| cyclosporine / Generic mfg. |
NCT00001626: Comparing Therapies for the Treatment of Severe Aplastic Anemia |
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| Completed | 2 | 33 | US | antithymocyte globulin, cyclophosphamide, cyclosporine | National Heart, Lung, and Blood Institute (NHLBI) | Severe Aplastic Anemia (SAA) | 02/01 | 03/08 | | |
NCT00005935: Mycophenolate Mofetil and Cyclosporine to Treat Relapsing Aplastic Anemia |
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| Completed | 2 | 130 | US | Mycophenolate mofetil, Cyclosporine | National Heart, Lung, and Blood Institute (NHLBI) | Aplastic Anemia | | 03/02 | | |
NCT00031980: Cyclosporine in Treating Patients With Low Blood Counts Caused By Hematologic Cancer |
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| Completed | 2 | 30 | US | cyclosporine | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI) | Anemia, Leukemia, Neutropenia, Thrombocytopenia | 05/05 | 05/05 | | |
NCT00004323: Phase II Study of Bone Marrow Transplantation Using Related Donors in Patients With Aplastic Anemia |
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| Completed | 2 | 10 | US | anti-thymocyte globulin, cyclophosphamide, cyclosporine, mesna, methotrexate, methylprednisolone | National Center for Research Resources (NCRR), University of California, Los Angeles | Aplastic Anemia | | | | |
NCT00061360: Improving Immunosuppressive Treatment for Patients With Severe Aplastic Anemia |
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| Completed | 2 | 77 | US | ATG+Rapamune+cyclosporine, ATG+cyclosporine | National Heart, Lung, and Blood Institute (NHLBI) | Severe Aplastic Anemia | 02/06 | 09/15 | | |
| Completed | 2 | 25 | NA | Cyclophosphamide, fludarabine, cyclosporine, methotrexate, G-CSF | Beth Israel Deaconess Medical Center, Amgen | AML, ALL, CML Chronic Phase, Accelerated Phase, or Blast Crisis, CLL, MDS, RELAPSED NON-HODGKIN'S OR HODGKIN'S LYMPHOMA, APLASTIC ANEMIA, MULTIPLE MYELOMA, MYELOPROLIFERATIVE DISORDER (P Vera, CMML, ET) | 03/06 | | | |
NCT00029380: Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia |
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| Completed | 2 | 30 | US, Canada | Sangstat, Cyclophosphamide, Busulfan, Mycophenolate Mofetil, Cyclosporine, Cord Blood Transplantation | National Heart, Lung, and Blood Institute (NHLBI) | Hematologic Diseases, Anemia, Sickle Cell, Beta-Thalassemia, Hematopoietic Stem Cell Transplantation | 08/06 | 08/06 | | |
NCT00533923: Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders |
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| Completed | 2 | 25 | US | Cyclophosphamide; Fludarabine; Cyclosporin; CAMPATH-1H (Alemtuzumab); GM-CSF, Cytoxan;, Fludara;, Leukine; | Beth Israel Deaconess Medical Center, Bayer | AML, ALL, CLL, Myelodysplastic Syndrome, Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma, Multiple Myeloma, Aplastic Anemia, Myeloproliferative Disorder | 01/07 | 01/07 | | |
NCT00005852: Bone Marrow Transplantation in Treating Patients With Severe Aplastic Anemia or Rejection of Previous Bone Marrow Transplant |
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| Terminated | 2 | | US | anti-thymocyte globulin, filgrastim, muromonab-CD3, cyclophosphamide, cyclosporine, methylprednisolone, allogeneic bone marrow transplantation | H. Lee Moffitt Cancer Center and Research Institute, National Cancer Institute (NCI) | Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes | 07/07 | 07/07 | | |
NCT00065260: Rabbit Antithymocyte Globulin Versus Campath-1H for Treating Severe Aplastic Anemia |
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| Completed | 2 | 54 | US | Campath-1H, Alemtuzumab, r-ATG, Rabbit Anti-Thymoglobulin, CsA, Cyclosporine | National Heart, Lung, and Blood Institute (NHLBI) | Aplastic Anemia | 12/10 | 02/16 | | |
NCT00301834: Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Patients With Hematologic Disorders |
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| Completed | 2 | 35 | US | alemtuzumab, busulfan, cyclosporine, fludarabine phosphate, methotrexate, methylprednisolone, allogeneic bone marrow transplantation, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, umbilical cord blood transplantation | University of California, San Francisco, National Cancer Institute (NCI) | Congenital Amegakaryocytic Thrombocytopenia, Diamond-blackfan Anemia, Leukemia, Myelodysplastic Syndromes, Severe Congenital Neutropenia | 09/11 | 09/11 | | |
