| cyclosporine / Generic mfg. |
ACTRN12610000697088: Ciclosporine Azathioprine versus Tacrolimus mycophenolate mofetil in renal transplantation |
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| Active, not recruiting | 4 | 300 | | | Assistance publique des Hopitaux de Marseille, Assistance publique des Hopitaux de Marseille | renal transplantation, Immunosuppressive treatment in renal transplantation, Acute rejection and transplant survival in renal transplantation | | | | |
ChiCTR-ONC-10001519: Multi-center, open-label, non-controlled study of the efficacy and safety of cyclosporine switched to Tacrolimus extended release capsules in renal transplant recipients. |
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| Completed | 4 | 105 | | tacrolimus extended release capsules replacing cyclosporine | People's Liberation Army; Astellas Pharma (China) Co., Ltd., Astellas Pharma (China) Co., Ltd. | renal transplant recipient | | | | |
ChiCTR-TRC-12002429: Comparison of cyclosporine-based, twice daily tacrolimus and once daily sustained-release tacrolimus based-regimen in renal transplant recipients a clinical trial. |
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| Completed | 4 | 360 | | Oral cyclosporine ;Oral tacrolimus capsule ;Oral tacrolimus sustained-release capsules | Fuzhou general hospital of nanjing military region; The capital university of medical sciences, Beijing friendship hospital affiliated, Astellas (China) pharmaceutical co., LTD | post-transplant | | | | |
2006-005565-18: Efficacy and tolerability of Ezetimibe in cardiac transplant recipients taking Cyclosporin |
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| Ongoing | 4 | 76 | Europe | Ezetimibe, Ezetrol, Ezetrol | Research and Development Department, University Hospital of South Manchester NHS Foundation Trust | Hyperlipidaemia in patients folowing cardiac transplantation | | | | |
2007-001190-28: Randomised controlled trial of tumour-necrosis-factor inhibitors against combination intensive therapy with conventional disease modifying anti-rheumatic drugs in established rheumatoid arthritis |
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| Ongoing | 4 | 190 | Europe | Methotrexate, Sulfasalazine, Hydroxychloroquine, Ciclosporin, Leflunomide, Sodium aurothiomalate (intramuscular gold), methylprednisolone, Prednisolone, Infliximab, Etanercept, Adalimumab, Azathioprine, Penicillamine, Methotrexate, Sulfasalazine, Hydroxychloroquine, Ciclosporin, Leflunomide, Sodium aurothiomalate (intramuscular gold), methylprednisolone, Prednisolone, Infliximab, Etanercept, Adalimumab, Azathioprine, Penicillamine, | King\'s College London | Rheumatoid Arthritis | | | | |
2008-000627-26: Conversion from cyclosporine to tacrolimus followed by randomized C0 or Bayesian monitoring using the C4 timepoint The effect on kidney function |
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| Ongoing | 4 | 50 | Europe | Prograft, Prograf(t), Prograf(t) | Leiden University Medical Center | Effect of immunosuppressive medication on renal function following livertransplantation | | | | |
| Ongoing | 4 | 70 | Europe | Nulojix R, Cyclosporine, 013116-D922, Nulojix R, Cyclosporine, Nulojix R, Cyclosporine | Medizinische Hochschule Hannover, Bristol-Myers Squibb | Kidney transplantation | | | | |
2008-005925-12: Polyomavirus BK nephropathy after renal transplantation: Randomized clinical trial to demonstrate that switching to mTOR inhibitor is more effective than a reduction of immunosuppressive therapy |
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| Ongoing | 4 | 120 | Europe | Everolimus 0.25 mg, Cyclosporin 100 mg, Tacrolimus 0.5 mg, Everolimus 0.75, Everolimus 1.0 mg, Cyclosporin 25 mg, Cyclosporin 50 mg, Everolimus 0.5 mg, Cyclosporin 10 mg, Tacrolimus 1.0 mg, Tacrolimus 5 mg, 001773-Z913, Certican 0.25mg, Sandimmun 100 mg, Prograf 0.5 mg, Certican 0.75mg, Certican 1.00 mg, Sandimmun 25 mg, Sandimmun 50 mg, Certican 0.5mg, Sandimmun 10 mg, Prograf 1.0 mg, Prograf 5 mg, Certican 0.25mg, Sandimmun 100 mg, Prograf 0.5 mg, Certican 0.75mg, Certican 1.00 mg, Sandimmun 25 mg, Sandimmun 50 mg, Certican 0.5mg, Sandimmun 10 mg, Prograf 1.0 mg, Prograf 5 mg | Medizinische Hochschule Hannover | Polyoma BK-virus nephropathy is a viral complication after renal transplantation attacking up to 10% of renal transplants and causing transplant failure in 45% of cases. No virustatic treatment exists. Modifying the infection is usually tried by lowering immunosuppression, which may lead to transplant failure by rejection as well. A randomized switch of immunosuppression to everolimus vs general lowering of immunosuppression has to be tested (prospect. random. parallel group comparison). | | | | |
2016-003592-21: Evaluating the benefits of using secukinumab rather than standard treatments as the first systemic treatment in moderate to severe psoriasis |
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| Ongoing | 4 | 148 | Europe | Secukinumab, Methotrexate 2.5mg tablets, Methotrexate 10 mg tablets, CICLOSPORIN 10mg capsule, CICLOSPORIN 25mg capsule, CICLOSPORIN 50mg capsule, CICLOSPORIN 100mg capsule, AIN457, Solution for injection in pre-filled syringe, Tablet, Capsule, COSENTYX | Novartis Pharmaceuticals UK Limited, Novartis Pharmaceuticals UK Limited | Moderate to severe plaque psoriasis, Moderate to severe plaque psoriasis. Psoriasis looks like red, raised scaly areas of skin., Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
ChiCTR2000029007: Clinical observation of subclinical dosage of cyclosporine combined with glucocorticoid in the treatment of moderate and severe bullous pemphigoid |
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| Recruiting | 4 | 60 | | subclinical dosage of Cyclosporine, Prednisone or Methylprednisolone and Halometasone Cream. ;Prednisone or Methylprednisolone, Halometasone Cream | The First Affiliated Hospital of Kunming Medical University; The First Affiliated Hospital of Kunming Medical University, Yunnan clinical medical research center for skin immune diseases | Bullous Pemphigoid | | | | |
