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ACTRN12606000265572: Cystoid Macular Edema Associated With Topical Latanoprost in Patients that Underwent Uncomplicated Cataract Surgery |
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| Not yet recruiting | 4 | 20 | | | Federal University of Uberlândia, Federal University of Uberlândia | Cystoid Macular Edema | | | | |
| Not yet recruiting | 4 | 240 | | | The Alfred , The Alfred Hospital | Cataract | | | | |
ACTRN12611000336987: Prospective study into the effect of an intraocular injection of a steroid in the prevention of Glaucoma drainage surgery failure after cataract surgery |
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| Recruiting | 4 | 110 | | | Royal Victorian Eye and Ear, Royal Victorian Eye and Ear | Glaucoma, Glaucoma filtration surgery failure after cataract surgery | | | | |
| Completed | 4 | 240 | | Loposome Encapsulate Indomethacin Eyedrops after phacoemulsification cataract surgery ;Indomethacin Eyedrops after phacoemulsification cataract surgery | LiBo Pharmaceuticals Science & Technology Co., Ltd.; Beijing Second Pharmaceuticals Co., Ttd, LiBo Pharmaceuticals Science & Technology Co., Ltd. | Inflammatory reaction following cataract phacoemulsification surgery | | | | |
ChiCTR-TRC-12002693: Comparative Study of Human Aqueous Humor Levels of Gatifloxacin 0.3% Eye Gel, Gatifloxacin 0.3% and Levofloxacin 0.5% Ophthalmic Solution after Topical Dosing |
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| Completed | 4 | 150 | | One drop of gatifloxacin 0.3% eye gel was administration ;One drop of gatifloxacin 0.3% ophthalmic solution ;One drop of levofloxacin 0.5% ophthalmic solution | Zhejiang University; Zhejiang University, Zhejiang Key Innovation Team Project of China (2009R50039); Zhejiang Key Laboratory Fund of China (2011E10006) | endoophthalmitis after cataract surgery | | | | |
2011-006066-40: The post-cataract inflammatory reaction with combination therapy of topical steroid and NSAID. ble |
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| Ongoing | 4 | 10 | Europe | Eye drops, suspension, NEVANAC | The Rotterdam Eye Hospital, Nuts OHRA | Ocular inflammatory reaction after cataract surgery., Ocular inflammatory reaction after cataract surgery., Body processes [G] - Immune system processes [G12] | | | | |
ChiCTR-TRC-12002566: Effect of Preoperative topical Diclofenac and Pranoprofen Eye drops with and without epinephrine intraoperatively on Pupil Dilatation Maintenance During Phacoemulsification |
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| Completed | 4 | 239 | | drug | Zhongshan Ophthalmic Center at Sun Yat-sen University; Zhongshan Ophthalmic Center at Sun Yat-sen University, sponsorship | Cataract | | | | |
ChiCTR-ONC-13003903: An Observation Study after Being Implanted AcrySof IQ ReSTOR Multifocal Toric intraocular lenses in Chinese cataract with Cornea Astigmatism patients |
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| Completed | 4 | 64 | | cataract extraction and bilateral implantation of AcrySof IQ ReSTOR Multifocal Toric IOLs. | the affiliated Eye Hospital of Wenzhou Medical University; Level of the institution：, Alcon (China) Ophthalmic Product Co., LTD | Cataract with Cornea Astigmatism | | | | |
ChiCTR-IPR-15006112: Compare recovery period with different doses of anesthetic drugs in cataract surgery in infant |
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| Not yet recruiting | 4 | 150 | | fentany l0.5ug/kg, dexmedetomidine 0.5ug/kg ;fentany l0.5ug/kg, dexmedetomidine 1ug/kg ;fentanyl 1ug/kg, dexmedetomidine 0.5ug/kg ;fentanyl 1ug/kg, dexmedetomidine 1ug/kg ;fentanyl 0.5ug/kg, dexmedetomidine 1ug/kg，Mivacurium Chloride0.2mg/kg | The Eye, Ear, Nose and Throat Hospital, Fudan University; The Eye, Ear, Nose and Throat Hospital, Fudan University, The Eye, Ear, Nose and Throat Hospital, Fudan University | the use of anesthetic drugs in cataract surgery in infant | | | | |
2015-003296-30: Efficacy of steroid and nonsteroidal anti-inflammatory eye drops after uncomplicated cataract surgery Anti-inflammatorisen lääkityksen valinta kaihileikkauksen jälkeen |
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| Ongoing | 4 | 300 | Europe | NEVANAC, PRED FORTE, Eye drops, suspension, Nevanac, PRED FORTE | Raimo Tuuminen, University of Helsinki | Cataract senilis Vanhuuden tumakaihi, Cataract Kaihi, Diseases [C] - Eye Diseases [C11] | | | | |
2005-001203-19: Does Hyaluronidase permit volume reduction in sub-Tenon anaestehesia? |
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| Ongoing | 4 | 98 | Europe | Hyalase, Lidocaine 2%, Hyalase, Lidocaine 2%, Hyalase, Lidocaine 2% | Department of research & development, TheLeeds teaching hospitals NHS trust | Cataract | | | | |
2006-001486-41: Effects of post-operative topical steroid versus intraoperative subconjunctival steroid injection and postoperative miotic on intraocular inflammation following cataract extraction. |
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| Ongoing | 4 | 400 | Europe | Celestone chronodose, Dexamethason ratiopharm 1 mgg/ml eye drops, physostigmine salicylate 1% eye cream, RVG 05399, RVG 56003, | Oogziekenhuis Rotterdam | Post-cataract extraction ocular inflammation. | | | | |
2007-002128-14: Anesthésie topique versus anesthésie épisclérale pour chirurgie de la cataracte |
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| Ongoing | 4 | 84 | Europe | OXYBUPROCAINE, MEPIVACAINE CHLORHYDRATE, OXYBUPROCAINE FAURE CHLORHYDRATE, CARBOCAINE 2 POUR CENT, OXYBUPROCAINE FAURE CHLORHYDRATE, CARBOCAINE 2 POUR CENT | CHU de Nîmes | Cataracte bilatérale | | | | |
