Leukemia  >>  cyclosporine  >>  Phase 2
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74 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
cyclosporine / Generic mfg.
ACTRN12605000380695: Induction Of Mixed Haematopoietic Chimerism In Patients Using Fludarabine, Low Dose Total Body Irradiation, Peripheral Blood Stem Cell Infusion And Post-Transplant Immunosuppression With Cyclosporine And Mycophenolate Mofetil

Active, not recruiting
2
40
 
A/Prof Durrant
Myelodysplastic syndromes., Myeloproliferative syndromes., Acute Leukemia with < 10% blasts., Amyloidosis, Hodgkins disease., Multiple Myeloma, Non-Hodgkins lymphoma, Chronic myeloid leukaemia, Chronic lymphocytic leukaemia, Renal cell carcinoma
 
 
NCT00003661: Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

Completed
2
3
US
anti-thymocyte globulin, busulfan, cyclosporine, melphalan, methylprednisolone, umbilical cord blood transplantation, radiation therapy
Roswell Park Cancer Institute
Graft Versus Host Disease, Leukemia, Lymphoma, Myelodysplastic Syndromes, Neuroblastoma
11/99
03/06
NCT00002785: Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia

Completed
2
US, Canada, RoW
filgrastim, asparaginase, cyclophosphamide, cyclosporine, cytarabine, daunorubicin hydrochloride, dexamethasone, etoposide, leucovorin calcium, mercaptopurine, mesna, methotrexate, methylprednisolone, pegaspargase, prednisone, therapeutic hydrocortisone, vincristine sulfate, allogeneic bone marrow transplantation, low-LET cobalt-60 gamma ray therapy, low-LET photon therapy
Children's Oncology Group, National Cancer Institute (NCI)
Leukemia
08/00
03/07
NCT00005641: Removal of T Cells to Prevent Graft-Versus-Host Disease in Patients Undergoing Bone Marrow Transplantation

Terminated
2
US
anti-thymocyte globulin, busulfan, cyclophosphamide, cyclosporine, leucovorin calcium, methotrexate, methylprednisolone, allogeneic bone marrow transplantation, in vitro-treated bone marrow transplantation, radiation therapy
H. Lee Moffitt Cancer Center and Research Institute, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
09/00
09/00
NCT00005854: Bone Marrow Transplantation in Treating Patients With Hematologic Cancer

Completed
2
US
cyclophosphamide, cyclosporine, methotrexate, allogeneic bone marrow transplantation, in vitro-treated bone marrow transplantation, radiation therapy
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
 
10/00
NCT00003662: Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Other Hematologic or Metabolic Diseases

Completed
2
90
US
anti-thymocyte globulin, busulfan, cyclophosphamide, cyclosporine, melphalan, methylprednisolone, umbilical cord blood transplantation, radiation therapy
Roswell Park Cancer Institute, National Cancer Institute (NCI)
Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes, Thymic Carcinoma
01/01
01/01
NCT00008151: Gemtuzumab Ozogamicin, Fludarabine, and Total-body Irradiation Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome

Completed
2
US
cyclosporine, fludarabine phosphate, gemtuzumab ozogamicin, methotrexate, mycophenolate mofetil, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation, radiation therapy
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia, Myelodysplastic Syndromes
07/02
07/02
NCT00041288: Study Of Two Non-Myeloablative Stem Cell Transplant Strategies For Low-Grade Lymphoma And CLL

Terminated
2
10
Canada, US
therapeutic allogeneic lymphocytes, cyclophosphamide, cyclosporine, fludarabine phosphate, methotrexate, mycophenolate mofetil, tacrolimus, peripheral blood stem cell transplantation, radiation therapy
University of Texas Southwestern Medical Center
Leukemia, Lymphoma
01/03
01/03
NCT00002792: Combination Chemotherapy Plus Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Myeloproliferative Disorders

Completed
2
20
US
busulfan, cyclophosphamide, cyclosporine, methotrexate, tacrolimus, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Leukemia, Myelodysplastic/Myeloproliferative Diseases
04/03
04/03
NCT00027924: Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous Leukemia or Myelodysplastic Syndrome

Completed
2
US
busulfan, cyclosporine, fludarabine phosphate, methotrexate, peripheral blood stem cell transplantation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia, Myelodysplastic Syndromes
05/03
05/03
NCT00016419: S0020 Immunosuppressive Therapy in Treating Patients With Myelodysplastic Syndrome

