Infertility |
ChiCTR-TRC-12002059: Study on effects of transcutaneous acupoint electrical stimulation at different acupoints on pregnant outcomes in women undergoing In Vitro Fertilization Pre-Embryo Transfer |
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| Completed | 2 | 800 | | blank ;TEAS in 4 acupoints in limbs ;TEAS in 4 acupoints in abdomen ;TEAS in 4 acupoints in abdomen | Neuroscience Research Institute, Peking University; National Natural Science Foundation of China, National Natural Science Foundation of China | infertility | | | | |
2010-020196-23: A phase II, multicentre, open label, prospective, interventional study to evaluate the sperm DNA fragmentation in idiopathic male infertility before and after treatment with Gonal-f PEN 900 IU. |
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| Ongoing | 2 | 120 | Europe | GONAL F 150, GONAL F 150 | MERCK SERONO SPA | Idiophatic male infertility | | | | |
2016-003993-42: Clinical study to investigate the effectiveness and safety of PKB171 in couples with infertility due to reduced sperm mobility who wish to conceive. Ensayo clínico para investigar la eficacia y la seguridad de PKB171 en parejas con infertilidad debido a una reducción en la mobilidad del esperma, que desean concebir. |
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| Ongoing | 2 | 72 | Europe | Gel PKB171, Vaginal gel | Prokrea BCN S.L., Prokrea BCN S.L. | Asthenozoospermia Astenozoospermia, Infertility due to reduced sperm mobility. Infertilidad debida a movilidad reducida del esperma., Diseases [C] - Male diseases of the urinary and reproductive systems [C12] | | | | |
2016-002385-31: Treatment of abnormal vaginal flora in patients attending in vitro fertilization treatment |
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| Ongoing | 2 | 333 | Europe | Clindamycin "Alternova", Lactin-V, 37826, Capsule, hard, Vaginal delivery system, Clindamycin "Alternova" | Professor Peter Humaidan, The Fertility Clinic Skive, Statens Serum Institut, Aarhus University, Osel. inc | Infertility, infertile women attending in vitro fertilization treatment, Diseases [C] - Bacterial Infections and Mycoses [C01] | | | | |
NCT03762967: Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility |
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| Enrolling by invitation | 2 | 40 | RoW | Lipoaspiration and SVF introduction., Standard therapy., healthy diet, physical exertion eliminate. hormone therapy. | State-Financed Health Facility "Samara Regional Medical Center Dinasty" | Azoospermia, Oligozoospermia | 12/20 | 12/21 | | |
| Completed | 2 | 95 | Europe | Denosumab, Prolia | Martin Blomberg Jensen | Infertility, Male | 01/21 | 05/23 | | |
NCT05143723: Luteal Phase Support With Daily Administration of Gonadotropin-releasing Hormone Agonist Compared to Progesterone/Estradiol in IVF/ICSI Cycles With Ovulation Triggering With GnRH-a |
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| Active, not recruiting | 2 | 102 | RoW | Gonadotropin-releasing hormone agonist | Kuban State Medical University | Infertility | 04/21 | 06/22 | | |
ChiCTR1900026669: The Clinical Observation for Chinese Medicine and Moxibustion in the treatment of low testosterone Oligoasthenozoospermia |
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| Not yet recruiting | 2 | 90 | | Moxibustion at Shenque (RN8), Guanyuan (RN4), Shenshu (BL23) and Sanyinjiao (SP6) ;Take 'Qizhenziyin-Mixture', 25 ml Oral liquid, tid ;Take 'Qizhenziyin-Mixture', 25 ml Oral liquid, tid., Moxibustion at Shenque (RN8), Guanyuan (RN4), Shenshu (BL23) and Sanyinjiao (SP6) | Longhua Hospital Shanghai University of Traditional Chinese Medicine; Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai Committee of Science and Technology, China | male infertility | | | | |
| Not yet recruiting | 2 | 282 | Europe | Denosumab, Solution for injection, Prolia (Denosumab) | Dept. of Growth and Reproduction, BioInnation Institute, Rigshospitalet, Vaekstfonden, Novo Nordisk Fonden, Forskningsraadet for sundhed og sygdom | Male infertility, Poor semen quality, Diseases [C] - Male diseases of the urinary and reproductive systems [C12] | | | | |