2009-017031-18: Treatment of Cystoid Macular Edema following cataract surgery. A randomized, double-masked, placebo-controlled, clinical trial. |
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| Ongoing | 4 | 120 | Europe | nepafenac, presnisolone-21-acetate, nepafenac, presnisolone-21-acetate, | Rotterdam Eye Hospital | cystoid macular edema | | | | |
2009-014054-14: Comparison of the Safety of Intracameral Levofloxacin to intracameral Cefuroxime for the prevention of endophthalmitis in cataract surgery (SILC) |
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| Ongoing | 4 | 30 | Europe | Oftaquix Unit Dose 5mg/mL eye drops, Zinacef, Oftaquix Unit Dose 5mg/mL eye drops, Zinacef | Guys\' and St Thomas\' NHS Foundation Trust, Joint Clinical Trials Office | Cataracts and endophthalmitis | | | | |
2013-000292-33: Comparative estudy of pupil dilatation induced by Mydriasert and an association of phenylephrine and tropicamide before cataract surgery Estudio de la comparación del tamaño de dilatación pupilar inducido por Mydriasert en comparación con el efecto inducido por la asociación de fenilefrina y tropicamida en el marco de una cirugÃa de cataratas |
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| Ongoing | 4 | 98 | Europe | Mydriasert, Phenylephrine chlorhydrate, Tropicamide, Mydriasert, Colircusà Fenilefrina 100mg/ml, Colisrcusà Tropicamida 10 mg/ml, Mydriasert, Colircusà Fenilefrina 100mg/ml, Colisrcusà Tropicamida 10 mg/ml | Laura Sararols Ramsay, Capio Hospital General de Catalunya | Cataract surgery CirugÃa de cataratas | | | | |
ChiCTR-TRC-14005104: effects of non-steroidal anti-inflammatory drugs at femtosecond laser-assisted cataract surgery |
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| Recruiting | 4 | 60 | | phacoemulsification with posterior chamber intraocular lens implantation ;the patients undergoing phacoemulsification with posterior chamber intraocular lens implantation received ophthalmic bromfenac sodium 0.1% twice per day for 1 month ;femtosecond laser assisted phacoemulsification with posterior chamber intraocular lens implantation | the 4th Affiliated Hospital, China Medical University; None, the 4th Affiliated Hospital of China Medical University | cataract | | | | |
2015-005313-79: Non-steroidal anti-inflammatory (NSAID) medication in cataract surgery Kaihileikkauksen non-steroidaalinen anti-inflammatorinen (NSAID) lääkitys |
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| Ongoing | 4 | 100 | Europe | Dicloabak, Nevanac 1mg/ml, Eye drops, solution, Eye drops, suspension, Dicloabak, Nevanac | Raimo Tuuminen, University of Helsinki | Cataract senilis Vanhuuden tumakaihi, Cataract Kaihi, Diseases [C] - Eye Diseases [C11] | | | | |
2016-004358-14: To compare the efficacy of bromfenac ophthalmic solution 0.09% to dexamethasone ophthalmic solution 0.1% for reducing postoperative inflammation after cataract surgery. Valutazione dell'efficacia di un collirio anti infiammatorio non steroideo (bromfenac) rispetto al trattamento farmacologico standard (desametasone) per ridurre l'infiammazione postoperatoria dopo l'intervento di cataratta. |
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| Not yet recruiting | 4 | 76 | Europe | Yellox 0,9 mg/ml collirio, soluzione, VISUMETAZONE 0,1% collirio sospensione, Eye drops, solution, YELLOX - 0.9 MG/ML - COLLIRIO, SOLUZIONE - USO OFTALMICO - FLACONE (PE) - 5 ML 1 FLACONE, VISUMETAZONE - 0.1% COLLIRIO, SOSPENSIONE FLACONE 3 ML | AZIENDA OSPEDALIERA ARCISPEDALE SANTA MARIA NUOVA/IRCCS DI REGGIO EMILIA, A.O. di Reggio Emilia Arcispedale "S. Maria Nuova" | Postoperative ocular inflammation after cataract surgery Infiammazione oculare dopo intervento di cataratta, Patients with cataract undergoing cataract surgery I pazienti inclusi nello studio sono soggetti affetti da cataratta sottoposti ad intervento di facoemulsificazione (= rimozione della cataratta)., Diseases [C] - Eye Diseases [C11] | | | | |
2016-004784-40: Anti-inflammatory medication in cataract surgery of pseudoexfoliation eyes |
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| Ongoing | 4 | 150 | Europe | Nevanac 1mg/ml, Pred Forte 10mg/ml, S01GX09, Ear drops, suspension, Eye drops, suspension, Nevanac 1mg/ml, Pred Forte 10mg/ml | Raimo Tuuminen, University of Helsinki | Cataract senilis, Cataract, Diseases [C] - Eye Diseases [C11] | | | | |
2016-004515-12: The effect of perioperative versus postoperative cortisone treatment in cataract surgery |
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| Ongoing | 4 | 100 | Europe | Oftan Dexa 1mg/ml, Triesence 40mg/ml, Eye drops, solution, Suspension for injection, Oftan Dexa 1mg/ml, Triesence 40mg/ml | Raimo Tuuminen, University of Helsinki | Cataract senilis, Cataract, Diseases [C] - Eye Diseases [C11] | | | | |
2016-004416-35: Comparative study of different therapeutic regimens based on tobramycin, dexamethasone and diclofenac for the prevention of macular edema after cataract surgery. Estudio comparativo de diferentes pautas terapéuticas basadas en tobramicina, dexametasona y diclofenaco para la prevención del edema macular post cirugía de catarata. |
