Sarcoma  >>  temozolomide  >>  Phase 1
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40 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
temozolomide / Generic mfg.
NCT00612638: Ph. I Temozolomide + O6-BG + Irinotecan in Treatment of Pts w Recurrent / Progressive Cerebral Anaplastic Gliomas

Completed
1
96
US
Temodar, O6-BG, and Irinotecan, Temodar-Temozolomide, O6-Benzylguanine-O6-BG, Irinotecan-Camptosar-CPT 11
Duke University, Keryx / AOI Pharmaceuticals, Inc., Pharmacia
Glioblastoma, Gliosarcoma
01/07
07/08
NCT00049387: Tipifarnib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

Completed
1
19
US
tipifarnib, R115777, Zarnestra, temozolomide, SCH 52365, Temodal, Temodar, TMZ, radiation therapy, irradiation, radiotherapy, therapy, radiation
National Cancer Institute (NCI)
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
06/07
06/07
NCT02227901: Tipifarnib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Completed
1
19
US
Tipifarnib, R115777, Zarnestra, External Beam Radiation Therapy, Definitive Radiation Therapy, EBRT, External Beam RT, Temozolomide, TMZ, Laboratory Biomarker Analysis
National Cancer Institute (NCI)
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
06/07
04/14
NCT00612989: Ph I 5-day Temozolomide + O6-BG in Treatment of Pts w Recurrent / Progressive GBM

Completed
1
42
US
Temodar and O6-Benzylguanine, Temodar, Temozolomide, O6-BG, O6-Benzylguanine, NSC637037, Neulasta, Pegfilgrastim
Duke University, Schering-Plough, Keryx / AOI Pharmaceuticals, Inc.
Glioblastoma, Gliosarcoma
08/07
07/08
NCT00077454: Erlotinib and Temozolomide in Treating Young Patients With Recurrent or Refractory Solid Tumors

Completed
1
95
US
erlotinib hydrochloride, CP-358,774, erlotinib, OSI-774, temozolomide, SCH 52365, Temodal, Temodar, TMZ, pharmacological study, pharmacological studies, laboratory biomarker analysis
National Cancer Institute (NCI)
Previously Treated Childhood Rhabdomyosarcoma, Recurrent Childhood Brain Tumor, Recurrent Childhood Cerebellar Astrocytoma, Recurrent Childhood Cerebral Astrocytoma, Recurrent Childhood Ependymoma, Recurrent Childhood Malignant Germ Cell Tumor, Recurrent Childhood Medulloblastoma, Recurrent Childhood Rhabdomyosarcoma, Recurrent Childhood Soft Tissue Sarcoma, Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor, Recurrent Neuroblastoma, Recurrent Osteosarcoma
09/07
 
NCT00612651: PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas

Completed
1
37
US
Temodar and SCH 66336, Temodar-Temozolomide, Farnesyl transferase inhibitor-SCH 66336
Duke University, Schering-Plough
Gliosarcoma, Glioblastoma, Anaplastic Astrocytoma
01/09
06/11
NCT00610571: Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas

Completed
1
62
US
Oral Topotecan and Temodar, Temodar - Temozolomide, Topotecan - Hycamtin
Katy Peters, GlaxoSmithKline, Schering-Plough
Glioblastoma, Gliosarcoma, Anaplastic Astrocytoma
09/09
04/12
NCT00303940: Talabostat Combined With Temozolomide or Carboplatin in Treating Young Patients With Relapsed or Refractory Brain Tumors or Other Solid Tumors

Completed
1
26
US
carboplatin, talabostat mesylate, temozolomide, pharmacological study
National Institutes of Health Clinical Center (CC), National Cancer Institute (NCI)
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Kidney Cancer, Liver Cancer, Neuroblastoma, Ovarian Cancer, Sarcoma, Unspecified Childhood Solid Tumor, Protocol Specific
 
02/10
NCT00734864: Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma

Withdrawn
1
0
US
enzyme-inducing anti-epileptic drugs
Annick Desjardins, Bristol-Myers Squibb
Glioblastoma Multiforme, Gliosarcoma, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Glioma
06/10
06/12
NCT00316849: Temsirolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Completed
1
56
US
pharmacological study, pharmacological studies, adjuvant therapy, 3-dimensional conformal radiation therapy, 3D conformal radiation therapy, 3D-CRT, intensity-modulated radiation therapy, IMRT, temsirolimus, CCI-779, cell cycle inhibitor 779, Torisel, temozolomide, SCH 52365, Temodal, Temodar, TMZ
National Cancer Institute (NCI)
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
11/10
 
