| topiramate / Generic mfg. |
NCT00236418: A Study of the Efficacy and Safety of Topiramate in Epilepsy Patients With Primary Generalized Tonic-clonic Seizures |
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| Completed | 3 | 80 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Epilepsy, Seizures | | 12/96 | | |
NCT00266591: A Study of the Efficacy and Safety of Topiramate Treatment in Patients With Epilepsy |
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| Completed | 3 | 51 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Epilepsy, Seizures | | 04/97 | | |
NCT00236704: A Study of the Efficacy and Safety of Topiramate as "Add on" Treatment in Epilepsy Patients With Primary Generalized Tonic-clonic Seizures |
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| Completed | 3 | 80 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Epilepsy, Seizures | | 12/99 | | |
NCT00236886: Prospective Pilot Study on Metabolism and Weight Changes in Topiramate-Treated Epilepsy Patients |
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| Completed | 3 | 49 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Epilepsy, Epilepsies, Partial, Epilepsy, Generalized, Seizures | | 06/00 | | |
NCT00236743: A Study of the Effectiveness and Safety of Topiramate in the Treatment of Children With Epilepsy |
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| Completed | 3 | 90 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Epilepsy, Epilepsies, Partial, Seizures | | 10/00 | | |
NCT00236717: A Study of the Effectiveness and Safety of Topiramate Compared With a Standard Therapy in Patients Newly Diagnosed With Epilepsy |
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| Completed | 3 | 865 | US | Topiramate; Carbamazepine; Valproate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Epilepsy, Seizures | | 11/00 | | |
NCT00236756: A Study of the Efficacy and Safety of Topiramate as an add-on Therapy in the Treatment of Epilepsy Patients With Lennox-Gastaut Syndrome |
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| Completed | 3 | 100 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Epilepsy, Seizures | | 02/01 | | |
NCT00253175: A Study of the Effectiveness and Safety of Topiramate for the Prevention of Migraine |
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| Completed | 3 | 211 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Ortho-McNeil Neurologics, Inc. | Vascular Headaches, Migraine | | 12/01 | | |
NCT00035802: A Study to Evaluate the Safety and Effectiveness of Topiramate Compared to Placebo in the Treatment of Patients With Bipolar I Disorder |
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| Completed | 3 | 13 | US | Topiramate, Placebo | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Bipolar Disorder, Affective Disorders, Psychotic, Mood Disorders, Mental Disorders | | 04/02 | | |
NCT00230698: A Study of the Effectiveness and Safety of Topiramate Monotherapy in Patients With Recently Diagnosed Partial-Onset Seizure |
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| Completed | 3 | 451 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Epilepsy, Epilepsies, Partial, Seizures | | 08/02 | | |
NCT00240721: A Study of the Effectiveness and Safety of Topiramate in the Treatment of Patients With Bipolar Disorder |
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| Completed | 3 | 363 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Bipolar Disorders, Mood Disorders, Affective Disorders, Psychotic | | 09/02 | | |
NCT00236509: A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine |
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| Completed | 3 | 763 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Migraine, Common Migraine, Classic Migraine, Headache | | 09/02 | | |
NCT00231595: A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine |
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| Completed | 3 | 768 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Migraine, Common Migraine, Classic Migraine, Headache | | 11/02 | | |
NCT00035230: A Study on the Safety and Efficacy of Topiramate in the Treatment of Patients With Bipolar I Disorder |
