| Hepatic Encephalopathy |
ChiCTR-TRC-12002342: Impact of lactulose treatment on cognition, assessment of quality of life and changes of intestinal flora in minimal hepatic encephalopathy patients: a multi-center, randomized, open-label and controlled clinical study |
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| Completed | 4 | 165 | | Lactulose Oral Solution ;Control | Zhong Shan Hospital, Fudan University; Zhong Shan Hospital, Fudan University, , research funding provided by researcher themselves and drug (lactulose oral solution) provided by Abbott Healthcare company without any compensation | cirrhosis with minimal hepatic encephalopathy | | | | |
2013-000563-81: Metformin treatment of minimal hepatic encephalopathy in patients with liver cirrhosis Tratamiento con metformina de la encefalopatÃa hepática mÃnima en pacientes con cirrosis hepática |
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| Ongoing | 4 | 30 | Europe | METFORMIN, HCL, Capsule | FUNDACION PUBLICA ANDALUZA PARA LA GESTION DE LA INVESTIGACION EN SALUD DE SEVILLA, FUNDACION PUBLICA ANDALUZA PARA LA GESTION DE LA INVESTIGACION EN SALUD DE SEVILLA | minimal hepatic encephalopathy in patients with liver cirrhosis encefalopatÃa hepática mÃnima en pacientes con cirrosis hepática, minimal hepatic encephalopathy in patients with liver cirrhosis encefalopatÃa hepática mÃnima en pacientes con cirrosis hepática, Diseases [C] - Digestive System Diseases [C06] | | | | |
2014-004809-33: Albumin infusion effects in patients with cirrhosis hepatic encephalopathy EFECTOS DE LA ADMINISTRACIÓN DE ALBÚMINA EN PACIENTES CON CIRROSIS Y ENCEFALOPATIA HEPÃTICA. |
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| Ongoing | 4 | 140 | Europe | Albúmina humana al 20%, Solution for infusion, Albúmina Humana Grifols al 20% | Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (VHIR), Instituto de Salud Carlos III | hepatic encephalopathty encefalopatÃa hepática, hepatic encephalopathty encefalopatÃa hepática, Diseases [C] - Digestive System Diseases [C06] | | | | |
NCT01846663: Efficacy, Safety, And Pharmacokinetics Of Rifaximin In Subjects With Severe Hepatic Impairment And Hepatic Encephalopathy |
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| Terminated | 4 | 6 | US | Placebo, Rifaximin, XIFAXAN® Tablets | Bausch Health Americas, Inc. | Hepatic Encephalopathy | 02/16 | 02/16 | | |
ChiCTR-IPR-16009578: Research of effect and mechanism of 'Babao Dan' in the prevetion and treatment in the minimal hepatic encephalopathy |
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| Recruiting | 4 | 120 | | Babao Dan ;Lactulose ;Babao Dan + Lactulose | Shuguang Hospital affiliated to Shanghai university of traditional Chinese medicine; Shuguang Hospital, Shanghai Science and Technology committee | Minimal Hepatic Encephalopathy | | | | |
2018-004323-37: Prevention of hepatic Encephalopathy by Administration of Rifaximin and Lactulose in patients with liver cirrhosis undergoing placement of a transjugular intrahepatic portosystemic shunt: a multi-centre randomized, double blind, placebo controlled trial. The PEARL trial |
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| Not yet recruiting | 4 | 238 | Europe | Xifaxan, Lactulose, Tablet, Syrup, Xifaxan, Lactulose | Academic Medical Centre, Academic Medical Centre, ZonMw, Norgine B.V. | post-TIPS Hepatic Encephalopathy (HE), Hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt placement, Diseases [C] - Symptoms and general pathology [C23] | | | | |
ChiCTR-IPR-16009588: Research about diagnostic markers and mechanism of Babao Dan treating Minimal Hepatic Encephalopathy |
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| Not yet recruiting | 4 | 90 | | Babao Dan ;Lactulose ;Babao Dan + Lactulose | Shuguang Hospital affiliated to Shanghai university of traditional Chinese medicine; Shuguang Hospital affiliated to Shanghai university of traditional Chinese medicine, Shuguang Hospital affiliated to Shanghai university of traditional Chinese medicine | Minimal Hepatic Encephalopathy | | | | |
ChiCTR2300068160: The efficacy and safety of arginine glutamate injection in the treatment of hepatic encephalopathy with cirrhosis: a randomized, open, positive-controlled, single-center clinical study |
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| Completed | 4 | 140 | | Arginine Glutamate Injection ;Ornithine Aspartate for Injection | Beijing You 'an Hospital, Capital Medical University; Xizang Shifang Marketing Management Co., LTD, Xizang Shifang Marketing Management Co., LTD | cirrhosis with hepatic encephalopathy | | | | |
PEARL, NCT04073290: Prevention of Post-TIPS Hepatic Encephalopathy by Administration of Rifaximin and Lactulose |
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| Recruiting | 4 | 238 | Europe | Rifaximin 550 milligram Oral Tablet [XIFAXAN], TARGAXAN, Placebo oral tablet, Placebo, Lactulose 667 milligram/milliliter Oral Solution, Lactulose syrup | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Erasmus Medical Center, Leiden University Medical Center, Maastricht University Medical Center, Radboud University Medical Center, University Medical Center Groningen, Universitaire Ziekenhuizen Leuven, Norgine | Hepatic Encephalopathy, Cirrhosis, Liver, Portal Hypertension, Liver Diseases, Pathological Processes | 09/22 | 09/23 | | |