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| Ongoing | 4 | 210 | Europe | Ear/eye drops, solution, Eye drops, solution, Eye drops, Tobrex 3 mg/ml, COLIRCUSÍ DEXAMETASONA 1 mg/ml, Diclofenaco-Lepori, tobradex | Fundació Parc Taulí, Fundació Parc Taulí | Pseudophakic macular edema is a pathology that results from cataract surgery, usually occurring 4-6 weeks after surgery, which directly affects the retina (specifically the macula, the region that provides maximum visual acuity). In this condition, for different reasons, an inflammatory exudate accumulates in the different layers of the retina and can lead to affect the visual acuity, to severe retinal alterations both acute or chronic. El edema macular pseudofáquico es una patología derivada de la cirugía de cataratas que ocurre generalmente entre las 4-6 semana posterior al acto quirúrgico, que afecta directamente a la retina (específicamente la mácula, región que brinda la máxima agudeza visual). En esta condición, por diversos mecanismos se acumula un exudado inflamatorio en las distintas capas de la retina que puede llevar a afectar la agudeza visual, hasta alteraciones retinianas mas severas tanto agudas como crónicas., Pseudophakic macular edema is a condition that can occur postoperatively in cataract surgery consisting on fluid accumulation in the retina. El edema macular pseudofáquico es una condición que puede ocurrir en el postoperatorio de la cirugía de cataratas que consiste en la acumulación de líquido en la retina., Diseases [C] - Eye Diseases [C11] | | | | |
ChiCTR1900021009: Anti-inflammatory Effect of Triamcinolone Acetonide in Acute Primary Angle-Closure Patients Receiving Phacoemulsification and Intraocular Lens Implantation |
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| Completed | 4 | 58 | | subconjunctival injection of dexamethasone (3mg) ;subconjunctival injectiointracameral injection of triamcinolone acetonide (0.5mg) ;subconjunctival injectiointracameral injection of triamcinolone acetonide (1.0mg) ;subconjunctival injectiointracameral injection of triamcinolone acetonide (1.5mg) | Chinese PLA General Hospital; Chinese PLA General Hospital, Science and technology innovation nursery fund of PLA general hospital | Cataracts, glaucoma | | | | |
ChiCTR1800018591: Effects of concentration and time of povidone iodine on the ocular surface before cataract surgery |
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| Completed | 4 | 270 | | 0.5% Povidone iodine irrigation ;0.1% Povidone iodine irrigation ;0.05% Povidone iodine irrigation | Hebei General Hospital; Hebei General Hospital, Key project of hebei health and Family Planning Commission | ocular surface | | | | |
ChiCTR-OPC-17013676: Clinical study of cataract patients before and after cleaning the eyelid with OCuSOFT |
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| Completed | 4 | 45 | | using OCuSOFT to clean the eyelids and eyelids before surgery | Peking Unversity Third Hospital; Peking Unversity Third Hospital, Enterprise financing | Preoperative cataract | | | | |
2017-003277-34: Clinical trial to evaluate the effects of Fydrane® and standard protocol on ocular surface after cataract surgery. Ensayo clÃnico para evaluar los efectos de Fydrane® y del protocolo estándar en la superficie ocular después de la cirugÃa de cataratas. |
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| Ongoing | 4 | 50 | Europe | Solution for injection, Intraocular instillation solution, Fydrane, Colircusi Anestésico Doble, Coliscusà fenilefrina, Colircusà Tropicamida | Laboratoires Théa, Laboratoires Théa | Cataracts Cataratas, Cataracts Cataratas, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
2017-004127-79: Comparison of treatment with preservative-free versus preserved dexamethasone 0.1% and diclofenac 0.1% eye drops after cataract surgery. |
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| Ongoing | 4 | 100 | Europe | Eye drops, solution in single-dose container, Eye drops, solution, Monofree Dexamethason 0.1%, Dicloabak 0.1%, Maxidex, Voltaren Ophtha | UZ Leuven, Thea Pharma | Treatment after cataract surgery, Treatment after cataract surgery, Diseases [C] - Eye Diseases [C11] | | | | |
ChiCTR1800015638: Comparison of visual outcomes of different design aspheric intraocular lens implatation |
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| Recruiting | 4 | 80 | | ABC design IOL implantation (iSert 251, HOYA) ;ABC design IOL implantation (Vivinex, HOYA) ;aspheric IOL implatation (SN60WF) ;aspheric IOL implatation (ZCB00) | Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, The Key Lenticular Laboratory of Liaoning Province; Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, The Key Lenticular Laboratory of Liaoning Province, self-raised expenses | Cataract | | | | |
ChiCTR-IIR-17013797: Clinical Safety and Efficacy of Crosslinked Polyisobutylene Polymer Intraocular Lens |
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| Not yet recruiting | 4 | 140 | | Crosslinked Polyisobutylene IOL ;Hydrophobic Acrylate Polymer IOL | The Eye Hospital of Wenzhou Medical University; Xi'an Pillar BioScience, Supporting funds of the national Key research and development projects | patients with cataract | | | | |
2018-002339-23: Comparison of two drugs (Standard eye Drops and injection solution) for dilation of the pupil in cataract surgery Vergleich zweier Medikamente (Standardaugentropfen und Lösung zur Injektion ins Auge) zur Pupillenerweiterung bei Kataraktoperationen |
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| Ongoing | 4 | 40 | Europe | Mydrane, 0,2 mg/ml +3,1 mg/ml + 10 mg/ml Injektionslösung, Minims, Mydriaticum „Agepha“ 0,5%, Injection, Eye drops, Eye drops, solution, Mydrane, 0,2mg/ml + 3,1 mg/ml + 10 mg/ml Injektionslösung, Minims® Phenylephrine Hydrochloride 10% w/v, Agepha | Medical University Graz, Department of Ophtalmology, Medical University of Graz | patients who need a cataract surgery in both eyes, patients who need a cataract surgery in both eyes, Body processes [G] - Ocular Physiological Phenomena [G14] | | | | |
NCT06266962: Comparing the Efficiency of Two Approaches in Patients at Risk of Developing Intraoperative Floppy Iris Syndrome |