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| Completed | 3 | 338 | US | Topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Bipolar Disorder | | 11/02 | | |
NCT00236561: A Study of the Efficacy and Safety of Two Doses of Topiramate Compared to Placebo and Propranolol in the Prevention of Migraine |
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| Completed | 3 | 786 | US | topiramate, propranolol | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Migraine, Common Migraine, Classic Migraine, Headache | | 12/02 | | |
NCT00037674: A Study on the Safety and Efficacy of Topiramate in the Treatment of Patients With Bipolar I Disorder |
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| Completed | 3 | 434 | US | Topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Bipolar Disorder | | 05/03 | | |
NCT00231556: A Study on Safety and Efficacy of Two Doses of Topiramate as Monotherapy in the Treatment of Newly Diagnosed or Recurrent Epilepsy |
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| Completed | 3 | 750 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Epilepsy, Seizures, Epilepsies, Partial, Epilepsy, Generalized, Epilepsy, Tonic-Clonic | | 09/03 | | |
NCT00237302: A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Preventing Migraine Headaches in Children |
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| Completed | 3 | 162 | US | topiramate | Ortho-McNeil Neurologics, Inc. | Migraine | | 09/03 | | |
NCT00237289: Topiramate Versus Placebo as add-on Treatment in Patients With Bipolar Disorder in the Outpatient Setting |
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| Completed | 3 | 287 | US | topiramate | Ortho-McNeil Neurologics, Inc. | Bipolar Disorder | | 10/03 | | |
NCT00210912: A Study of the Effectiveness and Safety of Topiramate Versus Placebo for Preventing Chronic Migraine Headaches |
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| Completed | 3 | 328 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Ortho-McNeil Neurologics, Inc. | Migraine | | 04/05 | | |
NCT00307619: An Efficacy and Tolerability Study for Topiramate in Obese Patients With Binge Eating Disorder. |
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| Completed | 3 | 73 | RoW | topiramate | Janssen-Cilag Farmaceutica Ltda. | Binge Eating | | 04/05 | | |
NCT00004776: Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramate for Lennox-Gastaut Syndrome |
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| Completed | 3 | 10 | US | topiramate | National Center for Research Resources (NCRR), University of California, Los Angeles | Lennox-Gastaut Syndrome | | | | |
NCT00216606: The Effectiveness and Safety of Topiramate on Prevention of Chronic Migraine |
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| Completed | 3 | 59 | Europe | topiramate | Janssen Pharmaceutica N.V., Belgium | Migraine | | 07/05 | | |
NCT00210873: An Open Label Extension of a Study of Topiramate in Chronic Migraine. |
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| Completed | 3 | 200 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Ortho-McNeil Neurologics, Inc. | Migraine | | 08/05 | | |
NCT00210821: Comparing the Safety and Effectiveness of Topiramate With the Safety and Effectiveness of Amitriptyline in Preventing Migraine Headaches |
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| Completed | 3 | 347 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Ortho-McNeil Neurologics, Inc. | Migraine, Headache | | 11/05 | | |
NCT00210860: An Open Label Extension of a Study Comparing Topiramate and Amitriptyline in Migraine Prevention. |
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| Completed | 3 | 142 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Ortho-McNeil Neurologics, Inc. | Migraine | | 03/06 | | |
| Completed | 3 | 834 | Europe, RoW | Topiramate, Topiramate - Placebo | Janssen Pharmaceutica N.V., Belgium | Migraine | | 08/06 | | |
NCT00210535: A Study of the Effectiveness and Safety of Topiramate for the Prevention of Migraine Attacks in Children |
