| cyclosporine / Generic mfg. |
ACTRN12610000697088: Ciclosporine Azathioprine versus Tacrolimus mycophenolate mofetil in renal transplantation |
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| Active, not recruiting | 4 | 300 | | | Assistance publique des Hopitaux de Marseille, Assistance publique des Hopitaux de Marseille | renal transplantation, Immunosuppressive treatment in renal transplantation, Acute rejection and transplant survival in renal transplantation | | | | |
ChiCTR-ONC-10001519: Multi-center, open-label, non-controlled study of the efficacy and safety of cyclosporine switched to Tacrolimus extended release capsules in renal transplant recipients. |
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| Completed | 4 | 105 | | tacrolimus extended release capsules replacing cyclosporine | People's Liberation Army; Astellas Pharma (China) Co., Ltd., Astellas Pharma (China) Co., Ltd. | renal transplant recipient | | | | |
ChiCTR-TRC-12002429: Comparison of cyclosporine-based, twice daily tacrolimus and once daily sustained-release tacrolimus based-regimen in renal transplant recipients a clinical trial. |
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| Completed | 4 | 360 | | Oral cyclosporine ;Oral tacrolimus capsule ;Oral tacrolimus sustained-release capsules | Fuzhou general hospital of nanjing military region; The capital university of medical sciences, Beijing friendship hospital affiliated, Astellas (China) pharmaceutical co., LTD | post-transplant | | | | |
2006-005565-18: Efficacy and tolerability of Ezetimibe in cardiac transplant recipients taking Cyclosporin |
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| Ongoing | 4 | 76 | Europe | Ezetimibe, Ezetrol, Ezetrol | Research and Development Department, University Hospital of South Manchester NHS Foundation Trust | Hyperlipidaemia in patients folowing cardiac transplantation | | | | |
2007-001190-28: Randomised controlled trial of tumour-necrosis-factor inhibitors against combination intensive therapy with conventional disease modifying anti-rheumatic drugs in established rheumatoid arthritis |
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| Ongoing | 4 | 190 | Europe | Methotrexate, Sulfasalazine, Hydroxychloroquine, Ciclosporin, Leflunomide, Sodium aurothiomalate (intramuscular gold), methylprednisolone, Prednisolone, Infliximab, Etanercept, Adalimumab, Azathioprine, Penicillamine, Methotrexate, Sulfasalazine, Hydroxychloroquine, Ciclosporin, Leflunomide, Sodium aurothiomalate (intramuscular gold), methylprednisolone, Prednisolone, Infliximab, Etanercept, Adalimumab, Azathioprine, Penicillamine, | King\'s College London | Rheumatoid Arthritis | | | | |
2008-000627-26: Conversion from cyclosporine to tacrolimus followed by randomized C0 or Bayesian monitoring using the C4 timepoint The effect on kidney function |
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| Ongoing | 4 | 50 | Europe | Prograft, Prograf(t), Prograf(t) | Leiden University Medical Center | Effect of immunosuppressive medication on renal function following livertransplantation | | | | |
| Ongoing | 4 | 70 | Europe | Nulojix R, Cyclosporine, 013116-D922, Nulojix R, Cyclosporine, Nulojix R, Cyclosporine | Medizinische Hochschule Hannover, Bristol-Myers Squibb | Kidney transplantation | | | | |
2008-005925-12: Polyomavirus BK nephropathy after renal transplantation: Randomized clinical trial to demonstrate that switching to mTOR inhibitor is more effective than a reduction of immunosuppressive therapy |
