilu Hospital of Shandong University, self-raised | Centrally mediated abdominal pain syndrome | | | | |
2020-001957-31: Sleep in patients having neuropathic pain Uni hermovauriokipupotilailla |
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| Ongoing | 4 | 40 | Europe | Capsule, hard, Lyrica | Eija Kalso | Neuropathic pain Hermovauriokipu, Pain due to nerve injury Hermovauriokipu, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Recruiting | 4 | 75 | RoW | Pregabalin, Duloxetine | Cairo University | Postoperative Pain | 08/21 | 09/21 | | |
ChiCTR2000030728: Effect of preabalin on cognitive function after general anesthesia in elderly patients |
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| Completed | 4 | 80 | | Preoperatively take pregabalin ;Take a placebo | Guanghan People's Hospital; Guanghan People's Hospital, At his own expense | Lower limb fracture | | | | |
2019-000515-84: Multimodal vs Opioid Analgesia in Cardiac Surgery: MONDAY-study. |
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| Not yet recruiting | 4 | 120 | Europe | dexmedetomidine, Fentanyl, Ketamine, Lidocaïne hydrochloride monohydraat, Pregabaline, Magnesium sulfate, Oxycodon, Paracetamol, Tramadolhydrochloride, Remifentanyl, Solution for infusion, Solution for injection, Capsule, hard, Capsule, Solution for injection/infusion, Dexdor 100 microgram/ml concentraat voor oplossing voor infusie, Fentanyl-Janssen 0,05 mg/ml oplossing voor injectie, Ketalar 50 mg/ml, oplossing voor injectie, Linisol 1 %, oplossing voor injectie, Lyrica 75 mg harde capsules, MAGNESIUM SULFATE STEROP 1g / 10ml Oplossing voor injectie, OxyNorm Instant 10 mg, orodispergeerbare tabletten, Paracetamol Fresenius Kabi 10 mg/ml oplossing voor infusie, TRADONAL, 100 mg, oplossing voor injectie, Ultiva 2 mg poeder voor concentraat voor oplossing voor injectie / infusie Ultiva 5 | Ghent University Hospital, Ghent University Hospital | Cardiac surgery., Cardiac Surgery., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
ChiCTR1900022356: Clinical study for the postoperative analgesia of reducing the dosage of opioids |
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| Recruiting | 4 | 1500 | | nerve block ;non-opioid drugs (pregabalin and non-steroidal anti-inflammatory drugs) ;postoperative analgesia pump major made up of sufentanil or fentany | Xiangya Hospital anesthesiology department of Central South University; Xiangya Hospita, private | Heart disease; Thoracic diseases; orthopedic diseases;Celiac disease | | | | |
2021-004417-40: The effect of pregabalin in the treatment of acute post-operative peripheral neuropathic pain – a pilot study |
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| Not yet recruiting | 4 | 50 | Europe | Lyrica | Helse Bergen HF, Helse Bergen HF | acute post-operative peripheral neuropathic pain, acute post-operative peripheral neuropathic pain, Diseases [C] - Nervous System Diseases [C10] | | | | |
ChiCTR2200056163: Effects of Pregabalin, Duloxetine and NSAIDs on Joint Pain and Function in Osteoarthritis Patients after Total Joint Arthroplasty |
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| Not yet recruiting | 4 | 84 | | 200mg celecoxib b.i.d. (morning and night) p.o. for 4 weeks ;75mg pregabalin b.i.d. (morning and night) p.o. for 4 weeks ;30mg duloxetine b.i.d. (morning and night) p.o. for 4 weeks | West China Hopital of Sichuan University; West China Hopital of Sichuan University, 1.3.5 Project of West China Hospital [No. 2021YFQ0028] | Osteoarthritis | | | | |
2022-001603-40: Influence of pregabalin and lacosamide on the respiratory depression caused by oxycodone |
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| Ongoing | 4 | 24 | Europe | Oxycodone, Lacosamide, Pregabalin, RVG 106669, N03AX18, N03AX16, Tablet, Film-coated tablet, Capsule, hard, Oxycodone, Vimpat, Lyrica | Leiden University Medical Center, Leiden University Medical Center | Healthy Volunteers, Healthy volunteers, Body processes [G] - Physiological processes [G07] | | | | |
