| topiramate / Generic mfg. |
ChiCTR-TRC-10001131: The efficacy and safety of topiramate and valproate in treatment of Chinese patients with partial and generalised epilepsy: a multi-center, long-term follow up randomised controlled trial |
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| Completed | 4 | 1000 | | The initial dosage for adolescents and adults was 25 milligram twice per day, with a weekly escalation of 25 milligram per day. ;The starting dosage of VPA for adolescents and adults was 400 mg/d, with a weekly escalation of 100mg/d until the target dosage (800-1800 mg/d) was reached. The maximum dosage was 2000 mg/d for adolescents and adults. | Chongqing Medical University; Xian-Janssen Pharmaceutical LTD., Xian-Janssen Pharmaceutical LTD. | Epilepsy | | | | |
| Completed | 4 | 1008 | | SRVPA ;TPM | The first affiliated hospital of Chongqing Medical University; Level of the institution：, This study was funded by National Natural Science of China No. 81071039, the Preeminent Medical Doctors' Foundation in Chongqing Medical University | Epilepsy | | | | |
| Completed | 4 | 220 | | Topiramate ;Ginkgo Biloba Extrai | Children's Hospital Affiliated to Chongqing Medical University; Children's Hospital Affiliated to Chongqing Medical University, Graduate student' funds | Pediatric Migraine | | | | |
ChiCTR-IPR-17013122: The effects and safety of topiramate or metformin on obesity induced by antipsychotics in patients with mental disorders: a randomized clinical trial |
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| Completed | 4 | 62 | | Topiramate ;Metformin | Huaian 3rd People's Hospital, Jiangsu Province; Huaian 3rd People's Hospital, The sources of funding were mainly from huaian city science and technology bureau and huaian 3rd people's hospital, Jiangsu Province | Obesity caused by antipsychotics | | | | |
ChiCTR1800019629: A clinical trial for the research of Tianshu capsule to prevent migraine attack by modulating gut microbiota |
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| Recruiting | 4 | 450 | | oral administration of Tianshu Capsule ;oral administration of topiramate ;oral administration of placebo | Neurology Department of Chinese PLA General Hospital; Chinese PLA General Hospital, Beijing Municipal Science Foundation | migraine | | | | |
STANDLOW, NCT03689114: Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy |
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| Active, not recruiting | 4 | 374 | Europe | Low dose carbamazepine, low carbamazepine, Standard dose carbamazepine, Standard carbamazepine, Low dose levetiracetam, Low levetiracetam, Standard dose levetiracetam, Standard levetiracetam, Low dose valproate, Low valproate, Standard dose valproate, Standard valproate, Low dose zonisamide, Low zonisamide, Standard dose zonisamide, Standard zonisamide, Low dose oxcarbazepine, Low oxcarbazepine, Standard dose oxcarbazepine, Standard oxcarbazepine, Low dose topiramate, Low topiramate, Standard dose topiramate, Standard topiramate, Low dose lamotrigine, Low lamotrigine, Standard dose lamotrigine, Standard lamotrigine, Low dose gabapentin, Low gabapentin, Standard dose gabapentin, Standard gabapentin | Mario Negri Institute for Pharmacological Research, Azienda Ospedaliera San Gerardo di Monza, Ministry of Health, Italy | Epilepsies, Partial | 06/24 | 08/24 | | |
ChiCTR2200063095: Efficacy and safety of topiramate and flunarizine in the prevention of migraine |
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| Not yet recruiting | 4 | 128 | | Topiramate ;Flunarizine | Sichuan Panzhihua Central Hospital; Sichuan Panzhihua Central Hospital, No | migraine | | | | |
NCT05759845: Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis |
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| Enrolling by invitation | 4 | 150 | RoW | Topiramate 25Mg Tab, Amitriptyline 25 Mg Oral Tablet, topiramate 25mg plus amitriptyline 25mg | Dr. Reaz Mahmud | Migraine | 02/23 | 05/23 | | |
NCT05663749: Topiramate vs Metformin on Cardio-Metabolic Profile in Schizophrenia on Atypical Antipsychotics |
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| Completed | 4 | 60 | RoW | Metformin, Dibeta SR, Metgen, Glycomet, Topiramate, Topamax, Topirol, Topaz | All India Institute of Medical Sciences, Bhubaneswar | Metabolic Syndrome, Schizophrenia | 07/23 | 08/23 | | |
NCT04404439: Treatment of Tinnitus With Migraine Medications |
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| Recruiting | 4 | 150 | US | Nortriptyline + topiramate, Verapamil + paroxetine, Placebo | University of California, Irvine | Tinnitus, Subjective, Tinnitus | 12/23 | 12/23 | | |
NCT06089356: Zolmitriptane as Prophylaxis for Chilhood Migraine |
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| Recruiting | 4 | 90 | RoW | zolmitriptanee, zolmitriptane tablet, topiramate, topiramate tablet, Valproate, Valproate tablet | Tanta University | Migraine | 01/24 | 01/24 | | |
NCT05582837: Treatment of Meniere's Disease With Migraine Medications |