NCT00960063: A Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Pediatric Participants With Advanced Solid Tumors (P05883, MK-7454-006)

Terminated
1
4
NA
Temozolomide, Vincristine, Ifosfamide, Irinotecan, Robatumumab, Doxorubicin, Cyclophosphamide, Etoposide
Merck Sharp & Dohme LLC
Neoplasms, Solid Tumors, Bone Cancer, Kidney Tumor, Neuroblastoma
12/10
12/10
NCT00946335: ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors

Checkmark ASCO 2013
May 2013 - May 2013: ASCO 2013
Completed
1
31
US
veliparib, ABT-888, temozolomide, SCH 52365, Temodal, Temodar, TMZ, pharmacological study, pharmacological studies, laboratory biomarker analysis
National Cancer Institute (NCI)
Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor, Childhood Craniopharyngioma, Childhood Ependymoblastoma, Childhood Grade I Meningioma, Childhood Grade II Meningioma, Childhood Grade III Meningioma, Childhood High-grade Cerebellar Astrocytoma, Childhood High-grade Cerebral Astrocytoma, Childhood Infratentorial Ependymoma, Childhood Low-grade Cerebellar Astrocytoma, Childhood Low-grade Cerebral Astrocytoma, Childhood Medulloepithelioma, Childhood Mixed Glioma, Childhood Oligodendroglioma, Childhood Supratentorial Ependymoma, Recurrent Childhood Brain Stem Glioma, Recurrent Childhood Brain Tumor, Recurrent Childhood Cerebellar Astrocytoma, Recurrent Childhood Cerebral Astrocytoma, Recurrent Childhood Ependymoma, Recurrent Childhood Medulloblastoma, Recurrent Childhood Pineoblastoma, Recurrent Childhood Spinal Cord Neoplasm, Recurrent Childhood Subependymal Giant Cell Astrocytoma, Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor, Recurrent Childhood Visual Pathway and Hypothalamic Glioma
10/11
06/14
NCT00884416: Sorafenib in Newly Diagnosed High Grade Glioma

Completed
1
17
Europe
Sorafenib dose escalation
University Hospital, Geneva, Bayer
Glioblastoma, Gliosarcoma, Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma, Anaplastic Oligodendroglioma
12/11
03/12
NCT00629343: Phase I Dose-Escalation Study Of Azacitidine In Combination With Temozolomide

Unknown status
1
28
US
Azacitidine In Combination With Temozolomide
Columbia University, Schering-Plough, Celgene Corporation
Soft Tissue Sarcoma, Mesothelioma
10/12
08/14
NCT01076530: Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors

Completed
1
27
US, Canada
vorinostat, L-001079038, SAHA, suberoylanilide hydroxamic acid, Zolinza, temozolomide, SCH 52365, Temodal, Temodar, TMZ, diagnostic laboratory biomarker analysis, pharmacological study, pharmacological studies
National Cancer Institute (NCI)
Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma, Childhood Central Nervous System Embryonal Tumor, Childhood Central Nervous System Germinoma, Childhood Central Nervous System Mixed Germ Cell Tumor, Childhood Central Nervous System Teratoma, Childhood Central Nervous System Yolk Sac Tumor, Childhood Choroid Plexus Tumor, Childhood Craniopharyngioma, Childhood Ependymoblastoma, Childhood Grade I Meningioma, Childhood Grade II Meningioma, Childhood Grade III Meningioma, Childhood High-grade Cerebellar Astrocytoma, Childhood High-grade Cerebral Astrocytoma, Childhood Infratentorial Ependymoma, Childhood Low-grade Cerebellar Astrocytoma, Childhood Low-grade Cerebral Astrocytoma, Childhood Medulloepithelioma, Childhood Mixed Glioma, Childhood Oligodendroglioma, Childhood Supratentorial Ependymoma, Extra-adrenal Paraganglioma, Recurrent Childhood Brain Stem Glioma, Recurrent Childhood Central Nervous System Embryonal Tumor, Recurrent Childhood Cerebellar Astrocytoma, Recurrent Childhood Cerebral Astrocytoma, Recurrent Childhood Ependymoma, Recurrent Childhood Medulloblastoma, Recurrent Childhood Pineoblastoma, Recurrent Childhood Spinal Cord Neoplasm, Recurrent Childhood Subependymal Giant Cell Astrocytoma, Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor, Recurrent Childhood Visual Pathway and Hypothalamic Glioma
10/12
 
