| Cataract |
2012-004873-14: Prevention of macular edema after cataract surgery Het voorkomen van netvlieszwelling na een staaroperatie |
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| Ongoing | 3 | 246 | Europe | Bromfenac, Dexamethasone, Bevacizumab, Triamcinolone Acetonide, Yellox, Dexamethasone, Avastin, Triesence, Yellox, Dexamethasone, Avastin, Triesence | University Eye Clinic Maastricht, University Eye Clinic Maastricht UMC, ESCRS (European Society of Cataract & Refractive Surgeons), Bausch + Lomb, ESCRS (European Society of Cataract and Refractive Surgeons), Bausch & Lomb | Pseudophakic cystoid macular edema (PCME) | | | | |
2016-003232-21: The efficacy of "Acular" eyedrops compared to a singular "Volon A 40" injection in patients with macular edema (swelling of the retina due to accumulation of fluid) following cataract (clouding of the eye lens) surgery. Die Wirkung von "Acular" Augentropfen, verglichen mit einer einmaligen "Volon A 40" Injektion bei Patienten mit Makulaödem (Schwellung der Netzhaut infolge einer Flüssigkeitsansammlung) nach einer Grauen Star Operation. |
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| Ongoing | 3 | 136 | Europe | Acular 0,5% Augentropfen, Volon A 40 Kristallsuspension Ampulle, Eye drops, Suspension for injection, Acular 0,5% Augentropfen, Volon A 40 Kristallsuspension Ampulle | Medizinische Universität Graz, Univers. Augenklinik, Medizinische Universität Graz | Pseudophakic macular edema Pseudophakes Makulaödem, Swelling of the retina caused by an accumulation of fluid following cataract (clouding of the eye lens) surgery Durch eine Flüssigkeitsansammlung hervorgerufene Schwellung der Netzhaut in Folge einer Katarakt (Linsentrübung: Grauer Star) Operation., Body processes [G] - Ocular Physiological Phenomena [G14] | | | | |
2017-001416-11: Comparison of macular thickness before and after cataract surgery with an antibiotic from two ways of preparation. Comparación del grosor macular antes y después de cirugÃa de cataratas no traumática asociada a antibiótico procedente de dos vÃas de preparación. |
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| Ongoing | 3 | 622 | Europe | Powder and solvent for solution for injection, Intraocular instillation solution, Cefuroxima NORMON 750mg, CEFUROXIMA PROKAM | Consorci Mar Parc de Salut de Barcelona (Parc de Salut MAR), None | Pseudophakic macular edema Edema macular pseudofáquico, Macular edema after cataract surgery Edema macular tras cirugÃa de cataratas, Diseases [C] - Eye Diseases [C11] | | | | |
ACTRN12618000202268: Comparing the effectiveness and safety of two treatments (OZURDEX® intravitreal implant versus Avastin®) for diabetic eye disease in adult Indigenous patients living in Western Australia.
