| lacosamide / Generic mfg. |
NCT00861068: A Multi-Centre, Randomized, Double-Blind, Placebo Controlled Pilot Trial to Assess the Efficacy, Safety, and Tolerability of SPM 927 in Subjects With Postherpetic Neuralgia (PHN). |
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| Completed | 2 | 44 | NA | SPM927/Lacosamide, Placebo, SPM927, Lacosamide, Vimpat® | UCB Pharma | Postherpetic Neuralgia | 12/02 | 01/03 | | |
NCT00861445: A Trial to Investigate Safety and Efficacy of SPM927 in Painful Diabetic Neuropathy |
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| Completed | 2 | 119 | US | SPM927/Lacosamide, Placebo, SPM927, Lacosamide, Vimpat® | UCB Pharma | Painful Diabetic Neuropathy | 01/03 | 02/03 | | |
NCT00800215: A Trial to Investigate the Safety, Tolerability and Pharmacokinetics of Intravenous SPM 927 |
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| Completed | 2 | 60 | NA | iv SPM 927 and oral placebo tablet, Lacosamide, Vimpat, oral SPM 927 tablet and iv placebo | UCB Pharma | Epilepsy | 08/04 | 11/04 | | |
NCT00861042: An Open-label follow-on Trial to Assess the Long-term Safety and Efficacy of Oral SPM 927 in Subjects With Diabetic Neuropathy |
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| Completed | 2 | 69 | NA | SPM927/Lacosamide, SPM927 / Lacosamide / Vimpat® | UCB Pharma | Painful Diabetic Neuropathy | 12/04 | 03/05 | | |
NCT00238511: An Open-Label Follow-on Trial to Assess the Long-Term Safety and Efficacy of Oral SPM 927 in Subjects With Postherpetic Neuralgia (PHN) |
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| Completed | 2 | | Europe | SPM 927 | UCB Pharma | Postherpetic Neuralgia | 01/05 | 01/05 | | |
| Terminated | 2 | 194 | Europe, RoW | lacosamide, VIMPAT, Placebo | UCB Pharma | Osteoarthritis | 11/07 | 01/08 | | |
NCT00401830: Assessing Efficacy and Safety of Lacosamide Compared to Placebo in Reducing Signs and Symptoms of Fibromyalgia Syndrome. |
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| Completed | 2 | 159 | US | Lacosamide, Vimpat, Harkoseride, Placebo | UCB Pharma | Fibromyalgia Syndrome | 02/08 | 02/08 | | |
NCT00440518: A Study Designed to Test the Effectiveness and Safety of Treating Patients With Lacosamide for Migraine Prophylaxis |
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| Completed | 2 | 218 | US | Lacosamide, LCM, Vimpat, Placebo | UCB Pharma | Migraine | 07/08 | 07/08 | | |
NCT00552305: To Determine Tolerability and Efficacy of Long-term Oral Lacosamide in Patients With Partial Seizures |
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| Completed | 2 | 370 | US, Europe | lacosamide, Vimpat | UCB Pharma | Partial Epilepsies | 02/10 | 02/10 | | |
NCT00237458: An Open-label Continuation Trial to Assess the Continued Efficacy and Safety of Ascending Doses of Lacosamide in Subjects With Chronic Refractory Neuropathic Pain |
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| Completed | 2 | 7 | Europe | Lacosamide, SPM 927, Vimpat | UCB Pharma | Chronic Refractory Neuropathic Pain | 03/11 | 03/11 | | |
NCT01118949 / 2014-004379-22: Open-Label Study to Assess Lacosamide Safety as Add-on Therapy for Primary Generalized Tonic-Clonic Seizures in Subjects With Epilepsy |
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| Completed | 2 | 49 | US | Lacosamide, Vimpat® | UCB BIOSCIENCES, Inc. | Epilepsy | 08/11 | 08/11 | | |
NCT01118962 / 2014-004375-23: Open-Label Extension Study to Assess the Safety and Seizure Frequency Associated With Lacosamide for Primary Generalized Tonic-Clonic Seizures in Subjects With Epilepsy |
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| Completed | 2 | 39 | US | Lacosamide, Vimpat® | UCB BIOSCIENCES, Inc. | Epilepsy | 10/12 | 10/12 | | |
NCT01458522: Intravenous Lacosamide Compared With Fosphenytoin in the Treatment of Patients With Frequent Nonconvulsive Seizures |