| Completed | 2 | 35 | Europe, RoW | rabbit antithymocyte globulin, Thymoglobuline | European Society for Blood and Marrow Transplantation, Genzyme, a Sanofi Company | Aplastic Anemia | 10/11 | 02/13 | | |
NCT01530555: Prospective Phase II Study of Rabbit Antithymocyte Globulin (ATG, Thymoglobuline®, Genzyme) With Ciclosporin for Patients With Acquired Aplastic Anaemia |
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| Completed | 2 | 35 | US, RoW | Rabbit ATG, Thymoglobuline (Genzyme) | King Faisal Specialist Hospital & Research Center | Acquired Aplastic Anaemia | 07/13 | 07/13 | | |
| Completed | 2 | 47 | US | Alemtuzumab (Campath ), Cyclosporine | National Heart, Lung, and Blood Institute (NHLBI) | Severe Aplastic Anemia, Refractory, Severe Aplastic Anemia, Relapse | 04/14 | 10/18 | | |
NCT00944749: Horse ATG/CsA in Aplastic Anemia Patients Unresponsive to or With a Suboptimal Response to Rabbit ATG/CsA Treatment |
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| Completed | 2 | 23 | US | h-ATG (ATGAM ), Cyclosporine (Gengraf ) | National Heart, Lung, and Blood Institute (NHLBI) | Anemia, Aplastic, Anemia, Hypoplastic | 12/15 | 12/16 | | |
NCT00260689: Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia |
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| Completed | 2 | 136 | US | Anti-thymocyte globulin (rabbit), Anti-thymocyte globulin (horse), Cyclosporine, Alemtuzumab, Campath | National Heart, Lung, and Blood Institute (NHLBI) | Immunosuppresion, Thrombocytopenia, Pancytopenia, Neutropenia | 05/16 | 05/16 | | |
NCT02203396: A Single-Arm Phase 2 Study With Optimized Standard Protocol for Severe Aplastic Anemia |
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| Unknown status | 2 | 40 | RoW | rabbit ATG, Cyclosporine, Levamisole, rATG, CSA, LMS | Yizhou Zheng | Aplastic Anemia | 09/16 | 09/17 | | |
NCT00987480: Hematopoietic Stem Cell Transplantation for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine |
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| Completed | 2 | 45 | US | Busulfan, fludarabine, & cyclophosphamide with immunosuppression with ATG and cyclosporine., CliniMACS device | Memorial Sloan Kettering Cancer Center, Boston Children's Hospital, Children's Hospital Medical Center, Cincinnati, Children's Hospital and Health System Foundation, Wisconsin, Rockefeller University, Fred Hutchinson Cancer Center | Aplastic Anemia, Leukemia, Myelodysplastic Syndrome | 07/17 | 07/17 | | |
NCT00309842: Myeloablative Umbilical Cord Blood Transplantation in Hematological Diseases |
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| Completed | 2 | 213 | US | filgrastim, G-CSF, cyclophosphamide, Cytoxan, cyclosporine, CSA, fludarabine phosphate, Fludara, mycophenolate mofetil, MMF, umbilical cord blood transplantation, UCBT, total-body irradiation, TBI | Masonic Cancer Center, University of Minnesota | Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, Chronic Myelogenous Leukemia, Myelofibrosis, MDS, Refractory Anemia, Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, Non-Hodgkin's Lymphoma, Leukemia, Lymphoma, Multiple Myeloma, Myelodysplastic Syndromes | 07/19 | 11/19 | | |
| Completed | 2 | 54 | Europe, RoW | eltrombopag, ETB115, Cyclosporine | Novartis Pharmaceuticals | Severe Aplastic Anemia | 11/20 | 05/22 | | |
ChiCTR2100043229: A Single-Center, Single-Arm, Phase II Clinical Study of the Efficacy and Safety of Cyclosporine Combined with Eltrombopag Olamine Tablets in Treatment-Naive Transfusion-Dependent Non-Severe Aplastic Anemia |
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| Recruiting | 2 | 61 | | Elrombopag combined with Cyclosporine | Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences; Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Beijing Novartis Pharma Co., Ltd. | Aplastic anemia | | | | |
NCT04304820: Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA) |