ChiCTR2100044033: A prospective randomized controlled trial of the clinical program of different doses of antithymoglobulin combined with cyclosporine in patients with blood transfusion dependent non-severe aplastic anemia |
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| Recruiting | 4 | 50 | | low-dose ;high-dose | Jiangsu Province Hospital; Jiangsu Province Hospital, Self support | Blood transfusion dependent non-severe aplastic anemia | | | | |
| Terminated | 4 | 116 | Europe | Biomarker, Tacrolimus, cyclosporine and/or mycophenolic acid, mycophenolate mofetil or azathioprine, IS | King's College London, King's College Hospital NHS Trust, National Institute for Health Research, United Kingdom | Transplantation, Liver | 12/21 | 12/21 | | |
ChiCTR1900022292: Clinical research of Umbilical Cord–Derived Mesenchymal Stromal Cells in the Prophylaxis of Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation |
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| Recruiting | 4 | 192 | | On the basis of conventional GVHD prevention, UC-MSCs were infused 4 hours before transplantation of peripheral hematopoietic stem cell on 01 days in the test group. UC-MSCs (+7 days, +14 days, +21 days, +28 days) were infused once a week on 1-4 weeks after transplantation; UC-MSCs (+42 days, +56 days)& ;(MMF) 0.5g q12h-7d-90d, Cyclosporine (CsA) 1.25mg/kg, continuous intravenous drip; - 1 day increment to 2.5mg/kg; patients can tolerate oral change to 5 mg/kg, the concentration maintained at 200-300 ng/ml; 180 days after transplantation, slow reduction; Methotrexate (MTX) 15mg/m2 d1, 10mg/m2 d3, 6, 11) | Department of Hematology, Xinqiao Hospital of Army Medical University; Department of Hematology, Xinqiao Hospital of Army Medical University, National Key R&D Program of China (2017YFA0105501) | Graft Versus Host Disease | | | | |
ChiCTR2100054899: A study to explore the efficacy of 0.05% CSA eye drops in the treatment of chronic ocular graft-versus-host disease |
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| Recruiting | 4 | 100 | | Treatment with 0.05% cyclosporine ;Treatment with 0.1% tacrolimus | Peking University Third Hospital; Peking University Third Hospital, Self-funded | Graft-versus-host disease | | | | |
NCT04172961: Clinical Efficacy of Two Topical Dry Eye Drops for Central Corneal Stain Clearing Over 90 Days |
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| Recruiting | 4 | 100 | US | nanomicellular cyclosporine 0.09%, Cequa, Lifitegrast, Xiidra | Toyos Clinic, Sun Pharmaceutical Industries Limited | Dry Eye | 12/22 | 12/22 | | |
ChiCTR2000030603: A multicenter prospective cohort clinical study of a short-course glucocorticoid therapy regimen for glucocorticoid-dependent immune thrombocytopenia |
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| Recruiting | 4 | 390 | | treat with glucocorticoid ;treat with eltrombopag ;treat with rituximab ;treat with splenectomy ;treat with azathioprine ;treat with cyclosporine | The Second Affiliated Hospital of Kunming Medical University; The Second Affiliated Hospital of Kunming Medical University, The Second Affiliated Hospital of Kunming Medical University | Primary Immune Thrombocytopenia | | | | |
NCT04895423: Evaluation of the Effectiveness and Safety of Immunosuppressive and Biological Therapy of Atopic Dermatitis in Childhood |
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| Not yet recruiting | 4 | 160 | RoW | Methotrexate therapy, Mycophenolate mofetil therapy, Cyclosporine therapy, Dupilumab therapy | National Medical Research Center for Children's Health, Russian Federation | Atopic Dermatitis | 07/23 | 07/23 | | |
NCT05696977: Effect of Obesity on Cyclosporine Blood Trough Level in Nephrotic Syndrome Patients |
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| Recruiting | 4 | 74 | RoW | Cyclosporine Capsule | Alexandria University | Nephrotic Syndrome | 02/24 | 04/24 | | |
ChiCTR2100049498: Study on the application of 0.05% cyclosporine in allergy-related dry eye |
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| Not yet recruiting | 4 | 90 | | Cycloome QID+HYLO-COMODTID ;Cycloome QID ;Patanol BID+HYLO-COMOD TID | Tianjin Medical University Eye Hospital; Tianjin Medical University Eye Hospital, Beijing Bethune Charity Foundation | allergy-related dry eye | | | | |
ChiCTR2200063335: Efficacy and safety of upadacitinib in the treatment of moderate to severe atopic dermatitis |
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| Not yet recruiting | 4 | 64 | | Upadacitinib + TCS ;Cyclosporine +TCS | Longgang district Central Hospital; Longgang district Central Hospital, self-funded | atopic dermatitis | | | | |
ChiCTR2100045718: Clinical study of Ruxolitinib combined with Sirolimus in preventing Graft-versus-Host Disease after allogeneic hematopoietic stem cell transplantation |
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| Recruiting | 4 | 48 | | Ruxolitinib combined with Sirolimus ;ciclosporin or tacrolimus | Sichuan Provincial People's Hospital, Affliated Hospital of University of Electronic Science and Technology of China; Sichuan Provincial People's Hospital, Affliated Hospital of University of Electronic Science and Technology of China, self-raised | Graft-versus-Host Disease after allogeneic hematopoietic stem cell transplantation | | | | |
NCT06364319: Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory cGVHD |
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| Not yet recruiting | 4 | 118 | NA | anti-CD25 rhMAb, Prednisone, Ruxolitinib, Cyclosporine | Peking University People's Hospital | cGVHD | 12/27 | 06/28 | | |
NCT05692739: Clinical Trial To Determine The Effectiveness And Safety Of Topical Insulin In Dry Eye |
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| Recruiting | 4 | 120 | Europe | Insulin, Cyclosporins, Artificial tears | Barbara Burgos Blasco | Dry Eye, Insulin | 10/24 | 10/24 | | |
NCT06009497: Romiplostim in Combination With CsA vs. CsA in the Treatment of Newly Diagnosed NSAA |
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| Not yet recruiting | 4 | 44 | RoW | Romiplostim, Ciclosporin | Peking Union Medical College Hospital | Non Severe Aplastic Anemia | 12/24 | 12/25 | | |