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| Completed | 2 | 74 | US | fPHT, Cerebyx, Fosphenytoin, LCM, Vimpat, Lacosamide | Aatif Husain, UCB Pharma | Nonconvulsive Seizures | 07/14 | 07/15 | | |
NCT00938431 / 2011-001558-27: A Multicenter, Open-Label Study To Investigate The Safety And Pharmacokinetics Of Lacosamide In Children With Partial Seizures |
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| Completed | 2 | 47 | US, Europe, RoW | Lacosamide, Vimpat | UCB Pharma | Epilepsy | 08/14 | 08/14 | | |
| Terminated | 2 | 72 | Canada | Lacosamide, Vimpat | Lawson Health Research Institute, UCB Pharma GmbH | Focal Epilepsy | 08/16 | 08/16 | | |
NCT02342977: Effects of Lacosamide on Post-operative Opioid Requirements After a Total Hip Arthroplasty: |
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| Withdrawn | 2 | 0 | US | Placebo, Lacosamide | Indiana University School of Medicine, VA Office of Research and Development | Osteoarthritis, Rheumatoid Arthritis, Avascular Necrosis | 08/16 | 08/16 | | |
NCT01969851 / 2012-001446-18: A Study to Investigate the Safety and Efficacy of Lacosamide Added to the Patients Current Therapy in Patients Aged 1 Month to Less Than 18 Years Old With Epilepsy Syndromes Associated With Generalized Seizures. |
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| Completed | 2 | 55 | US, Europe, RoW | Lacosamide, Vimpat | UCB Pharma | Epilepsy | 04/18 | 04/18 | | |
2016-001611-20: Cause-based treatment of patients with therapy resistant early onset epilepsy |
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| Ongoing | 2 | 25 | Europe | Phenytoin, Vimpat, Suspension for use in drinking water, Syrup, Vimpat Syrup | University of Tübingen, University of Tübingen | patients with epileptic encephalopathies Patienten mit epileptischen Enzephalopathien, patients with early onset diffucult to treat epilepsies Patienten mit früh beginnender schwer zu behandelnden Epilepsien, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT03897348: Pilot Human Lab Study of Lacosamide in Alcohol Use Disorder (AUD) |
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| Completed | 2 | 4 | US | Placebo, Placebo capsule identical in appearance to Lacosamide 100 mg and 200 mg capsules., Lacosamide 100 mg, Lacosamide 100 mg capsule identical in appearance to Placebo and Lacosamide 200 mg capsule, Lacosamide 200 mg, Lacosamide 200 mg capsule identical in appearance to Placebo and Lacosamide 100 mg capsules. | University of California, San Francisco, San Francisco VA Health Care System | Alcohol Use Disorder | 06/19 | 06/19 | | |
2019-000755-14: Trial in healthy subjects to investigate the effect of analgesic drug on pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity. Studio su soggetti sani volto ad indagare gli effetti di farmaci analgesici sulla elaborazione del dolore mediante misure neurofisiologiche del'attività del midollo del midollo spinale e del tronco dell'encefalo |
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| Ongoing | 2 | 56 | Europe | pregabalin, lacosamide, tapentadol, [N03AX16], [N/A], [N02AX06], Capsule, hard, Film-coated tablet, Tablet, LYRICA - 75 MG CAPSULA RIGIDA - USO ORALE 100 CAPSULE IN BLISTER IN UNITA' SEPARABILI PERFORATO (PVC/ALU), VIMPAT - 100 MG - COMPRESSE RIVESTITE CON FILM - USO ORALE - BLISTER (PVC/PVDC/ALU) 14 COMPRESSE, PALEXIA - 50 MG COMPRESSE RIVESTITE CON FILM 10 COMPRESSE IN BLISTER PVC/PVDC/AL | UMBERTO I - POLICLINICO DI ROMA, Teva Pharmaceutical Industries LTD, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmbH | Healthy volunteers (intended indication: pain) soggetti sani (indicazione: dolore), Healthy volunteers (intended indication: pain) soggetti sani (indicazione: dolore), Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
NCT03436433: Seizure Prophylaxis in Patients With Glioma or Brain Metastasis |