2021-004254-37: A trial to compare efficacy and safety of follitropin delta versus placebo (inactive treatment) in the treatment of men with idiopathic infertility (unexplained reduction of semen quality). |
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| Ongoing | 2 | 400 | Europe | Solution for injection in pre-filled pen, REKOVELLE | Ferring Pharmaceuticals A/S, Ferring Pharmaceuticals A/S | Idiopathic male infertility (including oligoasthenozoospermia), Unexplained reduction of semen quality in men, Diseases [C] - Male diseases of the urinary and reproductive systems [C12] | | | | |
NCT05105724: Autologous Platelet-rich Plasma to Improve Responsiveness and Embryo Quality in Patients With Poor Ovarian Response |
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| Recruiting | 2 | 50 | RoW | PRP | Nanjing University | Infertility | 07/22 | 07/22 | | |
2022-000753-80: Clinical research study to learn about the effect and safety of different doses of FE 999302 when given as a single dose for final development of the eggs after ovarian stimulation Estudio de investigación clínica para conocer el efecto y la seguridad de diferentes dosis de FE 999302 cuando se administra como dosis única para el desarrollo final de los óvulos después de la estimulación ovárica |
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| Ongoing | 2 | 500 | Europe | NOVAREL, OVITRELLE, FE 999302, FE 999086, Solution for injection, Powder and solvent for solution for injection, Solution for injection in pre-filled pen, Solution for injection in pre-filled syringe, NOVAREL, OVITRELLE | Ferring Pharmaceuticals A/S, Ferring Pharmaceuticals A(S | Infertility Infertilidad, Infertility Infertilidad, Body processes [G] - Reproductive physiologi cal processes [G08] | | | | |
NCT05804149: Effect of Acupuncture and Low Caloric Diet on Primary Hypothyroidism and Irregular Menstruation in Infertile Women |
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| Completed | 2 | 60 | RoW | acupuncture, Thyroxine, levothyroxine, low caloric diet | Cairo University | Primary Hypothyroidism, Acupuncture, Irregular Menstruation, PCO | 09/22 | 02/23 | | |
| Completed | 2 | 213 | Europe | Progesterone subcutaneous, Progesterone Vaginal Product | IBSA Institut Biochimique SA | Infertility | 09/22 | 12/22 | | |
NCT05200663: Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility |
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| Recruiting | 2 | 110 | RoW | Tab Tamoxifen 10 mg, Group A, Tab Tamoxifen 10mg,Cap vitamin E 400mg, Group B | Sharif Medical Research Center | Oligoasthenoteratozoospermia, Male Infertility | 10/22 | 10/22 | | |
NCT05847257: Impact of Co Enzyme Q10 as Adjuvant Therapy to Letrozole on Spermiogram |
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| Completed | 2 | 74 | RoW | Letrozole tablets, Coenzyme Q10 table | Al-Mustansiriyah University, Al-Nahrain University | Male Reproductive Problem, Infertility, Male | 10/22 | 10/22 | | |
ChiCTR2000038030: Phase II/III clinical trial of recombinant human follicle-stimulating hormone -CTP fusion protein injection in patients undergoing assisted reproductive technology (ART) |
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| Recruiting | 2 | 374 | | recombinant human follicle-stimulating hormone -CTP fusion protein injection +Recombinant Human Follitropin Alfa Solution for Injection ;Recombinant Human Follitropin Alfa Solution for Injection | The First Affiliated Hospital of Anhui Medical University; Suzhou Centergene Pharmaceuticals Co., Ltd., Fully self-raised | infertility | | | | |
2022-003879-42: randomized, controlled, double-blind clinical trial evaluating the effect of METformin treatment on endometrial function in women diagnosed with Idiopathic Infertility Badanie efektywności metforminy w leczeniu idiopatycznej niepłodności |