2022-002924-11: Study to test the effect of the drug "L-ornithine.L-aspertate" (LOLA) on microorganisms in the digestive tract in patients with liver cirrhosis (damage of the liver due to liver disease) Eine Beobachtungsstudie zur Wirkung von L-Ornithin-L-Aspartat (LOLA) auf die Darmflora von Patienten mit Leberzirrhose (Schädigung der Leber aufgrund einer Lebererkrankung) |
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| Ongoing | 4 | 55 | Europe | Hepa-Merz 3 g Granulat, Granules, Hepa-Merz-3 g Granulat | CBmed GmbH | Liver cirrhosis with covert or overt hepatic encephalopathy (grade 0-2) Leberzirrhose mit subklinischer oder manifester Hepatischer Enzephalopathie (Grad 0-2), Late stage liver disease with a related disorder of the brain Endstadium einer Lebererkrankung und damit verbundene Funktionsstörung des Gehirns, Body processes [G] - Digestive System and Oral Physiological Phenomena [G10] | | | | |
NCT05788627: Effectiveness of Oral Lactulose Versus Lactulose Enema in Hepatic Encephalopathy |
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| Not yet recruiting | 4 | 100 | NA | Tap water, tap water enema, Lactulose, Lactulose enema | Khyber Medical College, Peshawar | Hepatic Encephalopathy, Chronic Liver Disease | 09/23 | 11/23 | | |
NCT05539027: Efficacy of L-Ornithine L-Aspartate (LOLA) as an Adjunct to Branched Chain Amino Acids (BCAA) Enriched Solutions on Clinical Outcomes in ICU Patients With Hepatic Encephalopathy |
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| Recruiting | 4 | 140 | RoW | Branched-chain amino acids (BCAA), enriched solution (Aminoleban) and L-ornithine L-aspartate (LOLA), Branched-chain amino acids (BCAA), enriched solution (Aminoleban) | Ain Shams University | Hepatic Encephalopathy | 07/24 | 07/24 | | |
PEGHE, NCT04436601: Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Cirrhosis;( Trial) |
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| Recruiting | 4 | 102 | RoW | Polyethylene Glycols, Lactulose | Aga Khan University | Hepatic Encephalopathy | 12/23 | 12/23 | | |
NCT05920213: Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy |
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| Not yet recruiting | 4 | 360 | RoW | Polyethylene Glycols, Lactulose oral solution, L-ornithine L-aspartate | Jinnah Postgraduate Medical Centre | Hepatic Encephalopathy Stage 2, Hepatic Encephalopathy Stage 3, Hepatic Encephalopathy Stage 4 | 04/24 | 04/24 | | |
ChiCTR2200062996: Clinical study of live combined Bifidobacterium and Lactobacillus tablets regulating gut microbiota to prevent post-transjugular intrahepatic portosystemic shunt hepatic encephalopathy |
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| Not yet recruiting | 4 | 140 | | Live Combined Bifidobacterium and Lactobacillus Tablets ;No probiotics administered | West China Hospital, Sichuan University; West China Hospital, Sichuan University, Inner Mongolia Shuangqi Pharmaceutical Co., Ltd.PRC | Liver cirrhosis | | | | |
NCT05128305: Integrated Traditional Chinese and Clinical Medicine for Chronic Hepatitis B and Its Complication |
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| Not yet recruiting | 3 | 276 | RoW | traditional Chinese medicine1 and traditional Chinese medicine 2, traditional Chinese medicine1 simulant and traditional Chinese medicine 2 simulant | Qianfoshan Hospital | Hepatic Encephalopathy, Cirrhosis, Liver, Portosystemic Shunt | 06/22 | 12/22 | | |
ACTRN12619000891123: The impact of continuous terlipressin infusion on complications of end-stage liver disease |
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| Completed | 3 | 30 | | | Austin Health, Mallinckrodt Pharmaceuticals | Cirrhosis, Sarcopaenia, Inflammation, Malnutrition, Ascites, Infection, Immune function, Hepatic encephalopathy | | | | |
2017-002677-19: Biological mechanisms of Acute on Chronic Liver Failure (ACLF) and Mechanisms of Action of Plasma Exchange with Human Serum Albumin 5% in Subjects with cirrhosis with systemic inflammation and ACLF |
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| Not yet recruiting | 3 | 250 | Europe | Albutein 5%, [B05AA01], Solution for infusion, Human Albumin Grifols 50g/l | Instituto Grifols S.A., INSTITUTO GRIFOLS, S.A., Instituto Grifols S.A. | Group 1 and 2:Subjects with cirrhosis with ACLF-1b, ACLF-2, or ACLF-3a detected either at admission or duringhospitalization Group 3: Subject with cirrhosis hospitalized for Acute decompensation of cirrhosis (ascites, hepatic encephalopathy [HE], gastrointestinal hemorrhage, and/or bacterial infections), Group 1 and 2: Subjects with cirrhosis and diagnosed Acute-on-Chronic Liver FailureGroup 3: Subjects with cirrhosis without diagnosed Acute-on-Chronic Liver Failure, Diseases [C] - Digestive System Diseases [C06] | | | | |
NCT04244877: Rifaximin's Effect on Covert Hepatic Encephalopathy With SIBO and Gastrointestinal Dysmotility |
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| Withdrawn | 3 | 20 | NA | Rifaximin, Xifaxan | MetroHealth Medical Center | Cirrhosis, Liver, Minimal Hepatic Encephalopathy, Small Intestinal Bacterial Overgrowth, Gastrointestinal Motility Disorder | 05/23 | 12/23 | | |
NCT05754996: Comparing Nifuroxazide Plus Lactulose With Lactulose Alone in the Treatment of Hepatic Encephalopathy |
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| Recruiting | 3 | 102 | RoW | Nifuroxazide, Lactulose, Rifaximin 550Mg Tab | Cairo University | Hepatic Encephalopathy | 12/24 | 12/24 | | |