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| Completed | 4 | 164 | RoW | 1% Atropine drops, Epinephrine | University Hospital Olomouc, Palacky University | Intraoperative Floppy Iris Syndrome, Cataract, Age-related Cataract, Adrenergic Receptor Antagonist Adverse Reaction | 09/22 | 09/22 | | |
ChiCTR2200061802: Comparison of anti-inflammatory effects of two non-steroidal anti-inflammatory drugs in the postoperative stage of phacoemulsification surgery |
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| Completed | 4 | 90 | | drug treanment ;0.1% pramiphene eye drops | Qingdao Eye Hospital of Shandong First Medical University; Qingdao Eye Hospital of Shandong First Medical University, General Project of National Natural Science Foundation of China (81970788) | cataract | | | | |
NCT04530864: Pre-Surgical Ocular Surface Treatment With Intracanalicular Dexamethasone Insert And Effect On Intraocular Lens Measurement Accuracy |
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| Not yet recruiting | 4 | 35 | NA | Dextenza 0.4Mg Ophthalmic Insert | Prism Vision Group, Ocular Therapeutix, Inc. | Dry Eye Disease, Cataract Surgery, Ocular Surface Disease | 01/21 | 07/21 | | |
NCT04592081: Dextenza Within Upper Lid Canaliculus Compared With Lower Lid Canaliculus Following Bilateral Cataract Extraction Surgery With PCIOL. |
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| Recruiting | 4 | 20 | US | Dextenza 0.4Mg Ophthalmic Insert | Kerry Assil, MD | Post-Surgical Ocular Pain, Post-Surgical Ocular Inflammation | 02/21 | 03/21 | | |
NCT06555224: Role of Postoperative Lubrication in Cataract Surgery |
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| Completed | 4 | 100 | Europe | Systane Hydration MDPF eye drops | Vienna Institute for Research in Ocular Surgery | Dry Eye | 12/23 | 12/23 | | |
NCT04781335: "A Prospective Study of the Efficacy of Intracameral Dexamethasone (Dexycu™) Compared to Standard of Care Treatment for Post-Cataract Surgical Pain and Anterior Chamber Inflammation" |
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| Recruiting | 4 | 50 | US | Dexycu, Standard of Care post operative eye drops (steroid, antibiotic, NSAID) | The Eye Institute of West Florida, EyePoint Pharmaceuticals, Inc. | Cataract | 06/21 | 08/21 | | |
ENHANCE, NCT04863742: Evaluation Of Vision Recovery And Comfort Index In Patients With Borderline/Mild Dry Eyes Undergoing FLACS With Premium IOL |
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| Recruiting | 4 | 30 | US | Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate | Sight Medical Doctors PLLC, Ocular Therapeutix, Inc. | Dry Eye Syndromes | 07/21 | 09/21 | | |
NCT06497699: A Real-world Study of DEXYCU in the Treatment of Inflammation After Cataract Surgery |
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| Completed | 4 | 263 | RoW | Dexycu | Ocumension Therapeutics (Shanghai) Co., Ltd | Inflammation, Cataract | 07/23 | 12/23 | | |
| Active, not recruiting | 4 | 102 | US | Dexamethasone Ophthalmic implant | Frank A. Bucci, Jr., M.D. | Pharmacokinetics, Aqueous Dexamethasone, Inflammatory Cytokine Response | 10/21 | 01/23 | | |
NCT06221345: Hyaluronic Acid-containing Artificial Tears in Post-cataract Surgery Dry Eye Disease |
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| Completed | 4 | 70 | RoW | Systane HYDRATION® Preservative-Free Lubricant Eye Drops, Optive Fusion® Lubricant Eye Drops (Unit Dose) | Chang Gung Memorial Hospital | Dry Eye Disease, Cataract | 07/23 | 07/23 | | |
ChiCTR2300067483: Effect on Postoperative Inflammation during Phacoemulsification: Fortified balanced salt solution versus Ringer Lactate |
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| Completed | 4 | 80 | | Ringer solution ;fortified balanced salt solution ;Ringer solution ;fortified balanced salt solution | Tianjin Medical University Eye Hospital; Tianjin Medical University Eye Hospital, National Natural Science Foundation Project (81900891), Tianjin Clinical Key Discipline Construction Project (TJLCZDXKT004) | Cataract | | | | |
NCT05100186: The SITE Study - Dexamethasone Ophthalmic Insert In OR on Day of Surgery Versus In-office Post-Op Day 1 |
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| Not yet recruiting | 4 | 50 | NA | Dexamethasone 0.4 MG [Dextenza] | Joseph Kavanagh, MD | Cataract | 12/21 | 02/22 | | |
NCT04977427: Dextenza vs Prednisolone Acetate After Cataract Surgery for Patients With Diabetes |
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| Not yet recruiting | 4 | 200 | NA | Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp | Baylor Research Institute | Cataract Diabetic, Macula Edema | 01/22 | 03/22 | | |
ChiCTR2100042644: Determination of ED50 for a novel mixture of propofol, alfentanil, and lidocaine to inhibit body movement in cataract patients using Dixion's up-and-down sequential allocation method |
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| Recruiting | 4 | 180 | | Increase or decrease the concentration of 6-2-2 regimen depending on the OAA/S score (positive/negative) ;Increase or decrease the concentration of 6-2-2 regimen depending on the OAA/S score (positive/negative) ;Increase or decrease the concentration of 6-2-2 regimen depending on the OAA/S score (positive/negative) ;Increase or decrease the concentration of 6-2-2 regimen depending on the OAA/S score (positive/negative) ;Increase or decrease the concentration of 6-2-2 regimen depending on the OAA/S score (positive/negative) | Zhongshan Ophthalmic Center, Sun Yat-Sen University; Zhongshan Ophthalmic Center, Sun Yat-Sen University, Self-financing | Cataract surgery | | | | |
NCT04362241: DEXTENZA VS. PREDNISOLONE ACETATE 1% Macular Edema With Diabetic Retinopathy After Cataract Surgery |