Completed
2
130
US
anti-thymocyte globulin, cyclosporine
Southwest Oncology Group, National Cancer Institute (NCI)
Leukemia, Myelodysplastic Syndromes
07/03
01/07
NCT00055653: Donor Umbilical Cord Blood Transplantation in Treating Patients With Leukemia, Lymphoma, or Nonmalignant Hematologic Disorders

Completed
2
US
anti-thymocyte globulin, filgrastim, busulfan, cyclophosphamide, cyclosporine, fludarabine phosphate, melphalan, methylprednisolone, umbilical cord blood transplantation, radiation therapy
Roswell Park Cancer Institute, National Heart, Lung, and Blood Institute (NHLBI)
Leukemia, Lymphoma, Myelodysplastic Syndromes, Myelodysplastic-Myeloproliferative Diseases
09/03
09/05
AALL01P1, NCT00022126: Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia

Completed
2
6
US, Canada, RoW
asparaginase, cyclophosphamide, cyclosporine, cytarabine, daunorubicin hydrochloride, dexamethasone, doxorubicin hydrochloride, mercaptopurine, methotrexate, methylprednisolone, pegaspargase, thioguanine, vincristine sulfate, allogeneic bone marrow transplantation, radiation therapy
Children's Oncology Group, National Cancer Institute (NCI)
Leukemia
01/05
04/06
NCT00031980: Cyclosporine in Treating Patients With Low Blood Counts Caused By Hematologic Cancer

Completed
2
30
US
cyclosporine
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI)
Anemia, Leukemia, Neutropenia, Thrombocytopenia
05/05
05/05
NCT00053014: S0125, Chemotherapy, Total-Body Irradiation, and Peripheral Stem Cell Transplantation in Treating Older Patients With Acute Myeloid Leukemia

Terminated
2
5
US
therapeutic allogeneic lymphocytes, cyclosporine, fludarabine, mycophenolate mofetil, MMF, peripheral blood stem cell transplantation, radiation therapy
Southwest Oncology Group, National Cancer Institute (NCI)
Leukemia
06/05
06/06
NCT00003116: High-Dose Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer

Completed
2
66
US
filgrastim, busulfan, cyclophosphamide, cyclosporine, bone marrow ablation with stem cell support, peripheral blood stem cell transplantation
Case Comprehensive Cancer Center, National Cancer Institute (NCI)
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
03/06
06/09
NCT00089050: Gemtuzumab Ozogamicin and Cyclosporine in Treating Older Patients With Relapsed Acute Myeloid Leukemia

Completed
2
US
cyclosporine, gemtuzumab ozogamicin
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia
 
03/06
NCT00110058: Fludarabine and Radiation Therapy in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Phase or Accelerated Phase Chronic Myelogenous Leukemia

Completed
2
40
US
recombinant interferon alfa, therapeutic allogeneic lymphocytes, cyclosporine, fludarabine phosphate, imatinib mesylate, mycophenolate mofetil, peripheral blood stem cell transplantation, radiation therapy
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia
 
07/06
COG-AAML03P1, NCT00070174: Gemtuzumab Ozogamicin in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Undergoing Remission Induction and Intensification Therapy

Completed
2
350
US, Canada, Europe, RoW
asparaginase, busulfan, cyclophosphamide, cyclosporine, cytarabine, daunorubicin hydrochloride, etoposide, gemtuzumab ozogamicin, methotrexate, mitoxantrone hydrochloride, allogeneic bone marrow transplantation
Children's Oncology Group, National Cancer Institute (NCI)
Leukemia
09/06
12/13
NCT00044954: Total-Body Irradiation, Fludarabine, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer

Completed
2
US
therapeutic allogeneic lymphocytes, cyclosporine, fludarabine phosphate, mycophenolate mofetil, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation, radiation therapy
University of Texas Southwestern Medical Center
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
11/06
11/06
NCT00066417: Peripheral Stem Cell Transplant in Treating Patients With High-Risk Leukemia

Terminated
2
51
US
cyclophosphamide, cyclosporine, fludarabine phosphate, methylprednisolone, therapeutic allogeneic lymphocytes, thiotepa, allogeneic bone marrow transplantation, biological therapy, bone marrow ablation with stem cell support, bone marrow transplantation, chemotherapy, leukocyte therapy, non-specific immune-modulator therapy, peripheral blood lymphocyte therapy, peripheral blood stem cell transplantation, radiation therapy
National Heart, Lung, and Blood Institute (NHLBI)
Chronic Myeloproliferative Disorders, Leukemia, Myelodysplastic/Myeloproliferative Diseases
 