2021-003664-28: The effect of pregabalin on the plasma concentration of propofol that isneeded to achieve adequately deep anaesthesia in 50% of patients thatresults in no motor reaction to a surgical incision. Der Effekt des Medikaments Pregabalin auf die Blut-Plasmakonzentrationdes Medikaments Propofol, welche benötigt wird, um in der Hälfte derPatientinnen und Patienten eine ausreichend tiefe Narkose zu erreichen,welche ausreicht, um eine Abwehrreaktion auf einen chirurgischenHautschnitt zu verhindern. |
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| Ongoing | 4 | 90 | Europe | Capsule, hard, Emulsion for infusion in administration system, Pregabalin ratiopharm 300 mg Hartkapseln, Propofol „Fresenius“ 2% mit MCT - Emulsion zur Injektion oder Infusion | Medical University of Vienna, Department of Anaesthesia, Critical Care and Pain Medicine, Medical University of Vienna | This study aims to investigate the effect of a clinically used dose ofPregabalin on the Cp50 of propofol toprovide more information to clinicians using this adjunctive drug in theperioperative setting. Das Ziel dieser Studie ist es, den Effekt einer klinisch üblichen Dosis vonPregabalin auf die Cp50 von Propofol zu untersuchen., This study aims to investigate the effect of aclinically used dose ofPregabalin on propofol, which is a routinely used anaesthetic agent. Das Ziel dieser Studie ist es, den Effekt von einer klinisch üblichen Dosis vonPregabalin auf das Routinenarkosemedikament Propofol zu untersuchen., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
| Active, not recruiting | 4 | 67 | RoW | Pentoxifylline Oral Tablet, Ibuprofen, Paracetamol, pregabalin | St Joseph University, Beirut, Lebanon | Lumbar Radiculopathy, Lumbar Disc Herniation, Lumbar Disc Disease | 12/22 | 12/24 | | |
NCT05558397: Epidural Association of Morphine and Ropivacaine for Cancer Pain Treatment |
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| Recruiting | 4 | 30 | RoW | Interventional Group (Epidural morphine), Control Group (Oral morphine) | Universidade Federal de Alfenas, Fundação de Amparo à Pesquisa do estado de Minas Gerais | Cancer Pain, Opioid Use, Cost Analysis, Palliative Care, Epidural Route, Morphine-ropivacaine Association, Quality of Life, Rational Use of Medication | 12/22 | 08/23 | | |
NCT05432843: Comparing Pregabalin and Placebo in Patients With Persistent Globus Sensation |
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| Recruiting | 4 | 90 | Europe | Pregabalin, Lyrica, Placebo | Universitaire Ziekenhuizen Leuven | Globus Sensation | 01/23 | 01/23 | | |
NCT04015908: A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery |
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| Completed | 4 | 100 | US | Celecoxib, Celebrex, Acetaminophen, Paracetamol, Pregabalin, Lyrica, Oxycodone, Xtampza ER, Oxaydo, Roxicodone, Percocet, Oxycodone / Paracetamol | University of Utah | Opioid Use | 01/23 | 01/23 | | |
ChiCTR2100041595: In the preemptive analgesia mode: a randomized controlled study of pregabalin combined with celecoxib in total knee arthroplasty |
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| Recruiting | 4 | 160 | | placebo 350mg ;celecoxib 200mg ;pregabalin 150mg ;Celecoxib 200mg+ Pregabalin 150mg | The Third Affiliated Hospital of Zunyi Medical University; The Third Affiliated Hospital of Zunyi Medical University (Zunyi First People's Hospital), Joint Surgery Fund of the First People's Hospital of Zunyi City | Total knee replacement | | | | |
NCT05640479: Pregabalin Versus Dexmedetomidine for Delirium Prevention After Cardiac Surgery |
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| Recruiting | 4 | 60 | RoW | Pregabalin, Dexmedetomidine | Tanta University | Pregabalin, Dexmedetomidine, Delirium | 12/24 | 01/25 | | |
NCT05640453: Pregabalin Versus Dexmedetomidine for Delirium Treatment After Coronary Artery Bypass Grafting |
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| Recruiting | 4 | 70 | RoW | Pregabalin, Dexmedetomidine | Tanta University | Pregabalin, Delirium Treatment, Coronary Artery Bypass Grafting, Dexmedetomidine | 05/23 | 05/23 | | |