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| Recruiting | 4 | 30 | US | Prednisolone Acetate 1% Ophthalmic Suspension [PRED FORTE], Prednisolone Acetate 1% | Ophthalmic Consultants of the Capital Region | Retinopathy, Diabetic | 02/22 | 03/22 | | |
| Recruiting | 4 | 130 | Europe | Femtosecond Laser guided Arcuate Keratotomy | Medical University of Vienna | Age Related Cataracts, Astigmatism | 03/22 | 04/22 | | |
CONCEPT, NCT04295122: Comparing the Effectiveness of Phacoemulsification + ECP Laser and Phacoemulsification Alone for Glaucoma Patients |
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| Not yet recruiting | 4 | 160 | NA | Phacoemulsification+ Endoscopic cyclophotocoagulation (ECP) laser | Guy's and St Thomas' NHS Foundation Trust, King's College London, Imperial College London | Glaucoma Open-Angle Primary, Cataract | 03/22 | 03/23 | | |
| Enrolling by invitation | 4 | 21442 | NA | Cocoa extract, Multivitamin, Cocoa extract placebo, Multivitamin placebo | Brigham and Women's Hospital | Cataract, Age Related Macular Degeneration | 05/22 | 10/22 | | |
ChiCTR2100042499: Study on standardized use of topical antibiotics eye drops before cataract surgery |
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| Recruiting | 4 | 723 | | One group receive topical 0.5% levofloxacin eyedrops six times a day for 1 day ;One group receive topical 0.5% levofloxacin eyedrops four times a day for 2 days ;One group receive topical 0.5% levofloxacin eyedrops four times a day for 3 days | Beijing Chaoyang Hospital, Capital Medical University; Beijing Chaoyang Hospital, Capital Medical University, Beijing Hospitals Authority Youth Programme (No. QML20190303) | Endophthalmitis after cataract surgery | | | | |
STAMP, NCT03832179: Steroid vs. Anti-vascular Endothelial Growth Factor for Diabetic Macular Edema Prior to Phacoemulsification |
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| Recruiting | 4 | 32 | US | Bevacizumab, Avastin, Ranibizumab, Lucentis, Aflibercept, Eylea, Ozurdex, Dexamethasone implant | Bay Area Retina Associates, Allergan | Diabetic Macular Edema, Cataract | 07/22 | 10/22 | | |
NCT05023304: In Clinic Optometrist Insertion of Dextenza Prior to Cataract Surgery |
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| Not yet recruiting | 4 | 30 | NA | Dextenza 0.4Mg Ophthalmic Insert, Topical Prednisolone | Mitchel Ibach, Ocular Therapeutix, Inc. | Cataract | 07/22 | 10/22 | | |
NCT02681783: PRedictive Factors and Changes From Treatment in iPCV Versus CSR Versus nAMD With afLibercept |
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| Recruiting | 4 | 90 | Canada | aflibercept, Eylea | Sunnybrook Health Sciences Centre | Central Serous Chorioretinopathy, Age Related Macular Degeneration, Idiopathic Poplypoidal Choroidal Vasculopathy | 12/22 | 12/22 | | |
NCT04479748: DEXTENZA Compared to Topical Steroid Therapy Prior to Cataract Surgery in Patients Who Receive Premium Intraocular Lenses |
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| Completed | 4 | 13 | US | Dexamethasone, Prednisolone Acetate 1% Oph Susp | Prism Vision Group | Cataract | 12/22 | 12/22 | | |
ChiCTR2000031790: A randomized, double-blind, placebo-controlled, multicenter post market clinical study on the efficacy of benzyl lysine eye drops in delaying early senile cataract |
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| Recruiting | 4 | 500 | | benzalalysine eye drops ;placebo | Zhongshan Ophthalmic Center of Sun Yat-Sen University; Zhongshan Ophthalmic Center of Sun Yat-Sen University, Zhejiang Shapuaisi Pharmaceutical Co.,Ltd | early period senile cataract | | | | |
NCT05433428: Metabolomic Profile in Dry Eye Syndrome Patients. |
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| Recruiting | 4 | 250 | Europe | Lubricant Eye Drops, Preservative Free, Preservative | Ifocus Oyeklinikk, The Research Council of Norway | Dry Eye Syndromes, Cataract | 01/23 | 05/23 | | |
ChiCTR2200063490: To evaluate the efficacy and safety of Cycloome (0.05% cyclosporine eye drops II) after cataract surgery in patients with dry eye: a multicenter clinical study |
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| Not yet recruiting | 4 | 60 | | 0.05% Cyclosporine Eye Drops II (Cycloome) ;nothing | Shenyang Air Excellence Eye Hospital; Shenyang Air Excellence Eye Hospital, Shenyang Xingqi Pharmaceutical Co., Ltd | Cataract with dry eye | | | | |
NCT05143281: The SITE Study - Dexamethasone Ophthalmic Insert In OR on Day of Surgery Versus In-office Post-Op Day 1 |
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| Completed | 4 | 23 | US | Dexamethasone 0.4 MG [Dextenza], Dextenza | Grene Vision Group, Ocular Therapeutix, Inc. | Cataract | 02/23 | 02/23 | | |
NCT05386160: Phacoemulsification Combined With Intravitreal Injection of Ranibizumab Prevent Postoperative Capillary Non-perfusion Zone Progress in Non-proliferative Diabetic Retinopathy |
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| Recruiting | 4 | 96 | RoW | Ranibizumab Injection [Lucentis], Phacoemulsification | Ruijin Hospital | Mild Non-proliferative Diabetic Retinopathy, Cataract Diabetic, Diabetic Retinopathy | 03/23 | 03/23 | | |
SUSTAIN, NCT04200651: Prospective Study on DEXTENZA® Safety And Efficacy Following Concomitant MIGS and Cataract Surgery |
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| Terminated | 4 | 25 | US | Dexamethasone Ophthalmic Insert, DEXTENZA®, Prednisolone Acetate 1% Oph Susp, PRED FORTE®, OMNIPRED® | The New York Eye Surgery Center, Ocular Therapeutix, Inc. | Glaucoma, Cataract | 07/23 | 07/23 | | |
| Recruiting | 4 | 500 | Europe | Nepafenac Ophthalmic, Dexamethasone Ophthalmic | Oslo University Hospital | Cataract Surgery | 08/23 | 12/23 | | |