01/07
NCT00066794: S0301 Cyclosporine, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

Completed
2
69
US
filgrastim, sargramostim, cyclosporine, cytarabine, daunorubicin hydrochloride
Southwest Oncology Group, National Cancer Institute (NCI)
Leukemia
02/07
01/10
NCT00113828: Non-Myeloablative HLA-Matched Ex-Vivo T-cell Depleted Stem Cell Transplantation for Hematologic Malignancies

Terminated
2
5
US
Non-myeloablative Ex-Vivo T-cell Depleted PBSC Transplant, Cyclosporine iv beginning on transplant day -1, T-cell depleted peripheral blood stem cell transplant, Cyclosporine iv beginning on day -1.
Massachusetts General Hospital, Dana-Farber Cancer Institute
Lymphoma, Leukemia, Multiple Myeloma, Myelodysplastic Syndrome
03/07
03/07
NCT00544115: Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders

Active, not recruiting
2
260
NA
busulfan, cyclophosphamide, cyclosporine, etoposide, fludarabine phosphate, melphalan, methotrexate, mycophenolate mofetil, sirolimus, tacrolimus, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, total-body irradiation
City of Hope Medical Center, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases, Precancerous/Nonmalignant Condition
03/07
12/24
NCT00005852: Bone Marrow Transplantation in Treating Patients With Severe Aplastic Anemia or Rejection of Previous Bone Marrow Transplant

Terminated
2
US
anti-thymocyte globulin, filgrastim, muromonab-CD3, cyclophosphamide, cyclosporine, methylprednisolone, allogeneic bone marrow transplantation
H. Lee Moffitt Cancer Center and Research Institute, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
07/07
07/07
NCT00024050: Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Myelodysplastic Syndrome

Completed
2
US
busulfan, cyclophosphamide, cyclosporine, methotrexate, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia, Myelodysplastic Syndromes
 
08/07
NCT00003335: Umbilical Cord Blood Transplantation in Treating Patients With High-Risk Hematologic Cancer

Completed
2
44
US
anti-thymocyte globulin, busulfan, cyclosporine, melphalan, methylprednisolone, umbilical cord blood transplantation, radiation therapy
Case Comprehensive Cancer Center, National Cancer Institute (NCI)
Graft Versus Host Disease, Leukemia, Lymphoma, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
11/07
01/12
NCT00317785: Total-Body Irradiation and Cyclophosphamide in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer and Other Diseases

Completed
2
50
US
cyclophosphamide, cyclosporine, methotrexate, mycophenolate mofetil, sirolimus, tacrolimus, pharmacological study, allogeneic bone marrow transplantation, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, total-body irradiation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia, Lymphoma, Myelodysplastic Syndromes
11/07
 
NCT00001873: The Role of Cyclosporine in Blood Cell Transplants With T-Cell Add-Back for Blood Cancers

Completed
2
102
US
Isolex 300i plus MoAbs
National Heart, Lung, and Blood Institute (NHLBI)
Chronic Lymphocytic Leukemia, Graft vs Host Disease, Hematologic Neoplasm, Multiple Myeloma, Myelodysplastic Syndrome
12/07
06/17
NCT00281879: Donor Stem Cell Transplant or Donor White Blood Cell Infusions in Treating Patients With Hematologic Cancer

Terminated
2
200
US
anti-thymocyte globulin, ATG, filgrastim, G-CSF, busulfan, carmustine, cyclophosphamide, cyclosporine, cytarabine, etoposide, fludarabine phosphate, melphalan, methotrexate, methylprednisolone, mycophenolate mofetil, tacrolimus, FK-506, peripheral blood stem cell transplantation, umbilical cord blood transplantation, radiation therapy
OHSU Knight Cancer Institute, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Unusual Cancers of Childhood
02/08
03/08
NCT00354172: Donor Umbilical Cord Blood Natural Killer Cells, Aldesleukin and Umbilical Cord Blood Transplant in Patients With Refractory Hematologic Cancers.