RED-C-3131, NCT05071716: Study to Assess Rifaximin Soluble Solid Dispersion (SSD) for the Delay of Encephalopathy Decompensation in Cirrhosis |
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| Active, not recruiting | 3 | 524 | Canada, US, RoW | Rifaximin SSD, Placebo | Bausch Health Americas, Inc. | Hepatic Encephalopathy | 09/25 | 09/25 | | |
RED-C-3132, NCT05297448: Study to Assess Rifaximin Soluble Solid Dispersion (SSD) for the Delay of Encephalopathy Decompensation in Cirrhosis |
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| Active, not recruiting | 3 | 466 | Europe, Canada, US, RoW | Rifaximin SSD, Placebo | Bausch Health Americas, Inc. | Hepatic Encephalopathy | 01/26 | 01/26 | | |
NCT04161053: Efficacy and Safety of Nitazoxanide in Preventing Recurrence of Hepatic Encephalopathy |
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| Recruiting | 3 | 60 | RoW | Rifaximin, Gastrobiotic, Trencedia, Nitazoxanide, Nanazoxid | Tanta University | Hepatic Encephalopathy | 11/28 | 12/28 | | |
NCT05511766: Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis |
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| Recruiting | 2/3 | 150 | RoW | Allopurinol 300 MG, zyloric, Atorvastatin 20mg, Placebo | Tanta University | Cirrhosis, Hepatic Encephalopathy, Ascites, Varices, SBP - Spontaneous Bacterial Peritonitis | 04/24 | 01/25 | | |
ChiCTR2100052806: Treatment of minimal hepatic encephalopathy with berberine and caffeic acid |
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| Not yet recruiting | 2/3 | 90 | | Berberine hydrochloride tablets 0.3g oral taken TID(three times a day) ;Caffeic acid tablets 0.3g oral taken TID ;General life guidance and treatment of non-hepatic encephalopathy | Huadong Hospital Affiliated to Fudan University; Huadong Hospital Affiliated to Fudan University, Huadong Hospital Affiliated to Fudan University | Minimal hepatic encephalopathy | | | | |
ACTRN12618000802202: The Impact of Branched Chain Amino Acids (BCAA) Supplementation in Patients with Advanced Liver Disease |
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| Completed | 2 | 150 | | | Austin Health, Austin Medical Research Foundation | Cirrhosis
, Sarcopenia, Malnutrition, Hepatic encephalopathy, Infections, Insulin resistance, Immune function | | | | |
2021-002617-33: A clinical study to evaluate a new medicinal product VS-01 in patients with an acute episode on top of a chronic liver disease (called acute-on-chronic liver failure) who experience accumulation of fluid in the abdominal cavity (called ascites) as well as intellectual, behavioral decay and physical decay. |
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| Not yet recruiting | 2 | 70 | Europe | VS-01, Suspension for injection | Versantis AG, Versantis AG | Acute-on-chronic liver failure (ACLF) is characterized by hepatic andextrahepatic organ dysfunction and/or failure and highly activatedsystemic inflammation. It leads to an accumulation of different metabolites, interalias ammonia, which cannot be metabolized.Hyperammonemia leads to Hepatic Encephalopathy (HE). ACLF is amajor cause of death in cirrhosis, with an approximately 50% mortality rate. The selected patient population is ACLF grade 1 and 2 patients with ascites., Acute-on-chronic liver failure is an acute complication of a chronic liverdisease affecting other organs (e.g., kidney & brain) and leading tophysical, intellectual and behavioral decay or death., Diseases [C] - Nutritional and Metabolic Diseases [C18] | | | | |
NCT04899115: VE303 for Treatment of Hepatic Encephalopathy (HE) |
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| Completed | 2 | 19 | US | Placebo, VE303, oral vancomycin | Patricia Bloom, Vedanta Biosciences, Inc., American College of Gastroenterology, American Association for the Study of Liver Diseases | Cirrhosis, Hepatic Encephalopathy | 04/23 | 08/23 | | |
| Completed | 2 | 30 | US | Rifamycin SV MMX, Aemcolo, Placebo | Hunter Holmes Mcguire Veteran Affairs Medical Center | Hepatic Encephalopathy, Cirrhosis, Liver | 04/23 | 04/23 | | |
NCT04155099: Investigational Microbiota Restoration Therapeutic for Hepatic Encephalopathy |
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| Terminated | 2 | 5 | US | RBX7455, Microbiota Restoration Therapy, Placebo | Ochsner Health System, Rebiotix Inc. | Hepatic Encephalopathy, Cirrhosis, Liver | 07/23 | 07/23 | | |
NCT03420482: Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy |
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| Active, not recruiting | 2 | 30 | US | Fecal Microbiota Transplant (FMT) oral capsules, Placebo oral capsule | Massachusetts General Hospital, Center for Microbiome Informatics and Therapeutics | Hepatic Encephalopathy | 12/23 | 01/24 | | |
NCT06425380: Pilot Open-Label Trial of Resistant Potato Starch in Patients With Cirrhosis and Overt Hepatic Encephalopathy |
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| Not yet recruiting | 2 | 20 | US | Resistant Potato Starch | University of Michigan | Hepatic Encephalopathy, Cirrhosis | 03/26 | 04/26 | | |
NCT06072521: Efficacy of Lactoferrin as an Adjunct Therapy in Patients With Hepatic Encephalopathy |
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| Not yet recruiting | 2 | 45 | RoW | Lactoferrin Bovine, Pravotin sachets 100 mg | Al-Azhar University | Hepatic Encephalopathy | 09/24 | 10/24 | | |