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| Recruiting | 4 | 100 | US | nortriptyline + topiramate, Pamelor, Topamax | University of California, Irvine | Ménière | 12/26 | 12/26 | | |
GENESIS, NCT04759196: Generating Evidence on NonEpileptic, Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas |
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| Recruiting | 4 | 56 | Canada | Topamax, Topiramate, TPM, Levetiracetam, LEV, Keppra | Université de Sherbrooke | Chronic Subdural Hematoma, Epilepsy; Seizure, Cortical Depression; Cortical Depolarization, Nonepileptic, Stereotypical and Intermittent Symptoms, NESIS | 09/24 | 12/24 | | |
PREMI, NCT06499116: Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care |
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| Not yet recruiting | 4 | 460 | NA | Topiramate, Acomicil, Flunarizine, Sibelium, Amitriptyline, Tryptizol, Propranolol, Sumial | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina, Institut Català de la Salut, Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | Migraine | 12/26 | 12/26 | | |
ChiCTR2200061160: Study of topiramate on changes of body composition in migraine patients and rats |
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| Not yet recruiting | 4 | 120 | | topiramate ;Flunarizine hydrochloride | The Second Attached Hospital Of Fujian Medical University; The Second Attached Hospital Of Fujian Medical University, The Second Attached Hospital Of Fujian Medical University | migraine | | | | |
| Active, not recruiting | 4 | 82 | US | Cognitive Behavioral Therapy for Insomnia, CBT-I, Sleep Hygiene Education, SHE | VA Office of Research and Development, Coatesville Veterans Affairs Medical Center | Alcohol Use Disorder With Insomnia | 07/24 | 12/24 | | |
2007-003702-95: A MULTICENTRE RANDOMIZED CONTROLLED TRIAL COMPARING TOPIRAMATE, STIRIPENTOL AND CLOBAZAM AS ADJUNCTIVE THERAPY TO VALPROATE AND CLOBAZAM IN PAEDIATRIC PATIENTS WITH DRAVET'S SYNDROME (SMEI) NOT ADEQUATELY CONTROLLED WITH CLOBAZAM AND VALPROATE, AND AUXILIARY PHARMACOGENETIC STUDY |
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| Ongoing | 3 | 90 | Europe | Capsule, hard, stiripentolo, TOPAMAX, FRISIUM*30CPS 10MG | ISTITUTO C. MONDINO | Dravet Syndrome | | | | |
2011-005696-17: A clinical trial of topiramate vs placebo for newborns with perinatal asficia body treated with hypothermia. Ensayo clÃnico con topiramato vs placebo para el recien nacidos con asfixia perinatal tratados con hipotermia corporal. |
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| Ongoing | 3 | 152 | Europe | Topiramate, Spot-on suspension, Topiramato ratiopharm 200 | Instituto de Investigacion Sanitaria La Fe, INSTITUTO DE INVESTIGACION SANITARIA LA FE | Asphyxiated newborn infants evolving to moderate-to-severe hypoxic ischemic encephalopathy Recién nacidos con asfixia evolución de moderada a severa encefalopatÃa hipóxico-isquémica, Asphyxiated newborn infants evolving to moderate to severe hypoxic ischemic encephalopathy Recién nacidos con asfixia evolución de moderada a severa encefalopatÃa hipóxico-isquémica, Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | | | | |
2011-003432-32: Etude d'efficacité et de tolérance du Topiramate dans le Prader Willi |
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| Not yet recruiting | 3 | 125 | Europe | Topiramate, Capsule, Topiramate | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP) | Patients de plus de 12 ans présentant un Syndrome de Prader Willi, Syndrome de Prader Willi, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
2005-001234-32: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Topiramate for the Prophylaxis of Migraine in Pediatric Subjects 12 to 17 Years of Age. Estudio aleatorizado, doble ciego y controlado con placebo para evaluar la eficacia y seguridad de topiramato en la profilaxis de la migraña en población pediátrica de 12 a 17 años de edad |
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| Ongoing | 3 | 40 | Europe | Topiramate Tablets 25mg, GFI-17021-000-CA-008/FD-17021-AQ, | Janssen Cilag International NV | Migraine in Pediatric Population (12-17 year olds, inclusive) | | | | |
2005-001338-33: A Randomized, Double-Blind, Placebo Controlled, Fixed Dose-Ranging Study to Assess the Safety, Tolerability, and Efficacy of Topiramate Oral Liquid and Sprinkle Formulations as an Adjunct to Concurrent Anticonvulsant Therapy for Infants (1-23 Months of Age, Inclusive) With Refractory Partial-Onset Seizures, With Open-Label Extension |
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| | 3 | 9 | Europe | Topiramate Oral Solution, Topiramate Sprinkle Capsules, F017, Topamax Sprinkle Capsules, Topamax Sprinkle Capsules | Janssen-Cilag International N.V., JANSSEN-CILAG | Partial Onset Epilepsy and other Seizures | | 09/07 | | |
2021-003392-34: Aggressive or less aggressive treatment of persistent epileptic seizures |
