| cyclosporine / Generic mfg. |
ChiCTR2100044033: A prospective randomized controlled trial of the clinical program of different doses of antithymoglobulin combined with cyclosporine in patients with blood transfusion dependent non-severe aplastic anemia |
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| Recruiting | 4 | 50 | | low-dose ;high-dose | Jiangsu Province Hospital; Jiangsu Province Hospital, Self support | Blood transfusion dependent non-severe aplastic anemia | | | | |
NCT06009497: Romiplostim in Combination With CsA vs. CsA in the Treatment of Newly Diagnosed NSAA |
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| Not yet recruiting | 4 | 44 | RoW | Romiplostim, Ciclosporin | Peking Union Medical College Hospital | Non Severe Aplastic Anemia | 12/24 | 12/25 | | |
| Recruiting | 4 | 450 | | ciclosporin ;CsA combined with hematopoietic therapy ;Intensive immunosuppressive therapy ;Hematopoietic stem cell transplantation ;Promoting hematopoiesis therapy | Jiangsu Province Hospital; The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital, Self support | aplastic anemia | | | | |
NCT05996393: CsA+ATG+AVA vs. CsA+AVA for the Treatment of Newly-diagnosed SAA in the Elderly |
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| Not yet recruiting | 4 | 60 | RoW | Ciclosporin, Avatrombopag, Anti-Human Thymocyte Immunoglobulin, Rabbit | Peking Union Medical College Hospital | Aplastic Anemia | 10/25 | 10/26 | | |
ChiCTR2000041485: Efficacy of Danazol after no response to cyclosporin in transfusion independent aplastic anemia: a prospective study |
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| Recruiting | 4 | 228 | | Cyclosporine combined with danazol ;Cyclosporine | Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences, self-raised | transfusion independent aplastic anemia | | | | |
ChiCTR2200056659: Allopurinol in the treatment of cyclosporine-induced hyperuricemia in children with aplastic anemia：a randomized controlled study |
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| Not yet recruiting | 4 | 40 | | Receive allopurinol tablets ;Receive placebo | The Seventh Affiliated Hospital, Sun Yat-sen University; The Seventh Affiliated Hospital, Sun Yat-sen University, The Seventh Affiliated Hospital, Sun Yat-sen University Clinical Research 735 Program” | hyperuricemia | | | | |
NCT05057468: Second-line Treatment of Primary Autoimmune Hemolytic Anemia |
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| Recruiting | 3 | 30 | RoW | Cyclosporine, Rituximab | Assiut University | Primary Autoimmune Hemolytic Anemia | 11/22 | 11/22 | | |
TransIT, NCT05600426: A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (, BMT CTN 2202) |
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| Recruiting | 3 | 234 | US | cyclosporine, Matched Unrelated Donor Hematopoetic Stem Cell Transplant, horse anti-thymocyte globulin (ATG), ATGAM, rabbit anti-thymocyte globulin (ATG), thymoglobulin, Methotrexate, Fludarabine, Cyclophosphamide, low-dose total body irradiation (TBI), Immunosuppressive Therapy (IST) | Boston Children's Hospital, Center for International Blood and Marrow Transplant Research, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI), North American Pediatric Aplastic Anemia Consortium, Pediatric Transplantation and Cellular Therapy Consortium, Blood and Marrow Transplant Clinical Trials Network | Severe Aplastic Anemia | 12/29 | 12/29 | | |
ChiCTR1900028153: A Multi-centre Clinical Study of Pai-Neng-Da Capsule in the Treatment of Chronic Aplastic Anemia |
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| Completed | 2/3 | 100 | | Pai-Neng-Da Capsule + Testosterone undecanoate capsule (80mg / day), cyclosporine capsule (3-7mg / kg. D) ;Testosterone undecanoate capsule (80mg / day), cyclosporine capsule (3-7mg / kg. D) | Jinhua people's Hospital; None, Project of Zhejiang Province TCM Science Research Fund in 2015 | Aplstic Anemia | | | | |
ChiCTR2100043229: A Single-Center, Single-Arm, Phase II Clinical Study of the Efficacy and Safety of Cyclosporine Combined with Eltrombopag Olamine Tablets in Treatment-Naive Transfusion-Dependent Non-Severe Aplastic Anemia |
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| Recruiting | 2 | 61 | | Elrombopag combined with Cyclosporine | Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences; Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Beijing Novartis Pharma Co., Ltd. | Aplastic anemia | | | | |
NCT04304820: Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA) |
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| Recruiting | 2 | 39 | US | Eltrombopag, Cyclosporine, Horse-Anti-thymocyte-Globulin | National Heart, Lung, and Blood Institute (NHLBI) | Severe Aplastic Anemia | 03/25 | 05/28 | | |
NCT05797623: Safety and Effectiveness of Trappa Ethanolamine Tablets Combined With Ciclosporin in the Treatment of Primary Treatment of Non-severe Aplastic Anemia |
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| Recruiting | 2 | 78 | RoW | Trappa ethanolamine tablets ; ciclosporin, Placebo ; ciclosporin | Jiangsu HengRui Medicine Co., Ltd. | Non-severe Aplastic Anemia | 05/24 | 05/25 | | |
NCT06004752: Efficacy and Safety of CsA+AVA in the Treatment of NSAA in the Elderly |
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| Recruiting | 2 | 30 | RoW | Ciclosporin, Avatrombopag | Peking Union Medical College Hospital | Aplastic Anemia | 08/24 | 08/25 | | |
NCT00357565: Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia |
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| Active, not recruiting | 2 | 33 | US | filgrastim, G-CSF, busulfan, Busulfex, cyclosporine, CSA, fludarabine phosphate, Fludara, melphalan, Alkeran, mycophenolate mofetil, MMF, umbilical cord blood transplantation | Masonic Cancer Center, University of Minnesota | Leukemia, Myelodysplastic Syndromes, Childhood Acute Myeloid Leukemia in Remission, Recurrent Childhood Acute Myeloid Leukemia, Secondary Acute Myeloid Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission, Previously Treated Myelodysplastic Syndrome, Secondary Myelodysplastic Syndrome, Refractory Anemia With Excess Blasts in Transformation, Refractory Anemia With Excess Blasts, Refractory Anemia, De Novo Myelodysplastic Syndrome, Childhood Myelodysplastic Syndrome | 06/24 | 12/25 | | |
NCT01623167: Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia |
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| Recruiting | 1/2 | 207 | US | Cohort 1: hATG, CsA, EPAG Day 14 to Month 6, Horse Antithymocyte Globulin, Cyclosporine, Promacta, Eltrombopag, Cohort 2: hATG, CsA, EPAG Day 14 to Month 3, Cohort 3: hATG, CsA (dose reduced), EPAG day 1 to month 6, Extension Cohort, Horse Antithymocyte Globulin (hATG), Cyclosporine (CsA), Promacta, Eltrombopag (EPAG) | National Heart, Lung, and Blood Institute (NHLBI), Novartis | Severe Aplastic Anemia | 01/18 | 01/29 | | |
ChiCTR-IPR-14005720: A single center, Randomized controlled, opened clinical reserch for evaluating the effectiveness of recombinant human thrombopoietin combined with immunosuppressive therapy in the treatment of newly diagnosed acquired severe aplastic anemia |
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| Recruiting | 1 | 172 | | rTPO ;Ciclosporine | Blood Diseases Hospital, Chinese Academy of Medical Sciences; Level of the institution：, Nil | severe aplastic anemia | | | | |
ChiCTR-IOR-17011653: A prospective, randomized, controlled clinical study of non transfusion dependent non severe aplastic anemia treated with cyclosporine, androgen and levamisole hydrochloride |
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| Not yet recruiting | N/A | 248 | | none ;levamisole hydrochloride | The First affiliated Hospital of Zhejiang Chinese Medical University; The First affiliated Hospital of Zhejiang Chinese Medical University, raise independently | Aplastic anemia | | | | |
ChiCTR1900023476: Multicenter, prospective and open clinical study for rapamycin in the treatment of autoimmune hemolytic anemia |
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| Not yet recruiting | N/A | 80 | | glucocorticoid ;glucocorticoid ＆ Ciclosporin ;glucocorticoid ＆ rapamycin ;rapamycin | Tianjin Medical University General Hospital; Tianjin Medical University General Hospital, Clinical Founding | Autoimmune | | | | |
ChiCTR-IOR-16008738: A single center, randomized, controlled, opened label study for evaluating Cyclosporin alone or combined with Stanozolol in the treatment of aplastic anemia |
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| Recruiting | N/A | 200 | | Cyclosporin ;Cyclosporin and Stanozolol | The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University, The First Affiliated Hospital of Zhengzhou University Dr.Scientific Research Foundation | aplastic anemia | | | | |
ChiCTR1800019487: A clinical study for different infusion methods of mesenchymal stem cells in the treatment of aplastic anemia |
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| Recruiting | N/A | 60 | | Treatment regimen of ATG combined with cyclosporin immunosuppression ;MSCs+Treatment regimen of ATG combined with cyclosporin immunosuppression | Jiangmen Central Hospital; Jiangmen Central Hospital, Wu Jieping medical association foundation | Aplastic anemia | | | | |
ChiCTR2000038744: To explore the intervention effect of Xiaoyu Xiezhuo Yin on chronic cyclosporin nephropathy in patients with aplastic anemia based on autophagy and ACE2-Ang(1-7)-Mas axis |
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| Not yet recruiting | N/A | 60 | | none ;none ;Conventional treatment ;Conventional treatment+traditional Chinese medicine | The First Affiliated Hospital of ZheJiang Chinese Medical University; The First Affiliated Hospital of ZheJiang Chinese Medical University, Self-funded | Chronic cyclosporine nephropathy | | | | |
ChiCTR1900027553: Clinical therapies for patients in subtypes of non-severe aplastic anemia |
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| Not yet recruiting | N/A | 490 | | Cyclosporine ;Cyclosporine ;Cyclosporine+Danazol ;CSA+TPO+G-CSF | Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences; Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Tianjin Major Disease Prevention and Control Science and Technology Project | non-severe aplastic anemia | | | | |
NCT05571332: Efficacy and Safety of Avatrombopag Combined With IST for the Treatment of HAAA and SAA With Abnormal Liver Function |
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| Recruiting | N/A | 39 | RoW | Avatrombopag 20 MG Oral Tablet, porcine ATG, Cyclosporine(CsA) | Institute of Hematology & Blood Diseases Hospital | Aplastic Anemia | 12/23 | 06/24 | | |
NCT02845596: Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia |
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| Active, not recruiting | N/A | 40 | US | cyclosporine, Matched Unrelated Donor Hematopoietic Stem Cell Transplant, horse anti-thymocyte globulin (ATG), ATGAM, rabbit anti-thymocyte globulin (ATG), Thymoglobulin, methotrexate, fludarabine, cyclophosphamide, low-dose total body irradiation (TBI), Immunosuppressive Therapy (IST) | Michael Pulsipher, MD | Severe Aplastic Anemia | 04/24 | 04/24 | | |