NCT00960492: Safety Study of XL184 (Cabozantinib) in Combination With Temozolomide and Radiation Therapy in the Initial Treatment of Adults With Glioblastoma

Completed
1
26
US
XL184, temozolomide, Temodar®, Radiation Therapy
Exelixis
Glioblastoma, Giant Cell Glioblastoma, Gliosarcoma
11/12
10/13
NCT00650923: Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma

Completed
1
61
US
ziv-aflibercept, aflibercept, vascular endothelial growth factor trap, VEGF Trap, Zaltrap, radiation therapy, irradiation, radiotherapy, therapy, radiation, temozolomide, SCH 52365, Temodal, Temodar, TMZ, pharmacological study, pharmacological studies, laboratory biomarker analysis
National Cancer Institute (NCI)
Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Adult Mixed Glioma, Recurrent Adult Brain Tumor
06/13
12/13
NCT01119599: RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma

Completed
1
22
US
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Gamma-Secretase Inhibitor RO4929097, RO4929097, Intensity-Modulated Radiation Therapy, IMRT, Intensity Modulated RT, Intensity-Modulated Radiotherapy, Laboratory Biomarker Analysis, Pharmacological Study, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temodal, Temodar, Therapeutic Conventional Surgery
National Cancer Institute (NCI)
Acoustic Schwannoma, Adult Anaplastic (Malignant) Meningioma, Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Brain Stem Glioma, Adult Choroid Plexus Neoplasm, Adult Craniopharyngioma, Adult Diffuse Astrocytoma, Adult Ependymoblastoma, Adult Ependymoma, Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Adult Grade I Meningioma, Adult Grade II Meningioma, Adult Medulloblastoma, Adult Mixed Glioma, Adult Myxopapillary Ependymoma, Adult Oligodendroglioma, Adult Papillary Meningioma, Adult Pilocytic Astrocytoma, Adult Pineal Gland Astrocytoma, Adult Pineoblastoma, Adult Pineocytoma, Adult Primary Melanocytic Lesion of Meninges, Adult Subependymal Giant Cell Astrocytoma, Adult Subependymoma, Adult Supratentorial Primitive Neuroectodermal Tumor, Malignant Adult Intracranial Hemangiopericytoma
06/13
 
NCT00020150: Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors

Completed
1
US
O6-benzylguanine, temozolomide
National Cancer Institute (NCI)
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Kidney Cancer, Liver Cancer, Neuroblastoma, Ovarian Cancer, Sarcoma, Unspecified Childhood Solid Tumor, Protocol Specific
 
 
NCT02337426: Dimethyl Fumarate, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Completed
1
12
US
Dimethyl Fumarate, Fumaric Acid, Dimethyl Ester, Temozolomide, TMZ, Radiation Therapy, Cancer Radiotherapy, Irradiate, Irradiated, Irradiation, RT
Virginia Commonwealth University, National Cancer Institute (NCI)
Adult Brain Glioblastoma, Adult Giant Cell Glioblastoma, Adult Gliosarcoma
11/16
11/17
NCT01957956: Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Completed
1
21
US
Laboratory Biomarker Analysis, Malignant Glioma Tumor Lysate-Pulsed Autologous Dendritic Cell Vaccine, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
Mayo Clinic, National Cancer Institute (NCI)
Giant Cell Glioblastoma, Glioblastoma, Gliosarcoma
11/16
11/16
NRG-BN002, NCT02311920: Ipilimumab and/or Nivolumab in Combination With Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Completed
1
32
US
Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS-734016, Ipilimumab Biosimilar CS1002, MDX-010, MDX-CTLA4, Yervoy, Laboratory Biomarker Analysis, Nivolumab, BMS-936558, CMAB819, MDX-1106, NIVO, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ
National Cancer Institute (NCI), NRG Oncology
Gliosarcoma, Supratentorial Glioblastoma
12/17
12/22
ExCeL, NCT02664363: EGFRvIII CAR T Cells for Newly-Diagnosed WHO Grade IV Malignant Glioma

Terminated
1
3
US
EGFRvIII CAR T cells, EGFRvIII CARs, CAR-specific T cells, CAR T cells, CARs, 111Indium Labeled EGFRvIII CARs, 111In-Labeled EGFRvIII CARs, CAR gene-modified T cells, 111In-labeled CARs
Daniel Landi
Glioblastoma, Gliosarcoma
09/18
09/19
NCT00268385: Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Active, not recruiting
1
83
US
Laboratory Biomarker Analysis, Pharmacological Study, Temozolomide, CCRG-81045, Gliotem, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temizole, Temodal, Temodar, Temomedac, TMZ, Vorinostat, L-001079038, MSK-390, SAHA, Suberanilohydroxamic Acid, Suberoylanilide Hydroxamic Acid, Zolinza
National Cancer Institute (NCI)
Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Adult Mixed Glioma, Recurrent Adult Brain Neoplasm
10/18
04/25
NCT03139331: PAZIT Study for Children and Young Adults With Relapsed or Refractory Sarcoma