Terminated
2
16
US
aldesleukin, IL-2, interleukin-2, filgrastim, granulocyte colony-stimulating factor (G-CSF), natural killer cell (NK) therapy, NK cells, cyclophosphamide, Cytoxan, cyclosporine, cyclosporin, fludarabine phosphate, Fludara, methylprednisolone, Medrol, Solu-Medrol, Depo-Medrol, methylprednisolone sodium succinate, mycophenolate mofetil, mycophenolic acid, Umbilical Cord Blood Transplantation (UCBT), allogeneic transplant, Total body irradiation (TBI), radiation
Masonic Cancer Center, University of Minnesota
Leukemia, Myelodysplastic Syndromes
08/08
08/08
NCT00719849: Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematological Cancer or Other Disease

Terminated
2
13
US
anti-thymocyte globulin, cyclophosphamide, cyclosporine, fludarabine phosphate, mycophenolate mofetil, umbilical cord blood transplantation, total body irradiation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
11/08
12/09
NCT00027560: Melphalan, Fludarabine, and Alemtuzumab Followed by Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer

Completed
2
51
US
alemtuzumab, Campath, cyclosporine, fludarabine phosphate, melphalan, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation
Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI)
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
04/09
04/09
NCT00795132: Hematopoietic Cell Transplantation for Pediatric Patients With Hematologic Malignancies

Completed
2
47
US
Busulfan, Busulfex, Anti-Thymocyte Globulin, Thymoglobulin® [Anti-thymocyte Globulin, (Rabbit)], Fludarabine, Fludara, Cyclosporine, Mycophenolate mofetil, MMF, CellCept
University of Utah
Acute Leukaemia, Chronic Disease, Leukemia, Myelodysplasia, Lymphoma
07/09
07/09
NCT02701517: Cyclosporine Plus Methotrexate or Alemtuzumab

Terminated
2
72
Europe
Cyclosporine + METHOTREXATE, Cyclosporine + CAMPATH-1H, Alemtuzumab
Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea
Unrecognized Condition: Mature B or T-cell Neoplasm
11/09
11/09
NCT00740467: Stem Cell Transplant in Treating Patients With Hematological Cancer or Other Disorders

Unknown status
2
50
Europe
anti-thymocyte globulin, busulfan, cyclophosphamide, cyclosporine, fludarabine phosphate, mycophenolate mofetil, nonmyeloablative allogeneic hematopoietic stem cell transplantation
Institut Paoli-Calmettes
Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Precancerous Condition
01/10
 
NCT00388102: Cyclophosphamide, Fludarabine, Total-Body Irradiation, and Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer or Other Disease

Recruiting
2
30
US
filgrastim, cyclophosphamide, cyclosporine, fludarabine phosphate, mycophenolate mofetil, cytogenetic analysis, flow cytometry, laboratory biomarker analysis, umbilical cord blood transplantation, total-body irradiation
Memorial Sloan-Kettering Cancer Center
Leukemia, Lymphoma, Myelodysplastic Syndromes
03/10
 
NCT00534430: Busulfan, Etoposide, and Total-Body Irradiation in Treating Patients Undergoing Donor Stem Cell or Bone Marrow Transplant for Advanced Hematologic Cancer

Active, not recruiting
2
30
NA
busulfan, cyclosporine, etoposide, mycophenolate mofetil, allogeneic bone marrow transplantation, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, total-body irradiation
City of Hope Medical Center, National Cancer Institute (NCI)
Leukemia, Myelodysplastic Syndromes
04/10
12/24
NCT00186628: Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD

Completed
2
36
US
Total lymphoid irradiation, TLI, Rituximab, Rituxan, Anti-thymoglobulin, rabbit (ATG, rabbit ATG), Cyclosporine, CSP, Sandimmune, Mycophenylate mofetil, MMF, CellCept, Filgrastim, G-CSF, Granulocyte-colony stimulating factor, Neupogen, Granisetron, Sancuso, Solumedrol, Medrol, Depo-Medrol, A-Methapred, Acetaminophen, Tylenol, Diphenhydramine, Benadryl, Hydrocortisone, Westcort
Stanford University, The Leukemia and Lymphoma Society, National Cancer Institute (NCI)
Leukemia, Mast-Cell, Mantle-cell Lymphoma
11/10
12/10
NCT00363779: Effect of Cyclosporine Therapy on Gene Expression in Patients With Large Granular Lymphocyte Leukemia

Terminated
2
5
US
Cyclosporine, Ciclosporin, Gene expression analysis, Microarray analysis, Laboratory biomarker analysis
National Cancer Institute (NCI)
Large Granular Lymphocytic Leukemia, LGL Leukemia
11/10
11/10
NCT00185692: Allogeneic Transplantation From Related Haploidentical Donors