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| Not yet recruiting | 2 | 200 | Europe | Tablet, Glucophage | Medical Univeristy of Bialystok, Medical University of Bialystok | Potential causes of idiopathic infertility include in particular: abnormal function of the endometrium, including implantation disorders and immunological abnormalities, genetic abnormalities and the functioning of reproductive cells and embryos, functional abnormalities of reproductive cells and embryos, dysfunctions and discreet anatomical anomalies of the fallopian tubes transport of reproductive cells and embryos. Potencjalne podłoże niepłodności idiopatycznej wymienia się w szczególności: nieprawidłową funkcję endometrium, w tym zaburzenia implantacji oraz nieprawidłowości immunologiczne, nieprawidłowości genetyczne i funkcjonowanie komórek rozrodczych i zarodków, nieprawidłowości funkcjonalne komórek rozrodczych i zarodków, zaburzenia funkcji oraz dyskretne anomalie anatomiczne jajowodów (pomimo zachowanej drożności) zaburzające transport komórek rozrodczych oraz zarodków., Idiopathic infertility is diagnosed after all other medically known symptoms of infertility are excluded. This category includes 5 - 10% of all infertile couples. Niepłodność diopatyczną rozpoznaje się po wykluczeniu wszystkich innych medycznie znanych objawów niepłodności. Ta kategoria obejmuje 5 - 10% wszystkich niepłodnych par., Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13] | | | | |
NCT04938011: A Randomized Controlled Study of Prolonging the Time of Progesterone Supplementation to Improve the Pregnancy Outcome of Single Day 6 Blastocyst Transfer of Freeze-thaw Cycle |
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| Not yet recruiting | 2 | 900 | RoW | progesterone | Nanjing University | Infertility | 06/23 | 06/24 | | |
| Completed | 2 | 10 | US | Elagolix, Orilissa, Oral Contraceptive | Wake Forest University Health Sciences, University of North Carolina, Chapel Hill, Stanford University | Endometriosis, Unexplained Infertility | 08/23 | 08/23 | | |
NCT05166746: The Effect of Clindamycin and a Live Biotherapeutic on the Reproductive Outcomes of IVF Patients With Abnormal Vaginal Microbiota |
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| Recruiting | 2 | 333 | Europe | Clindamycin, LACTIN-V, Placebo | Peter Humaidan | Bacterial Vaginoses, Infertility, Female | 10/23 | 10/23 | | |
| Completed | 2 | 408 | Europe, RoW | OXO-001, Placebo | OXOLIFE | Infertility, Female, Infertility | 08/23 | 12/23 | | |
| Not yet recruiting | 2 | 150 | RoW | Double trigger, Augmented trigger, HCG trigger, Conventional trigger | Bedaya Hospital | Infertility | 03/25 | 12/25 | | |
PRO_ART, NCT03727971: Treatment With the Anti-IgE Monoclonal Antibody Omalizumab in Women With Asthma Undergoing Fertility Treatment. - A Proof of Concept Study. |
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| Active, not recruiting | 2 | 66 | Europe | Omalizumab Injection, NaCl | Rigshospitalet, Denmark, Novartis, Hvidovre University Hospital, Herlev Hospital, Zealand University Hospital | Asthma, Infertility, Female | 12/23 | 12/29 | | |
NCT05290558: The Therapeutic Effects of Bu Shen Yi Jing Pill on Semen Quality in Sub Fertile Males: a Randomized Controlled Trial |
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| Recruiting | 2 | 200 | RoW | Bu Shen Yi Jing Pill, BSYJ Pill, Placebo Drug, Control drug | KK Women's and Children's Hospital | Male Infertility, Infertility, Traditional Chinese Medication (TCM), Reproductive Issues | 12/23 | 12/24 | | |
NCT04955574: Probiotic and Antibiotic Therapies in Women With Unexplained Infertility |
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| Withdrawn | 2 | 39 | NA | SH-DS01 + Antibiotic Placebo, SH-DS01 + Metronidazole, Probiotic Placebo + Antibiotic Placebo | McMaster University, One Fertility | Unexplained Infertility, Endometriosis | 01/24 | 12/24 | | |
NCT06212102: Dydrogesterone Versus GnRH Antagonist in Poor Responders Undergoing Double Ovarian Stimulation |