Completed
1
16
US
Pazopanib, Irinotecan, Temozolomide
University of California, San Francisco, UCSF Benioff Children's Hospital Oakland, Dana-Farber Cancer Institute, Alex's Lemonade Stand Foundation
Sarcoma, Refractory Sarcoma
10/19
09/20
NCT02502708: Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primary Malignant Brain Tumors

Checkmark From trial for front-line DIPG at ESMO-IO 2019
Dec 2019 - Dec 2019: From trial for front-line DIPG at ESMO-IO 2019
Checkmark Data in combination with radiation and chemotherapy for children with diffuse intrinsic pontine glioma at ISPNO
Jul 2018 - Jul 2018: Data in combination with radiation and chemotherapy for children with diffuse intrinsic pontine glioma at ISPNO
Checkmark In pediatric brain cancer at AACR 2018
More
Completed
1
81
US
Indoximod, 1-methyl-D-tryptophan, D-1MT, Temozolomide, Temodar, Methazolastone, Conformal Radiation, Cyclophosphamide, Etoposide
NewLink Genetics Corporation
Glioblastoma Multiforme, Glioma, Gliosarcoma, Malignant Brain Tumor, Ependymoma, Medulloblastoma, Diffuse Intrinsic Pontine Glioma, Primary CNS Tumor
12/19
02/20
NCT02044120 / 2014-005541-50: ESP1/SARC025 Global Collaboration: A Phase I Study of a Combination of the PARP Inhibitor, Niraparib and Temozolomide and/or Irinotecan Patients With Previously Treated, Incurable Ewing Sarcoma

Checkmark Initiation of trial for Ewing's sarcoma
May 2014 - May 2014: Initiation of trial for Ewing's sarcoma
Completed
1
34
Europe, US
niraparib, Temozolomide, Irinotecan
Sarcoma Alliance for Research through Collaboration
Ewing Sarcoma
01/21
01/21
NCT01858168: Phase I Study of Olaparib and Temozolomide for Ewings Sarcoma or Rhabdoomyosarcoma

Active, not recruiting
1
93
US
Olaparib, AZD2281, Temozolomide, Temodal, SCH52365, Temodar, Irinotecan, Camptosar
Massachusetts General Hospital
Ewing Sarcoma, Rhabdomyosarcoma
11/24
12/24
NCT00102648: Lonafarnib and Temozolomide in Treating Patients With Glioblastoma Multiforme That Is Recurrent or Did Not Respond to Previous Treatment With Temozolomide

Active, not recruiting
1
35
US
Lonafarnib, 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide, Sarasar, SCH 66336, SCH-66336, SCH66336, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Malignant Supratentorial Neoplasm, Recurrent Glioblastoma, Recurrent Gliosarcoma
12/22
12/22
NCT01430351: Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy

Active, not recruiting
1
144
US
Mefloquine, Memantine Hydrochloride, Ebixia, Namenda, Metformin Hydrochloride, APO-Metformin, Cidophage, Dimefor, Glifage, Glucoformin, Glucophage, Glucophage ER, Metformin HCl, Riomet, Siofor, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma, Supratentorial Glioblastoma
09/25
09/25
NYMC195, NCT04308330 / 2008-003800-73: Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

Recruiting
1
30
US
Vorinostat, Zolinza
New York Medical College
Ewing Sarcoma, Rhabdomyosarcoma, Wilms Tumor, Neuroblastoma, Hepatoblastoma, Germ Cell Tumor
12/23
12/24
NCT05698524: A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

Recruiting
1
18
US
PCI 24781, Abexinostat, Temozolomide, Temodar
University of Nebraska, Xynomic Pharmaceuticals, Inc.
Recurrent High Grade Glioma, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Glioblastoma, Gliosarcoma
02/25
06/27
NCT04397679: Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma

Active, not recruiting
1
2
US
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Radiation, 3D Conformal, Intensity-Modulated Radiation Therapy (IMRT), IMRT, Intensity Modulated RT, INTENSITY-MODULATED RADIATION THERAPY, Intensity-Modulated Radiotherapy, Temozolomide, 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 362856, 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, 85622-93-1, CCRG-81045, imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, Imidazo[5,1-d], 1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temomedac, TMZ, Chloroquine, 54-05-7, Tumor Treating Fields Therapy (TTF), Alternating Electric Field Therapy, TTF, TTFields
Barbara Ann Karmanos Cancer Institute, National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma
04/25
04/26
NCT04337177: Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Recruiting
1
20
US
VAL-413, Orotecan®, Temozolomide, Temodar, Temodal, Temcad, TMZ
Valent Technologies, LLC
Solid Tumors, Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma, Hepatoblastoma, Medulloblastoma
06/24
06/24
NCT01189643: Irinotecan, Temozolomide and Bevacizumab in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Newly Diagnosed Patients With Desmoplastic Small Round Cell Tumor

Active, not recruiting
1
15
US
irinotecan, temozolomide, and bevacizumab incorporated into an existing schedule of high dose alkylator
Memorial Sloan Kettering Cancer Center, Genentech, Inc.
Sarcoma, Desmoplastic Small Round Cell Tumor (DSRCT)
08/24
08/24
NCT03715933: Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

Recruiting
1
240
US
INBRX-109, Carboplatin, Cisplatin, Pemetrexed, 5-fluorouracil, Irinotecan, Temozolomide
Inhibrx, Inc.
Solid Tumors, Malignant Pleural Mesothelioma, Gastric Adenocarcinoma, Colorectal Adenocarcinoma, Sarcoma, Pancreatic Adenocarcinoma, Ewing Sarcoma, Chondrosarcoma, GIST, SDH-deficient Solid Tumors
12/25
07/26
NCT04477200: Mycophenolate Mofetil Combined With Radiation Therapy in Glioblastoma

Recruiting
1
68
US
Mycophenolate Mofetil, MMF, Radiation Therapy, RT, Re-resection (as part of standard of care), Temozolomide, TMZ
University of Michigan Rogel Cancer Center, National Cancer Institute (NCI)
Recurrent Glioblastoma, Recurrent Gliosarcoma, Recurrent Astrocytoma, Grade IV, Newly Diagnosed Glioblastoma, Newly Diagnosed Gliosarcoma, Newly Diagnosed Astrocytoma, Grade IV
10/24
10/27
NCT04199026: Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma

Not yet recruiting
1
20
US
Doxorubicin, Adriablastin, Hydroxydaunomycin, Hydroxyl Daunorubicin, Hydroxyldaunorubicin, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, hydroxydaunorubicin, Rubex, Drug Delivery Microdevice, Microdevice, Everolimus, 42-O-(2-Hydroxy)ethyl Rapamycin, Afinitor, Certican, RAD 001, RAD001, Votubia, Zortress, Ganitumab, AMG 479, Anti-IGF-1R Human Monoclonal Antibody AMG-479, Ifosfamide, Asta Z 4942, Asta Z-4942, Cyfos, Holoxan, Holoxane, Ifex, IFO, IFO-Cell, Ifolem, Ifomida, Ifomide, Ifosfamidum, Ifoxan, IFX, Iphosphamid, Iphosphamide, Iso-Endoxan, Isoendoxan, Isophosphamide, Mitoxana, MJF 9325, MJF-9325, Naxamide, Seromida, Tronoxal, Z 4942, Z-4942, Irinotecan, Pazopanib, GW786034, Polyethylene Glycol, Glycol, polyethylene, PEG, Poly(oxyethylene), Polyethylene Glycol 400, Polyethylene Glycol 8000, POLYETHYLENE GLYCOL, UNSPECIFIED, Polyethylene Oxide, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ, Temsirolimus, CCI-779, CCI-779 Rapamycin Analog, Cell Cycle Inhibitor 779, Rapamycin Analog, Rapamycin Analog CCI-779, Torisel, Therapeutic Conventional Surgery, Vincristine, LEUROCRISTINE, VCR, Vincrystine
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Metastatic Sarcoma, Recurrent Sarcoma, Resectable Sarcoma
12/25
12/25
NCT04216329: Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

Active, not recruiting
1
6
US
Selinexor, Temozolomide, Generic Radiation therapy (RT)
National Cancer Institute (NCI)
Gliosarcoma, Newly Diagnosed, Glioblastoma
09/23
07/26
NCT04555577: Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

Recruiting
1
29
US
Peposertib, Radiation Therapy, Cancer Radiotherapy, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Resection, Surgical Resection, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma
10/25
10/25

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