| Recruiting | 2 | 30 | US | Albumin Infusion, Albutein | Hunter Holmes Mcguire Veteran Affairs Medical Center, Grifols Biologicals, LLC | Cirrhosis, Hepatic Encephalopathy | 03/25 | 06/25 | | |
| Recruiting | 2 | 163 | US | High-dose methylprednisolone, Solu-Medrol, Equine anti-thymocyte globulin, ATGAM, Prednisolone, 15 mg/mL oral solution National Drug Code: 62135-250-37, Placebo for prednisolone, Placebo for infusions, 0.9% Sodium chloride, Diphenhydramine, Benadryl, Methylprednisolone | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Ann & Robert H Lurie Children's Hospital of Chicago | Acute Liver Failure, Fulminant Hepatic Failure, Hepatic Encephalopathy, Acute Liver Injury, Immune Dysregulation | 01/26 | 01/27 | | |
2016-003651-30: A double-blinded, randomized, placebo-controlled phase I/IIa study in healthy subjects and patients with liver cirrhosis evaluating safety, pharmacokinetics and preliminary effect of single and multiple doses of GR3027. |
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| Ongoing | 1/2 | 106 | Europe | GR3027, GR3027, Capsule, hard | Umecrine Cognition AB, Umecrine Cognition AB | Hepatic encephalopathy (HE), Hepatic encephalopathy (HE) is a neuropsychiatric complication of either acute or chronic hepatic insufficiency (cirrhosis), Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT05070351: Deprescribing Proton Pump Inhibitors to Reduce Post-TIPS Hepatic Encephalopathy |
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| Recruiting | 1/2 | 40 | US | PPI deprescribing | Duke University | Hepatic Encephalopathy | 10/28 | 10/28 | | |
| Completed | 1/2 | 60 | US | Fecal Microbial transplant Capsules, Fecal Microbial Transplant Enema, Placebo | VA Office of Research and Development | Cirrhosis, Hepatic Encephalopathy | 12/23 | 12/23 | | |
NCT06368895: Fecal Microbiota Transplantation by Oral Capsules for Hepatic Encephalopathy Treatment |
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| Recruiting | 1 | 60 | Europe | Fecal microbiota transplantation delivery through colonoscopy, Fecal microbiota transplantation delivery through oral capsules | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Hepatic Encephalopathy, Dysbiosis | 06/25 | 06/25 | | |
NCT05279586: Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhotic Patients |
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| Not yet recruiting | 1 | 316 | NA | lactulose, duphlac, colistin | Madonna Magdy Fahmy | Hepatic Encephalopathy | 02/23 | 03/23 | | |
| Recruiting | 1 | 226 | RoW | Branch Chain Amino Acid, Lactulose | Post Graduate Institute of Medical Education and Research, Chandigarh, Amrita Institute of Medical Sciences & Research Center, Asian Institute of Gastroenterology, India, All India Institute of Medical Sciences, Bhubaneswar, Kalinga Institute of Medical Sciences, Bhubaneswar | Hepatic Encephalopathy, Acute-On-Chronic Liver Failure | 04/25 | 04/25 | | |
| Recruiting | 1 | 124 | RoW | Rifaximin 200 mg, Standard Treatment without Rifaximin | Sun Yat-sen University | Liver Failure, Acute on Chronic, Hepatic Encephalopathy, HBV, Hepatitis B, Rifaximin, Effect of Drug | 07/25 | 10/25 | | |
ChiCTR-IOR-14005663: The influence of different doses of Lactose in cirrhotic patients after transjugular intrahepatic portosystemic shunt |
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| Not yet recruiting | N/A | 60 | | Low-dose of Lactose ;High-dose of Lactose | West China Hospital, Sichuan University; West China Hospital, Sichuan University, Self-financing | Cirrhosis | | | | |
ChiCTR-OOC-14005527: Investigation of inflammatory factors in post-transjugular intrahepatic portosystemic shunt hepatic encephalopathy |
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| Not yet recruiting | N/A | 80 | | N/A | West China Hospital, Sichuan University; Level of the institution：, Self-financing | hepatic cirrhosis Hepatic encephalopathy | | | | |
ChiCTR-TQR-13003788: A single-center, open label, randomized controlled trial of hypertonic saline vs mannitol to treat the brain edema in acute on chronic liver failure |
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| Recruiting | N/A | 60 | | 10%saline ;20%mannitol | 302 Military Hospital; Level of the institution：, 302 Military Hospital | Hepatic encephalopathy | | | | |
ChiCTR1800014275: Risk Factors of Early Readmission in Patients With Cirrhosis After the Resolution of Hepatic Encephalopathy |
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| Not yet recruiting | N/A | 470 | | Nil | the Second Affiliated Hospital of Chongqing Medical University; Second Affiliated Hospital of Chongqing Medical University, Self-raised | Cirrhosis,Hepatic Encephalopathy | | | | |
ChiCTR1800019954: Validation of combination of PHES and Stroop test in the diagnosis of covert hepatic encephalopathy |
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| Recruiting | N/A | | | | Changzheng Hospital, Shanghai; Changzheng Hospital, 81770600 | Hepatic encephalopathy | | | | |
ChiCTR1800015280: Clinical study on the therapeutic effects of JianPi HuaZhuo XingNao formula on patients with MHE, caused by CHB induced hepatocirrhosis. |
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| Not yet recruiting | N/A | 72 | | JianPi HuaZhuo XingNao formula plus basic treatment ;JianPi HuaZhuo XingNao formula placebo plus basic treatment | Dongzhimen hospital affiliated to Beijing university of Chinese Medicine; Dongzhimen hospital affiliated to Beijing university of Chinese Medicine, The '111' Collaborative Innovation Project, Dongzhimen hospital affiliated to BUCM | Minimal hepatic encephalopathy | | | | |