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| Recruiting | 2 | 39 | US | Eltrombopag, Cyclosporine, Horse-Anti-thymocyte-Globulin | National Heart, Lung, and Blood Institute (NHLBI) | Severe Aplastic Anemia | 03/25 | 05/28 | | |
NCT05797623: Safety and Effectiveness of Trappa Ethanolamine Tablets Combined With Ciclosporin in the Treatment of Primary Treatment of Non-severe Aplastic Anemia |
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| Recruiting | 2 | 78 | RoW | Trappa ethanolamine tablets ; ciclosporin, Placebo ; ciclosporin | Jiangsu HengRui Medicine Co., Ltd. | Non-severe Aplastic Anemia | 05/24 | 05/25 | | |
NCT06004752: Efficacy and Safety of CsA+AVA in the Treatment of NSAA in the Elderly |
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| Recruiting | 2 | 30 | RoW | Ciclosporin, Avatrombopag | Peking Union Medical College Hospital | Aplastic Anemia | 08/24 | 08/25 | | |
NCT00357565: Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia |
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| Active, not recruiting | 2 | 33 | US | filgrastim, G-CSF, busulfan, Busulfex, cyclosporine, CSA, fludarabine phosphate, Fludara, melphalan, Alkeran, mycophenolate mofetil, MMF, umbilical cord blood transplantation | Masonic Cancer Center, University of Minnesota | Leukemia, Myelodysplastic Syndromes, Childhood Acute Myeloid Leukemia in Remission, Recurrent Childhood Acute Myeloid Leukemia, Secondary Acute Myeloid Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission, Previously Treated Myelodysplastic Syndrome, Secondary Myelodysplastic Syndrome, Refractory Anemia With Excess Blasts in Transformation, Refractory Anemia With Excess Blasts, Refractory Anemia, De Novo Myelodysplastic Syndrome, Childhood Myelodysplastic Syndrome | 06/24 | 12/25 | | |
NCT00005898: Phase I/II Study of Total Body Irradiation, Cyclophosphamide, and Fludarabine Followed by Alternate Donor Hematopoietic Cell Transplantation in Patients With Fanconi's Anemia |
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| Completed | 1/2 | 30 | US | anti-thymocyte globulin, cyclophosphamide, cyclosporine, filgrastim, fludarabine, methylprednisolone | University of Minnesota | Fanconi's Anemia | | | | |
NCT00004485: Bone Marrow Transplantation in Treating Children With Sickle Cell Disease |
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| Completed | 1/2 | 50 | US | cyclosporine, fludarabine, mycophenolate mofetil, Bone Marrow Transplantation | Fred Hutchinson Cancer Center | Sickle Cell Anemia | 08/07 | | | |
NCT00319878: Sirolimus and Cyclosporine for Treatment-Resistant Aplastic Anemia |
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| Unknown status | 1/2 | 52 | US | Sirolimus, Cyclosporine | Office of Rare Diseases (ORD), Rare Diseases Clinical Research Network | Anemia, Aplastic | 07/09 | 12/09 | | |
NCT01193283: Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia |
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| Completed | 1/2 | 22 | US | Cyclophosphamide, Cytoxan, Cyclosporine, Gengraf, Neoral, Sandimmune | National Heart, Lung, and Blood Institute (NHLBI) | Aplastic Anemia, Neutropenia, Pancytopenia, Severe Aplastic Anemia | 09/14 | 09/14 | | |
NCT01623167: Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia |
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| Recruiting | 1/2 | 207 | US | Cohort 1: hATG, CsA, EPAG Day 14 to Month 6, Horse Antithymocyte Globulin, Cyclosporine, Promacta, Eltrombopag, Cohort 2: hATG, CsA, EPAG Day 14 to Month 3, Cohort 3: hATG, CsA (dose reduced), EPAG day 1 to month 6, Extension Cohort, Horse Antithymocyte Globulin (hATG), Cyclosporine (CsA), Promacta, Eltrombopag (EPAG) | National Heart, Lung, and Blood Institute (NHLBI), Novartis | Severe Aplastic Anemia | 01/18 | 01/29 | | |
NCT00630253: Cytoxan, Fludara, and Antithymocyte Globulin Conditioning Followed By Stem Cell Transplant in Treating Fanconi Anemia |
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| Completed | 1/2 | 31 | US | Anti-Thymocyte Globulin, ATG, Cyclophosphamide, Cytoxan, Fludarabine, Fludara, Hematopoietic Stem Cell Transplantation, HSCT, Methylprednisolone, MP, Filgrastim, G-CSF, Cyclosporine, CSA, Mycophenolate Mofetil, MMF | Masonic Cancer Center, University of Minnesota | Fanconi Anemia | 10/20 | 10/20 | | |