ChiCTR2300070388: Clinical observation of treating metabolic cataract with Zhangyanming tablets |
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| Not yet recruiting | 4 | 94 | | Conventional hypoglycemic drug treatment was supplemented with Zhangyanming tablets ;Conventional hypoglycemic drug treatment | Guangzhou First People's Hospital; Guangzhou First People's Hospital, Guangzhou Baiyunshan Zhongyi Pharmaceutical Co. Ltd | Metabolic cataract | | | | |
NCT05665270: A Study for Post op Inflammation After Cataract Surgery |
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| Enrolling by invitation | 4 | 40 | US | Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate 1% | Wyse Eyecare | Cataract | 10/23 | 12/23 | | |
NCT05853978: The Evaluation of Balanced Salt Solution During Cataract Surgery |
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| Recruiting | 4 | 27 | US | BSS Plus, BSS | Adam Fedyk, MD, FACS, Alcon Research | Fuchs Dystrophy, Cataract | 12/23 | 01/24 | | |
| Recruiting | 4 | 64 | US | Symfony IOL, Vivity IOL | Carolina Eyecare Physicians, LLC, Science in Vision | Cataract | 12/24 | 12/24 | | |
NCT05191706: Evaluate the Safety of DEXYCU for the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract |
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| Recruiting | 4 | 60 | US | Dexamethasone, Prednisolone Acetate Ophthalmic | EyePoint Pharmaceuticals, Inc. | Cataract | 01/25 | 02/25 | | |
NCT05990712: The Effect of a Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and Inflammatory Markers |
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| Not yet recruiting | 4 | 68 | Canada | Omega-3, Trehalose, Thealoz Duo Drops, Zocular Eyelid System Treatment, ZEST, Blephadex cleansing eyelid wipes | Uptown Eye Specialists, WIlliam Osler Health Systems, Forsee Canada | Dry Eye, Dry Eye Syndromes, Cataract | 01/24 | 01/24 | | |
NCT06404541: A Comparative Study Between Preservative With Benzalkonium Chloride vs Preservative Free Eye Drops on the Ocular Surface |
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| Active, not recruiting | 4 | 60 | RoW | Dexamethasone, tobramycin, netilimicin | Kasr El Aini Hospital | Ocular Surface Disease, Dry Eye Syndromes | 04/24 | 05/24 | | |
| Not yet recruiting | 4 | 120 | US | Remimazolam, Byfavo, Midazolam, Versed | University of California, Los Angeles | Cataract Surgery, Cognitive Impairment | 05/25 | 06/25 | | |
| Not yet recruiting | 4 | 80 | | Application of Remimazolam Tosilate Combined with Remifentanil ;Application of propofol combined with remifentanil | Beijing Huaxin Hospital (the First Affiliated Hospital of Tsinghua Uinversity); Beijing Huaxin Hospital (the First Affiliated Hospital of Tsinghua Uinversity), Chinese Red Cross Foundation | Cataract | | | | |
NCT04050644: Comparison of Treatment With Preservative-free Dexamethasone 0.1% (Monofree Dexamethason) and Diclofenac 0.1% (Dicloabak) Eye Drops Versus Preserved Dexamethasone 0.1% (Maxidex) and Diclofenac 0.1% (Voltaren Ophtha) Eye Drops After Cataract Surgery |
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| Recruiting | 4 | 100 | Europe | Preservative Free drop treatment, Preserved drop treatment | Universitaire Ziekenhuizen KU Leuven, Laboratoires Thea | Age-related Cataract | 06/24 | 12/24 | | |
NCT05157113: Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population |
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| Recruiting | 4 | 70 | US | Dropless Regimen, Standard Regimen | University of California, San Francisco | Cataract, Surgery, Compliance, Patient, Compliance, Medication, Satisfaction, Patient | 06/24 | 06/24 | | |
NCT05626478: Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract Surgery |
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| Recruiting | 4 | 100 | US | Dextenza 0.4Mg Ophthalmic Insert, Dexamethasone 0.4mg, Prednisolone Acetate 1% Oph Susp, Prolensa 0.07% Ophthalmic Solution | Nicole Fram M.D. | Corneal Edema, Corneal Defect, Anterior Chamber Inflammation, Ocular Pain, Corneal Staining, Visual Outcome, CME - Cystoid Macular Edema | 06/24 | 06/24 | | |
| Recruiting | 4 | 44 | US, RoW | CT LUCIA 621P | Carl Zeiss Meditec AG | Cataract | 12/24 | 12/24 | | |
ChiCTR2400080575: Clinical Trial of 0.05% Cyclosporine Eye Drops II (Zirun®) for Perioperative Use in Cataract Surgery |
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| Not yet recruiting | 4 | 60 | | Starting from the first day after cataract surgery, use Ziren? (0.05% Cyclosporine Eye Drops II) twice daily, one drop each time, for a total duratio; None | Beijing Friendship Hospital ,Capital Medical University; Beijing Friendship Hospital ,Capital Medical University, Beijing Bethune Charitable Foundation | Post-Cataract Surgery Dry Eye Syndrome | | | | |
ACTRN12609000553279: Topical vs Oral agents to lower intra-ocular pressure following cataract surgery (Acetazolamide vs Brimonidine) |
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| Not yet recruiting | 3/4 | 56 | | | Sir Charles Gairdner Hospital, Jamie Chew | Elevations of intra-ocular pressure following cataract surgery. | | | | |
2012-004873-14: Prevention of macular edema after cataract surgery Het voorkomen van netvlieszwelling na een staaroperatie |
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| Ongoing | 3 | 246 | Europe | Bromfenac, Dexamethasone, Bevacizumab, Triamcinolone Acetonide, Yellox, Dexamethasone, Avastin, Triesence, Yellox, Dexamethasone, Avastin, Triesence | University Eye Clinic Maastricht, University Eye Clinic Maastricht UMC, ESCRS (European Society of Cataract & Refractive Surgeons), Bausch + Lomb, ESCRS (European Society of Cataract and Refractive Surgeons), Bausch & Lomb | Pseudophakic cystoid macular edema (PCME) | | | | |