ChiCTR1900022400: Screening for risk factors of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with liver cirrhosis |
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| Not yet recruiting | N/A | 299 | | TIPS | West China Hospital, Sichuan University; West China Hospital, Sichuan University, National Natural Science Foundation of China, Foundation of Health and Family Planning Commission of Sichuan Province, etc | Liver cirrhosis | | | | |
ChiCTR-ROC-17014215: Impact of previous episodes of hepatic encephalopathy on brain function recovery after liver transplantation：structural and functional MRI study |
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| Not yet recruiting | N/A | 60 | | liver transplantation | Tianjin First Central Hospital; Tianjin First Central Hospital, Tianjin First Central Hospital | hepatic encephalopathy | | | | |
ChiCTR1900026254: Establishment and application of early warning platform for covert hepatic encephalopathy in patients with cirrhosis |
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| Not yet recruiting | N/A | 380 | | Platform follow-up ;Telephone follow-up | The Second Affiliated Hospital of Chongqing Medical University; The Second Affiliated Hospital of Chongqing Medical University, Chongqing Science and Technology Bureau | Liver disease | | | | |
ChiCTR2100053664: Impact of TIPS on intestinal microbiota and its association with hepatic encephalopathy and survival in cirrhotic patients with portal hypertension complications |
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| Completed | N/A | 106 | | No | Xijing hospital; Xijing Hospital, National Natural Science Foundation of China (81172145 and 81420108020) | Hepatic encephalopathy | | | | |
ChiCTR1800016632: Development of a visualized risk assessment tool for covert hepatic encephalopathy |
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| Not yet recruiting | N/A | 120 | | NO | Third Affiliated Hospital of Zhongshan University, The Third Affiliated Hospital of Sun YAT-Sen University; Third Affiliated Hospital of Zhongshan University, The Third Affiliated Hospital of Sun YAT-Sen University, Nurturing funds for nursing young talents of Sun Yat-Sen University | covert hepatic encephalopathy | | | | |
ChiCTR-ICR-15006829: The effect of different stents configuration in reducing the rate of restenosis andHepatic encephalopathy based on Multi-center clinical study |
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| Completed | N/A | 240 | | D=8mm L=10cm bare metal stent + L=6cm Fluency stent ;D=8mm L=2+8cm Viatorr stent ;D=8mm L=8cm Fluency stent | Gastrointestinal Department of Internal Medicine the First Affiliated Hospital of Xian Jiao Tong University; The First Affiliated Hospital of Xi'an Jiao Tong University, The First Affiliated Hospital of Xian Jiao Tong University | portal hypertension | | | | |
ChiCTR2000040960: Comparison of probiotics and rifaximin in the prevention and treatment of minimal hepatic encephalopathy and their effects on intestinal flora in patients with liver cirrhosis |
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| Recruiting | N/A | 60 | | 3 bid capsules of Bifidobacterium Triple Live bacteria ;Rifaximin0.6g, bid ;Lactulose (Adjust freely according to the number of stools) | Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University; Level of the institution：, The science and technology Department of Anhui Province | minimal hepatic encephalopathy | | | | |
ChiCTR2200055895: Investigation on the prevalence of covert hepatic encephalopathy in Chinese cirrhotic patients and validation study of SNS test in the diagnosis of covert hepatic encephalopathy |
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| Recruiting | N/A | 800 | | None | Changzheng Hospital affiliated to PLA Naval Military Medical University; Changzheng Hospital affiliated to PLA Naval Military Medical University, Wuhan QR Pharmaceutical Co，LTD | Covert hepatic encephalopathy | | | | |
ChiCTR2200055609: Evaluation of Diagnostic Efficacy of the STROOP Test for Minimal Hepatic Encephalopathy |
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| Recruiting | N/A | | | | Beijing Municipal Administration of Hospitals; Beijing ditan hospital, Beijing Municipal Administration of Hospitals | Minimal hepatic encephalopathy | | | | |
ChiCTR2200055582: Application Value of Nutritional Screening in Mild Hepatic Encephalopathy Associated with Small Intestine Bacterial Overgrowth of Liver Cirrhosis |
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| Recruiting | N/A | 100 | | Nutritional risk score ;Nutritional risk score | Affiliated Hospital of Qingdao University; Affiliated Hospital of Qingdao University, Special Project of Science and Technology to benefit the people in the West Coast New area of Qingdao in 2020 | Mild hepatic encephalopathy | | | | |
ChiCTR2100055086: Efficacy evaluation of mild hepatic encephalopathy based on ''STROOP test'' |
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| Recruiting | N/A | 100 | | Comprehensive Western Medicine Treatment ;Comprehensive Western Medicine Treatment + Chinese Medicine Program | Beijing Ditan Hospital Affiliated to Capital Medical University; Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing Municipal Administration of Hospitals | Minimal hepatic encephalopathy | | | | |