| Withdrawn | 4 | 50 | US | Cyclosporine, Cequa, Artificial tear, Preservative-free artificial tears | Vishal Jhanji, Sun Pharmaceutical Industries Limited | Dry Eye | 12/23 | 12/23 | | |
| Recruiting | 4 | 450 | | ciclosporin ;CsA combined with hematopoietic therapy ;Intensive immunosuppressive therapy ;Hematopoietic stem cell transplantation ;Promoting hematopoiesis therapy | Jiangsu Province Hospital; The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital, Self support | aplastic anemia | | | | |
ChiCTR2300068607: Cyclosporine in the treatment of chronic urticaria: a real-world study on efficacy and safety |
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| Not yet recruiting | 4 | 500 | | N/A | The First Affiliated Hospital of Guangxi Medical University; The First Affiliated Hospital of Guangxi Medical University, Sponsored by Hangzhou Zhongmei Huadong Pharmaceutical Co., LTD | Urticaria | | | | |
| Not yet recruiting | 4 | 270 | | Interferon Alpha-2a ;Adalimumab ;Cyclosporine | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Raise independently | Uveitis in Behcet's Disease | | | | |
NCT05996393: CsA+ATG+AVA vs. CsA+AVA for the Treatment of Newly-diagnosed SAA in the Elderly |
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| Not yet recruiting | 4 | 60 | RoW | Ciclosporin, Avatrombopag, Anti-Human Thymocyte Immunoglobulin, Rabbit | Peking Union Medical College Hospital | Aplastic Anemia | 10/25 | 10/26 | | |
ChiCTR2000041485: Efficacy of Danazol after no response to cyclosporin in transfusion independent aplastic anemia: a prospective study |
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| Recruiting | 4 | 228 | | Cyclosporine combined with danazol ;Cyclosporine | Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences, self-raised | transfusion independent aplastic anemia | | | | |
NCT05839314: Effect of Huaier Granule on the Treatment of Idiopathic Membranous Nephropathy |
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| Recruiting | 4 | 480 | RoW | Huaier granule, Jinke, Renin-angiotensin-aldosterone system inhibitors (RASI), Ciclosporin soft capsules | Chinese PLA General Hospital, LinkDoc Technology (Beijing) Co. Ltd., Huazhong University of Science and Technology | Nephropathy, Glomerular Diseases, Idiopathic Membranous Nephropathy | 05/27 | 07/27 | | |
| Recruiting | 4 | 162 | US | Cyclosporine Injection (IV), Sandimmune, Cyclosporine Oral Product, Upadacitinib Extended Release Oral Tablet, Rinvoq, Intravenous Methylprednisolone, Solu-Medrol, Prednisone Oral Product, Rayos | Berinstein, Jeffrey | Ulcerative Colitis Acute | 05/26 | 05/26 | | |
ChiCTR2200056659: Allopurinol in the treatment of cyclosporine-induced hyperuricemia in children with aplastic anemia：a randomized controlled study |
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| Not yet recruiting | 4 | 40 | | Receive allopurinol tablets ;Receive placebo | The Seventh Affiliated Hospital, Sun Yat-sen University; The Seventh Affiliated Hospital, Sun Yat-sen University, The Seventh Affiliated Hospital, Sun Yat-sen University Clinical Research 735 Program” | hyperuricemia | | | | |
2020-004194-51: A clinical trial evaluating the efficacy and safety of the drugs - cyclosporine and methotrexate in children and adolescents with moderate to severe atopic dermatitis. Badanie kliniczne oceniające skuteczność i bezpieczeństwo stosowania leków - cyklosporyny i metotreksatu u dzieci i młodzieży z atopowym zapaleniem skóry o nasileniu umiarkowanym do ciężkiego. |
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| Not yet recruiting | 3 | 317 | Europe | Cyclosporin, Methotrexate, Mometasone furoate, Tacrolimus, Oral solution, Ointment | Medical University of Lodz, Medical Research Agency | Atopic dermatitis Atopowe Zapalenie Skóry, Atopic dermatitis Atopowe Zapalenie Skóry, Diseases [C] - Skin and Connective Tissue Diseases [C17] | | | | |
jRCTs031180243: JCOG0907: A Non-Randomized Validation Trial of a Therapy Incorporating Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Adult T-Cell Leukemia and Lymphoma |
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| Completed | 3 | 110 | Japan | carboplatin - Generic mfg., cytarabine - Generic mfg., methotrexate - Generic mfg., prednisolone - Generic mfg., vincristine - Generic mfg., cyclophosphamide - Generic mfg., doxorubicin hydrochloride - Generic mfg., Cymerin (ranimustine) - Mitsubishi Tanabe, vindesine - Generic mfg., etoposide oral - Generic mfg., busulfan - Generic mfg., cyclosporine - Generic mfg., tacrolimus oral - Generic mfg., fludarabine oral - Generic mfg., prednisolone - Generic mfg., Lioplim (filgrastim) - Abbott, Neu-up (nartograstim) - Yakult Honsha, Granocyte (lenograstim) - Roche, Poteligeo (mogamulizumab-kpkc) - Kyowa Kirin | Saitama Medical University International Medical Center | Adult T-cell leukemia-lymphoma | | | | |
2008-003540-11: Preventie van ernstige Graft versus Host ziekte na allogene stamcel transplantatie gegeven als immuuntherapie voor patienten met een hematologische ziekte. Een gerandomiseerde fase III studie (HOVON 96 GVHD). |
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| Ongoing | 3 | 500 | Europe | Ciclosporine, Myfortic, cyclophosphamide, Capsule, soft, Tablet, Powder for solution for infusion, Concentrate for solution for infusion, Myfortic 180 mg, Myfortic 360 mg | HOVON Foundation, Dutch Cancer Society, HOVON Foundation, Novartis Pharma BV, Novartis Pharma NV, Fresenius, Dutch Cancer society, Hovon Foundation, Novartis pharma BV, Novartis Pharma Belgium | Graft versus Host Disease, Graft versus Host Disease, Diseases [C] - Cancer [C04] | | | | |
2014-000699-24: Essai de phase 3 visant à améliorer la survie globale des LAM de l’adulte de 18 à 60 ans en comparant l’idarubicine à forte dose à la daunorubicine à l’induction, la cytarabine à haute-dose et à dose intermédiaire en consolidation et le mycophénolate mofétil à la prophylaxie standard dans la prévention de la maladie du greffon contre l’hôte chez les patients allogreffés en première rémission complète : essai Backbone Inter-Group-1 (BIG-1) Essai de phase 3 visant à améliorer la survie globale des LAM de l’adulte de 18 à 60 ans en comparant l’idarubicine à forte dose à la daunorubicine à l’induction, la cytarabine à haute-dose et à dose intermédiaire en consolidation et le mycophénolate mofétil à la prophylaxie standard dans la prévention de la maladie du greffon contre l’hôte chez les patients allogreffés en première rémission complète : essai Backbone Inter-Group-1 (BIG-1) |