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| Active, not recruiting | 3 | 50 | | | LIONS EYE INSTITUTE LTD, ALLERGAN AUSTRALIA PTY LTD | Diabetic Macular Oedema | | | | |
2019-004890-21: Prevention of macular edema after cataract surgery Het voorkomen van netvlieszwelling (maculaoedeem) na een staaroperatie |
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| Ongoing | 3 | 808 | Europe | Bromfenac, Dexamethasone disodium phosphate, Triamcinolone Acetonide, Ketorolac/phenylephrine, Eye drops, solution, Suspension for injection, Irrigation solution, Yellox, Dexamethasone disodium phosphate, Triesence or Vistrec, Omidria | Academic Hospital Maastricht (azM), ESCRS (European Society of Cataract & Refractive Surgeons) | cystoid macular edema (CME) cystoide maculaoedeem (CMO), macular edema after cataract surgery maculaoedeem na staaroperatie, Diseases [C] - Eye Diseases [C11] | | | | |
NCT04668456: Subtenon and Intravenous Dexmedetomidine Effect on Patients Undergoing Cataract Surgery |
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| Active, not recruiting | 3 | 75 | RoW | Dexmedetomidine, lidocaine 2%, bupivacine 0.5%, Normal saline | Menoufia University | Acute Postoperative Pain | 03/21 | 03/21 | | |
NCT04711642: Comprehensive Study on Dry Eye and Ocular Surface Disease Prior and After Cataract Surgery |
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| Not yet recruiting | 3 | 100 | NA | The study will include three arms, one non interventional and 2 interventions. The intervention arms will include two commercially available sodium hyaluronate 0.1% (Systane ultra plus and Hylo-comod) | Fundación Oftalmológica Los Andes, Alcon Research | Dry Eye Disease, Dry Eye Syndrome, Evaporative Dry Eye, Cataract, Phacoemulsification | 01/22 | 07/23 | | |
NCT04810962: Efficacy and Safety of APP13007 for Treatment of Inflammation and Pain After Cataract Surgery Including a Corneal Endothelial Cell Sub-study |
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| Completed | 3 | 370 | US | APP13007, 0.05%, Matching Vehicle Placebo for APP13007, 0.05% | Formosa Pharmaceuticals, Inc. | Ocular Inflammation and Pain After Cataract Surgery | 07/22 | 07/22 | | |
NCT06429306: Study of Dexycu in Treating Intraocular Inflammation |
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| Completed | 3 | 285 | RoW | Dexycu, Investigational product, Placebo | Ocumension Therapeutics (Shanghai) Co., Ltd | Inflammation, Cataract | 11/23 | 04/24 | | |
NCT04539548: A Study Assessing the Safety and Efficacy of Dextenza® for the Treatment of Ocular Pain and Inflammation Following Surgery for Pediatric Cataract |
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| Completed | 3 | 65 | US | Dextenza Ophthalmic Insert, DEXTENZA, Prednisolone acetate ophthalmic suspension USP 1% | Ocular Therapeutix, Inc. | Cataract | 12/23 | 12/23 | | |
2022-000624-37: Clinical trial to assess the safety and efficacy of Clobetasol propionate ophthalmic nanoemulsion 0.05% compared to Prednisolone acetate, 1% in the treatment of inflammation after cataract surgery in pediatric population 0 to 3 years of age. Ensayo clínico para evaluar la seguridad y eficacia de clobetasol propionato 0,05% nanoemulsión oftálmica en comparación con acetato de prednisolona 1% en el tratamiento de la inflamación después de la cirugía de cataratas en población pediátrica de 0 a 3 años. |
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| Not yet recruiting | 3 | 60 | Europe | Clobetasol propionate ophthalmic nanoemulsion, 0.05%, Clobetasol propionate, Ear/eye drops, solution, Ear/eye drops, suspension, Pred Forte 10 mg/ml colirio en suspensión | Laboratorios Salvat, S.A., Laboratorios Salvat, S.A. | Inflammation and pain associated with ocular surgery. Inflamación y dolor después de la cirugía de cataratas., Inflammation and pain associated with ocular surgery. Inflamación y dolor después de la cirugía de cataratas., Diseases [C] - Eye Diseases [C11] | | | | |
ChiCTR2000037527: A clinical trial to evaluate the efficacy and safety of foldable, monofocal, aspherical hydrophobic acrylic intraocular lens |