| Withdrawn | N/A | 10 | Europe | Gelsectan | Consorci Sanitari de l'Alt Penedès i Garraf | Covert Hepatic Encephalopathy | 05/22 | 07/22 | | |
LTeCRRT, NCT04317222: Early Postoperative CRRT After Liver Transplantation in ACLF Patients With Overt HE |
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| Not yet recruiting | N/A | 250 | NA | eCRRT | Third Affiliated Hospital, Sun Yat-Sen University | Acute-On-Chronic Liver Failure, Hepatic Encephalopathy | 05/22 | 08/22 | | |
ChiCTR2300075024: Effect of stratified care based on Triangle model in prevention and intervention of cirrhotic patients with hepatic encephalopathy |
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| Completed | N/A | 200 | | Usual care ;Usual care+ Stratified care plan | Second Hospital, Chongqing Medical University; Second Hospital, Chongqing Medical University, 2022 Nursing Backbone Research Funding Project of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China（HL2022-15） | Hepatic encephalopathy | | | | |
ALPACA, NCT06248736: Description of Lactulose Administration by Balloon Rectal Tube in Severe Hepatic Encephalopathy |
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| Recruiting | N/A | 25 | Europe | | University Hospital, Grenoble | Hepatic Encephalopathy | 03/24 | 12/24 | | |
ChiCTR1900024168: Early diagnosis of minimal hepatic encephalopathy based on multiscale dynamic functional connectivity |
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| Recruiting | N/A | | | | Tianjin First Central Hospital; Tianjin First Central Hospital, Self-financing | minimal hepatic encephalopathy | | | | |
ChiCTR1900024242: Neuroimaging study for brain changes after transjugular intrahepatic portosystemic shunt (TIPS) |
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| Not yet recruiting | N/A | 80 | | none | Tianjin First Central Hospital; Tianjin First Central Hospital, Self-financing | hepatic encephalopathy | | | | |
ChiCTR2200061590: The effect of proton pump inhibitors on hepatic encephalopathy in liver cirrhosis and its electroencephalographic mechanism |
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| Not yet recruiting | N/A | 20 | | No interventions | The Third Xiangya Hospital of Central South University; The Third Xiangya Hospital of Central South University, Natural Science Foundation of Hunan Province (2020JJ4862) | Hepatic encephalopathy in liver cirrhosis | | | | |
ChiCTR2000035661: Chinese medicine Babaodan in the treatment of mild hepatic encephalopathy |
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| Not yet recruiting | N/A | 70 | | Babaodan combined with lactulose; Lactulose | Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Three year (2020-2022) action plan for promoting clinical skills and clinical innovation in municipal hospitals major clinical research projects | Hepaticencephalopathy | | | | |
ChiCTR-OOC-16009225: Establishment and validation of risk prediction system for post-TIPS hepatic encephalopathy in patients with liver cirrhosis |
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| Not yet recruiting | N/A | 280 | | TIPS ;TIPS | West China Hospital, Sichuan University; West China Hospital, Sichuan University, Self-financing | Liver cirrhosis | | | | |
NCT04675775: The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy. |
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| Completed | N/A | 17 | US | Medically-tailored meals (MTM), Protein supplements, Nutrition education handout | University of Michigan, National Institute on Aging (NIA) | Cirrhosis, Ascites, Liver Diseases, Frailty, Sarcopenia, Hepatic Encephalopathy | 11/22 | 03/23 | | |
NCT05376488: Effect of Brief Dietary Intervention on Ammonia Levels |
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| Completed | N/A | 30 | US | One meal | Hunter Holmes Mcguire Veteran Affairs Medical Center | Cirrhosis, Hepatic Encephalopathy | 12/22 | 04/23 | | |
NCT05229289: Efficacy and Safety of Fecal Microbiota Transplant for Secondary Prophylaxis of Hepatic Encephalopathy |
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| Not yet recruiting | N/A | 66 | RoW | Standard Medical Treatment, Fecal Microbiota Transplant | Institute of Liver and Biliary Sciences, India | Hepatic Encephalopathy | 12/22 | 12/22 | | |
Evencipor, NCT04807803: Evaluation of Minimal Hepatic Encephalopathy in Patients With Cirrhosis and Portal Hypertension |
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| Recruiting | N/A | 100 | Europe | Assessment of Minimal hepatic encephalopathy (MHE) | IHU Strasbourg | Cirrhosis, Portal Hypertension | 03/24 | 03/25 | | |
| Recruiting | N/A | 75 | US | Critical flicker frequency | University of Washington, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Hepatic Encephalopathy | 05/23 | 06/23 | | |
NCT04131205: Role of MRI in Detection of Minimal Hepatic Encephalopathy |
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| Recruiting | N/A | 40 | Europe | Magnetic Resonance Imaging, Ammonia Levels, Child Pugh Score, West-Haven grade of Hepatic Encephalopathy | University Medical Centre Ljubljana, University of Ljubljana, Faculty of Medicine, Medical University of Graz, Johns Hopkins University | Liver Cirrhoses, Hepatic Encephalopathy | 06/23 | 06/23 | | |
ChiCTR2200063747: The use of probiotics in prevention of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt (TIPS) in liver cirrhosis patients: a multicentre randomised, double blind, placebo controlled trial |