NCT04471233: Influence of Patient Sex on Pain Control and Multimodal Analgesia in Total Knee Arthroplasty |
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| Completed | 4 | 250 | US | Multimodal analgesia including pregabalin, Multimodal analgesia not including pregabalin | Northwell Health | Knee Osteoarthritis, Pain, Postoperative | 06/23 | 06/23 | | |
NCT04990804: Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery |
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| Terminated | 4 | 8 | US | Opioid Analgesic, Opioid-Free Postoperative Pain Regimen | Vanderbilt University Medical Center, Cervical Spine Research Society | Opioid Use, Spinal Diseases, Surgery--Complications, Surgery, Postoperative Pain | 02/22 | 02/22 | | |
| Recruiting | 4 | 120 | RoW | Pregabalin 75mg, capsule, adductor canal block, peripheral nerve block | Bahrain Defence Force Hospital | Postoperative Pain | 06/25 | 07/25 | | |
ChiCTR2100054831: Clinical efficacy and safety of duloxetine hydrochloride and amitriptyline combined with pregabalin in patients with herpes zoster neuralgia |
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| Recruiting | 4 | 80 | | Duloxetine combined with pregabalin ;Amitriptyline combined with pregabalin | Nanjing Drum Tower Hospital, School of Medicine, Nanjing University; Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University | Herpes zoster neuralgia | | | | |
POLO, NCT05598905: Combined Effect of Pregabalin and Oxycodone, and Lacosamide and Oxycodone, on Breathing |
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| Completed | 4 | 24 | Europe | Pregabalin 150mg, Lyrica capsule 150 mg, Oxycodone 10mg, Oxycodone tablet 10 mg, Lacosamide 150 mg, Vimpat 150 mg capsule | Leiden University Medical Center | Opioid-induced Respiratory Depression | 01/24 | 01/24 | | |
NCT04894864: Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair |
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| Recruiting | 4 | 40 | Europe | Opioid-Based Anesthesia-Analgesia Strategy, Opioid-Based Anesthesia, OBA-A, Opioid-free Anesthesia-Analgesia Strategy, Opioid-Free Anesthesia, OFA-A | University of Crete, University Hospital of Crete | Elective Surgical Procedures, Postoperative Pain, Anesthesia, Opioid Use, Abdominal Aortic Aneurysm Without Rupture, Vascular Surgical Procedure, Interleukin 6, Immunomodulators | 10/25 | 10/27 | | |
NCT05933486: Efficacy and Safety of Tongluo-Kaibi Tablet in Patients With Fibromyalgia Syndrome |
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| Not yet recruiting | 4 | 150 | NA | Tongluo-Kaibi tablet plus placebo of pregabalin, placebo of Tongluo-Kaibi tablet plus pregabalin | Quan Jiang | Fibromyalgia Syndrome | 11/23 | 09/24 | | |
NCT05488847: Opioid-Free Pain Protocol After Shoulder Arthroplasty |
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| Recruiting | 4 | 80 | US | Celecoxib, Celebrex, Pregabalin, Lyrica, Tramadol, Ultram, Dexamethasone, Decadron, Acetaminophen, tylenol, Ropivicaine, naropin, Epinephrine, Ketorolac, Tizanidine, Zanaflex, Magnesium, magnesium oxide, Ibuprofen, Motrin, Oxycodone Hydrochloride 5 Mg, Roxicodone | Henry Ford Health System | Shoulder Arthropathy, Shoulder Pain | 12/24 | 12/25 | | |
ChiCTR2300070092: Effects of pregabalin combined with paracetamol and tramadol on acute pain in patients with CT-guided puncture localization of pulmonary nodules: a prospective, randomized controlled trial |
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| Not yet recruiting | 4 | 120 | | Two placebos were taken orally before localization ;Pregabalin and placebo were taken orally before localization ;Paracetamol and tramadol and placebo were taken orally before localization ;Pregabalin and paracetamol and tramadol were taken orally before localization | Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University; The Affiliated Hospital of Xuzhou Medical University, None | CT-guided puncture localization of pulmonary nodules | | | | |
NCT05447364: Efficacy of Different Doses of Pregabalin as a Multimodal Analgesic Agent in Postoperative Pain Control After Total Knee Arthroplasty |