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| Ongoing | 3 | 140 | Europe | Briviracetam, e.g. Keppra, e.g. Topimax, e.g. orfiril, Vimpat, n.a. many producers, different producers, Concentrate and solvent for solution for infusion, Infusion, Tablet, Briviract, Levetiracetam, Fosfenytoin, Topriamate, Orfiril/valproic acid, Vimpat, Propofol, Midazolam | Odense Universitetshospital, In-house funding Odense University Hospital | Verfied non convulsive status epilepticus refractory to standard treatment with benzodiazepines and at least one first line drug, Persistent epileptic seizures that do not respond to standard treatment, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Completed | 3 | 600 | RoW | Valproic acid, group A, Topiramate 50 MG, group B | Kafrelsheikh University | Migraine Disorders | 06/24 | 06/24 | | |
| Recruiting | 3 | 600 | RoW | Lacosamide 50 MG, group A, Topiramate 50Mg Tab, group B | Kafrelsheikh University | Migraine Disorders | 02/25 | 02/25 | | |
| Recruiting | 3 | 600 | RoW | Zonisamide 50 MG, group A, Topiramate 50 MG, group B | Kafrelsheikh University | Migraine | 04/25 | 05/25 | | |
TEMPLE, NCT05748483: Comparative Study of Oral Atogepant Versus Oral Topiramate to Assess Adverse Events in Adult Participants With Migraine |
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| Recruiting | 3 | 520 | Europe, Canada, RoW | Atogepant, QULIPTA, Placebo for Atogepant, Topiramate, Placebo for Topiramate | AbbVie | Migraine | 06/26 | 06/26 | | |
| Completed | 2/3 | 100 | US | topiramate, prolonged exposure, placebo | VA Office of Research and Development, University of California, San Diego | PTSD and Alcohol Use Disorder | 10/22 | 09/23 | | |
NCT05403229: The Role of Migraine Prophylaxis Agent Topiramate in Treating Patients With Sudden Sensorineural Hearing Loss |
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| Recruiting | 2 | 140 | RoW | Topiramate, Systemic Steroids | Chang Gung Memorial Hospital | Sudden Deafness, Sudden Sensorineural Hearing Loss | 05/25 | 09/25 | | |
NCT03667846: Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD |
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| Recruiting | 2 | 150 | US | Topiramate, Topamax, Placebo | NYU Langone Health, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Post Traumatic Stress Disorder, Alcohol Use Disorder | 08/25 | 08/25 | | |
NCT01765218: Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy |
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| Terminated | 1/2 | 34 | US | Topiramate, Topamax, Topiragen, Placebo | Kristin R Hoffman | Hypoxic Ischemic Encephalopathy | 01/22 | 01/22 | | |
ChiCTR-ONC-16008130: Different frequency of transcutaneous electrical nerve stimulation in migraine prophylactic treatment |
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| Not yet recruiting | N/A | 80 | | TENS 2Hz ;TENS100Hz ;TENS 2Hz/100Hz ;topiramate | Department of Neurology, Chinese PLA General Hospital; Chinese PLA General Hospital, self-financing | migraine | | | | |
NCT05516251: Transcutaneous Supraorbital Nerve Stimulator Versus Topiramate in Prevention of Recurrent Migraine |
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| Recruiting | N/A | 200 | RoW | Transcutaneous Supraorbital Nerve Stimulator, Topiramate 25Mg Tab | Tongji Hospital | Migraine, Classic | 04/23 | 09/23 | | |
NCT06322407: Ultrasound-guided Stellate Ganglion Block for Treatment of Chronic Migraine in Adult |
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| Recruiting | N/A | 206 | RoW | Stellate Ganglion Block (SGB), Ultrasound-guided Stellate Ganglion Block (SGB), standardized drug treatment, topiramate plus ibuprofen | Beijing Tiantan Hospital | Chronic Migraine | 12/25 | 12/25 | | |
NCT02808533: Topiramate and Schizophrenia: Effects on Weight and Psychopathology |
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| Recruiting | N/A | 50 | Canada | Topiramate, Topamax, Placebo | Centre for Addiction and Mental Health, Ontario Ministry of Health and Long Term Care | Schizophrenia, Schizoaffective Disorder | 07/24 | 07/24 | | |
| Recruiting | N/A | 1000 | Europe | Valproic acid, carbamazepine, phenobarbital, phenytoin, levetiracetam, lamotrigine, topiramate, oxcarbazepine, stiripentol, clobazam, brivaracétam, felbamate, lacosamide, rufinamide, gabapentine, pregabaline, sultiame, tiagabine, vigabatrine, mesuximide, primidone, perampanel, ethosuximide, zonisamide, cannabidiol, genetic polymorphisms | Assistance Publique - Hôpitaux de Paris | Epilepsy | 06/26 | 06/26 | | |
| Recruiting | N/A | 10400 | | carbamazepine ;sodium valproate ;lamotrigine ;topiramate ;oxcarbazepine ;levetiracetam ;gabapentin ;phenytoin ;phenobarbital ;clonazepam ;The antiepileptic drug 1 which will obtain marketing authorization in China in the future ;The antiepileptic drug 2 which will obtain marketing authorization in China in the future ;The antiepileptic drug 3 which will obtain marketing authorization in China in the future | The Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical Association | epilepsy | | | | |