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| Not yet recruiting | N/A | 146 | | Tetralogy of viable bifidobacterium tablets ;Placebo | Second Affiliated Hospital of Army Medical University; Second Affiliated Hospital of Army Medical University, self-funded | Liver cirrhosis | | | | |
NCT05526404: Prevention of Hepatic Encephalopathy With Mobile Application Based Lactulose Titration |
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| Completed | N/A | 50 | US | Dieta mobile application | Mayo Clinic | Hepatic Encephalopathy | 07/23 | 07/23 | | |
NCT05566548: Role of Bilirubin Molecular Species in Hepatic Encephalopathy and Acute-on-chronic Liver Failure |
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| Recruiting | N/A | 50 | RoW | Liquid Chromatography-Mass Spectrometry Method to identify bilirubin molecular species | Medica Sur Clinic & Foundation | Hepatic Encephalopathy, Acute-On-Chronic Liver Failure | 07/23 | 08/23 | | |
ChiCTR2100048081: Investigation on the incidence of hepatic encephalopathy and postoperative cognitive dysfunction in patients with hepatopulmonary syndrome |
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| Not yet recruiting | N/A | 323 | | Nil | The First Affiliated Hospital, Army Medical University; The First Affiliated Hospital, Army Medical University, National Natural Science Foundation of China | Hepatopulmonary syndrome(HPS) | | | | |
ChiCTR2100050880: Effect of cholinergic system on cognitive function of patients with mild hepatic encephalopathy and its imaging evaluation |
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| Recruiting | N/A | 45 | | No ;No ;No | General Hospital of Ningxia Medical University; General Hospital of Ningxia Medical University, Ningxia Hui Autonomous Region Science and Technology Department | Minimal hepatic encephalopathy | | | | |
EH-CASIMIR, NCT05772585: Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver Failure With Hepatic Encephalopathy |
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| Not yet recruiting | N/A | 30 | NA | Blood collection, Metabolomics analyses, High resolution liquid phase mass spectrometry | Assistance Publique - Hôpitaux de Paris | Hepatic Encephalopathy, Acute Liver Failure, Acute on Chronic Liver Failure | 10/23 | 10/23 | | |
NCT06367127: Utility of the Clamping Bean Test (CBT) for Covert Hepatic Encephalopathy Screening |
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| Enrolling by invitation | N/A | 200 | RoW | | Shanghai Changzheng Hospital | Hepatic Encephalopathy, Covert Hepatic Encephalopathy | 12/24 | 12/24 | | |
| Recruiting | N/A | 30 | Europe | Eye-tracker Mobile EBT | Assistance Publique - Hôpitaux de Paris | Cirrhosis | 10/23 | 10/23 | | |
NCT04014413: Safety and Efficacy of Fecal Microbiota Transplantation |
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| Recruiting | N/A | 450 | RoW | Fecal Microbiota Transplantation | Chinese University of Hong Kong | Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome, Functional Dysphonia, Constipation, Clostridium Difficile Infection, Diabetes Mellitus, Obesity, Multidrug -Resistant Infection, Hepatic Encephalopathy, Multiple Sclerosis, Pseudo-Obstruction, Carbapenem-Resistant Enterobacteriaceae Infection, Vancomycin Resistant Enterococci Infection, Multiple Organ Dysfunction Syndrome, Dysbiotic Bowel Syndrome, MRSA Enteritis, Pseudomembranous Enterocolitis, Alopecia, Autism, Graft-versus-host Disease, Idiopathic Thrombocytopenic Purpura, Atopy or Allergy, Liver Disease, Alcohol Dependence, Psoriatic Arthropathy | 10/23 | 10/30 | | |
| Not yet recruiting | N/A | | | | People's Hospital of Ningxia Hui Autonomous Region; People's Hospital of Ningxia Hui Autonomous Region, Key Research and Development Project of Ningxia Hui Autonomous Region | minimal hepatic encephalopathy | | | | |
ChiCTR2200066161: Neurologic Safety of remimazolam for cirrhotic patients undergoing EVL and/or EVS |
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| Recruiting | N/A | 186 | | propofol drug ;remimazolam drug ;sevoflurane drug | Liaocheng People's Hospital; Liaocheng People's Hospital, Self-raised | minimal hepatic encephalopathy | | | | |
NCT03825848: The Influence of Post-transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy |
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| Recruiting | N/A | 130 | RoW | trans jugular intrahepatic portal systemic shunt | Shanghai Zhongshan Hospital | Portal Hypertension, Hepatic Encephalopathy | 12/23 | 12/23 | | |
ChiCTR2200059388: Study on the efficacy and safety of fecal transplantation in the treatment of patients with liver cirrhosis combined with hepatic encephalopathy |
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| Not yet recruiting | N/A | 30 | | Lactulose, Ornithine Menthylate + Fecal bacteria capsules ;Lactulose, Ornithine Menthylate | Rizhao City People's Hospital; Rizhao City People's Hospital, Self-financed | Hepatic encephalopathy | | | | |
NCT06179368: Throid Dysfunction in Liver Failure and Its Eddects Upon Outcome |
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| Recruiting | N/A | 100 | RoW | hypothroidism, euothyroid | Assiut University | Hepatic Encephalopathy, Hepatic Impairment, Hypothyroidism, Hepatic Failure | 04/24 | 05/24 | | |