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| Ongoing | 3 | 3000 | Europe | idarubicine, cytarabine, daunorubicine, ciclosporine, methotrexate, acide mycophénolique, Solution for infusion, Powder for solution for infusion, Capsule, soft, Solution for injection, Tablet, Oral solution | CHU Angers-DAMR, PHRC | Leucémie aiguë myéloïde Leucémie aiguë myéloïde, Leucémie aiguë myéloïde Leucémie aiguë myéloïde, Diseases [C] - Blood and lymphatic diseases [C15] | | | | |
2005-000380-26: A 12 month, multicenter, randomized, parallel, open-label study, to evaluate renal function and efficacy of Certican® (everolimus) with Simulect® (basiliximab) and cyclosporine discontinuation at 3 month post-transplant vs minimization, in de novo kidney transplant recipients |
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| Ongoing | 3 | 168 | Europe | Certican®, RAD001, Certican®, Certican® | Novartis Farmacéutica S.A. | Renal Transplant | | | | |
2010-018353-36: BeTACTIC Study. Best Therapy After Cardiac Transplantation, the Italian Challenge. A multicenter, prospective, randomized, open-label study to compare the efficacy and safety of Everolimus and Mycophenolate (either mofetil or sodium) in association with Cyclosporine in patients with acute multiple/late rejection, cardiac allograft vasculopathy, renal dysfunction after cardiac transplantation |
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| Ongoing | 3 | 400 | Europe | CERTICAN, CELLCEPT, MYFORTIC, CERTICAN, CELLCEPT, MYFORTIC | AZIENDA OSPEDALIERA OSPEDALE NIGUARDA CA, GRANDA (A.O. DI RILIEVO NAZIONALE) | Paitents will be enrolled at least one year after heart transplant | | | | |
2011-000088-28: A Randomized Phase III Study to Determine the Most Promising Postgrafting Immunosuppression for Prevention of Acute GVHD after Unrelated Donor Hematopoietic Cell Transplantation using Nonmyeloablative Conditioning for Patients with Hematologic Malignancies A Multi-Center Trial |
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| Ongoing | 3 | 300 | Europe | Sirolimus, Mycophenolatmofetil, Cyclosporine, EU/1/01/171/007, EU/1/01/171/001, EU/1/96/005/001, EU/1/96/005/004, EU/1/96/005/005, Coated tablet, Oral liquid, Capsule, Tablet, Powder for concentrate for solution for infusion, Capsule, soft, Oral suspension, Concentrate and solvent for concentrate for solution for infusion, Rapamune, CellCept, Sandimmun | Fred Hutchinson Cancer Research Center | Graft versus host disease, Graft versus host disease is a process where donor cells may react against cells of your body causing inflammation that can involve the skin, liver and gastrointestinal system., Not possible to specify | | | | |
BREEZE-AD4, NCT03428100 / 2017-004574-34: A Long-term Study of Baricitinib (LY3009104) With Topical Corticosteroids in Adults With Moderate to Severe Atopic Dermatitis That Are Not Controlled With Cyclosporine or for Those Who Cannot Take Oral Cyclosporine Because it is Not Medically Advisable |
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| Completed | 3 | 463 | Europe, Japan, RoW | Baricitinib, LY3009104, Placebo, Topical corticosteroid | Eli Lilly and Company, Incyte Corporation | Atopic Dermatitis | 11/19 | 04/23 | | |
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NCT04979884: Safety and Effectiveness of Cyclosporin in the Management of COVID19 ARDS Patients in Alexandria University Hospital |
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| Completed | 3 | 102 | RoW | cyclosporine, interleukin-2 | Alexandria University, Science and Technology Development Fund (STDF), ,Egypt | COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome, Pulmonary Fibrosis | 09/22 | 12/22 | | |
NCT05057468: Second-line Treatment of Primary Autoimmune Hemolytic Anemia |
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| Recruiting | 3 | 30 | RoW | Cyclosporine, Rituximab | Assiut University | Primary Autoimmune Hemolytic Anemia | 11/22 | 11/22 | | |
NCT05149313 / 2021-002967-23: A Study of Lebrikizumab in Combination With Topical Corticosteroids in Participants Having Atopic Dermatitis (AD) That Are Not Adequately Controlled or Non-eligible for Cyclosporine |
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| Completed | 3 | 331 | Europe | Lebrikizumab, Lebrikizumab-matching Placebo | Almirall, S.A. | Dermatitis, Atopic, Eczema | 01/23 | 05/24 | | |
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NCT04743739: Rituximab Combined With Cyclosporine Versus Rituximab Alone in the Treatment of iMN |
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| Recruiting | 3 | 126 | RoW | Rituximab, CD20 antibody, cyclosporine, CsA | Peking Union Medical College Hospital, Beijing Tongren Hospital, Chinese Academy of Medical Sciences, Fuwai Hospital, The Luhe Teaching Hospital of the Capital Medical University, The Seventh Affiliated Hospital, Sun Yat-sen University, First Affiliated Hospital of Xinjiang Medical University, Nanyang Nanshi Hospital of Henan University, Shanghai Fosun Pharmaceutical Development Co, Ltd. | Idiopathic Membranous Nephropathy | 03/23 | 03/25 | | |
| Recruiting | 3 | 190 | RoW | Sitagliptin + Standard Prophylaxis, Cyclosporine (CsA),Methotrexate (MTX), Mycopherol ester (MMF) and Antithymic Globulin, Standard Prophylaxis | The First Affiliated Hospital of Soochow University, The First Affiliated Hospital with Nanjing Medical University, The Second People's Hospital of Huai'an, The First People's Hospital of Changzhou, Xinqiao Hospital of Chongqing, Shenzhen People's Hospital | Acute-graft-versus-host Disease, Allogeneic Hematopoietic Stem Cell Transplantation | 05/23 | 02/24 | | |
NCT05862233: A Clinical Study of MIL62 in Primary Membranous Nephropathy |
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| Recruiting | 3 | 150 | RoW | MIL62, Cyclosporine | Beijing Mabworks Biotech Co., Ltd. | Primary Membranous Nephropathy | 12/24 | 06/26 | | |