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| Completed | 4 | 82 | RoW | Pregabalin 75mg, Pregabalin 150mg | Thammasat University | Knee Osteoarthritis | 09/23 | 03/24 | | |
ChiCTR2300072115: A randomized, double-blind, position-controlled, multicenter clinical study on the efficacy and safety of Kobotide injection in relieving severe nerve pain and preventing PHN in herpes zoster |
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| Recruiting | 4 | 80 | | Intramuscular injection of cobopeptide, oral pregabalin simulator ;Intramuscular injection of cobopeptide injection simulator, oral pregabalin capsule | The First Hospital of China Medical University; The First Hospital of China Medical University, Yunnan Nanzhao Pharmaceutical Co., LTD | Herpes zoster | | | | |
ChiCTR2300071850: Effect of oral pregabalin on postoperative sleep in patients undergoing video-assisted thoracoscopic surgery: a prospective, randomized controlled trial. |
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| Not yet recruiting | 4 | 120 | | On the night of operation, the morning and evening of the first and second day after operation, one pregabalin capsule (75mg) and one placebo with the same shape and smell were taken orally ;On the night of operation, the morning and evening of the first and second day after operation, two pregabalin capsules (150mg) were taken orally ;On the night of operation, the morning and evening of the first and second day after operation, two placebos with the same shape and smell were taken orally | Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University; The Affiliated Hospital of Xuzhou Medical University, None | Pulmonary nodules | | | | |
NCT06401499: The Effect of Pregabalin and Etoricoxib on Pain Alone Versus in Combination |
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| Not yet recruiting | 4 | 140 | NA | etoricoxib 60mg, pregabalin 75mg | Muhammad Ilyas | Back Pain Lower Back Chronic | 10/24 | 12/24 | | |
NCT05974501: Pre vs Post Block in Total Knee Arthroplasty (TKA) |
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| Completed | 4 | 84 | US | Dexamethasone, Acetaminophen, Lyrica, Celebrex, Meloxicam, Oxycodone, Ropivacaine, Adductor Canal Block | University of Miami | Knee Osteoarthritis, Arthroplasty Complications, Postoperative Pain | 01/24 | 01/24 | | |
| Recruiting | 4 | 84 | US | Escitalopram, Lexapro, Duloxetine, Cymbalta | University of Cincinnati | Anxious Depression, Depression | 07/25 | 12/25 | | |
NCT06367998: Effect of Pregabalin on Shoulder Pain in Patients With Central Sensitization After Arthroscopic Rotator Cuff Repair |
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| Not yet recruiting | 4 | 76 | NA | Pregabalin, Lyrica | The Catholic University of Korea, Viatris Korea | Rotator Cuff Tears, Central Sensitisation, Neuropathic Pain | 05/25 | 05/26 | | |
ChiCTR2400079841: Analysis of the efficacy of duloxetine and pregabalin for analgesia after total knee arthroplasty: a prospective, randomized controlled study |
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| Not yet recruiting | 4 | 120 | | Oral duloxetine 60 mg/dose once daily beginning two days before surgery and continuing through 14 days postoperatively; Oral pregabalin 150 mg/dose twice daily beginning two days before surgery and continuing through 14 days postoperatively; Oral duloxetine 60 mg/dose once a day and oral pregabalin 150 mg/dose twice a day starting two days prior to surgery and continuing until 14 days postoperatively; After the 6h postoperative fasting period, oral erixib tablets 0.1g, codeine 500mg, starting on the second postoperative day and up to 14 days postoperatively, oral erixib tablets 0.1g/dose, 2 times/day, oral codeine 500mg/dose, 2 times/day | Honghui Hospital, Xi'an Jiaotong University; Honghui Hospital, Xi'an Jiaotong University, self-finance | osteoarthritis of the knee | | | | |
NCT05804591: Pregabalin in the Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy (LSG). |
