Sarcoma  >>  gemcitabine  >>  Phase 1
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22 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
gemcitabine / Generic mfg.
NCT02784795: A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors

Completed
1b
94
Europe, US
LY3039478, Taladegib, LY2940680, Abemaciclib, LY2835219, Cisplatin, Gemcitabine, Carboplatin, LY3023414
Eli Lilly and Company
Solid Tumor, Breast Cancer, Colon Cancer, Cholangiocarcinoma, Soft Tissue Sarcoma
08/18
02/20
NCT02959164: Decitabine and Gemcitabine for Pancreatic Cancer and Sarcoma

Completed
1b
36
US
Decitabine, Dacogen, Gemcitabine, Gemzar
Mohammed Milhem, Holden Comprehensive Cancer Center, University of Iowa
Pancreatic Ductal Adenocarcinoma, Sarcoma
09/19
10/20
ANNOUNCE 2, NCT02659020 / 2015-001316-34: A Study of Olaratumab (LY3012207) in Participants With Advanced Soft Tissue Sarcoma

Completed
1b
310
Europe, US, RoW
Olaratumab, LY3012207, IMC-3G3, Gemcitabine, LY188011, Gemzar, Docetaxel, Placebo
Eli Lilly and Company
Soft Tissue Sarcoma
07/20
04/21
NCT00014456: Combination Chemotherapy Plus Filgrastim in Treating Patients With Advanced Solid Tumors

Completed
1
35
US
filgrastim, docetaxel, gemcitabine hydrochloride
Dartmouth-Hitchcock Medical Center, National Cancer Institute (NCI)
Bladder Cancer, Breast Cancer, Carcinoma of Unknown Primary, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Lung Cancer, Melanoma (Skin), Ovarian Cancer, Pancreatic Cancer, Prostate Cancer, Sarcoma
10/05
10/05
NCT00620295: Bortezomib and Gemcitabine in Treating Older Patients With Advanced Solid Tumors

Completed
1
17
US
bortezomib, Velcade, gemcitabine hydrochloride, Gemzar
Masonic Cancer Center, University of Minnesota
Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Kidney Cancer, Lung Cancer, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer, Sarcoma
02/09
10/09
NCT00276055: Phase IB Study of Gemcitabine, Docetaxel and Bevacizumab in Patients With Soft Tissue Sarcoma

Completed
1
38
US
Gemcitabine, Docetaxel and Bevacizumab, Taxotere, Gemzar, Avastin
New Mexico Cancer Care Alliance
Sarcoma
11/10
11/10
NCT01652794: Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer

Completed
1
12
US
stereotactic body radiation therapy, SBRT, stereotactic radiation therapy, stereotactic radiotherapy, carboplatin, Carboplat, CBDCA, JM-8, Paraplat, Paraplatin, gemcitabine hydrochloride, dFdC, difluorodeoxycytidine hydrochloride, gemcitabine, Gemzar, laboratory biomarker analysis, pharmacogenomic studies, Pharmacogenomic Study
Case Comprehensive Cancer Center, National Cancer Institute (NCI)
Leydig Cell Tumor, Ovarian Sarcoma, Ovarian Stromal Cancer, Pseudomyxoma Peritonei, Recurrent Cervical Cancer, Recurrent Endometrial Carcinoma, Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Cancer, Recurrent Ovarian Germ Cell Tumor, Recurrent Primary Peritoneal Cavity Cancer, Recurrent Uterine Sarcoma, Recurrent Vaginal Cancer, Recurrent Vulvar Cancer
05/14
03/15
NCT01426633: Combination Therapy of Gemcitabine and Trabectedin in L-sarcomas

Completed
1
5
Europe
Gemcitabine + Trabectedin
Heidelberg University
Leiomyosarcoma, Liposarcoma
12/14
12/14
NCT02046304: PP-Gemcitabine & External Beam Radiation-Sarcomas

Completed
1
41
US
Gemcitabine, Gemcitabine Hydrochloride, Gemzar, Radiation Therapy, XRT, EBRT, Radiotherapy
M.D. Anderson Cancer Center, Eli Lilly and Company
Sarcoma
03/15
03/15
NCT01106872: Bevacizumab, Chemotherapy and Valproic Acid in Advanced Sarcomas