Completed
2
16
US
non-myeloablative hematopoietic cell transplantation, Peripheral-blood stem-cell transplantation, Anti-Thymocyte Globulin, ATG, Cyclosporine, INN/BAN, USAN, CSA, Mycophenolate Mofetil, MMF, CellCept, G-CSF, Granulocyte colony-stimulating factor, CSF 3, Solumedrol, 6-Methylprednisolone, Methylprednisolone Acetate, Methylprednisolone Sodium Succinate, Acetaminophen, Tylenol, Diphenydramine, Benadryl, Allermax, Q-Dryl, Diphen Cough, Hydrocortisone, Hydrocortisone Sodium Phosphate
Stanford University
Blood Cancer, Leukemia, Graft Versus Host Disease, Malignancy, CLL, NHL, Hodgkin's Disease, MDS
12/10
12/10
NCT00398346: Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease

Recruiting
2
68
US
therapeutic allogeneic lymphocytes, cyclophosphamide, cyclosporine, fludarabine phosphate, tacrolimus, allogeneic hematopoietic stem cell transplantation, in vitro-treated peripheral blood stem cell transplantation, peripheral blood stem cell transplantation, total-body irradiation
National Heart, Lung, and Blood Institute (NHLBI)
Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Secondary Myelofibrosis, Small Intestine Cancer
12/10
 
NCT00066300: Allogeneic Peripheral Stem Cell Transplantation Followed By Donor Lymphocyte Infusions in Treating Patients With Hematologic Cancer

Active, not recruiting
2
US
graft-versus-tumor induction therapy, therapeutic allogeneic lymphocytes, cyclophosphamide, cyclosporine, fludarabine phosphate, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation, radiation therapy
National Heart, Lung, and Blood Institute (NHLBI)
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
 
 
NCT00301834: Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Patients With Hematologic Disorders

Completed
2
35
US
alemtuzumab, busulfan, cyclosporine, fludarabine phosphate, methotrexate, methylprednisolone, allogeneic bone marrow transplantation, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, umbilical cord blood transplantation
University of California, San Francisco, National Cancer Institute (NCI)
Congenital Amegakaryocytic Thrombocytopenia, Diamond-blackfan Anemia, Leukemia, Myelodysplastic Syndromes, Severe Congenital Neutropenia
09/11
09/11
NCT00916045 / 2007-001657-26: Pilot Study of Unrelated Cord Blood Transplantation

Terminated
2
40
Europe
Thiotepa, Fludarabine, Intravenous busulphan, Busilvex, Thymoglobulin, Ciclosporin, Mycophenolate mofetil (MMF), Cyclophosphamide, Radiotherapy, Melphalan
King's College Hospital NHS Trust
Leukemia, Myeloid, Acute, Myelodysplastic Syndromes, Leukemia, Lymphoblastic, Acute, Lymphoma, Non-Hodgkin, Hodgkin Disease, Chronic Lymphocytic Leukemia
03/12
03/12
NCT00619645: Donor Peripheral Stem Cell Transplant, Fludarabine, and Busulfan in Treating Patients With Hematologic Cancers

Completed
2
8
US
busulfan, cyclosporine, fludarabine phosphate, mycophenolate mofetil, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation
University of California, Davis
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
10/13
11/13
NCT00008307: Combination Chemotherapy Followed by Donor Bone Marrow Transplant or Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer or Genetic Disorders

Unknown status
2
52
US
anti-thymocyte globulin, cyclosporine, fludarabine phosphate, melphalan, methylprednisolone, mycophenolate mofetil, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation, syngeneic bone marrow transplantation
Herbert Irving Comprehensive Cancer Center, National Cancer Institute (NCI)
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
 
 
NCT00387959: Chemotherapy, Radiation Therapy, Rituximab, and Umbilical Cord Blood Transplant in Treating Patients With B-Cell Non-Hodgkin's Lymphoma

Checkmark P2 data in B-cell NHL
Nov 2011 - Nov 2011: P2 data in B-cell NHL
Completed
2
17
US
filgrastim, rituximab, cyclophosphamide, cyclosporine, fludarabine phosphate, mycophenolate mofetil, allogeneic hematopoietic stem cell transplantation, umbilical cord blood transplantation, total-body irradiation
Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI)
Leukemia, Lymphoma
04/14
04/14
NCT00081055: OTI-010 for Graft-Versus-Host Disease Prophylaxis in Treating Patients Who Are Undergoing Donor Peripheral Stem Cell Transplantation for Hematologic Malignancies

