| Hepatic Encephalopathy |
ChiCTR-TRC-12002342: Impact of lactulose treatment on cognition, assessment of quality of life and changes of intestinal flora in minimal hepatic encephalopathy patients: a multi-center, randomized, open-label and controlled clinical study |
|
|
| Completed | 4 | 165 | | Lactulose Oral Solution ;Control | Zhong Shan Hospital, Fudan University; Zhong Shan Hospital, Fudan University, , research funding provided by researcher themselves and drug (lactulose oral solution) provided by Abbott Healthcare company without any compensation | cirrhosis with minimal hepatic encephalopathy | | | | |
2013-000563-81: Metformin treatment of minimal hepatic encephalopathy in patients with liver cirrhosis Tratamiento con metformina de la encefalopatÃa hepática mÃnima en pacientes con cirrosis hepática |
|
|
| Ongoing | 4 | 30 | Europe | METFORMIN, HCL, Capsule | FUNDACION PUBLICA ANDALUZA PARA LA GESTION DE LA INVESTIGACION EN SALUD DE SEVILLA, FUNDACION PUBLICA ANDALUZA PARA LA GESTION DE LA INVESTIGACION EN SALUD DE SEVILLA | minimal hepatic encephalopathy in patients with liver cirrhosis encefalopatÃa hepática mÃnima en pacientes con cirrosis hepática, minimal hepatic encephalopathy in patients with liver cirrhosis encefalopatÃa hepática mÃnima en pacientes con cirrosis hepática, Diseases [C] - Digestive System Diseases [C06] | | | | |
2014-004809-33: Albumin infusion effects in patients with cirrhosis hepatic encephalopathy EFECTOS DE LA ADMINISTRACIÓN DE ALBÚMINA EN PACIENTES CON CIRROSIS Y ENCEFALOPATIA HEPÁTICA. |
|
|
| Ongoing | 4 | 140 | Europe | Albúmina humana al 20%, Solution for infusion, Albúmina Humana Grifols al 20% | Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (VHIR), Instituto de Salud Carlos III | hepatic encephalopathty encefalopatía hepática, hepatic encephalopathty encefalopatía hepática, Diseases [C] - Digestive System Diseases [C06] | | | | |
NCT01846663: Efficacy, Safety, And Pharmacokinetics Of Rifaximin In Subjects With Severe Hepatic Impairment And Hepatic Encephalopathy |
|
|
| Terminated | 4 | 6 | US | Placebo, Rifaximin, XIFAXAN® Tablets | Bausch Health Americas, Inc. | Hepatic Encephalopathy | 02/16 | 02/16 | | |
ChiCTR-IPR-16009578: Research of effect and mechanism of 'Babao Dan' in the prevetion and treatment in the minimal hepatic encephalopathy |
|
|
| Recruiting | 4 | 120 | | Babao Dan ;Lactulose ;Babao Dan + Lactulose | Shuguang Hospital affiliated to Shanghai university of traditional Chinese medicine; Shuguang Hospital, Shanghai Science and Technology committee | Minimal Hepatic Encephalopathy | | | | |
2018-004323-37: Prevention of hepatic Encephalopathy by Administration of Rifaximin and Lactulose in patients with liver cirrhosis undergoing placement of a transjugular intrahepatic portosystemic shunt: a multi-centre randomized, double blind, placebo controlled trial. The PEARL trial |
|
|
| Not yet recruiting | 4 | 238 | Europe | Xifaxan, Lactulose, Tablet, Syrup, Xifaxan, Lactulose | Academic Medical Centre, Academic Medical Centre, ZonMw, Norgine B.V. | post-TIPS Hepatic Encephalopathy (HE), Hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt placement, Diseases [C] - Symptoms and general pathology [C23] | | | | |
ChiCTR-IPR-16009588: Research about diagnostic markers and mechanism of Babao Dan treating Minimal Hepatic Encephalopathy |
|
|
| Not yet recruiting | 4 | 90 | | Babao Dan ;Lactulose ;Babao Dan + Lactulose | Shuguang Hospital affiliated to Shanghai university of traditional Chinese medicine; Shuguang Hospital affiliated to Shanghai university of traditional Chinese medicine, Shuguang Hospital affiliated to Shanghai university of traditional Chinese medicine | Minimal Hepatic Encephalopathy | | | | |
ChiCTR2300068160: The efficacy and safety of arginine glutamate injection in the treatment of hepatic encephalopathy with cirrhosis: a randomized, open, positive-controlled, single-center clinical study |
|
|