| Recruiting | 3 | 267 | US | Harmonized supportive care, Cyclosporine 5 mg/kg bid days 0-14, Etanercept 50 mg sc day 0 and day 3 | Vanderbilt University Medical Center, University of Ottawa, University of Toronto | Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses | 08/27 | 08/28 | | |
TransIT, NCT05600426: A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (, BMT CTN 2202) |
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| Recruiting | 3 | 234 | US | cyclosporine, Matched Unrelated Donor Hematopoetic Stem Cell Transplant, horse anti-thymocyte globulin (ATG), ATGAM, rabbit anti-thymocyte globulin (ATG), thymoglobulin, Methotrexate, Fludarabine, Cyclophosphamide, low-dose total body irradiation (TBI), Immunosuppressive Therapy (IST) | Boston Children's Hospital, Center for International Blood and Marrow Transplant Research, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI), North American Pediatric Aplastic Anemia Consortium, Pediatric Transplantation and Cellular Therapy Consortium, Blood and Marrow Transplant Clinical Trials Network | Severe Aplastic Anemia | 12/29 | 12/29 | | |
ChiCTR1900028153: A Multi-centre Clinical Study of Pai-Neng-Da Capsule in the Treatment of Chronic Aplastic Anemia |
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| Completed | 2/3 | 100 | | Pai-Neng-Da Capsule + Testosterone undecanoate capsule (80mg / day), cyclosporine capsule (3-7mg / kg. D) ;Testosterone undecanoate capsule (80mg / day), cyclosporine capsule (3-7mg / kg. D) | Jinhua people's Hospital; None, Project of Zhejiang Province TCM Science Research Fund in 2015 | Aplstic Anemia | | | | |
NCT05553496: Assessment of Rituximab Therapeutic Response Versus Conventional Treatment |
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| Not yet recruiting | 2/3 | 40 | NA | Rituximab, Dexamethasone, Tacrolimus, Mycophenloatemofetil, Cyclophosphamide, Cyclosporine | Ain Shams University | Pharmacological Action | 04/23 | 10/23 | | |
BIG-1, NCT02416388: Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR |
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| Recruiting | 2/3 | 3100 | Europe | Idarubicin, Daunorubicin, HD Cytarabine, Cyclosporine, Methotrexate, Mycophenolic acid (MPA), vosaroxin, ID cytarabine, Dexamethasone, Venetoclax | University Hospital, Angers | Acute Myeloid Leukemia (AML) | 06/24 | | | |
NCT06470191: A Clinical Study of B007 in the Treatment of Primary Membranous Nephropathy. |
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| Not yet recruiting | 2/3 | 216 | RoW | B007, Cyclosporin Capsules | Shanghai Jiaolian Drug Research and Development Co., Ltd, Shanghai Pharmaceuticals Holding Co., Ltd | Primary Membranous Nephropathy | 12/26 | 12/26 | | |
| Recruiting | 2/3 | 60 | | MAFU Granules + basic treatment ;cyclosporine + basic treatment | Beijing Hospital of TCM, Capital Medical University; Beijing Hospital of TCM, Capital Medical University, China association of Chinese medicine | Membranous Nephropathy | | | | |
ACTRN12605000380695: Induction Of Mixed Haematopoietic Chimerism In Patients Using Fludarabine, Low Dose Total Body Irradiation, Peripheral Blood Stem Cell Infusion And Post-Transplant Immunosuppression With Cyclosporine And Mycophenolate Mofetil |
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| Active, not recruiting | 2 | 40 | | | A/Prof Durrant | Myelodysplastic syndromes., Myeloproliferative syndromes., Acute Leukemia with < 10% blasts., Amyloidosis, Hodgkins disease., Multiple Myeloma, Non-Hodgkins lymphoma, Chronic myeloid leukaemia, Chronic lymphocytic leukaemia, Renal cell carcinoma | | | | |
NCT00544115: Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders |
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| Active, not recruiting | 2 | 260 | NA | busulfan, cyclophosphamide, cyclosporine, etoposide, fludarabine phosphate, melphalan, methotrexate, mycophenolate mofetil, sirolimus, tacrolimus, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, total-body irradiation | City of Hope Medical Center, National Cancer Institute (NCI) | Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases, Precancerous/Nonmalignant Condition | 03/07 | 12/24 | | |
NCT00388102: Cyclophosphamide, Fludarabine, Total-Body Irradiation, and Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer or Other Disease |
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| Recruiting | 2 | 30 | US | filgrastim, cyclophosphamide, cyclosporine, fludarabine phosphate, mycophenolate mofetil, cytogenetic analysis, flow cytometry, laboratory biomarker analysis, umbilical cord blood transplantation, total-body irradiation | Memorial Sloan-Kettering Cancer Center | Leukemia, Lymphoma, Myelodysplastic Syndromes | 03/10 | | | |
NCT00534430: Busulfan, Etoposide, and Total-Body Irradiation in Treating Patients Undergoing Donor Stem Cell or Bone Marrow Transplant for Advanced Hematologic Cancer |
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| Active, not recruiting | 2 | 30 | NA | busulfan, cyclosporine, etoposide, mycophenolate mofetil, allogeneic bone marrow transplantation, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, total-body irradiation | City of Hope Medical Center, National Cancer Institute (NCI) | Leukemia, Myelodysplastic Syndromes | 04/10 | 12/24 | | |
NCT00010348: Study of Total Body Irradiation in Combination With Allogeneic Peripheral Blood Stem Cell or Bone Marrow Transplantation Followed By Cyclosporine and Mycophenolate Mofetil in High Risk-Patients With Human Immunodeficiency Virus-1 |
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| Recruiting | 2 | 20 | US | Cyclosporine, Mycophenolate mofetil, Total body irradiation and stem cell or bone marrow transplantation | Fred Hutchinson Cancer Research Center | HIV Infections | 12/10 | 12/15 | | |
NCT00398346: Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease |
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| Recruiting | 2 | 68 | US | therapeutic allogeneic lymphocytes, cyclophosphamide, cyclosporine, fludarabine phosphate, tacrolimus, allogeneic hematopoietic stem cell transplantation, in vitro-treated peripheral blood stem cell transplantation, peripheral blood stem cell transplantation, total-body irradiation | National Heart, Lung, and Blood Institute (NHLBI) | Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Secondary Myelofibrosis, Small Intestine Cancer | 12/10 | | | |