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| Completed | 3 | 110 | US | Topiramate; Placebo | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Migraine, Vascular Headaches | | 11/06 | | |
NCT00113815: Topiramate as Adjunctive Therapy in Infants 1-24 Months for the Control of Partial Onset Seizures |
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| Completed | 3 | 118 | US, Canada, Europe, RoW | topiramate, placebo | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Partial Seizure Disorder, Epilepsy, Seizures | 06/07 | 11/07 | | |
2007-003702-95: A MULTICENTRE RANDOMIZED CONTROLLED TRIAL COMPARING TOPIRAMATE, STIRIPENTOL AND CLOBAZAM AS ADJUNCTIVE THERAPY TO VALPROATE AND CLOBAZAM IN PAEDIATRIC PATIENTS WITH DRAVET'S SYNDROME (SMEI) NOT ADEQUATELY CONTROLLED WITH CLOBAZAM AND VALPROATE, AND AUXILIARY PHARMACOGENETIC STUDY |
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| Ongoing | 3 | 90 | Europe | Capsule, hard, stiripentolo, TOPAMAX, FRISIUM*30CPS 10MG | ISTITUTO C. MONDINO | Dravet Syndrome | | | | |
NCT00210782: A Comparison of the Effectiveness and Safety of Topiramate and Phenytoin in Patients With New Onset Epilepsy Requiring Rapid Initiation of Antiepileptic Drug Treatment |
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| Completed | 3 | 262 | US | topiramate, phenytoin | Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Ortho-McNeil Neurologics, Inc. | Epilepsy | | 08/07 | | |
NCT00463775: Topiramate for Treatment of Patients With Borderline Personality Disorder and Alcohol Dependence |
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| Withdrawn | 3 | 0 | US | Topiramate | Elizabeth Ralevski | Alcohol Dependence, Borderline Personality Disorder | 05/09 | 05/09 | | |
ACTRN12609000600246: Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-Epileptic Drugs (AEDs) in Patients With Epilepsy. |
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| Terminated | 3 | 600 | | | Ortho-McNeil Janssen Scientific Affairs, LLC, Ortho-McNeil Janssen Scientific Affairs, Limited Liability Company,(LLC) | Epilepsy Seizures | | | | |
NCT00812006: A Study of Rizatriptan for the Treatment of Acute Migraine in Patients on Topiramate for Migraine Prophylaxis |
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| Completed | 3 | 108 | NA | rizatriptan benzoate, Maxalt, Comparator: placebo | Organon and Co | Migraine | 10/09 | 10/09 | | |
NCT00563459: Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-epileptic Drugs (AEDs) in Patients With Epilepsy. |
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| Terminated | 3 | 89 | US | carisbamate, topiramate, levetiracetam | SK Life Science, Inc. | Epilepsy, Seizures | 04/10 | 04/10 | | |
| Completed | 3 | 191 | US | propranolol LA, Inderal LA, topiramate, placebo | Anne Lindblad, National Institute of Neurological Disorders and Stroke (NINDS), Ortho-McNeil Janssen Scientific Affairs, LLC | Chronic Migraine | 09/10 | 09/10 | | |
2007-002198-30: A MULTICENTRE RANDOMIZED CONTROLLED TRIAL COMPARING TOPIRAMATE, STIRIPENTOL AND CLOBAZAM AT THE MAXIMAL TOLERATED DOSAGE, AS ADJUNCTIVE THERAPY TO VALPROATE AND CLOBAZAM IN PAEDIATRIC PATIENTS WITH DRAVET`S SYNDROME (SMEI), AND AUXILIARY PHARMACOGENETIC STUDY Studio clinico multicentrico, randomizzato, controllato che confronta Topiramato, Stiripentolo e Clobazam al massimo dosaggio tollerato, come terapia aggiuntiva al Valproato e Clobazam in pazienti pediatrici con sindrome di Dravet (SMEI), e studio ausiliare farmacogenetico. |
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| Terminated | 3 | 90 | Europe | Capsule, hard, stiripentolo, TOPAMAX, FRISIUM*30CPS 10MG | Inserm-ISP Pole Recherches cliniques et thérapeutiques | Dravet Syndrome sindrome di Dravet, Diseases [C] - Nervous System Diseases [C10] | | | | |
2011-005696-17: A clinical trial of topiramate vs placebo for newborns with perinatal asficia body treated with hypothermia. Ensayo clÃnico con topiramato vs placebo para el recien nacidos con asfixia perinatal tratados con hipotermia corporal. |