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| Not yet recruiting | 2 | 120 | RoW | Progestin primed ovarian stimulation, GnRH antagonist | Bedaya Hospital | Infertility | 03/26 | 12/26 | | |
ChiCTR2300068556: Linggui Yangyuan Paste for patients with male infertility: a study protocol for a multicenter, double-blind, double-dummy, randomized controlled trial |
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| Not yet recruiting | 2 | 162 | | Ling-Gui-Yang-Yuan Gel and Wu-Zi-Yan-Zong oral solution mimetics ;Wu-Zi-Yan-Zong oral solution and Ling-Gui-Yang-Yuan Gel mimetics | Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China; Xiyuan Hospital of China Academy of Chinese Medical Sciences, Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences | male infertility (asthenozoospermia and oligoasthenozoospermia) | | | | |
NCT03989778: Vitamin D and Polycystic Ovarian Syndrome (PCOS) |
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| Recruiting | 2 | 300 | RoW | Vitamin D | Aga Khan University | Infertility, Female, Infertility, Vitamin D Deficiency | 06/24 | 06/25 | | |
ChiCTR2300071064: Clinical efficacy evaluation of treating kidney-yang asthenospermia with Guilutianjing Capsules based on the theory of "kidney master reproduction" |
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| Not yet recruiting | 2 | 72 | | Therapeutic drugs: turtle deer capsules filled with essence; Administration method: Orally, twice a day, 5 capsules in the morning and evening; Course of treatment: 90 days. ;Therapeutic drugs: Wu Zi Yan Zong Pill; Administration method: Orally, twice a day, 6g in the morning and evening; Course of treatment: 90 days. | Hospital of Chengdu University of Traditional Chinese Medicine; Hospital of Chengdu University of Traditional Chinese Medicine, Science and Technology Development Fund of Hospital of Chengdu University of Traditional Chinese Medicine | Male infertility | | | | |
| Recruiting | 2 | 282 | Europe | Denosumab, Prolia, Sodium chloride, NaCl | Martin Blomberg Jensen | Infertility, Male | 12/24 | 09/25 | | |
| Not yet recruiting | 2 | 64 | Canada | Active multi-ingredient supplement (Fertility Enhancer, FE), Inactive placebo (Placebo; PLA) | Hamilton Health Sciences Corporation, One Fertility | Male Infertility | 02/25 | 02/25 | | |
NCT05403476: A Trial to Compare Efficacy and Safety of Follitropin Delta Versus Placebo (Inactive Treatment) in the Treatment of Men With Idiopathic Infertility (Unexplained Reduction of Semen Quality) (ADAM) |
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| Recruiting | 2 | 400 | Europe, US | FE 999049, REKOVELLE, Follitropin Delta, Placebo | Ferring Pharmaceuticals | Male Idiopathic Infertility | 07/26 | 07/26 | | |
METIN, NCT06012682: Clinical Trials Evaluating the Effect of Metformin Treatment on Function Endometrium in Women Diagnosed With Idiopathic Infertility |
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| Not yet recruiting | 2 | 200 | NA | Metformin Hydrochloride, Placebo | Medical University of Bialystok, Medical Research Agency, Poland | Infertility, Female | 09/27 | 09/27 | | |
NCT03527043: Impact of Escitalopram on Sperm DNA Fragmentation |
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| Recruiting | 2 | 70 | US | Escitalopram, Placebo | Weill Medical College of Cornell University | Sperm DNA Fragmentation, Infertility, Male | 12/28 | 02/29 | | |
ChiCTR-TRC-10000869: A Phase II, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of L-O-M MCS-5 in Treating Male Oligoasthenospermia |
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| Completed | 1/2 | 115 | | MCS-5 5mg per day, for 16 weeks ;MCS-5 10mg per day, for 16 weeks ;MCS-5 20mg per day, for 16 weeks ;MCS-5 20mg per day, for 16 weeks | Renji Hospital Affliated to Shanghai Jiaotong University; Health Ever Bio-Tech Co., Ltd(Shanghai), Health Ever Bio-Tech Co., Ltd(Shanghai) | Infertility, Male | | | | |