NCT00066300: Allogeneic Peripheral Stem Cell Transplantation Followed By Donor Lymphocyte Infusions in Treating Patients With Hematologic Cancer |
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| Active, not recruiting | 2 | | US | graft-versus-tumor induction therapy, therapeutic allogeneic lymphocytes, cyclophosphamide, cyclosporine, fludarabine phosphate, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation, radiation therapy | National Heart, Lung, and Blood Institute (NHLBI) | Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms | | | | |
2007-003707-12: Tandem Autografting-Allografting after Induction Chemotherapy with New Drugs For Newly Diagnosed Myeloma |
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| Ongoing | 2 | 120 | Europe | Ciclosporin, Mycophenolic acid, | FONDAZIONE NEOPLASIE SANGUE ONLUS | Newly Diagnosed Myeloma patients | | | | |
2008-004486-26: Efficacy of monoclonal anti CD 20 antibodies in steroid and cyclosporin dependent nephrotic syndrome in children |
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| Ongoing | 2 | 40 | Europe | MABTHERA, MABTHERA | ISTITUTO GIANNINA GASLINI | Nephrotic Syndrome | | | | |
2008-006729-15: OPEN PILOT STUDY, TWO ARMS, WITH HISTORIC CONTROL, MULTICENTRIC TO EVALUATE SAFETY AND EFFICACY OF ASSOCIATION WITH EVEROLIMUS AND LOW DOSES OF CYCLOSPORIN AND STEROIDS AFTER INDUCTION WITH MONOCLONAL ANTIBODY ANTI CD25 IN PEDIATRIC PATIENTS AFTER KIDNEY TRANSPLANTS |
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| Ongoing | 2 | 70 | Europe | CERTICAN, CERTICAN | ISTITUTO GIANNINA GASLINI | pediatric patient after kidney transplant | | | | |
2013-000238-37: Treatment guided by detection of Minimal Residual Disease after allogeneic stem cell transplantation in Acute Myeloid Leukaemia |
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| Ongoing | 2 | 31 | Europe | ciclosporin, mofetil mycophenolate, L04AD01, L04AA06, | VU University medical center, VU University medical center | Minimal residual disease after allogeneic stem cell transplantation in Acute Myeloid Leukaemia | | | | |
NCT00110110: Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma |
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| Active, not recruiting | 2 | 71 | Canada, RoW | filgrastim, granulocyte colony-stimulating factor (G-CSF), Carboplatin, Cyclosporine, Etoposide, vincristine sulfate, vincristine, cryosurgery, cryotherapy, laser therapy | The Hospital for Sick Children, Terry Fox Foundation | Retinoblastoma | 04/16 | 12/24 | | |
2014-002628-29: Ciclosporin to reduce damage to the heart during routine treatment for a heart attack (CAPRI) |
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| Not yet recruiting | 2 | 68 | Europe | N/A, N/A, Concentrate for solution for infusion, Sandimmun (concentrate for solution for infusion 50mg/ml) | Newcastle upon Tyne Hospitals NHS Foundation Trust, NIHR Newcastle Biomedical Research Centre | Myocardial ischemia/reperfusion injury, Heart attack, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2019-004831-21: Long-term follow-up of the patients enrolled in the SCHEDULE trial, in which we randomly allocated heart transplant recipients to standard treatment with the immunosuppressant ciclosporine or the newer imunosuppressant everolimus. |
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| Ongoing | 2 | 120 | Europe | EVEROLIMUS, RAD001, Tablet, Certican | Oslo University Hospital, Oslo University Hospital | Herat transplant, Herat transplant, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
ChiCTR-OIC-17012860: Efficacy and Safety of Thalidomide Combined with Cyclosporine in the Treatment of Corticosteroid-resistant or Relapsed ITP: a Single Arm Clinical Study |
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| Recruiting | 2 | 33 | | Thalidomide + Cyclosporine | Affiliated Hospital of Guangdong Medical University; Affiliated Hospital of Guangdong Medical University, The Clinical research project, Affiliated Hospital of Guangdong Medical University | Immune Thrombocytopenia | | | | |
ChiCTR2100043229: A Single-Center, Single-Arm, Phase II Clinical Study of the Efficacy and Safety of Cyclosporine Combined with Eltrombopag Olamine Tablets in Treatment-Naive Transfusion-Dependent Non-Severe Aplastic Anemia |
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| Recruiting | 2 | 61 | | Elrombopag combined with Cyclosporine | Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences; Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Beijing Novartis Pharma Co., Ltd. | Aplastic anemia | | | | |
| Recruiting | 2 | 152 | RoW | Mesenchymal stem cells, Glucocorticoids, cyclosporine | Nanfang Hospital of Southern Medical University, Sun Yat-sen University, Xinqiao Hospital, Army Medical University, Peking University People's Hospital | Chronic Graft-versus-host Disease | 12/22 | 06/23 | | |
NCT04781803: Cyclosporine on Day Zero as Prophylaxis for Cytokine Release Syndrome |
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| Recruiting | 2 | 32 | RoW | Cyclosporine | Hospital Universitario Dr. Jose E. Gonzalez | Stem Cell Transplant Complications, Cytokine Release Syndrome | 01/23 | 02/23 | | |
| Recruiting | 2 | 1500 | US | Remdesivir, GS-5734, Imatinib Mesylate, Dexamethasone, Cenicriviroc, Icatibant, Firazyr, Apremilast, Otezla, dornase alfa, Pulmozyme, Celecoxib, celebrex, Famotidine, Pepcid, IC14, Aviptadil, Zyesami, narsoplimab, OMS721, Cyproheptadine, periactin, Cyclosporine, CsA | QuantumLeap Healthcare Collaborative, University of California, San Francisco, University of Pennsylvania, Emory University, University of Alabama at Birmingham, University of Colorado, Denver, University of Southern California, Yale University, Wake Forest University Health Sciences, Sanford Health, Long Beach Memorial Medical Center, Georgetown University, University of California, Davis, Hoag Memorial Hospital Presbyterian, Main Line Health, DHR Health Institute for Research and Development, University of California, Irvine, Corewell Health, Kaiser Permanente, University of Michigan, West Virginia University, University of Miami, University Hospitals Cleveland Medical Center, Virtua Health, M.D. Anderson Cancer Center | COVID-19 | 07/28 | 07/30 | | |