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| Recruiting | 4 | 90 | Europe | Pregabalin 150mg, Placebo | Medical University of Warsaw | Obesity, Postoperative Pain, Postoperative Nausea and Vomiting, Opioid Use | 04/25 | 08/25 | | |
| Terminated | 4 | 20 | US | Pregabalin 75mg, Study | University of Iowa | Osteo Arthritis Knee, Central Nervous System Sensitization | 01/24 | 01/24 | | |
NCT05172739: Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC |
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| Recruiting | 4 | 70 | Europe | Opioid-Based Anesthesia-Analgesia Strategy, Opioid-Based Anesthesia, OBA-A, Opioid-free Anesthesia-Analgesia Strategy, Opioid-Free Anesthesia, OFA-A | University of Crete | Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic, Infections Postoperative, Opioid Use, Anesthesia, Non-small Cell Lung Cancer | 11/25 | 11/26 | | |
NCT04705480: Pregabalin vs. Gabapentin on Reducing Opioid Usage |
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| Recruiting | 4 | 210 | US | Pregabalin 50mg, Lyrica, Gabapentin 300mg, Neurontin, Neither Pregabalin nor Gabapentin | CAMC Health System | Analgesics, Gabapentin, Injuries, Narcotics, Pain, Trauma | 12/25 | 12/25 | | |
NCT05478382: Pregabalin is an Effective Treatment for Acute Postoperative Pain Following Spinal Surgery Without Major Side Effects |
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| Not yet recruiting | 4 | 132 | NA | Pregabalin 25 MG, Placebo | Ajou University School of Medicine, HK inno.N Corporation | Postoperative Pain, Pregabalin, Spine Surgery, Adverse Reaction to Pregabalin | 12/25 | 12/25 | | |
ChiCTR2400081990: Duloxetine and pregabalin: High-dose monotherapy or their combination? -A prospective, randomised, triple-blind, parallel-group study of patients with postoperative pain after TKA based on the classification of Central Sensitization Inventory scores |
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| Not yet recruiting | 4 | 1200 | | All received 200 mg celecoxib as prophylactic pain control 2 hours before surgery, and all were given 1 mL of a 100-mL mixture containing 2,000 mg of fentanyl as needed after surgery using an intravenous patient-controlled anaesthesia (PCA) pump. After patients resumed oral intake, they were given 1 mg of oxycodone every 12 hours for 7 days, and 200 mg of celecoxib, 37.5 mg of tramadol, and 650 mg of acetaminophen every 12 hours for 6 weeks after surgry; During the initial 6-week treatment period, patients received 60 mg of duloxetine per day and thereafter, during the 6-week combination/high-dose treatment period, only non-responders (response rate assessed on the basis of a 30% reduction in mean 24-h pain on the BPI, or a score of 2) received 120 mg of duloxetine per day; During the initial 6-week treatment period, patients received 60 mg of duloxetine per day. Thereafter, during the 6-week combination/high-dose treatment period, only non-responders (response rate assessed on the basis of a 30% reduction in mean 24-h pain on the BPI or a score of 2) received the combination of 60 mg duloxetine daily and 300 mg pregabalin daily; During the initial 6-week treatment period, patients received 300 mg of pregabalin daily. Thereafter, during the 6-week combination/high-dose treatment period, only non-responders (response rate assessed on the basis of a 30% reduction in mean 24-h pain on the BPI or a score of 2) received the combination of 60 mg duloxetine daily and 300 mg pregabalin daily; During the initial 6-week treatment period, patients received 300 mg of pregabalin per day. Thereafter, during the 6-week combination/high-dose treatment period, only non-responders (response rate assessed on the basis of a 30 per cent reduction in mean 24-h pain on the BPI or a score of 2) received 600 mg of pregabalin per day; All received 200 mg celecoxib as prophylactic pain control 2 hours before surgery, and all were given 1 mL of a 100-mL mixture containing 2,000 mg of fentanyl as needed after surgery using an intravenous patient-controlled anaesthesia (PCA) pump. After patients resumed oral intake, they were given 1 mg of oxycodone every 12 hours for 7 days, and 200 mg of celecoxib, 37.5 mg of tramadol, and 650 mg of acetaminophen every 12 hours for 6 weeks after surgry | Honghui Hospital, Xi'an Jiaotong University; Honghui Hospital, Xi'an Jiaotong University, self-finance | osteoarthritis of the knee | | | | |