Withdrawn
2
0
US
autologous expanded mesenchymal stem cells OTI-010, busulfan, cyclophosphamide, cyclosporine, methotrexate, peripheral blood stem cell transplantation, radiation therapy
Mesoblast International Sàrl, National Cancer Institute (NCI)
Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes
 
 
NCT01020734: Donor Stem Cell Transplant or Bone Marrow Transplant in Treating Patients With Acute Myeloid Leukemia in Remission

Completed
2
263
RoW
anti-thymocyte globulin, busulfan, cyclophosphamide, cyclosporine, fludarabine phosphate, methotrexate, allogeneic hematopoietic stem cell transplantation
Asan Medical Center
Leukemia
07/15
07/15
2013-000238-37: Treatment guided by detection of Minimal Residual Disease after allogeneic stem cell transplantation in Acute Myeloid Leukaemia

Ongoing
2
31
Europe
ciclosporin, mofetil mycophenolate, L04AD01, L04AA06,
VU University medical center, VU University medical center
Minimal residual disease after allogeneic stem cell transplantation in Acute Myeloid Leukaemia
 
 
NCT00425802: Chemotherapy, Total-Body Irradiation, Rituximab, and Donor Stem Cell Transplant in Treating Patients With B-Cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia

Completed
2
61
US
anti-thymocyte globulin, filgrastim, graft-versus-tumor induction therapy, rituximab, cyclophosphamide, cyclosporine, fludarabine phosphate, mycophenolate mofetil, nonmyeloablative allogeneic hematopoietic stem cell transplantation, total-body irradiation
Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI)
Leukemia, Lymphoma
10/16
10/16
NCT00987480: Hematopoietic Stem Cell Transplantation for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine

Completed
2
45
US
Busulfan, fludarabine, & cyclophosphamide with immunosuppression with ATG and cyclosporine., CliniMACS device
Memorial Sloan Kettering Cancer Center, Boston Children's Hospital, Children's Hospital Medical Center, Cincinnati, Children's Hospital and Health System Foundation, Wisconsin, Rockefeller University, Fred Hutchinson Cancer Center
Aplastic Anemia, Leukemia, Myelodysplastic Syndrome
07/17
07/17
NCT00003270: Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

Completed
2
20
US
anti-thymocyte globulin, filgrastim, busulfan, cyclophosphamide, cyclosporine, methylprednisolone, bone marrow ablation with stem cell support, umbilical cord blood transplantation, radiation therapy
Roswell Park Cancer Institute
Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
10/17
10/17
NCT01690520: Donor Umbilical Cord Blood Transplant With or Without Ex-vivo Expanded Cord Blood Progenitor Cells in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, or Myelodysplastic Syndromes

Completed
2
163
US
Cyclophosphamide, Cyclosporine, Ex Vivo-Expanded Cord Blood Progenitor Cell Infusion, NLA101, Dilanubicel, Fludarabine Phosphate, Mycophenolate Mofetil, Thiotepa, Total-Body Irradiation, Umbilical Cord Blood Transplantation, Cord Blood Transplantation, UCB transplantation
Nohla Therapeutics, Inc., National Cancer Institute (NCI), National Heart, Lung, and Blood Institute (NHLBI)
Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission, Chronic Myelogenous Leukemia, Myelodysplastic Syndrome
09/18
05/20
NCT00003838: Specialized Blood Cell Transplants for Cancers of the Blood and Bone Marrow

Completed
2
202
US
T-cell replete PBPC allograft, Peripheral blood hematopoietic progenitor cell (PBPC) transplant, Methotrexate, MTX, Cyclosporine, CSA, G-CSF, granulocyte colony-stimulating factor (G-CSF)
National Heart, Lung, and Blood Institute (NHLBI)
Myeloproliferative Disorders, Acute Myelogenous Leukemia, Chronic Myelogenous Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia
12/18
06/20
NCT00303719: Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy

Terminated
2
342
US
anti-thymocyte globulin, ATG, cyclophosphamide, Cytoxan, cyclosporine, CSA, fludarabine, Fludara, mycophenolate mofetil, MMF, stem cell transplantation, peripheral blood stem cell transplantation, bone marrow transplant, total body irradiation, TBI, filgrastim, G-CSF
Masonic Cancer Center, University of Minnesota
Kidney Cancer, Leukemia, Lymphoma, Multiple Myeloma, Plasma Cell Neoplasm, Myelodysplastic Syndromes
05/19
05/19
NCT00309842: Myeloablative Umbilical Cord Blood Transplantation in Hematological Diseases