NCI-2022-02150, NCT05293509: Pharmacologic Pretransplant Immunosuppression (PTIS) + Reduced Toxicity Conditioning (RTC) Allogeneic Stem Cell Transplantation in Inherited Hematologic Disorders |
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| Withdrawn | 2 | 24 | US | Fludarabine, Fludara™, Dexamethasone, Cyclophosphamide, Cytoxan™, Bortezomib, Velcade®, Rituximab, Rituxan®, Busulfan, Busulfex™, Cyclophosphamide (Cy), Tacrolimus (or cyclosporine), Mycophenolate mofetil (MMF), Rabbit ATG | M.D. Anderson Cancer Center | Stem Cell Transplantation | 09/23 | 09/23 | | |
NCT03434730: Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation |
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| Active, not recruiting | 2 | 46 | US | Total Body Irradiation, TBI, Cyclosporine, Sandimmune, Mycophenolate Mofetil, CellCept, Tocilizumab, Acemtra, Filgrastim, Granulocyte-Colony Stimulating Factor, Neupogen | Memorial Sloan Kettering Cancer Center | Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Acute Leukemia, Myelodysplastic Syndromes, Myelodysplastic-Myeloproliferative Diseases, Myeloproliferative Disorder, Non Hodgkin Lymphoma, Hodgkin Lymphoma, Leukemia | 02/25 | 02/25 | | |
NCT04304820: Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA) |
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| Recruiting | 2 | 39 | US | Eltrombopag, Cyclosporine, Horse-Anti-thymocyte-Globulin | National Heart, Lung, and Blood Institute (NHLBI) | Severe Aplastic Anemia | 03/25 | 05/28 | | |
NCT05797623: Safety and Effectiveness of Trappa Ethanolamine Tablets Combined With Ciclosporin in the Treatment of Primary Treatment of Non-severe Aplastic Anemia |
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| Recruiting | 2 | 78 | RoW | Trappa ethanolamine tablets ; ciclosporin, Placebo ; ciclosporin | Jiangsu HengRui Medicine Co., Ltd. | Non-severe Aplastic Anemia | 05/24 | 05/25 | | |
NCT05459649: Combined Steroid and Cyclosporin as First-line Treatment in Adults With Primary Immune Thrombocytopenia |
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| Not yet recruiting | 2 | 253 | RoW | Cyclosporine Oral Product, Prednisone | Peking University People's Hospital | Immune Thrombocytopenia | 07/24 | 07/25 | | |
NCT06004752: Efficacy and Safety of CsA+AVA in the Treatment of NSAA in the Elderly |
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| Recruiting | 2 | 30 | RoW | Ciclosporin, Avatrombopag | Peking Union Medical College Hospital | Aplastic Anemia | 08/24 | 08/25 | | |
| Recruiting | 2 | 24 | Europe | Cyclosporin, ILT101, Placebo | Assistance Publique - Hôpitaux de Paris, Iltoo Pharma | Type 1 Diabetes | 10/24 | 07/26 | | |
NCT00977977: Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy |
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| Recruiting | 2 | 30 | US | Rituximab Infusion, Oral Cyclosporine | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Nephrotic Syndrome, Proteinuria, Autoimmune Disease, Glomerular Disease, Membranous Glomerulonephritis | 12/24 | 01/25 | | |
NCT03456817: HIgh Dose Thymoglobulin Instead of Cyclosporine With a Low Dose of Thymoglobulin for GVHD Prophylaxis |
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| Recruiting | 2 | 200 | Canada | Treatment Arm - high dose ATG, Control Arm - standard of care | AHS Cancer Control Alberta | Graft-versus-host-disease, Relapse | 09/25 | 09/25 | | |
NCT00357565: Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia |
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| Active, not recruiting | 2 | 33 | US | filgrastim, G-CSF, busulfan, Busulfex, cyclosporine, CSA, fludarabine phosphate, Fludara, melphalan, Alkeran, mycophenolate mofetil, MMF, umbilical cord blood transplantation | Masonic Cancer Center, University of Minnesota | Leukemia, Myelodysplastic Syndromes, Childhood Acute Myeloid Leukemia in Remission, Recurrent Childhood Acute Myeloid Leukemia, Secondary Acute Myeloid Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission, Previously Treated Myelodysplastic Syndrome, Secondary Myelodysplastic Syndrome, Refractory Anemia With Excess Blasts in Transformation, Refractory Anemia With Excess Blasts, Refractory Anemia, De Novo Myelodysplastic Syndrome, Childhood Myelodysplastic Syndrome | 06/24 | 12/25 | | |
| Recruiting | 2 | 400 | Europe | Thymoglobulin, ATG, Cyclophosphamide, Cyclosporine, Sirolimus, Mycophenolate Mofetil, MMF | University of Birmingham, IMPACT (funded by NHS Blood & Transplant, Anthony Nolan and Leukaemia UK) | Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes, Non Hodgkin Lymphoma, Hodgkin Lymphoma, Multiple Myeloma, Chronic Myelogenous Leukemia, Myelofibrosis | 01/26 | 01/26 | | |
NCT05579769: A Phase II Pediatric Study of a Graft-VS.-Host Disease (GVHD) Prophylaxis Regimen With no Calcineurin Inhibitors After Day +60 Post First Allogeneic Hematopoietic Cell Transplant for Hematological Malignancies |
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| Recruiting | 2 | 32 | US | Ruxolitinib, (Jakafi®), Mesna, (Mesnex), Anti-thymocyte globulin (ATG), (Thymoglobulin®, rabbit ATG), Cyclosporine, (Gengraf), Cyclophosphamide, (Cytoxan), Fludarabine, (Fludara), Methotrexate, Total Body Irradiation (radiation treatment), TBI, Bone marrow infusion, Busulfan, Busulfex), Thiotepa, Triplex by Immunex, TESPA, TSPA | St. Jude Children's Research Hospital | Hematologic Malignancy, Myeloid Malignancy | 04/26 | 04/27 | | |
NCT05303727: Allogeneic Hematopoietic Stem Cell Transplantation for 4/M Neuroblastoma |
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| Not yet recruiting | 2 | 64 | RoW | Anti Thymocyte Globulin, ATG, Fludarabine, Fludara, Cyclophosphamide injection, CTX, Topotecan, Topotecan Hydrochloride, Melphalan, Alkeran, Thiotepa, thiophosphoramide, Busulfan, Busulfex, Cyclosporine, Sandimmune, Tacrolimus, Prograf, Mycophenolate Mofetil, Cellcept, Methotrexate, amethopterin | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Neuroblastoma | 08/27 | 08/27 | | |
NCT01623167: Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia |
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| Recruiting | 1/2 | 207 | US | Cohort 1: hATG, CsA, EPAG Day 14 to Month 6, Horse Antithymocyte Globulin, Cyclosporine, Promacta, Eltrombopag, Cohort 2: hATG, CsA, EPAG Day 14 to Month 3, Cohort 3: hATG, CsA (dose reduced), EPAG day 1 to month 6, Extension Cohort, Horse Antithymocyte Globulin (hATG), Cyclosporine (CsA), Promacta, Eltrombopag (EPAG) | National Heart, Lung, and Blood Institute (NHLBI), Novartis | Severe Aplastic Anemia | 01/18 | 01/29 | | |
NCT03842696: Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation |
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| Recruiting | 1/2 | 49 | US | Vorinostat, Blood and Marrow Transplant (BMT), Tacrolimus (or cyclosporine), Methotrexate, Mycophenolate Mofetil (MMF), Cyclophosphamide | University of Michigan Rogel Cancer Center, National Institutes of Health (NIH), National Center for Advancing Translational Sciences (NCATS) | Hematologic Diseases, Acute Leukemia in Remission, Chronic Myelogenous Leukemia - Chronic Phase, Chronic Myelogenous Leukemia, Accelerated Phase, Chronic Myelogenous Leukemia, Blastic Phase, Myelodysplastic Syndromes, Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B Cell Lymphoma, Non Hodgkin Lymphoma, Graft Vs Host Disease, Graft-versus-host-disease | 06/25 | 06/26 | | |
NCT05398653: A Clinical Study of MIL62 in Primary Membranous Nephropathy |
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| Recruiting | 1/2 | 120 | RoW | MIL62, Cyclosporine | Beijing Mabworks Biotech Co., Ltd. | Primary Membranous Nephropathy | 11/24 | 10/25 | | |
| Recruiting | 1 | 12 | US | Dasatinib and Cyclosporine | University of Colorado, Denver, National Cancer Institute (NCI), The Leukemia and Lymphoma Society | Chronic Myelogenous Leukemia | 12/12 | 09/13 | | |
ChiCTR-IPR-14005720: A single center, Randomized controlled, opened clinical reserch for evaluating the effectiveness of recombinant human thrombopoietin combined with immunosuppressive therapy in the treatment of newly diagnosed acquired severe aplastic anemia |
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| Recruiting | 1 | 172 | | rTPO ;Ciclosporine | Blood Diseases Hospital, Chinese Academy of Medical Sciences; Level of the institution：, Nil | severe aplastic anemia | | | | |
NCT05573230: A Drug Interaction Study of Cyclosporine and LY3502970 in Healthy Participants |
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| Completed | 1 | 32 | RoW | Midazolam, LY3502970, Cyclosporine | Eli Lilly and Company | Healthy | 01/23 | 01/23 | | |
| Enrolling by invitation | 1 | 50 | US | Cyclosporine, Methylprednisolone and Prednisone | University of Southern California | DRESS Syndrome, Drug-Induced Hypersensitivity Syndrome | 04/25 | 06/25 | | |
NCT05745701: A Drug-Drug Interaction Study to Examine the Impact of Itraconazole and Cyclosporine on PF-07081532 Pharmacokinetics in Overweight or Obese Adults |
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| Completed | 1 | 16 | US | PF-07081532, Cyclosporine, Itraconazole | Pfizer | Healthy | 05/23 | 05/23 | | |
NCT04813653: Cyclosporine in Combination With Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma Refractory to Carfilzomib and High Expression of PPIA Gene in Myeloma Cells |
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| Recruiting | 1 | 10 | RoW | cyclosporine in combination with carfilzomib and dexamethasone | Tel-Aviv Sourasky Medical Center, Weizmann Institute of Science | Multiple Myeloma in Relapse, Multiple Myeloma, Refractory | 04/24 | 05/24 | | |
NCT00547196: AlloHCT From Matched Unrelated Donors in Pts w/ Advanced Hematologic Malignancies & Disorders |
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| Completed | N/A | 10 | US | filgrastim, Busulfan, Busilvex, Cyclophosphamide, CTX, Cyclosporine, CsA, Fludarabine phosphate, Fludara, Melphalan, Alkeran, Mycophenolate Mofetil, MMF, allogeneic hematopoietic stem cell transplantation, AlloHCT, umbilical cord blood transplantation, total-body irradiation, TBI, Fractionated total body irradiation, FTBI | City of Hope Medical Center, National Cancer Institute (NCI) | Leukemia, Lymphoma, Myelodysplastic Syndromes | 11/09 | 05/24 | | |
NCT00633373: Cyclosporine Inhalation Solution (CIS) in Lung Transplant Recipients |
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| No Longer Available | N/A | | US | Cyclosporine Inhalation Solution | APT Pharmaceuticals, Inc. | Lung Transplant | | | | |
ChiCTR-IOR-17010993: Conversion From Tacrolimus To Lower-Dose Cyclosporine Verse Reduction Of Tacrolimus In Kidney-Transplant Recipients With BKVAN: A Prospective, Single-Center, Randomized Controlled Trial |
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| Completed | N/A | 90 | | Tac was switch to CsA (150-200mg/d) with target trough concentration of 70-110 ng/ml ;Tac dosage was reduced by 25-50% with target trough concentration of 4-6 ng/ml | The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; The First Affiliated Hospital, Sun Yat-sen University, The National Natural Science Foundation of China (Youth Foundation 81400754); Sun Yat-Sen University Clinical Research 5010 Program | BK virus associated nephropathy | | | | |
ChiCTR-INR-17012212: Use of sirolimus in patients with primary idiopathic membranous nephropathy: a prospective randomized control trial |
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| Recruiting | N/A | 70 | | Cyclosporine ;cyclosporine combined with sirolimus | Renal Division, Peking University First Hospital; Renal Division, Peking University First Hospital, Huabei Pharmaceutical Company. | idiopathic membranous nephropathy | | | | |
ChiCTR-IOR-17011653: A prospective, randomized, controlled clinical study of non transfusion dependent non severe aplastic anemia treated with cyclosporine, androgen and levamisole hydrochloride |
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| Not yet recruiting | N/A | 248 | | none ;levamisole hydrochloride | The First affiliated Hospital of Zhejiang Chinese Medical University; The First affiliated Hospital of Zhejiang Chinese Medical University, raise independently | Aplastic anemia | | | | |