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| Ongoing | 3 | 152 | Europe | Topiramate, Spot-on suspension, Topiramato ratiopharm 200 | Instituto de Investigacion Sanitaria La Fe, INSTITUTO DE INVESTIGACION SANITARIA LA FE | Asphyxiated newborn infants evolving to moderate-to-severe hypoxic ischemic encephalopathy Recién nacidos con asfixia evolución de moderada a severa encefalopatÃa hipóxico-isquémica, Asphyxiated newborn infants evolving to moderate to severe hypoxic ischemic encephalopathy Recién nacidos con asfixia evolución de moderada a severa encefalopatÃa hipóxico-isquémica, Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | | | | |
NCT01581281: The Childhood and Adolescent Migraine Prevention Study |
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| Terminated | 3 | 488 | US | Amitriptyline, Topiramate, Placebo | Children's Hospital Medical Center, Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS) | Migraine, Migraine Disorders, Headache | 04/15 | 01/16 | | |
2015-001222-42: A comparison of the effectiveness and safety of topiramate and phenytoin in patients with new onset epilepsy requiring rapid initiation of antiepileptic drug treatment |
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| | 3 | 261 | US | TOPAMAX, PHENYTEK, Tablet, Capsule, TOPAMAX, PHENYTEK | Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Johnson & Johnson Pharmaceutical Research and Development | New onset epilepsy, Seizures unprovoked, Diseases [C] - Nervous System Diseases [C10] | | | | |
2011-003432-32: Etude d'efficacité et de tolérance du Topiramate dans le Prader Willi |
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| Not yet recruiting | 3 | 125 | Europe | Topiramate, Capsule, Topiramate | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP) | Patients de plus de 12 ans présentant un Syndrome de Prader Willi, Syndrome de Prader Willi, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2005-001234-32: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Topiramate for the Prophylaxis of Migraine in Pediatric Subjects 12 to 17 Years of Age. Estudio aleatorizado, doble ciego y controlado con placebo para evaluar la eficacia y seguridad de topiramato en la profilaxis de la migraña en población pediátrica de 12 a 17 años de edad |
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| Ongoing | 3 | 40 | Europe | Topiramate Tablets 25mg, GFI-17021-000-CA-008/FD-17021-AQ, | Janssen Cilag International NV | Migraine in Pediatric Population (12-17 year olds, inclusive) | | | | |
2005-001338-33: A Randomized, Double-Blind, Placebo Controlled, Fixed Dose-Ranging Study to Assess the Safety, Tolerability, and Efficacy of Topiramate Oral Liquid and Sprinkle Formulations as an Adjunct to Concurrent Anticonvulsant Therapy for Infants (1-23 Months of Age, Inclusive) With Refractory Partial-Onset Seizures, With Open-Label Extension |
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| | 3 | 9 | Europe | Topiramate Oral Solution, Topiramate Sprinkle Capsules, F017, Topamax Sprinkle Capsules, Topamax Sprinkle Capsules | Janssen-Cilag International N.V., JANSSEN-CILAG | Partial Onset Epilepsy and other Seizures | | 09/07 | | |
2007-002929-78: A Randomized, Double-blind, Parallel-group, Multicenter Study to Evaluate the Retention Rate, Efficacy, Safety, and Tolerability of Carisbamate, Topiramate and Levetiracetam as Adjunctive Therapy in Subjects with Partial Onset Seizures |
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| | 3 | 66 | Europe | Carisbamate, Topiramate, levetiracetam, RWJ-333369, Topamax, Keppra, Topamax, Keppra | Ortho-McNeil Janssen Scientific Affairs, LLC, ORTHO-MCNEIL JANSSEN SCIENTIFIC AFFAIRS, LLC | Partial onset seizures | | 05/10 | | |
NCT00571246: The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder |
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| Withdrawn | 3 | 0 | US | Topiramate, lamotrigine, Placebo | Yale University | Alcohol Dependence, Post Traumatic Stress Disorder | 06/16 | 06/16 | | |
NCT02374567: Pharmacovigilance in Gerontopsychiatric Patients |