Completed
1
47
US
Bevacizumab, Gemcitabine, Docetaxel and Valproic Acid, Avastin, Gemzar, Taxotere, Depakene, Stavzor
Mohammed M Milhem, Genentech, Inc.
Sarcoma, Soft Tissue Sarcoma, Locally Advanced Sarcoma, Unresectable Sarcoma, Metastatic Sarcoma
07/17
08/17
NCT02574663: TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors

Completed
1
66
US
TGR-1202, nab-paclitaxel + gemcitabine, Abraxane (nab-paclitaxel) + Gemzar (gemcitabine), Oxaliplatin + Folinic acid + Fluorouracil, Eloxatin (Oxaliplatin) + Leucovorin (Folinic acid) + 5-FU (Fluorouracil), Oxaliplatin + Folinic acid + Fluorouracil + Bevacizumab, Eloxatin (Oxaliplatin) + Leucovorin (Folinic acid) + 5-FU (Fluorouracil) + Avastin (Bevacizumab)
TG Therapeutics, Inc., SCRI Development Innovations, LLC
Pancreatic Cancer, Colorectal Cancer, Rectal Cancer, Gastric Cancer, Esophageal Cancer, Gastrointestinal Stromal Tumor (GIST)
08/18
08/18
NCT01803152: Dendritic Cell Vaccine for Children and Adults With Sarcoma

Active, not recruiting
1
19
US
Dendritic Cells Vaccine, DC Vaccine, Lysate of Tumor, Lysate, Tumor Lysate, Gemcitabine, Gemzar, Imiquimod, Aldara, Leukapheresis, Pheresis
Macarena De La Fuente, MD
Sarcoma, Soft Tissue Sarcoma, Bone Sarcoma
09/19
07/24
NCT03483883: Avelumab/Gemcitabine in Sarcomatoid RCC

Terminated
1
6
US
Avelumab, Gemcitabine
Abramson Cancer Center of the University of Pennsylvania
Metastatic sRCC
07/20
02/21
NCT03056599: Precise Local Injection of Anti-cancer Drugs Using Presage's CIVO Device in Soft Tissue Sarcoma

Completed
1
23
US
Multiple drug microinjection, Doxorubicin, Docetaxel, Gemcitabine, Interferon gamma, Pembrolizumab, Ipilimumab, Interferon alfa-2B, Bortezomib, Aldesleukin, Trabectedin, Eribulin, Olaratumab, Atezolizumab, Durvalumab, Avelumab, Nivolumab, Larotrectinib, Entrectinib, Avapritinib, Saline, CIVO device
Presage Biosciences, Fred Hutchinson Cancer Center, University of Washington, Northwell Health, Oregon Health and Science University
Soft Tissue Sarcoma Adult
07/21
09/21
SJDAWN, NCT03434262: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Completed
1
68
US
Gemcitabine, Gemzar®, ribociclib, LEE011, LEE-011, KISQALI®, sonidegib, LDE225, LDE-225, ODOMZO®, trametinib, TMT212, TMT-212, MEKINIST(TM), filgrastim, G-CSF
St. Jude Children's Research Hospital, Novartis Pharmaceuticals
Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Ganglioglioma, Anaplastic Meningioma, Anaplastic Oligodendroglioma, Pleomorphic Xanthoastrocytoma, Anaplastic, Atypical Teratoid/Rhabdoid Tumor, Brain Cancer, Brain Tumor, Central Nervous System Neoplasms, Choroid Plexus Carcinoma, CNS Embryonal Tumor With Rhabdoid Features, Ganglioneuroblastoma of Central Nervous System, CNS Tumor, Embryonal Tumor of CNS, Ependymoma, Glioblastoma, Glioma, Glioma, Malignant, Medulloblastoma, Medulloblastoma; Unspecified Site, Medulloepithelioma, Neuroepithelial Tumor, Neoplasms, Neoplasms, Neuroepithelial, Papillary Tumor of the Pineal Region (High-grade Only), Pediatric Brain Tumor, Pineal Parenchymal Tumor of Intermediate Differentiation (High-grade Only), Pineoblastoma, Primitive Neuroectodermal Tumor, Recurrent Medulloblastoma, Refractory Brain Tumor, Neuroblastoma. CNS, Glioblastoma, IDH-mutant, Glioblastoma, IDH-wildtype, Medulloblastoma, Group 3, Medulloblastoma, Group 4, Glioma, High Grade, Neuroepithelial Tumor, High Grade, Medulloblastoma, SHH-activated and TP53 Mutant, Medulloblastoma, SHH-activated and TP53 Wildtype, Medulloblastoma, Chromosome 9q Loss, Medulloblastoma, Non-WNT Non-SHH, NOS, Medulloblastoma, Non-WNT/Non-SHH, Medulloblastoma, PTCH1 Mutation, Medulloblastoma, WNT-activated, Ependymoma, Recurrent, Glioma, Recurrent High Grade, Glioma, Recurrent Malignant, Embryonal Tumor, NOS, Glioma, Diffuse Midline, H3K27M-mutant, Embryonal Tumor With Multilayered Rosettes (ETMR), Ependymoma, NOS, WHO Grade III, Ependymoma, NOS, WHO Grade II, Medulloblastoma, G3/G4, Ependymoma, RELA Fusion Positive
09/22
05/24
NCT04521686: Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations

Active, not recruiting
1
200
Europe, Japan, US, RoW
LY3410738, Gemcitabine, LY188011, Cisplatin, Durvalumab
Eli Lilly and Company, Loxo Oncology, Inc.
Cholangiocarcinoma, Chondrosarcoma, Glioma, Any Solid Tumor
07/23
05/25
NCT04037527: Gemcitabine and Docetaxel With Radiation in Adults With Soft Tissue Sarcoma of the Extremities

Suspended
1
27
US
Gemcitabine, Docetaxel, Taxotere, Radiation, Surgical Resection, Blood draws
Wake Forest University Health Sciences, National Cancer Institute (NCI)
Soft Tissue Sarcoma
09/24
09/24
SELISARC, NCT04595994: Selinexor Plus Gemcitabine in Selected Advanced Soft-tissue Sarcoma and Osteosarcoma

Recruiting
1
14
Europe
Selinexor, Gemcitabine
Grupo Espanol de Investigacion en Sarcomas
Sarcoma,Soft Tissue
11/25
05/26
NCT06308419: A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

Not yet recruiting
1
12
US
Gemcitabine, Gemcitabine Hydrochloride, Gemzar®, Nab-Sirolimus
M.D. Anderson Cancer Center, Aadi Bioscience
Leiomyosarcoma, Soft-tissue Sarcomas
02/29
02/31
NCT04634227: Gemcitabine Plus Ascorbate for Sarcoma in Adults (Pilot)

Recruiting
1
40
US
Ascorbate
Mohammed Milhem, MBBS, University of Iowa
Sarcoma, Soft Tissue Sarcoma, Unresectable Soft Tissue Sarcoma, Metastatic Bone Tumor, Bone Sarcoma
08/24
08/24
NCT04877587: Gemcitabine With Ascorbate Including Adolescents

Withdrawn
1
20
US
Ascorbate, Vitamin C, Gemcitabine, Gemzar®
David Dickens
Soft Tissue Sarcoma, Bone Sarcoma, Unresectable Soft Tissue Sarcoma, Metastatic Bone Sarcoma, Metastatic Soft-tissue Sarcoma, Unresectable Bone Sarcoma
05/25
05/25
IGM-8444-001, NCT04553692: Phase 1a/1b Study of Aplitabart (IGM-8444) Alone or in Combination in Participants With Relapsed, Refractory, or Newly Diagnosed Cancers

Recruiting
1
430
Europe, US, RoW
Aplitabart (IGM-8444), FOLFIRI, Fluorouracil or 5-FU, Leucovorin, Irinotecan, Bevacizumab (and approved biosimilars), Avastin, Birinapant, Venetoclax, Venclexta, Gemcitabine, Gemzar, Docetaxel, Taxotere, Docefrez, Azacitidine, VIDAZA
IGM Biosciences, Inc.
Solid Tumor, Colorectal Cancer, Non Hodgkin Lymphoma, Sarcoma, Chondrosarcoma, Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia
06/26
08/27

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