| Not yet recruiting | 3/4 | 120 | | | John Hunter Hospital-Hunter Integrated Pain Service, Pfizer Inc | Persistent phantom limb pain post amputation | | | | |
| Recruiting | 3/4 | 30 | | | The University of Queensland, NHMRC Centre of Research Excellence in Road Traffic Injury Recovery, Menzies Health Institute of Queensland | Whiplash Injury | | | | |
| Recruiting | 3/4 | 120 | | | Bahrain defence forces hospital, royal medical services, Bahrain defence forces hospital, royal medical services | postoperative Pain, Total knee replacement | | | | |
ACTRN12615001175561: Efficacy of Pregabalin for peri-operative pain relief in arthroscopic or minimally invasive shoulder surgery – A randomised, double-blind, prospective clinical trial. |
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| Not yet recruiting | 3 | 160 | | | Epworth HealthCare, Australian Orthopaedic Association | Rotator cuff tear | | | | |
| Not yet recruiting | 3 | 160 | | | University of Technology Sydney, NHMRC | Neuropathic Cancer Pain; Cancer | | | | |
| Recruiting | 3 | 84 | | | University of Technology Sydney, NHMRC | Neuropathic Cancer Pain, Cancer | | | | |
NCT00631891: Pregabalin in Treating Pain in Women Undergoing Mastectomy or Lumpectomy |
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| Recruiting | 3 | 80 | US | pregabalin, placebo | Simmons Cancer Center | Pain, Perioperative/Postoperative Complications | 05/09 | | | |
2005-002130-35: A Multicenter, Randomized, Parallel groups, Double-Blind, Placebo-controlled and 12 weeks follow-up Study to Evaluate the Safety, Tolerability and Efficacy of Pregabalin in Idiopathic Restless Legs Syndrome patients.Estudio multicéntrico, aleatorizado de grupos paralelos, doble ciego, controlado con placebo y de doce semanas de duración para evaluar la eficacia, seguridad y tolerabilidad de pregabalina en pacientes con síndrome de las piernas inquietas idiopático (SPI) |
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| Ongoing | 3 | 64 | Europe | Pregabalin (Lyrica, Lyrica, Lyrica | INSTITUTO DE ESTUDIOS DEL SISTEMA NERVIOSO | Idiopathic Restless legs Syndrome | | | | |
2008-002131-32: A RANDOMIZED, OPEN COMPARISON BETWEEN PREGABALIN/TRANSDERMAL BUPRENORPHINE AND PREGABALIN/DICLOFENAC IN CHRONIC NEUROPATHIC PAIN PATIENTS |
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| Ongoing | 3 | 110 | Europe | TRANSTEC*5CER 20MG 35MCG/H, LYRICA*14CPS 150MG, VOLTAREN*30CPR GASTROR 50MG, TRANSTEC*5CER 20MG 35MCG/H, LYRICA*14CPS 150MG, VOLTAREN*30CPR GASTROR 50MG | ASSOCIAZIONE ITALIANA PER LO STUDIO DEL DOLORE | PERIPHERAL NEUROPATHIC PAIN DUE TO POST-HERPETIC NEURALGIA OR DIABETIC POLYNEUROPATHY | | | | |
2009-011384-36: Randomized, controlled, trial, phase III, pregabalin vs placebo on postoperative morphine request after pectus escavatum surgery in children |
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| Ongoing | 3 | 40 | Europe | LYRICA, LYRICA | ISTITUTO GIANNINA GASLINI | Acute pain management | | | | |
2010-024538-51: Pregabalin in pain control after abdominal hysterectomy Pregabalina en el control del dolor tras histrectomía abdominal |
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| Ongoing | 3 | 180 | Europe | Lyrica, diprivan, fentanest, ultiva, esmeron, sevorane, bupivacaina hiperbarica, Lyrica, diprivan, fentanest, ultiva, esmeron, sevorane, bupivacaina hiperbarica | Silvia Gil Trujillo, Hospital General de Ciudad Real | The presence of acute postoperative pain remains a major cause of preoperative morbidity.The objective is to evaluate the analgesic efficacy of pregabalin in thepostoperatory of abdominal hysterectomy associated with 3 types of anesthesia. La presencia de dolor agudo postoperatio continúa siendo una causa importante de morbilidad perioperatoria. El objetivo es evaluar la eficacia analgésica de lapregabalina en el postopeatorio de histerectomia abdominal asociada a 3 tipos de anestesia. | | | | |