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| Not yet recruiting | 3 | 184 | | The intraocular lens with the model of SM60AS produed by Simedice company ;The intraocular lens with the model of SN60WF produed by Alcon company | Zhongshan Opthalmic center, Sun Yat-sen University; Henan Simedice Biotechnologies Co., Ltd., Self-finance | Cataract | | | | |
NCT05147233: OCS-01: A Phase 3 Study Evaluating the Efficacy and Safety of OCS-01 Eyedrops Compared to Vehicle for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery |
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| Recruiting | 3 | 240 | US | Dexamethasone, OCS-01, Vehicle Placebo, Placebo | Oculis | Disorders of the Eye Following Cataract Surgery | 03/23 | 06/23 | | |
NCT05528172: A Study to Investigate the Safety and Efficacy of Ripasudil (K-321) Eye Drops After Cataract Surgery |
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| Completed | 3 | 331 | US | Ripasudil, K-321, Placebo | Kowa Research Institute, Inc. | Corneal Edema After Cataract Surgery | 06/23 | 06/23 | | |
OPTIMIZE-2, NCT06128369: Study Evaluating the Efficacy and Safety of OCS-01 Eye Drops in Subjects Following Cataract Surgery |
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| Recruiting | 3 | 160 | US | Dexamethasone Ophthalmic Suspension, OCS-01, Vehicle of OCS-01 | Oculis, ORA, Inc. | Inflammation Eye, Pain, Postoperative, Cataract | 07/24 | 12/24 | | |
| Recruiting | 3 | 808 | Europe | Bromfenac, Yellox, Product code: EU/1/11/692, Dexamethasone, Dexamethasone ophthalmic solution, Product code (NL): RVG 56003, Triamcinolone Acetonide, Triesence or Vistrec, Product code (NL): RVG 106092, Ketorolac-Phenylephrine Ophthalmic 0.3%-1% Intraocular Solution, Omidria | Luigi Rondas, European Society of Cataract and Refractive Surgeons | Macular Edema, Cystoid Macular Edema, Retinal Disease, Cataract, Lens Diseases, Eye Diseases | 12/23 | 04/24 | | |
NCT05826353: A Study to Investigate the Safety and Efficacy of K-321 Eye Drops After Simultaneous Cataract Surgery and Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD) |
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| Recruiting | 3 | 100 | Europe, Canada, US | Ripasudil, K-321, Placebo | Kowa Research Institute, Inc. | Fuchs Endothelial Corneal Dystrophy | 06/24 | 01/25 | | |
NCT05550363: A Study to Evaluate the Efficacy and Safety of DEXYCU® for the Treatment of Ocular Pain Associated With Cataract Surgery (2) |
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| Withdrawn | 3 | 150 | NA | Dexycu, Placebo/Vehicle | EyePoint Pharmaceuticals, Inc. | Cataract | 09/23 | 09/23 | | |
NCT05550350: A Study to Evaluate the Efficacy and Safety of DEXYCU® for the Treatment of Ocular Pain Associated With Cataract Surgery |
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| Not yet recruiting | 3 | 150 | NA | Dexycu, Placebo/Vehicle | EyePoint Pharmaceuticals, Inc. | Cataract | 04/24 | 04/24 | | |
NCT06383273: A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR) |
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| Recruiting | 3 | 528 | US | MELT-300 sublingual tablet, Midalozam sublingual tablet, Placebo sublingual tablet | Melt Pharmaceuticals, MedTrials Incorporated, Evolution Research Group, Catalent, Pharmalex | Cataract | 12/24 | 01/25 | | |
NCT06048380: The Effects of Ripasudil in Patients With FED Undergoing Femtosecond Laser Assisted Cataract Surgery |
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| Recruiting | 3 | 120 | RoW | Ripasudil, Glanatec, Placebo | Singapore Eye Research Institute | Fuchs' Endothelial Dystrophy, Cataract | 07/24 | 07/25 | | |
CLOSE-3, NCT05724446: Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% in the Treatment of Inflammation After Cataract Surgery in Pediatric Population |
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| Recruiting | 3 | 60 | Europe | Clobetasol Propionate, SVT-15473, Prednisolone acetate ophthalmic suspension, 1% | Salvat | Cataracts Infantile | 12/25 | 12/25 | | |
NCT06061718: Travoprost Intraocular Implant in Conjunction With Cataract Surgery |