| Recruiting | N/A | 660 | RoW | Test for CMV reactivation, Test and examine the severity of hepatic encephalopathy | Nanfang Hospital, Southern Medical University | Decompensated Cirrhosis, CMV Reactivation, Overt Hepatic Encephalopathy | 04/24 | 12/25 | | |
NCT06328088: Vegetarian Versus Non Vegetarian Based Diet in the Recurrence of Hepatic Encephalopathy in Patients With Cirrhosis: An Open Label Pilot Study |
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| Recruiting | N/A | 40 | RoW | Non vegetarian | Sir Ganga Ram Hospital | Hepatic Encephalopathy | 04/24 | 10/24 | | |
| Recruiting | N/A | 60 | Europe | blood sample | Assistance Publique - Hôpitaux de Paris | Hepatic Encephalopathy, Cirrhosis | 04/24 | 04/24 | | |
NCT05421351: Immune Profile, Neuronal Dysfunction, Metabolomics and Ammonia in Therapeutic Response of HE in ACLF |
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| Recruiting | N/A | 135 | RoW | | Postgraduate Institute of Medical Education and Research | Hepatic Encephalopathy, Acute-On-Chronic Liver Failure, Decompensated Cirrhosis | 05/24 | 05/25 | | |
NCT04096014: Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy |
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| Recruiting | N/A | 40 | US | Ensure Enlive, Standard Of Care | The Cleveland Clinic | Hepatic Encephalopathy | 06/26 | 10/26 | | |
| Active, not recruiting | N/A | 251 | US | Home Recordings, In-patient Recordings, Same-Day Study Visit - Regular Appointment, Same-Day Study Visit - Procedure, Phone Call Follow-up Visits | University of Michigan, Winterlight Labs | Hepatic Encephalopathy | 08/24 | 08/24 | | |
ChiCTR2200064205: A clinical study of mini-invasive vascular interventional surgery for refractory hepatic encephalopathy |
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| Not yet recruiting | N/A | 90 | | vascular interventional surgery ;treat with lactulose | West China Hospital, Sichuan University; West China Hospital, Sichuan University, The new clinical technology project, West China Hospital, Sichuan University (2022-179) | Liver cirrhosis | | | | |
ChiCTR2300074985: Study on metabolome and microbiome changes in patients with hepatic encephalopathy |
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| Not yet recruiting | N/A | 50 | | NA ;NA ;NA | The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital); The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Alpha Sigma (Beijing) Pharmaceutical Consulting Co., LTD. | hepatic encephalopathy | | | | |
NCT06075875: Vegetable Proteins Versus Mixed Animal Proteins on the Outcome of Hepatic Encephalopathy |
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| Not yet recruiting | N/A | 196 | RoW | mixed animal and vegetable proteins, pure vegetable proteins | National Hepatology & Tropical Medicine Research Institute | Hepatic Encephalopathy | 09/24 | 01/25 | | |
ChiCTR2100050743: A randomized, double-blind, controlled clinical trial of live combined bifidobacterium and lactobacillus tablets in the prevention of hepatic encephalopathy in cirrhotic patients |
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| Recruiting | N/A | 140 | | live combined bifidobacterium and lactobacillus tablets ;Placebo | West China Hospital, Sichuan University; West China Hospital, Sichuan University, Inner Mongolia Shuangqi Pharmaceutical Co., Ltd. | Hepatic encephalopathy | | | | |
NCT05140837: Early Diagnosis and Timely Treatment of Cirrhotic Patients With Minimal Hepatic Encephalopathy (CHESS-NCRCID 2106) |
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| Recruiting | N/A | 10000 | RoW | Psychometric hepatic encephalopathy score & Stroop test, Drug therapy | Hepatopancreatobiliary Surgery Institute of Gansu Province, The First Affiliated Hospital of Anhui Medical University, Beijing Ditan Hospital, Chongqing Public Health Medical Treatment Center, Meng Chao Hepatobiliary Hospital of Fujian Medical University, Guangxi Zhuang Autonomous Region People's Hospital, Shenzhen Third People's Hospital, Guizhou people's Hospital, Wuhan Union Hospital, China, Xiangya Hospital of Central South University, The Second Affiliated Hospital of Hainan Medical University, The Third Affiliated Hospital of Hebei Medical University, The Second Affiliated Hospital of Harbin Medical University, Henan Provincial People's Hospital, Ganzhou Fifth People's Hospital, The First Hospital of Jilin University, Jiangsu People's Hospital, First Hospital of China Medical University, The Second Affiliated Hospital of Baotou Medical College, Ningxia Medical University General Hospital, The Fourth People's Hospital of Qinghai Province, Xi'an High-tech Hospital, The 10th People's Hospital affiliated to Tongji University, Qilu Hospital of Shandong University, The Third People's Hospital of Taiyuan, Xichang People's Hospital, Tianjin Third Central Hospital, The Third People's Hospital of Tibet Autonomous Region, Xinjiang Autonomous Region People's Hospital, Second People's Hospital of Yunnan Province, Hangzhou Xixi hospital, LanZhou University | Hepatic Encephalopathy, Cirrhosis | 12/24 | 12/24 | | |
NCT05346029: Role of Sarcopenia and Nutritional/Physical Therapy Intervention in Post-TIPS Hepatic Encephalopathy |
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| Recruiting | N/A | 140 | Europe | Lifestyle intervention | Anna Baiges, Instituto de Salud Carlos III, Hospital Universitario Ramon y Cajal, Gregorio Marañón Hospital | Cirrhosis, Liver, Hepatic Encephalopathy, Sarcopenia | 12/24 | 12/25 | | |