Completed
2
213
US
filgrastim, G-CSF, cyclophosphamide, Cytoxan, cyclosporine, CSA, fludarabine phosphate, Fludara, mycophenolate mofetil, MMF, umbilical cord blood transplantation, UCBT, total-body irradiation, TBI
Masonic Cancer Center, University of Minnesota
Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, Chronic Myelogenous Leukemia, Myelofibrosis, MDS, Refractory Anemia, Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, Non-Hodgkin's Lymphoma, Leukemia, Lymphoma, Multiple Myeloma, Myelodysplastic Syndromes
07/19
11/19
NCT03434730: Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation

Active, not recruiting
2
46
US
Total Body Irradiation, TBI, Cyclosporine, Sandimmune, Mycophenolate Mofetil, CellCept, Tocilizumab, Acemtra, Filgrastim, Granulocyte-Colony Stimulating Factor, Neupogen
Memorial Sloan Kettering Cancer Center
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Acute Leukemia, Myelodysplastic Syndromes, Myelodysplastic-Myeloproliferative Diseases, Myeloproliferative Disorder, Non Hodgkin Lymphoma, Hodgkin Lymphoma, Leukemia
02/25
02/25
NCT00357565: Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia

Active, not recruiting
2
33
US
filgrastim, G-CSF, busulfan, Busulfex, cyclosporine, CSA, fludarabine phosphate, Fludara, melphalan, Alkeran, mycophenolate mofetil, MMF, umbilical cord blood transplantation
Masonic Cancer Center, University of Minnesota
Leukemia, Myelodysplastic Syndromes, Childhood Acute Myeloid Leukemia in Remission, Recurrent Childhood Acute Myeloid Leukemia, Secondary Acute Myeloid Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission, Previously Treated Myelodysplastic Syndrome, Secondary Myelodysplastic Syndrome, Refractory Anemia With Excess Blasts in Transformation, Refractory Anemia With Excess Blasts, Refractory Anemia, De Novo Myelodysplastic Syndrome, Childhood Myelodysplastic Syndrome
06/24
12/25
MoTD, NCT04888741 / 2019-002419-24: Methods of T Cell Depletion Trial

Recruiting
2
400
Europe
Thymoglobulin, ATG, Cyclophosphamide, Cyclosporine, Sirolimus, Mycophenolate Mofetil, MMF
University of Birmingham, IMPACT (funded by NHS Blood & Transplant, Anthony Nolan and Leukaemia UK)
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes, Non Hodgkin Lymphoma, Hodgkin Lymphoma, Multiple Myeloma, Chronic Myelogenous Leukemia, Myelofibrosis
01/26
01/26
NCT00027547: Combination Chemotherapy and Total-Body Irradiation Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia

Completed
1/2
US, Europe
therapeutic allogeneic lymphocytes, cyclosporine, cytarabine, fludarabine phosphate, methotrexate, mycophenolate mofetil, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation, radiation therapy
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia
 
07/04
NCT00365287: Combination Chemotherapy and Total-Body Irradiation Before Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematologic Cancer, Metastatic Breast Cancer, or Kidney Cancer

Completed
1/2
148
NA
anti-thymocyte globulin, cyclophosphamide, cyclosporine, fludarabine phosphate, mycophenolate mofetil, radiation therapy, umbilical cord blood transplantation
Masonic Cancer Center, University of Minnesota, National Cancer Institute (NCI)
Breast Cancer, Kidney Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
12/05
12/05
NCT00054340: Combination Chemotherapy and Antithymocyte Globulin in Reducing Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplantation For Myelodysplastic Syndrome or Myeloproliferative Disorder

Completed
1/2
US
anti-thymocyte globulin, busulfan, cyclophosphamide, cyclosporine, methotrexate, allogeneic bone marrow transplantation, peripheral blood stem cell transplantation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
 
09/06
NCT00085449: Alemtuzumab Plus Fludarabine and Melphalan With or Without Cyclosporine, Mycophenolate Mofetil, and Low-Dose Total-Body Irradiation Therapy Followed by Donor Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer