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| Active, not recruiting | 3 | 60 | RoW | iDose TR, travoprost intraocular implant | Glaukos Corporation | Open Angle Glaucoma, Ocular Hypertension | 03/24 | 12/24 | | |
| Recruiting | 3 | 186 | | The control group diffractive multifocal intraocular lens was implanted; Diffractive multifocal intraocular lens of the experimental group was implanted | Eye Hospital, WMU Zhejiang Eyehospital; Eye Hospital, WMU Zhejiang Eyehospital, Tianjin Shi Ji Kang Tai Biomedical Engineering Co.,Ltd | Cataract | | | | |
ChiCTR2300071151: A multicenter, randomized, open, parallel-controlled trial of lengthening depth of field intraocular lens for visual acuity correction after cataract extraction |
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| Not yet recruiting | 3 | 176 | | Implanting depth-of-field elongated intraocular lens ;Implanting TECNIS Symfony Extended Range of Vision IOL | Eye Hospital, WMU Zhejiang Eye Hospital; Eye Hospital, WMU Zhejiang Eye Hospital, Tianjin Shiji Kangtai Biomedical Engineering Co. Ltd. | Cataract | | | | |
ChiCTR2300076680: A Multicenter, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of APP13007 for the Treatment of Inflammation and Pain after Cataract Surger |
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| Recruiting | 3 | 252 | | Drip into the conjunctival sac of the study eye; APP13007 Placebo | Beijing Tongren Hospital, Capital Medical University; Grandpharma (China) CO., LTD., Enterprise self-raised | Treatment of Inflammation and Pain after Cataract Surgery | | | | |
| Suspended | 3 | 142 | US | Pilocarpine, Isopto®, Prednisolone, Pred Forte, Ofloxacin, Ocuflox, Floxin | Montefiore Medical Center | Glaucoma | 12/25 | 12/25 | | |
ChiCTR2400081377: A multicenter, open, parallel, randomized controlled clinical trial comparing the safety and efficacy of Jinghua Shikang MPA-01 foldable posterior chamber hydrophobic aspheric intraocular lens and Johnson vision care foldable posterior chamber acrylic intraocular lens |
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| Not yet recruiting | 3 | 188 | | Phacoemulsification of cataract combined with intraocular lens implantation; Phacoemulsification of cataract combined with intraocular lens implantation | Peking Union Medical College Hospital; Peking Union Medical College Hospital, Xiamen Jinghua Sighkang Medical Equipment Co., LTD | cataract | | | | |
ChiCTR2400086960: To evaluate the efficacy and safety of multifocal intraocular lens in cataract phacoemulsification and intraocular lens implantation in a prospective, multicenter, randomized controlled clinical trial |
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| Not yet recruiting | 3 | 188 | | Intraocular lens implantation after cataract phacoemulsification; Intraocular lens implantation after cataract phacoemulsification | Beijing Tongren Hospital, Capital Medical University; Sichuan Xingtaipule Medical Technology Co., LTD, Sichuan Xingtaipule Medical Technology Co., LTD | Cataract | | | | |
ACTRN12615000118505: Is it possible to use long acting steroid preparations such as the dexamethasone intravitreal implant Ozurdex to prevent a deterioration in vision in patients with diabetes undergoing cataract surgery in central Australia. |
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| Recruiting | 2/3 | 40 | | | Alice Springs Hospital, ALLERGAN AUSTRALIA PTY. LTD | Diabetic retinopathy, Diabetic macular edema, Cataract | | | | |
ACTRN12613001189718: Clinical Investigation of the Extended Range of Vision (ERV) Intraocular Lenses (IOLs), Model XRA03 and Toric Series ZXT in Participants Requiring Bilateral Cataract Removal and Lens Replacement.
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| Active, not recruiting | 2/3 | 75 | | | Abbott Medical Optics Inc, Abbott Medical Optics Inc | Bilateral Cataract removal and replacment of crystalline lens with an investigational extended range of vision IOL, in otherwise healthy eyes | | | | |
NCT03244072: Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery |
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| Not yet recruiting | 2/3 | 60000 | US | Moxifloxacin, active, Placebo, sham | Jason Ahee, M.D. | Endophthalmitis | 10/25 | 10/25 | | |