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| Terminated | 2 | 4 | US | Lacosamide, LCM, Vimpat, Levetiracetam, LEV, Keppra | Duke University | Glioma, Glioma of Brain, Brain Tumor | 12/20 | 12/20 | | |
2020-001285-11: A Randomized, open label, Non-inferiority trial on the efficacy of Lacosamide versus Duloxetine in Patients with Chemotherapy-induced Polyneuropathy – A strategy trial |
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| Ongoing | 2 | 100 | Europe | Duloxetine, Lacosamide, N06AX21, N03AX18, Capsule, Film-coated tablet, Cymbalta, Vimpat | Leiden University Medical Center, Leiden University Medical Center | Chemotherapy-induced polyneuropathy, Nerve pain after chemotherapy, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Completed | 2 | 366 | Europe, Japan, US, RoW | Lacosamide, Vimpat® | UCB BIOSCIENCES, Inc. | Epilepsy | 05/21 | 05/21 | | |
2019-000942-36: The effects of lacosamide, pregabalin and tapentadol on biomarkers of peripheral pain processing |
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| Not yet recruiting | 2 | 60 | Europe | lacosamide, Pregabalin, Tapentadol, [N02AX06], [N/A], [N03AX16], Tablet, Capsule, Vimpat 100 mg film coated tablets, Lyrica 75 mg hard capsules, Palexia 50 mg film-coated tablets | Aarhus University, UMBERTO I - POLICLINICO DI ROMA, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmbH, Teva Pharmaceutical Industries LTD | Healthy volunteers (intended indication: pain), Study in healthy volunteers to examine drug effects on biomarkers in experimental pain, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
| Terminated | 2 | 63 | Europe | Lacosamide, Placebo | Danish Pain Research Center, Odense University Hospital | Neuropathic Pain, Neuropathy;Peripheral, Neuropathy, Painful, Neuropathy, Diabetic, Neuropathy | 06/22 | 06/22 | | |
2019-001204-37: The effects of lacosamide, pregabalin and tapentadol on biomarkers of pain processing |
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| Not yet recruiting | 2 | 56 | Europe | lacosamide, pregabalin, tapentadol, [N02AX06], [N03AX16], [N/A], Film-coated tablet, Capsule, Tablet, Vimpat 100mg film coated tablets, Lyrica 75 mg hard capsules, Palexia 50 mg film-coated tablets | Institute of Neuroscience (IoNS), Université catholique de Louvain, UMBERTO I - POLICLINICO DI ROMA, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under Grant Agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmBH, Teva Pharmaceutical Industries LTD | Healthy subjects (intended indication: pain), Study in healthy subjects to examine drug effects on biomarkers in experimental pain, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
2019-000908-15: The effects of lacosamide, pregabalin and tapentadol on pain processing |
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| Not yet recruiting | 2 | 36 | Europe | lacosamide, Pregabalin, Tapentadol, Tablet, Capsule, Vimpat 100 mg film coated tablets, Lyrica 75 mg hard capsules, Palexia 50 mg film-coated tablets | Aarhus University, Innovatice Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement, Eli Lilly and Company LTD, Esteve Pharmaceutical Industries LTD, Grünenthal GmbH, Teva Pharmaceutical Industries LTD | Healthy volunteers (intended indication: pain), Study in healthy volunteers to examine drug effects on biomarkers in experimental pain, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
LENS, NCT04519645 / 2020-001066-10: A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Lacosamide in Neonates With Repeated Electroencephalographic Neonatal Seizures |
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| Recruiting | 2 | 32 | Canada, US, RoW | Lacosamide intravenous, LCM, Lacosamide oral, Active Comparator | UCB Biopharma SRL | Electroencephalographic Neonatal Seizures, Epilepsy | 08/25 | 08/25 | | |
| Completed | 1/2 | 7 | Japan | Lacosamide | Chiba University | Amyotrophic Lateral Sclerosis | 04/20 | 05/20 | | |