| Completed | 4 | 140 | | Arginine Glutamate Injection ;Ornithine Aspartate for Injection | Beijing You 'an Hospital, Capital Medical University; Xizang Shifang Marketing Management Co., LTD, Xizang Shifang Marketing Management Co., LTD | cirrhosis with hepatic encephalopathy | | | | |
PEARL, NCT04073290: Prevention of Post-TIPS Hepatic Encephalopathy by Administration of Rifaximin and Lactulose |
|
|
| Recruiting | 4 | 238 | Europe | Rifaximin 550 milligram Oral Tablet [XIFAXAN], TARGAXAN, Placebo oral tablet, Placebo, Lactulose 667 milligram/milliliter Oral Solution, Lactulose syrup | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Erasmus Medical Center, Leiden University Medical Center, Maastricht University Medical Center, Radboud University Medical Center, University Medical Center Groningen, Universitaire Ziekenhuizen Leuven, Norgine | Hepatic Encephalopathy, Cirrhosis, Liver, Portal Hypertension, Liver Diseases, Pathological Processes | 09/22 | 09/23 | | |
2022-002924-11: Study to test the effect of the drug "L-ornithine.L-aspertate" (LOLA) on microorganisms in the digestive tract in patients with liver cirrhosis (damage of the liver due to liver disease) Eine Beobachtungsstudie zur Wirkung von L-Ornithin-L-Aspartat (LOLA) auf die Darmflora von Patienten mit Leberzirrhose (Schädigung der Leber aufgrund einer Lebererkrankung) |
|
|
| Ongoing | 4 | 55 | Europe | Hepa-Merz 3 g Granulat, Granules, Hepa-Merz-3 g Granulat | CBmed GmbH | Liver cirrhosis with covert or overt hepatic encephalopathy (grade 0-2) Leberzirrhose mit subklinischer oder manifester Hepatischer Enzephalopathie (Grad 0-2), Late stage liver disease with a related disorder of the brain Endstadium einer Lebererkrankung und damit verbundene Funktionsstörung des Gehirns, Body processes [G] - Digestive System and Oral Physiological Phenomena [G10] | | | | |
NCT05788627: Effectiveness of Oral Lactulose Versus Lactulose Enema in Hepatic Encephalopathy |
|
|
| Not yet recruiting | 4 | 100 | NA | Tap water, tap water enema, Lactulose, Lactulose enema | Khyber Medical College, Peshawar | Hepatic Encephalopathy, Chronic Liver Disease | 09/23 | 11/23 | | |
NCT05539027: Efficacy of L-Ornithine L-Aspartate (LOLA) as an Adjunct to Branched Chain Amino Acids (BCAA) Enriched Solutions on Clinical Outcomes in ICU Patients With Hepatic Encephalopathy |
|
|
| Recruiting | 4 | 140 | RoW | Branched-chain amino acids (BCAA), enriched solution (Aminoleban) and L-ornithine L-aspartate (LOLA), Branched-chain amino acids (BCAA), enriched solution (Aminoleban) | Ain Shams University | Hepatic Encephalopathy | 10/24 | 10/24 | | |
PEGHE, NCT04436601: Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Cirrhosis;( Trial) |
|
|
| Recruiting | 4 | 102 | RoW | Polyethylene Glycols, Lactulose | Aga Khan University | Hepatic Encephalopathy | 12/23 | 12/23 | | |
NCT05920213: Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy |
|
|
| Not yet recruiting | 4 | 360 | RoW | Polyethylene Glycols, Lactulose oral solution, L-ornithine L-aspartate | Jinnah Postgraduate Medical Centre | Hepatic Encephalopathy Stage 2, Hepatic Encephalopathy Stage 3, Hepatic Encephalopathy Stage 4 | 04/24 | 04/24 | | |
ARGO-HEC, ChiCTR2300075925: Assessment of reversal in grades of overt hepatic encephalopathy by comparing the efficacy of rifaximin, probiotic and L-ornithine- L aspartate with lactulose as control drug for clinical trial. |
|
|
| Not yet recruiting | 4 | 240 | | LACTULOSE; RIFAXIMIN + LACTULOSE; PROBIOTIC + LACTULOSE; (L-Ornithine L- Aspartate) LOLA + LACTULOSE | The Islamia University of Bahawalpur; The Islamia University of Bahawalpur (IUB), self | Hepatic Encephalopathy | | | | |
ChiCTR2200062996: Clinical study of live combined Bifidobacterium and Lactobacillus tablets regulating gut microbiota to prevent post-transjugular intrahepatic portosystemic shunt hepatic encephalopathy |
|
|
| Not yet recruiting | 4 | 140 | | Live Combined Bifidobacterium and Lactobacillus Tablets ;No probiotics administered | West China Hospital, Sichuan University; West China Hospital, Sichuan University, Inner Mongolia Shuangqi Pharmaceutical Co., Ltd.PRC | Liver cirrhosis | | | | |