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| Terminated | 3 | 407 | Europe | Phenobarbital, Phenytoin, Carbamazepine, Oxcarbazepine, Valproic Acid, Lamotrigine, Topiramate, Gabapentin, Levetiracetam, Pregabalin, Lacosamide, Clonazepam, Biperiden, Levomepromazine, Fluphenazine, Perphenazine, Perazine, Thioridazine, Haloperidol, Melperone, Pipamperone, Bromperidol, Benperidol, Sertindole, Ziprasidone, Flupentixol, Chlorprothixene, Zuclopenthixol, Fluspirilene, Pimozide, Clozapine, Olanzapine, Quetiapine, Sulpiride, Tiapride, Amisulpride, Prothipendyl, Risperidone, Aripiprazole, Paliperidone, Diazepam, Oxazepam, Lorazepam, Bromazepam, Clobazam, Alprazolam, Hydroxyzine, Buspirone, Chloral Hydrate, Flurazepam, Nitrazepam, Triazolam, Lormetazepam, Temazepam, Midazolam, Brotizolam, Zopiclone, Zolpidem, Zaleplon, Melatonin, Clomethiazole, Diphenhydramine, Promethazine, Imipramine, Clomipramine, Opipramol, Trimipramine, Amitriptyline, Nortriptyline, Doxepin, Maprotiline, Amitriptyline oxide, Fluoxetine, Citalopram, Paroxetine, Sertraline, Fluvoxamine, Escitalopram, Tranylcypromine, Moclobemide, Mianserin, Trazodone, Mirtazapine, Bupropion, Venlafaxine, Reboxetine, Duloxetine, Agomelatine, Pyritinol, Piracetam, Donepezil, Rivastigmine, Galantamine, Memantine, Nicergoline, Acamprosate, Lithium | Hannover Medical School | Dementia, Depression, Schizophrenia, Psychosomatic Disorders, Anxiety Disorders | 06/17 | 06/17 | | |
NCT02201251 / 2012-001552-19: A Study to Investigate the Safety of the Drugs Topiramate and Levetiracetam in Treating Children Recently Diagnosed With Epilepsy |
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| Completed | 3 | 63 | Europe, Canada, US, RoW | Topiramate, Levetiracetam | Janssen Research & Development, LLC | Epilepsy | 04/20 | 04/20 | | |
2021-003392-34: Aggressive or less aggressive treatment of persistent epileptic seizures |
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| Ongoing | 3 | 140 | Europe | Briviracetam, e.g. Keppra, e.g. Topimax, e.g. orfiril, Vimpat, n.a. many producers, different producers, Concentrate and solvent for solution for infusion, Infusion, Tablet, Briviract, Levetiracetam, Fosfenytoin, Topriamate, Orfiril/valproic acid, Vimpat, Propofol, Midazolam | Odense Universitetshospital, In-house funding Odense University Hospital | Verfied non convulsive status epilepticus refractory to standard treatment with benzodiazepines and at least one first line drug, Persistent epileptic seizures that do not respond to standard treatment, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Completed | 3 | 600 | RoW | Valproic acid, group A, Topiramate 50 MG, group B | Kafrelsheikh University | Migraine Disorders | 06/24 | 06/24 | | |
| Recruiting | 3 | 600 | RoW | Lacosamide 50 MG, group A, Topiramate 50Mg Tab, group B | Kafrelsheikh University | Migraine Disorders | 02/25 | 02/25 | | |
| Recruiting | 3 | 600 | RoW | Zonisamide 50 MG, group A, Topiramate 50 MG, group B | Kafrelsheikh University | Migraine | 04/25 | 05/25 | | |
TEMPLE, NCT05748483: Comparative Study of Oral Atogepant Versus Oral Topiramate to Assess Adverse Events in Adult Participants With Migraine |
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| Recruiting | 3 | 520 | Europe, Canada, RoW | Atogepant, QULIPTA, Placebo for Atogepant, Topiramate, Placebo for Topiramate | AbbVie | Migraine | 06/26 | 06/26 | | |
NCT00210808: A Study of the Effectiveness and Safety of Topiramate in the Treatment of Moderate to Severe Binge-eating Disorder Associated With Obesity |
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| Completed | 2/3 | 407 | US | topiramate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Ortho-McNeil Neurologics, Inc. | Obesity, Binge-Eating Disorder | | 03/05 | | |
NCT00131443: Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine |
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| Completed | 2/3 | 40 | US | Topiramate | Monarch Medical Research, Ortho-McNeil Neurologics, Inc. | Basilar Migraine | | 08/06 | | |
NCT00204386: Safety & Efficacy Study Using Topiramate in Posttraumatic Stress Disorder |
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| Completed | 2/3 | 50 | US | Topiramate | University of Oklahoma, Ortho-McNeil Neurologics, Inc. | Posttraumatic Stress Disorder | | 05/07 | | |
| Completed | 2/3 | 100 | US | topiramate, prolonged exposure, placebo | VA Office of Research and Development, University of California, San Diego | PTSD and Alcohol Use Disorder | 10/22 | 09/23 | | |