2016-003232-21: The efficacy of "Acular" eyedrops compared to a singular "Volon A 40" injection in patients with macular edema (swelling of the retina due to accumulation of fluid) following cataract (clouding of the eye lens) surgery. Die Wirkung von "Acular" Augentropfen, verglichen mit einer einmaligen "Volon A 40" Injektion bei Patienten mit Makulaödem (Schwellung der Netzhaut infolge einer Flüssigkeitsansammlung) nach einer Grauen Star Operation. |
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| Ongoing | 3 | 136 | Europe | Acular 0,5% Augentropfen, Volon A 40 Kristallsuspension Ampulle, Eye drops, Suspension for injection, Acular 0,5% Augentropfen, Volon A 40 Kristallsuspension Ampulle | Medizinische Universität Graz, Univers. Augenklinik, Medizinische Universität Graz | Pseudophakic macular edema Pseudophakes Makulaödem, Swelling of the retina caused by an accumulation of fluid following cataract (clouding of the eye lens) surgery Durch eine Flüssigkeitsansammlung hervorgerufene Schwellung der Netzhaut in Folge einer Katarakt (Linsentrübung: Grauer Star) Operation., Body processes [G] - Ocular Physiological Phenomena [G14] | | | | |
2017-001416-11: Comparison of macular thickness before and after cataract surgery with an antibiotic from two ways of preparation. Comparación del grosor macular antes y después de cirugÃa de cataratas no traumática asociada a antibiótico procedente de dos vÃas de preparación. |
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| Ongoing | 3 | 622 | Europe | Powder and solvent for solution for injection, Intraocular instillation solution, Cefuroxima NORMON 750mg, CEFUROXIMA PROKAM | Consorci Mar Parc de Salut de Barcelona (Parc de Salut MAR), None | Pseudophakic macular edema Edema macular pseudofáquico, Macular edema after cataract surgery Edema macular tras cirugÃa de cataratas, Diseases [C] - Eye Diseases [C11] | | | | |
ACTRN12618000202268: Comparing the effectiveness and safety of two treatments (OZURDEX® intravitreal implant versus Avastin®) for diabetic eye disease in adult Indigenous patients living in Western Australia.
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| Active, not recruiting | 3 | 50 | | | LIONS EYE INSTITUTE LTD, ALLERGAN AUSTRALIA PTY LTD | Diabetic Macular Oedema | | | | |
2019-004890-21: Prevention of macular edema after cataract surgery Het voorkomen van netvlieszwelling (maculaoedeem) na een staaroperatie |
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| Ongoing | 3 | 808 | Europe | Bromfenac, Dexamethasone disodium phosphate, Triamcinolone Acetonide, Ketorolac/phenylephrine, Eye drops, solution, Suspension for injection, Irrigation solution, Yellox, Dexamethasone disodium phosphate, Triesence or Vistrec, Omidria | Academic Hospital Maastricht (azM), ESCRS (European Society of Cataract & Refractive Surgeons) | cystoid macular edema (CME) cystoide maculaoedeem (CMO), macular edema after cataract surgery maculaoedeem na staaroperatie, Diseases [C] - Eye Diseases [C11] | | | | |
NCT04668456: Subtenon and Intravenous Dexmedetomidine Effect on Patients Undergoing Cataract Surgery |
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| Active, not recruiting | 3 | 75 | RoW | Dexmedetomidine, lidocaine 2%, bupivacine 0.5%, Normal saline | Menoufia University | Acute Postoperative Pain | 03/21 | 03/21 | | |
NCT04711642: Comprehensive Study on Dry Eye and Ocular Surface Disease Prior and After Cataract Surgery |
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| Not yet recruiting | 3 | 100 | NA | The study will include three arms, one non interventional and 2 interventions. The intervention arms will include two commercially available sodium hyaluronate 0.1% (Systane ultra plus and Hylo-comod) | Fundación Oftalmológica Los Andes, Alcon Research | Dry Eye Disease, Dry Eye Syndrome, Evaporative Dry Eye, Cataract, Phacoemulsification | 01/22 | 07/23 | | |
NCT04810962: Efficacy and Safety of APP13007 for Treatment of Inflammation and Pain After Cataract Surgery Including a Corneal Endothelial Cell Sub-study |
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| Completed | 3 | 370 | US | APP13007, 0.05%, Matching Vehicle Placebo for APP13007, 0.05% | Formosa Pharmaceuticals, Inc. | Ocular Inflammation and Pain After Cataract Surgery | 07/22 | 07/22 | | |
NCT06429306: Study of Dexycu in Treating Intraocular Inflammation |
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| Completed | 3 | 285 | RoW | Dexycu, Investigational product, Placebo | Ocumension Therapeutics (Shanghai) Co., Ltd | Inflammation, Cataract | 11/23 | 04/24 | | |
NCT04539548: A Study Assessing the Safety and Efficacy of Dextenza® for the Treatment of Ocular Pain and Inflammation Following Surgery for Pediatric Cataract |
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| Completed | 3 | 65 | US | Dextenza Ophthalmic Insert, DEXTENZA, Prednisolone acetate ophthalmic suspension USP 1% | Ocular Therapeutix, Inc. | Cataract | 12/23 | 12/23 | | |
2022-000624-37: Clinical trial to assess the safety and efficacy of Clobetasol propionate ophthalmic nanoemulsion 0.05% compared to Prednisolone acetate, 1% in the treatment of inflammation after cataract surgery in pediatric population 0 to 3 years of age. Ensayo clínico para evaluar la seguridad y eficacia de clobetasol propionato 0,05% nanoemulsión oftálmica en comparación con acetato de prednisolona 1% en el tratamiento de la inflamación después de la cirugía de cataratas en población pediátrica de 0 a 3 años. |