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| Ongoing | 4 | 120 | Europe | Everolimus 0.25 mg, Cyclosporin 100 mg, Tacrolimus 0.5 mg, Everolimus 0.75, Everolimus 1.0 mg, Cyclosporin 25 mg, Cyclosporin 50 mg, Everolimus 0.5 mg, Cyclosporin 10 mg, Tacrolimus 1.0 mg, Tacrolimus 5 mg, 001773-Z913, Certican 0.25mg, Sandimmun 100 mg, Prograf 0.5 mg, Certican 0.75mg, Certican 1.00 mg, Sandimmun 25 mg, Sandimmun 50 mg, Certican 0.5mg, Sandimmun 10 mg, Prograf 1.0 mg, Prograf 5 mg, Certican 0.25mg, Sandimmun 100 mg, Prograf 0.5 mg, Certican 0.75mg, Certican 1.00 mg, Sandimmun 25 mg, Sandimmun 50 mg, Certican 0.5mg, Sandimmun 10 mg, Prograf 1.0 mg, Prograf 5 mg | Medizinische Hochschule Hannover | Polyoma BK-virus nephropathy is a viral complication after renal transplantation attacking up to 10% of renal transplants and causing transplant failure in 45% of cases. No virustatic treatment exists. Modifying the infection is usually tried by lowering immunosuppression, which may lead to transplant failure by rejection as well. A randomized switch of immunosuppression to everolimus vs general lowering of immunosuppression has to be tested (prospect. random. parallel group comparison). | | | | |
2016-003592-21: Evaluating the benefits of using secukinumab rather than standard treatments as the first systemic treatment in moderate to severe psoriasis |
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| Ongoing | 4 | 148 | Europe | Secukinumab, Methotrexate 2.5mg tablets, Methotrexate 10 mg tablets, CICLOSPORIN 10mg capsule, CICLOSPORIN 25mg capsule, CICLOSPORIN 50mg capsule, CICLOSPORIN 100mg capsule, AIN457, Solution for injection in pre-filled syringe, Tablet, Capsule, COSENTYX | Novartis Pharmaceuticals UK Limited, Novartis Pharmaceuticals UK Limited | Moderate to severe plaque psoriasis, Moderate to severe plaque psoriasis. Psoriasis looks like red, raised scaly areas of skin., Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
ChiCTR2000029007: Clinical observation of subclinical dosage of cyclosporine combined with glucocorticoid in the treatment of moderate and severe bullous pemphigoid |
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| Recruiting | 4 | 60 | | subclinical dosage of Cyclosporine, Prednisone or Methylprednisolone and Halometasone Cream. ;Prednisone or Methylprednisolone, Halometasone Cream | The First Affiliated Hospital of Kunming Medical University; The First Affiliated Hospital of Kunming Medical University, Yunnan clinical medical research center for skin immune diseases | Bullous Pemphigoid | | | | |
ChiCTR2100044033: A prospective randomized controlled trial of the clinical program of different doses of antithymoglobulin combined with cyclosporine in patients with blood transfusion dependent non-severe aplastic anemia |
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| Recruiting | 4 | 50 | | low-dose ;high-dose | Jiangsu Province Hospital; Jiangsu Province Hospital, Self support | Blood transfusion dependent non-severe aplastic anemia | | | | |
| Terminated | 4 | 116 | Europe | Biomarker, Tacrolimus, cyclosporine and/or mycophenolic acid, mycophenolate mofetil or azathioprine, IS | King's College London, King's College Hospital NHS Trust, National Institute for Health Research, United Kingdom | Transplantation, Liver | 12/21 | 12/21 | | |
ChiCTR1900022292: Clinical research of Umbilical Cord–Derived Mesenchymal Stromal Cells in the Prophylaxis of Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation |
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| Recruiting | 4 | 192 | | On the basis of conventional GVHD prevention, UC-MSCs were infused 4 hours before transplantation of peripheral hematopoietic stem cell on 01 days in the test group. UC-MSCs (+7 days, +14 days, +21 days, +28 days) were infused once a week on 1-4 weeks after transplantation; UC-MSCs (+42 days, +56 days)& ;(MMF) 0.5g q12h-7d-90d, Cyclosporine (CsA) 1.25mg/kg, continuous intravenous drip; - 1 day increment to 2.5mg/kg; patients can tolerate oral change to 5 mg/kg, the concentration maintained at 200-300 ng/ml; 180 days after transplantation, slow reduction; Methotrexate (MTX) 15mg/m2 d1, 10mg/m2 d3, 6, 11) | Department of Hematology, Xinqiao Hospital of Army Medical University; Department of Hematology, Xinqiao Hospital of Army Medical University, National Key R&D Program of China (2017YFA0105501) | Graft Versus Host Disease | | | | |