Withdrawn
1/2
0
US
alemtuzumab, cyclosporine, fludarabine phosphate, melphalan, mycophenolate mofetil, peripheral blood stem cell transplantation, radiation therapy
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI)
Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
01/07
01/07
NCT00002761: Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous Leukemia

Withdrawn
1/2
0
US
filgrastim, recombinant interferon gamma, busulfan, cyclophosphamide, cyclosporine, cytarabine, idarubicin, peripheral blood stem cell transplantation
Columbia University
Leukemia
02/07
10/07
NCT00049634: Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome, Acute Myeloid Leukemia, or Myeloproliferative Disorder

Completed
1/2
30
US
busulfan, cyclophosphamide, cyclosporine, methotrexate, in vitro-treated peripheral blood stem cell transplantation
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
02/07
 
NCT00119340: Fludarabine, Total-Body Irradiation, and Donor Stem Cell Transplant Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Chronic Myelogenous Leukemia

Completed
1/2
75
US
cyclosporine, fludarabine phosphate, mycophenolate mofetil, peripheral blood stem cell transplantation, radiation therapy
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Leukemia
 
11/07
NCT00816413: Donor Stem Cell Transplant, Pentostatin, and Total-Body Irradiation in Treating Patients With Hematological Cancer

Withdrawn
1/2
0
NA
cyclosporine, Gengraf, Neoral, and Sandimmune, mycophenolate mofetil, CellCept, pentostatin, Nipent, cytogenetic analysis, fluorescence in situ hybridization, protein analysis, flow cytometry, immunoenzyme technique, laboratory biomarker analysis, reduced-intensity transplant conditioning procedure, nonmyeloablative allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation (PBSC), total-body irradiation
University of Nebraska, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Myelodysplastic Syndromes, Nonmalignant Neoplasm
02/10
02/10
NCT00609739: Cytosine Arabinoside and Mitoxantrone for Patients With Juvenile Myelomonocytic Leukemia Receiving Repeat Stem Cell Transplantation

Terminated
1/2
1
US
cyclosporine, CSA, cytarabine, Ara-C, filgrastim, G-CSF, methotrexate, MTX, methylprednisolone, Medrol, mitoxantrone hydrochloride, Mitoxantrone, allogeneic bone marrow transplantation, umbilical cord blood transplantation, Cis-Retinoic acid, isotretinoin
Masonic Cancer Center, University of Minnesota
Leukemia
06/10
06/10
NCT00281983: Fludarabine and Cyclophosphamide in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Lymphocytic Leukemia or Waldenstrom's Macroglobulinemia

Completed
1/2
100
Canada, Europe
alemtuzumab, anti-thymocyte globulin, filgrastim, rituximab, therapeutic allogeneic lymphocytes, busulfan, cyclophosphamide, cyclosporine, fludarabine phosphate, methotrexate, mycophenolate mofetil, peripheral blood stem cell transplantation, radiation therapy
German CLL Study Group
Chronic Lymphocytic Leukemia
 
07/10
NCT00002790: Prevention of Graft-Versus-Host Disease in Patients With Hematologic Malignancies Who Are Receiving a Bone Marrow Transplant

Withdrawn
1/2
0
US
cyclosporine, methotrexate, sirolimus
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes
 
 
NCT00245037: Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer

Completed
1/2
147
US
therapeutic allogeneic lymphocytes, busulfan, cyclosporine, fludarabine phosphate, mycophenolate mofetil, peripheral blood stem cell transplantation, Total Body Irradiation (TBI), Granulocyte colony-stimulating factor (G-CSF), Phenytoin, Methotrexate
OHSU Knight Cancer Institute, National Cancer Institute (NCI)
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Precancerous Condition
08/15
08/15
NCT03842696: Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

Recruiting
1/2
49
US
Vorinostat, Blood and Marrow Transplant (BMT), Tacrolimus (or cyclosporine), Methotrexate, Mycophenolate Mofetil (MMF), Cyclophosphamide
University of Michigan Rogel Cancer Center, National Institutes of Health (NIH), National Center for Advancing Translational Sciences (NCATS)
Hematologic Diseases, Acute Leukemia in Remission, Chronic Myelogenous Leukemia - Chronic Phase, Chronic Myelogenous Leukemia, Accelerated Phase, Chronic Myelogenous Leukemia, Blastic Phase, Myelodysplastic Syndromes, Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B Cell Lymphoma, Non Hodgkin Lymphoma, Graft Vs Host Disease, Graft-versus-host-disease
06/25
06/26

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