ChiCTR-TRC-11001780: Effect of transcutaneous acupoint electrical stimulation on pregnant outcomes in women undergoing in Embryo Transfer- a multi-center randomized placebo-controlled trial |
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| Completed | 1/2 | 704 | | blank ;mock TEAS ;2 Hz TEAS ;100 Hz TEAS | Neuroscience Research Institute, Peking University; National Natural Science Foundation of China, National Natural Science Foundation of China | infertility | | | | |
CS-EOSP-ICSI, NCT04071574: Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility |
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| Completed | 1/2 | 200 | RoW | Human Chorionic Gonadotropin (hCG), OVITRELLE / PREGNYL, Gonadotropins, MENOPUR, GNRH-A Triptorelin, DECAPEPTYL, GnRH antagonist, CETROTIDE / ORGULATRON | Lebanese University | Female Infertility, Female Infertility Due to Ovulatory Disorder, Premature Ovarian Failure, Polycystic Ovary Syndrome, Female Infertility of Tubal Origin, Ectopic Pregnancy, Salpingitis, Female Infertility Due to Tubal Block, Female Infertility Due to Tubal Occlusion, Hydrosalpinx, Female Infertility - Cervical/Vaginal, Female Infertility Endocrine, Endometriosis, Fibroids, Congenital Uterine Anomaly, Infections Uterine, Female Infertility of Other Origin | 08/19 | 05/23 | | |
NCT04268563: Comparing the Effect of Sitagliptin/Metformin and Metformin in PCOS Patients |
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| Recruiting | 1/2 | 80 | RoW | placebo, rehydration solution, metformin, Glucophage, Sitagliptin, JANUVIA, Sitagliptin/metformin, JANUMET | Shahid Beheshti University of Medical Sciences | Polycystic Ovary Syndrome, Infertility, ART | 07/21 | 07/21 | | |
NCT05103982: Testing a New Self-help Intervention for Infertility Related Distress: a Pilot Study |
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| Recruiting | 1/2 | 20 | Canada | Coping with Infertility Program | University of Regina | Infertility, Female | 03/22 | 04/22 | | |
NCT05183568: Mindful Self-Compassion (MSC) for Infertility Related Distress |
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| Recruiting | 1/2 | 50 | Canada | Mindful Self-Compassion | University of Regina | Infertility, Female, Distress, Emotional, Depressive Symptoms, Anxiety | 03/22 | 05/22 | | |
NCT01662466: Effect of Testosterone Treatment on Embryo Quality |
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| Recruiting | 1/2 | 180 | US | Testosterone cream (0.5mg per gram), Testosterone, DHEA, Dehydroepiandrosterone, Placebo, Carrier cream without added testosterone | Center for Human Reproduction, Foundation for Reproductive Medicine | Primary Ovarian Insufficiency, Female Infertility Due to Diminished Ovarian Reserve | 06/22 | 12/22 | | |
NCT04233892: Clinical Study of in Situ Regeneration of Endometrium |
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| Recruiting | 1/2 | 345 | RoW | CBD-bFGF, Collagen/BMMNCs, Estrogen | Yali Hu, Chinese Academy of Sciences | Infertility, Female, of Uterine Origin, Endometrial Fibrosis | 12/22 | 12/24 | | |
NCT05279768: Stem Cells and Secretomes for Infertility Therapy in Polycystic Ovary Syndrome (PCOS) Patients With Insulin Resistance. |
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| Recruiting | 1/2 | 40 | RoW | UC-MSCs, Secretomes, UC-MSCs and Secretomes, Control | PT. Prodia Stem Cell Indonesia | Polycystic Ovary Syndrome | 12/23 | 12/23 | | |
| Not yet recruiting | 1/2 | 42 | Europe | Denosumab, Prolia, sodium chloride, sodium chloride (NaCl) | Martin Blomberg Jensen | Infertility, Male | 12/24 | 12/25 | | |
NCT06379659: Effectiveness of Intrauterine Growth Hormone Administration as an add-on Therapy to Conventional Hormone Therapy Compared to Placebo in Patients With Thin Endometrium Undergoing Frozen Thawed Embryo Transfer |
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| Recruiting | 1/2 | 54 | RoW | Growh hormone, Placebo | Isfahan University of Medical Sciences | Thin Endometrium, Infertility Female, Infertility | 07/24 | 11/24 | | |