ChiCTR2100054899: A study to explore the efficacy of 0.05% CSA eye drops in the treatment of chronic ocular graft-versus-host disease |
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| Recruiting | 4 | 100 | | Treatment with 0.05% cyclosporine ;Treatment with 0.1% tacrolimus | Peking University Third Hospital; Peking University Third Hospital, Self-funded | Graft-versus-host disease | | | | |
NCT04172961: Clinical Efficacy of Two Topical Dry Eye Drops for Central Corneal Stain Clearing Over 90 Days |
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| Recruiting | 4 | 100 | US | nanomicellular cyclosporine 0.09%, Cequa, Lifitegrast, Xiidra | Toyos Clinic, Sun Pharmaceutical Industries Limited | Dry Eye | 12/22 | 12/22 | | |
ChiCTR2000030603: A multicenter prospective cohort clinical study of a short-course glucocorticoid therapy regimen for glucocorticoid-dependent immune thrombocytopenia |
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| Recruiting | 4 | 390 | | treat with glucocorticoid ;treat with eltrombopag ;treat with rituximab ;treat with splenectomy ;treat with azathioprine ;treat with cyclosporine | The Second Affiliated Hospital of Kunming Medical University; The Second Affiliated Hospital of Kunming Medical University, The Second Affiliated Hospital of Kunming Medical University | Primary Immune Thrombocytopenia | | | | |
NCT04895423: Evaluation of the Effectiveness and Safety of Immunosuppressive and Biological Therapy of Atopic Dermatitis in Childhood |
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| Not yet recruiting | 4 | 160 | RoW | Methotrexate therapy, Mycophenolate mofetil therapy, Cyclosporine therapy, Dupilumab therapy | National Medical Research Center for Children's Health, Russian Federation | Atopic Dermatitis | 07/23 | 07/23 | | |
NCT05696977: Effect of Obesity on Cyclosporine Blood Trough Level in Nephrotic Syndrome Patients |
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| Recruiting | 4 | 74 | RoW | Cyclosporine Capsule | Alexandria University | Nephrotic Syndrome | 02/24 | 04/24 | | |
ChiCTR2100049498: Study on the application of 0.05% cyclosporine in allergy-related dry eye |
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| Not yet recruiting | 4 | 90 | | Cycloome QID+HYLO-COMODTID ;Cycloome QID ;Patanol BID+HYLO-COMOD TID | Tianjin Medical University Eye Hospital; Tianjin Medical University Eye Hospital, Beijing Bethune Charity Foundation | allergy-related dry eye | | | | |
ChiCTR2200063335: Efficacy and safety of upadacitinib in the treatment of moderate to severe atopic dermatitis |
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| Not yet recruiting | 4 | 64 | | Upadacitinib + TCS ;Cyclosporine +TCS | Longgang district Central Hospital; Longgang district Central Hospital, self-funded | atopic dermatitis | | | | |
ChiCTR2100045718: Clinical study of Ruxolitinib combined with Sirolimus in preventing Graft-versus-Host Disease after allogeneic hematopoietic stem cell transplantation |
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| Recruiting | 4 | 48 | | Ruxolitinib combined with Sirolimus ;ciclosporin or tacrolimus | Sichuan Provincial People's Hospital, Affliated Hospital of University of Electronic Science and Technology of China; Sichuan Provincial People's Hospital, Affliated Hospital of University of Electronic Science and Technology of China, self-raised | Graft-versus-Host Disease after allogeneic hematopoietic stem cell transplantation | | | | |
NCT06364319: Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory cGVHD |