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| Not yet recruiting | 3 | 60 | Europe | Clobetasol propionate ophthalmic nanoemulsion, 0.05%, Clobetasol propionate, Ear/eye drops, solution, Ear/eye drops, suspension, Pred Forte 10 mg/ml colirio en suspensión | Laboratorios Salvat, S.A., Laboratorios Salvat, S.A. | Inflammation and pain associated with ocular surgery. Inflamación y dolor después de la cirugía de cataratas., Inflammation and pain associated with ocular surgery. Inflamación y dolor después de la cirugía de cataratas., Diseases [C] - Eye Diseases [C11] | | | | |
ChiCTR2000037527: A clinical trial to evaluate the efficacy and safety of foldable, monofocal, aspherical hydrophobic acrylic intraocular lens |
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| Not yet recruiting | 3 | 184 | | The intraocular lens with the model of SM60AS produed by Simedice company ;The intraocular lens with the model of SN60WF produed by Alcon company | Zhongshan Opthalmic center, Sun Yat-sen University; Henan Simedice Biotechnologies Co., Ltd., Self-finance | Cataract | | | | |
NCT05147233: OCS-01: A Phase 3 Study Evaluating the Efficacy and Safety of OCS-01 Eyedrops Compared to Vehicle for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery |
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| Recruiting | 3 | 240 | US | Dexamethasone, OCS-01, Vehicle Placebo, Placebo | Oculis | Disorders of the Eye Following Cataract Surgery | 03/23 | 06/23 | | |
NCT05528172: A Study to Investigate the Safety and Efficacy of Ripasudil (K-321) Eye Drops After Cataract Surgery |
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| Completed | 3 | 331 | US | Ripasudil, K-321, Placebo | Kowa Research Institute, Inc. | Corneal Edema After Cataract Surgery | 06/23 | 06/23 | | |
OPTIMIZE-2, NCT06128369: Study Evaluating the Efficacy and Safety of OCS-01 Eye Drops in Subjects Following Cataract Surgery |
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| Recruiting | 3 | 160 | US | Dexamethasone Ophthalmic Suspension, OCS-01, Vehicle of OCS-01 | Oculis, ORA, Inc. | Inflammation Eye, Pain, Postoperative, Cataract | 07/24 | 12/24 | | |
| Recruiting | 3 | 808 | Europe | Bromfenac, Yellox, Product code: EU/1/11/692, Dexamethasone, Dexamethasone ophthalmic solution, Product code (NL): RVG 56003, Triamcinolone Acetonide, Triesence or Vistrec, Product code (NL): RVG 106092, Ketorolac-Phenylephrine Ophthalmic 0.3%-1% Intraocular Solution, Omidria | Luigi Rondas, European Society of Cataract and Refractive Surgeons | Macular Edema, Cystoid Macular Edema, Retinal Disease, Cataract, Lens Diseases, Eye Diseases | 12/23 | 04/24 | | |
NCT05826353: A Study to Investigate the Safety and Efficacy of K-321 Eye Drops After Simultaneous Cataract Surgery and Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD) |
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| Recruiting | 3 | 100 | Europe, Canada, US | Ripasudil, K-321, Placebo | Kowa Research Institute, Inc. | Fuchs Endothelial Corneal Dystrophy | 06/24 | 01/25 | | |
NCT05550363: A Study to Evaluate the Efficacy and Safety of DEXYCU® for the Treatment of Ocular Pain Associated With Cataract Surgery (2) |
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| Withdrawn | 3 | 150 | NA | Dexycu, Placebo/Vehicle | EyePoint Pharmaceuticals, Inc. | Cataract | 09/23 | 09/23 | | |
NCT05550350: A Study to Evaluate the Efficacy and Safety of DEXYCU® for the Treatment of Ocular Pain Associated With Cataract Surgery |
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| Not yet recruiting | 3 | 150 | NA | Dexycu, Placebo/Vehicle | EyePoint Pharmaceuticals, Inc. | Cataract | 04/24 | 04/24 | | |
NCT06383273: A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR) |
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| Recruiting | 3 | 528 | US | MELT-300 sublingual tablet, Midalozam sublingual tablet, Placebo sublingual tablet | Melt Pharmaceuticals, MedTrials Incorporated, Evolution Research Group, Catalent, Pharmalex | Cataract | 12/24 | 01/25 | | |
NCT06048380: The Effects of Ripasudil in Patients With FED Undergoing Femtosecond Laser Assisted Cataract Surgery |
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| Recruiting | 3 | 120 | RoW | Ripasudil, Glanatec, Placebo | Singapore Eye Research Institute | Fuchs' Endothelial Dystrophy, Cataract | 07/24 | 07/25 | | |
CLOSE-3, NCT05724446: Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% in the Treatment of Inflammation After Cataract Surgery in Pediatric Population |
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| Recruiting | 3 | 60 | Europe | Clobetasol Propionate, SVT-15473, Prednisolone acetate ophthalmic suspension, 1% | Salvat | Cataracts Infantile | 12/25 | 12/25 | | |
NCT06061718: Travoprost Intraocular Implant in Conjunction With Cataract Surgery |
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| Active, not recruiting | 3 | 60 | RoW | iDose TR, travoprost intraocular implant | Glaukos Corporation | Open Angle Glaucoma, Ocular Hypertension | 03/24 | 12/24 | | |
| Recruiting | 3 | 186 | | The control group diffractive multifocal intraocular lens was implanted; Diffractive multifocal intraocular lens of the experimental group was implanted | Eye Hospital, WMU Zhejiang Eyehospital; Eye Hospital, WMU Zhejiang Eyehospital, Tianjin Shi Ji Kang Tai Biomedical Engineering Co.,Ltd | Cataract | | | | |
ChiCTR2300071151: A multicenter, randomized, open, parallel-controlled trial of lengthening depth of field intraocular lens for visual acuity correction after cataract extraction |
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| Not yet recruiting | 3 | 176 | | Implanting depth-of-field elongated intraocular lens ;Implanting TECNIS Symfony Extended Range of Vision IOL | Eye Hospital, WMU Zhejiang Eye Hospital; Eye Hospital, WMU Zhejiang Eye Hospital, Tianjin Shiji Kangtai Biomedical Engineering Co. Ltd. | Cataract | | | | |