2016-003146-89: Optimal pathway for treating neuropathic pain in diabetes mellitus. |
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| Ongoing | 3 | 392 | Europe | Amitriptyline 25mg, Duloxetine, Pregabalin, Capsule, Gastro-resistant capsule, hard, , Amitriptyline 25mg, Duloxetine, Pregabalin 75mg | Sheffield Teaching Hospitals NHS Foundation Trust | Diabetic peripheral neuropathic pain., Painful nerve damage as a result of diabetes., Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT04161027: RCT for Pregabalin in Restless Legs Syndrome in South Korea |
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| Completed | 3 | 116 | RoW | Pregabalin 75mg, Placebos | Seoul National University Hospital | Restless Legs Syndrome | 04/22 | 04/22 | | |
NCT02884908: Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD |
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| Completed | 3 | 57 | US | Pregabalin plus BBCET, Lyrica, Placebo plus BBCET | University of Maryland, Baltimore, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | PTSD, Alcohol Use Disorder | 01/22 | 01/22 | | |
NCT05539924: Pregabalin Versus Gabapentin Opioid Sparing Effect in Discectomy |
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| Enrolling by invitation | 3 | 72 | RoW | Pregabalin 150mg gabapentin 400mg, vitamin B12 | Research Institute of Ophthalmology, Egypt, Cairo University | Opioid Use | 11/22 | 11/22 | | |
| Completed | 3 | 140 | Europe | Capsaicin, qutenza EU/1/09/524/001, Pregabalin, Lyrica | Institut Cancerologie de l'Ouest, Grünenthal GmbH | Breast Cancer Patient | 11/22 | 11/22 | | |
| Completed | 3 | 1 | Canada | Pregabalin, Placebo | The Hospital for Sick Children, Epidemolysis Bullosa Research Partnership | Pain, Neuropathic, Itch, Epidermolysis Bullosa | 03/23 | 02/24 | | |
LOBUXALIII, NCT05324059: Efficacy and Safety of Pregabalin/Tramadol Combination Versus Pregabalin in Acute Pain of Neuropathic Origin |
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| Completed | 3 | 110 | RoW | Pregabalin 75mg/ Tramadol 50 mg, LOBUXAL, Pregabalin 75mg, Pregabalin | Laboratorios Silanes S.A. de C.V. | Neuropathic Pain | 04/23 | 04/23 | | |
NCT05021263: Does IV Magnesium Improve Quality of Recovery With ERAS Protocols in Laparoscopic Colorectal Surgery? |
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| Completed | 3 | 90 | US | IV Medications, placebo | Thomas Jefferson University | Colo-rectal Cancer, Anesthesia | 12/23 | 12/23 | | |
NCT06025474: Comparison of Vortioxetine Versus Other Antidepressants With Pregabalin Augmentation in Burning Mouth Syndrome |
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| Recruiting | 3 | 203 | Europe | Vortioxetine 20Mg Tab, Brintellix, Paroxetine 20 Mg Oral Tablet, Sertraline 50 MG, Citalopram 20mg, Escitalopram 10mg, Duloxetine 60 MG, Pregabalin 75mg | Federico II University | Burning Mouth Syndrome | 10/23 | 07/24 | | |
NCT04666714: Efficacy and Safety of Praga Formulation in the Treatment of Neuropathic Pain |
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| Recruiting | 3 | 136 | RoW | Praga formulation, Placebo pregabalin 75mg, Placebo Pregabalin 150mg, Pregabalin 75mg, Pregabalin 150mg, Placebo Praga formulation | EMS | Neuropathic Pain | 12/24 | 08/25 | | |
NCT06180707: Pregabalin Gel in Reducing Post-operative Tooth Sensitivity Surgery Caused by Bleaching With 35% Hydrogen Peroxide |
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| Not yet recruiting | 3 | 75 | RoW | pregabalin gel, GPG, gel with 5% potassium nitrate and 2% sodium fluoride, NKFG, Placebo gel, PG | Universidade Federal do Para | Tooth Bleaching, Sensitivity, Tooth | 03/24 | 04/24 | | |
NCT06271486: Pregabalin in Treatment of Postdural Puncture Headache |
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| Recruiting | 3 | 75 | RoW | Pregabalin 75mg, An epidural blood patch (EBP), conservative treatment. | Al-Azhar University, Benha University | Postdural Puncture Headache | 08/24 | 08/24 | | |
NCT06516094: Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain |
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| Recruiting | 3 | 192 | RoW | Celecoxib+Pregabalin+Vitamin B fixed dose, Cele+Pre+Vit B, Celecoxib + Vitamin B fixed dose, Cele+Vit B, Pregabalin + Vitamin B fixed dose, Pre+Vit B | Laboratorios Silanes S.A. de C.V. | Chronic Low-back Pain | 01/25 | 02/25 | | |
PREVENT, NCT03216187: Swiss Multi-centre, Randomized, Placebo Controlled Trial of Pregabalin for Prevention of Persistent Pain in High Risk Patients Undergoing Breast Cancer Surgery |
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| Active, not recruiting | 3 | 126 | Europe | Pregabalin, Pregabalin 150mg capsules, Placebos, placebo capsules | Benno Rehberg-Klug, University Hospital, Geneva, Centre Hospitalier Universitaire Vaudois, Insel Gruppe AG, University Hospital Bern | Persistent Postoperative Pain | 06/24 | 11/24 | | |
ACTRN12623001356651: Pregabalin for the treatment of Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS) associated chronic cough. |
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| Not yet recruiting | 2/3 | 18 | | | Richard Roxburgh, Neurological Foundation of New Zealand | Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS), chronic cough | | | | |
ACTRN12617000889358: Efficacy of Perioperative Pregabalin as an Adjunct in Adolescent Scoliosis Surgery |
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| Not yet recruiting | 2/3 | 68 | | | Associate Professor Dr. Mohd Shahnaz Hasan | Adolescent Idiopathic Scoliosis | | | | |
ACTRN12614001153606: The vulvo-vaginal pain study:
A study looking at the effectiveness of an intra-vaginal cream for treatment of chronic vulvo-vaginal pain. . |
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| Not yet recruiting | 2/3 | 70 | | | Dr Jane Manning, International Urogynaecology Society | vulvo-vaginal pain | | | | |
NCT04689984: The Benefits of Astaxanthin as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient |
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| Recruiting | 2/3 | 60 | RoW | Standard therapy, Astaxanthin | Duta Wacana Christian University, PT SOHO Global Health Tbk | Painful Diabetic Neuropathy | 11/21 | 11/21 | | |
SOHOBION, NCT04689971: The Benefits of Vitamin B Combination as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient |
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| Recruiting | 2/3 | 60 | RoW | Standard therapy, Vitamin B combination, Vitamin B complex | Duta Wacana Christian University, PT SOHO Global Health Tbk | Painful Diabetic Neuropathy | 11/21 | 11/21 | | |
NCT04689958: The Benefits of Vitamin D 5000 IU as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient |
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| Recruiting | 2/3 | 60 | RoW | Standard therapy, Vitamin D 5,000IU Oral Tablet | Duta Wacana Christian University, PT SOHO Global Health Tbk | Painful Diabetic Neuropathy | 11/21 | 11/21 | | |
NCT05096468: Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms. |
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| Completed | 2/3 | 90 | RoW | S-ketamine and pregabalin, Normal saline and placebo capsule | Beijing Tiantan Hospital | Esketamine, Pregabalin, Acute Postoperative Pain, Neurosurgical Procedures, Perioperative Complication, Spinal Cord Neoplasms | 06/22 | 10/22 | | |
NCT04647773: To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Diabetic Peripheral Neuropathic Pain |
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| Not yet recruiting | 2/3 | 687 | RoW | HSK16149 20mg BID, HSK16149 40mg BID, HSK16149 60mg BID, HSK16149 80mg BID, Pregabalin 150mg BID, Placebo BID | Haisco Pharmaceutical Group Co., Ltd. | Diabetic Peripheral Neuropathic Pain | 11/22 | 11/22 | | |
NCT05509946: Preemptive Analgesia Combination of Celecoxib and Pregabalin in THA |
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| Not yet recruiting | 2/3 | 30 | NA | Single dose of celecoxib 400 mg and pregabalin 150 mg, Repeated dose of celecoxib 200 mg and pregabalin 75 mg, Placebo | Indonesia University | Arthroplasty Complications, Analgetic, Celecoxib, Pregabalin | 04/23 | 04/23 | | |