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| Not yet recruiting | 4 | 118 | NA | anti-CD25 rhMAb, Prednisone, Ruxolitinib, Cyclosporine | Peking University People's Hospital | cGVHD | 12/27 | 06/28 | | |
NCT05692739: Clinical Trial To Determine The Effectiveness And Safety Of Topical Insulin In Dry Eye |
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| Recruiting | 4 | 120 | Europe | Insulin, Cyclosporins, Artificial tears | Barbara Burgos Blasco | Dry Eye, Insulin | 10/24 | 10/24 | | |
NCT06009497: Romiplostim in Combination With CsA vs. CsA in the Treatment of Newly Diagnosed NSAA |
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| Not yet recruiting | 4 | 44 | RoW | Romiplostim, Ciclosporin | Peking Union Medical College Hospital | Non Severe Aplastic Anemia | 12/24 | 12/25 | | |
| Withdrawn | 4 | 50 | US | Cyclosporine, Cequa, Artificial tear, Preservative-free artificial tears | Vishal Jhanji, Sun Pharmaceutical Industries Limited | Dry Eye | 12/23 | 12/23 | | |
| Recruiting | 4 | 450 | | ciclosporin ;CsA combined with hematopoietic therapy ;Intensive immunosuppressive therapy ;Hematopoietic stem cell transplantation ;Promoting hematopoiesis therapy | Jiangsu Province Hospital; The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital, Self support | aplastic anemia | | | | |
ChiCTR2300068607: Cyclosporine in the treatment of chronic urticaria: a real-world study on efficacy and safety |
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| Not yet recruiting | 4 | 500 | | N/A | The First Affiliated Hospital of Guangxi Medical University; The First Affiliated Hospital of Guangxi Medical University, Sponsored by Hangzhou Zhongmei Huadong Pharmaceutical Co., LTD | Urticaria | | | | |
| Not yet recruiting | 4 | 270 | | Interferon Alpha-2a ;Adalimumab ;Cyclosporine | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Raise independently | Uveitis in Behcet's Disease | | | | |
NCT05996393: CsA+ATG+AVA vs. CsA+AVA for the Treatment of Newly-diagnosed SAA in the Elderly |
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| Not yet recruiting | 4 | 60 | RoW | Ciclosporin, Avatrombopag, Anti-Human Thymocyte Immunoglobulin, Rabbit | Peking Union Medical College Hospital | Aplastic Anemia | 10/25 | 10/26 | | |
ChiCTR2000041485: Efficacy of Danazol after no response to cyclosporin in transfusion independent aplastic anemia: a prospective study |
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| Recruiting | 4 | 228 | | Cyclosporine combined with danazol ;Cyclosporine | Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences, self-raised | transfusion independent aplastic anemia | | | | |
NCT05839314: Effect of Huaier Granule on the Treatment of Idiopathic Membranous Nephropathy |
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| Recruiting | 4 | 480 | RoW | Huaier granule, Jinke, Renin-angiotensin-aldosterone system inhibitors (RASI), Ciclosporin soft capsules | Chinese PLA General Hospital, LinkDoc Technology (Beijing) Co. Ltd., Huazhong University of Science and Technology | Nephropathy, Glomerular Diseases, Idiopathic Membranous Nephropathy | 05/27 | 07/27 | | |
| Recruiting | 4 | 162 | US | Cyclosporine Injection (IV), Sandimmune, Cyclosporine Oral Product, Upadacitinib Extended Release Oral Tablet, Rinvoq, Intravenous Methylprednisolone, Solu-Medrol, Prednisone Oral Product, Rayos | Berinstein, Jeffrey | Ulcerative Colitis Acute | 05/26 | 05/26 | | |
ChiCTR2200056659: Allopurinol in the treatment of cyclosporine-induced hyperuricemia in children with aplastic anemia：a randomized controlled study |
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| Not yet recruiting | 4 | 40 | | Receive allopurinol tablets ;Receive placebo | The Seventh Affiliated Hospital, Sun Yat-sen University; The Seventh Affiliated Hospital, Sun Yat-sen University, The Seventh Affiliated Hospital, Sun Yat-sen University Clinical Research 735 Program” | hyperuricemia | | | | |
